Home Deuterated Building Blocks 1665-48-1
1665-48-1,MFCD00867700
Catalog No.:AA001WP7

1665-48-1 | 5-(3,5-dimethylphenoxymethyl)-1,3-oxazolidin-2-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
98%
in stock  
$6.00   $4.00
- +
1g
95%
in stock  
$16.00   $12.00
- +
5g
95%
in stock  
$45.00   $32.00
- +
25g
95%
in stock  
$143.00   $100.00
- +
100g
98%
in stock  
$272.00   $191.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001WP7
Chemical Name:
5-(3,5-dimethylphenoxymethyl)-1,3-oxazolidin-2-one
CAS Number:
1665-48-1
Molecular Formula:
C12H15NO3
Molecular Weight:
221.2524
MDL Number:
MFCD00867700
SMILES:
O=C1NCC(O1)COc1cc(C)cc(c1)C
Properties
Properties
 
BP:
453.6°C at 760 mmHg  
Form:
Solid  
MP:
121-123 °C  
Refractive Index:
1.5200 (estimate)  
Solubility:
DMSO: ≥2mg/mL (warmed to 60 °C)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
247  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.2  

Upstream Synthesis Route

[1]Patent:US2007/185177,2007,A1,.Locationinpatent:Page/Pagecolumn8

[1]Patent:US6562980,2003,B1,

[2]Patent:WO2012/104139,2012,A1,.Locationinpatent:Page/Pagecolumn14-15

[1]Patent:WO2008/6096,2008,A1,.Locationinpatent:Page/Pagecolumn2-4

[2]Patent:WO2008/6096,2008,A1,.Locationinpatent:Page/Pagecolumn2-4

[3]Patent:WO2008/6096,2008,A1,.Locationinpatent:Page/Pagecolumn2-6

[4]Patent:WO2008/6096,2008,A1,.Locationinpatent:Page/Pagecolumn2-6

[1]Patent:US2009/270469,2009,A1,.Locationinpatent:Page/Pagecolumn28

[2]JournaloftheAmericanChemicalSociety,1960,vol.82,p.1166-1171

[3]Patent:US2011/306773,2011,A1,.Locationinpatent:Page/Pagecolumn2

[1]JournalofMedicinalChemistry,1995,vol.38,#20,p.3983-3994

Downstream Synthesis Route

[1]Patent:US2009/270469,2009,A1.Locationinpatent:Page/Pagecolumn28

[2]JournaloftheAmericanChemicalSociety,1960,vol.82,p.1166-1171

[3]Patent:US2011/306773,2011,A1.Locationinpatent:Page/Pagecolumn2

[1]CurrentPatentAssignee:YUNG-SHINPHARMAIND.,CO.LTD.;UNGSHINPHARM;YONGXINPHARMACEUTICALINDUSTR-US6562980,2003,B1

[2]CurrentPatentAssignee:AZIENDECHIMICHERIUNITEANGELINIFRANCESCO-A.C.R.A.F.-S.P.A.ENUNCIABILEANCHEA.C.R.A.F.S.P.A.,ACRAFS.P.A.,ANGELINIS.P.A.-WO2012/104139,2012,A1Locationinpatent:Page/Pagecolumn14-15

[1]CurrentPatentAssignee:FRESENIUSSE&CO.KGAA-US2007/185177,2007,A1Locationinpatent:Page/Pagecolumn8

[1]CrystalGrowthandDesign,2018,vol.18,p.6627-6639

Literature

Title: Metaxalone estimation in biological matrix using high-throughput LC-MS/MS bioanalytical method.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120801

Title: Muscle relaxants for pain management in rheumatoid arthritis.

Journal: The Cochrane database of systematic reviews 20120118

Title: New Stability-Indicating RP-HPLC Method for Determination of Diclofenac Potassium and Metaxalone from their Combined Dosage Form.

Journal: Scientia pharmaceutica 20120101

Title: Development of a Stability-Indicating RP-UPLC Method for Rapid Determination of Metaxalone and its Degradation Products in Solid Oral Dosage Form.

Journal: Scientia pharmaceutica 20120101

Title: In Vitro and In Vivo Study of Poly(ethylene glycol) Conjugated Ibuprofen to Extend the Duration of Action.

Journal: Scientia pharmaceutica 20110101

Title: Fibrodysplasia ossificans progressiva: clinical and genetic aspects.

Journal: Orphanet journal of rare diseases 20110101

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Pharmaceutical factories as a source of drugs in water.

Journal: Environmental health perspectives 20100901

Title: Pharmaceutical formulation facilities as sources of opioids and other pharmaceuticals to wastewater treatment plant effluents.

Journal: Environmental science & technology 20100701

Title: Pharmacologic management of chronic pain.

Journal: The Korean journal of pain 20100601

Title: Adult metaxalone ingestions reported to Texas poison control centers, 2000-2006.

Journal: Human & experimental toxicology 20100101

Title: Pediatric metaxalone ingestions reported to Texas poison control centers, 2000-2007.

Journal: Pediatric emergency care 20100101

Title: Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tools, and possible solutions.

Journal: Clinical interventions in aging 20100101

Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Fibromyalgia and myofascial pain syndrome-a dilemma.

Journal: Indian journal of anaesthesia 20091001

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Choosing a skeletal muscle relaxant.

Journal: American family physician 20080801

Title: HPLC-ESI-MS/MS validated method for simultaneous quantification of zopiclone and its metabolites, N-desmethyl zopiclone and zopiclone-N-oxide in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080315

Title: Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults.

Journal: PloS one 20080101

Title: High throughput LC-MS/MS method for simultaneous quantification of lamivudine, stavudine and nevirapine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

Title: Synthesis of poly(ethylene glycol)-metaxalone conjugates and study of its controlled release in vitro.

Journal: International journal of pharmaceutics 20070306

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Quantification of metaxalone in human plasma by liquid chromatography coupled to tandem mass spectrometry.

Journal: Journal of analytical toxicology 20060501

Title: A fatality involving metaxalone.

Journal: Forensic science international 20050510

Title: Postmortem distribution of tramadol, amitriptyline, and their metabolites in a suicidal overdose.

Journal: Journal of analytical toxicology 20050101

Title: Auditory hallucinations elicited by combined meclizine and metaxalone use at bedtime.

Journal: The Annals of pharmacotherapy 20041101

Title: Metaxalone (Skelaxin)-related death.

Journal: Journal of analytical toxicology 20040901

Title: Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone.

Journal: Clinical therapeutics 20040901

Title: Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.

Journal: Journal of pain and symptom management 20040801

Title: Comparison of the dissolution of metaxalone tablets (Skelaxin) using USP Apparatus 2 and 3.

Journal: AAPS PharmSciTech 20040301

Title: Polydrug fatality involving metaxalone.

Journal: Journal of forensic sciences 20030301

Title: Centrally acting oral skeletal muscle relaxants.

Journal: American journal of hospital pharmacy 19801001

Title: http://en.wikipedia.org/wiki/Metaxalone

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Tags:1665-48-1 Molecular Formula|1665-48-1 MDL|1665-48-1 SMILES|1665-48-1 5-(3,5-dimethylphenoxymethyl)-1,3-oxazolidin-2-one