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Journal: Toxicology and applied pharmacology 20140115
Title: Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20121201
Title: The vascular-disrupting agent, combretastatin-A4-phosphate, enhances neurogenic vasoconstriction in rat small arteries.
Journal: European journal of pharmacology 20121115
Title: Spatiotemporally controlled co-delivery of anti-vasculature agent and cytotoxic drug by octreotide-modified stealth liposomes.
Journal: Pharmaceutical research 20121001
Title: The vascular targeting agent Combretastatin-A4 directly induces autophagy in adenocarcinoma-derived colon cancer cells.
Journal: Biochemical pharmacology 20120901
Title: Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.
Journal: Molecular nutrition & food research 20120901
Title: Fluorescence lifetime imaging of E-combretastatin uptake and distribution in live mammalian cells.
Journal: European journal of cancer (Oxford, England : 1990) 20120801
Title: In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4.
Journal: European journal of medicinal chemistry 20120801
Title: Colon tumor growth and antivascular treatment in mice: complementary assessment with MR elastography and diffusion-weighted MR imaging.
Journal: Radiology 20120801
Title: Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
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Title: High-sensitivity in vivo imaging for tumors using a spectral up-conversion nanoparticle NaYF4: Yb3+, Er3+ in cooperation with a microtubulin inhibitor.
Journal: Nanoscale 20120707
Title: Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer.
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Title: Pharmacokinetics, excretion, and distribution of combretastatin A4 phosphate in rats.
Journal: Die Pharmazie 20120601
Title: Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cells.
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Title: Discovery of small molecule inhibitors that interact with γ-tubulin.
Journal: Chemical biology & drug design 20120501
Title: Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
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Title: Dehydrative fragmentation of 5-hydroxyalkyl-1H-tetrazoles: a mild route to alkylidenecarbenes.
Journal: Organic letters 20120316
Title: Diffusion-weighted MR imaging allows monitoring the effect of combretastatin A4 phosphate on rabbit implanted VX2 tumor model: 12-day dynamic results.
Journal: European journal of radiology 20120301
Title: Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents.
Journal: Bioorganic & medicinal chemistry 20120115
Title: Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.
Journal: Journal of medicinal chemistry 20120112
Title: Targeted delivery of a combination therapy consisting of combretastatin A4 and low-dose doxorubicin against tumor neovasculature.
Journal: Nanomedicine : nanotechnology, biology, and medicine 20120101
Title: Phase Ib trial of radiotherapy in combination with combretastatin-A4-phosphate in patients with non-small-cell lung cancer, prostate adenocarcinoma, and squamous cell carcinoma of the head and neck.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20120101
Title: Comparison of two vascular-disrupting agents at a clinically relevant dose in rodent liver tumors with multiparametric magnetic resonance imaging biomarkers.
Journal: Anti-cancer drugs 20120101
Title: c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.
Journal: Anti-cancer drugs 20120101
Title: Vascular disrupting agent drug classes differ in effects on the cytoskeleton.
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Title: [Liposome formulations of combretastatin A4 and 4-arylcoumarin analog prodrugs: antitumor effect in the mouse model of breast cancer].
Journal: Biomeditsinskaia khimiia 20120101
Title: 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2.
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Title: Patterning cells and shear flow conditions: convenient observation of endothelial cell remoulding, enhanced production of angiogenesis factors and drug response.
Journal: Lab on a chip 20111221
Title: Endostar enhances the antineoplastic effects of combretastatin A4 phosphate in an osteosarcoma xenograft.
Journal: Cancer letters 20111215
Title: Vascular effects dominate solid tumor response to treatment with combretastatin A-4-phosphate.
Journal: International journal of cancer 20111015
Title: The metabolic fate of isocombretastatin A-4 in human liver microsomes: identification, synthesis and biological evaluation of metabolites.
Journal: ChemMedChem 20111004
Title: Design, synthesis, and cytotoxicity of novel 3-arylidenones derived from alicyclic ketones.
Journal: Chemical biology & drug design 20111001
Title: Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
Journal: Journal of medicinal chemistry 20110908
Title: Synthesis and structure-activity relationships of constrained heterocyclic analogues of combretastatin A4.
Journal: ChemMedChem 20110905
Title: Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to vascular targeting agents.
Journal: Medical engineering & physics 20110901
Title: Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110901
Title: Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI.
Journal: Methods (San Diego, Calif.) 20110801
Title: Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.
Journal: Journal of medicinal chemistry 20110728
Title: Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1.
Journal: Journal of natural products 20110722
Title: Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Journal: Journal of medicinal chemistry 20110714
Title: A novel class of trans-methylpyrazoline analogs of combretastatins: synthesis and in-vitro biological testing.
Journal: European journal of medicinal chemistry 20110701
Title: A pharmacokinetic and safety study of single dose intravenous combretastatin A4 phosphate in Chinese patients with refractory solid tumours.
Journal: British journal of clinical pharmacology 20110601
Title: In vivo near-infrared spectroscopy and magnetic resonance imaging monitoring of tumor response to combretastatin A-4-phosphate correlated with therapeutic outcome.
Journal: International journal of radiation oncology, biology, physics 20110601
Title: Imidazolone-amide bridges and their effects on tubulin polymerization in cis-locked vinylogous combretastatin-A4 analogues: synthesis and biological evaluation.
Journal: Bioorganic & medicinal chemistry 20110601
Title: Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins. Part 2.
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Title: TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice.
Journal: The Journal of clinical investigation 20110502
Title: 4,5-Diaryl-3-aminopyrazole derivatives as analogs of Combretastatin A-4: synthesis and biological evaluation.
Journal: Archiv der Pharmazie 20110501
Title: BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted ß-lactam analogue in human cancer cells.
Journal: International journal of molecular medicine 20110501
Title: Design and synthesis of novel enhanced water soluble hydroxyethyl analogs of combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20110401
Title: Acetyl analogs of combretastatin A-4: synthesis and biological studies.
Journal: Bioorganic & medicinal chemistry 20110401
Title: Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d]imidazol)-7-sulfonamide analogs of combretastatin A-4.
Journal: Journal of Asian natural products research 20110401
Title: Enhanced anti-tumor activity by the combination of TRAIL/Apo-2L and combretastatin A-4 against human colon cancer cells via induction of apoptosis in vitro and in vivo.
Journal: Cancer letters 20110301
Title: Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system.
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Title: Support of a free radical mechanism for enhanced antitumor efficacy of the microtubule disruptor OXi4503.
Journal: Microvascular research 20110101
Title: Combretastatin-induced hypertension and the consequences for its combination with other therapies.
Journal: Vascular pharmacology 20110101
Title: Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues.
Journal: European journal of medicinal chemistry 20110101
Title: Developments of combretastatin A-4 derivatives as anticancer agents.
Journal: Current medicinal chemistry 20110101
Title: Stable combretastatin A-4 analogues with sub-nanomolar efficacy against chemoresistant HT-29 cells.
Journal: International journal of clinical pharmacology and therapeutics 20110101
Title: Computational modeling of tumor response to vascular-targeting therapies--part I: validation.
Journal: Computational and mathematical methods in medicine 20110101
Title: Biological potential and structure-activity relationships of most recently developed vascular disrupting agents: an overview of new derivatives of natural combretastatin a-4.
Journal: Current medicinal chemistry 20110101
Title: Combretastatin A4 phosphate induces programmed cell death in vascular endothelial cells.
Journal: Oncology research 20110101
Title: Multifunctional dendrimer/combretastatin A4 inclusion complexes enable in vitro targeted cancer therapy.
Journal: International journal of nanomedicine 20110101
Title: Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
Journal: Journal of medicinal chemistry 20101223
Title: Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.
Journal: European journal of medicinal chemistry 20101201
Title: Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.
Journal: Molecular cancer therapeutics 20101201
Title: Synthesis of antimitotic polyalkoxyphenyl derivatives of combretastatin using plant allylpolyalkoxybenzenes.
Journal: Journal of natural products 20101129
Title: Self-assembled core-shell vascular-targeted nanocapsules for temporal antivasculature and anticancer activities.
Journal: Small (Weinheim an der Bergstrasse, Germany) 20101122
Title: Effects of a combretastatin A4 analogous chalcone and its Pt-complex on cancer cells: A comparative study of uptake, cell cycle and damage to cellular compartments.
Journal: Biochemical pharmacology 20101115
Title: The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.
Journal: The Journal of pharmacology and experimental therapeutics 20101101
Title: Non-invasive imaging of combretastatin activity in two tumor models: Association with invasive estimates.
Journal: Acta oncologica (Stockholm, Sweden) 20101001
Title: 4-(3-Halo/amino-4,5-dimethoxyphenyl)-5-aryloxazoles and -N-methylimidazoles that are cytotoxic against combretastatin A resistant tumor cells and vascular disrupting in a cisplatin resistant germ cell tumor model.
Journal: Journal of medicinal chemistry 20100923
Title: 1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents.
Journal: Bioorganic & medicinal chemistry 20100915
Title: Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.
Journal: Journal of medicinal chemistry 20100909
Title: Structure-activity relationships of indole compounds derived from combretastatin A4: synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents.
Journal: European journal of medicinal chemistry 20100901
Title: Targeted polymeric micelle system for delivery of combretastatin A4 to tumor vasculature in vitro.
Journal: Pharmaceutical research 20100901
Title: A nanocapsular combinatorial sequential drug delivery system for antiangiogenesis and anticancer activities.
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Title: Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4.
Journal: European journal of medicinal chemistry 20100901
Title: [Progress in the study of tubulin inhibitors].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100901
Title: Evaluation of 5-hydroxy-2,3-diaryl (substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anti angiogenic and anticancer agents.
Journal: Investigational new drugs 20100801
Title: Novel combretastatin A-4 derivative XN0502 induces cell cycle arrest and apoptosis in A549 cells.
Journal: Investigational new drugs 20100801
Title: Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model.
Journal: British journal of pharmacology 20100801
Title: Combretastatin A4 phosphate: a novel vascular disrupting agent.
Journal: Future oncology (London, England) 20100801
Title: Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100701
Title: Binding conformations and QSAR of CA-4 analogs as tubulin inhibitors.
Journal: Journal of enzyme inhibition and medicinal chemistry 20100601
Title: [New strategies for NSCLC: is inhibition of tumour vasculature useful].
Journal: Pneumologie (Stuttgart, Germany) 20100601
Title: Highly chemo- and stereoselective palladium-catalyzed transfer semihydrogenation of internal alkynes affording cis-alkenes.
Journal: The Journal of organic chemistry 20100507
Title: Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.
Journal: European journal of medicinal chemistry 20100501
Title: Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae.
Journal: Bioorganic & medicinal chemistry letters 20100501
Title: A Phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin, and paclitaxel in patients with advanced cancer.
Journal: British journal of cancer 20100427
Title: Design and in vitro evaluation of branched peptide conjugates: turning nonspecific cytotoxic drugs into tumor-selective agents.
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Title: Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.
Journal: Journal of enzyme inhibition and medicinal chemistry 20100401
Title: An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins.
Journal: Journal of natural products 20100326
Title: Targeted delivery of RGD-modified liposomes encapsulating both combretastatin A-4 and doxorubicin for tumor therapy: in vitro and in vivo studies.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100301
Title: Oxazole-bridged combretastatin A analogues with improved anticancer properties.
Journal: ChemMedChem 20100301
Title: A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
Journal: Bioorganic & medicinal chemistry 20100115
Title: Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4.
Journal: Journal of medicinal chemistry 20100114
Title: Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents.
Journal: European journal of medicinal chemistry 20100101
Title: Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs.
Journal: Bioorganic & medicinal chemistry letters 20091215
Title: Development of a rapid and sensitive LC-MS/MS assay for the determination of combretastatin A4 phosphate, combretastatin A4 and combretastatin A4 glucuronide in beagle dog plasma and its application to a pharmacokinetic study.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091115
Title: Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
Journal: Bioorganic & medicinal chemistry 20091115
Title: Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin A4 phosphate and bevacizumab in a two-centre phase I clinical trial.
Journal: European radiology 20091101
Title: Synthesis, biological evaluation of 1,1-diarylethylenes as a novel class of antimitotic agents.
Journal: ChemMedChem 20091101
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Journal: Cancer research 20091001
Title: AVE8062: a new combretastatin derivative vascular disrupting agent.
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Title: 1,4-Diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126) enhances the cytotoxicity of combretastatin A4 independently of mitogen-activated protein kinase kinase.
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Title: Anticancer strategies involving the vasculature.
Journal: Nature reviews. Clinical oncology 20090701
Title: A phase I trial of radioimmunotherapy with 131I-A5B7 anti-CEA antibody in combination with combretastatin-A4-phosphate in advanced gastrointestinal carcinomas.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090701
Title: A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4.
Journal: European journal of medicinal chemistry 20090601
Title: Targeted treatment of choroidal neovascularization using integrin-mediated sterically stabilized liposomes loaded with combretastatin A4.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601
Title: Nitric oxide synthase inhibition enhances the tumor vascular-damaging effects of combretastatin a-4 3-o-phosphate at clinically relevant doses.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090601
Title: Vascular disrupting agents: a novel mechanism of action in the battle against non-small cell lung cancer.
Journal: The oncologist 20090601
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Title: Preclinical evaluation of vascular-disrupting agents in Ewing's sarcoma family of tumours.
Journal: European journal of cancer (Oxford, England : 1990) 20090301
Title: Synthesis and biological evaluation of cis-locked vinylogous combretastatin-A4 analogues: derivatives with a cyclopropyl-vinyl or a cyclopropyl-amide bridge.
Journal: Bioorganic & medicinal chemistry letters 20090301
Title: Diffusion-weighted MRI of hepatic tumor in rats: comparison between in vivo and postmortem imaging acquisitions.
Journal: Journal of magnetic resonance imaging : JMRI 20090301
Title: A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome.
Journal: Thyroid : official journal of the American Thyroid Association 20090301
Title: Up-regulation of connective tissue growth factor in endothelial cells by the microtubule-destabilizing agent combretastatin A-4.
Journal: Molecular cancer research : MCR 20090201
Title: A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P).
Journal: Expert opinion on investigational drugs 20090201
Title: In vitro and in vivo phase II metabolism of combretastatin A-4: evidence for the formation of a sulphate conjugate metabolite.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090201
Title: Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
Journal: Journal of medicinal chemistry 20090122
Title: Treatment of rodent liver tumor with combretastatin a4 phosphate: noninvasive therapeutic evaluation using multiparametric magnetic resonance imaging in correlation with microangiography and histology.
Journal: Investigative radiology 20090101
Title: Combination of combretastatin A4 phosphate and doxorubicin-containing liposomes affects growth of B16-F10 tumors.
Journal: Acta biochimica Polonica 20090101
Title: Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats.
Journal: Vascular pharmacology 20090101
Title: Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.
Journal: Journal of medicinal chemistry 20081009
Title: Vibrational spectra and ab initio molecular orbital calculations of the novel anti-cancer drug combretastatin A-4 prodrug.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081001
Title: Synthesis and biological evaluation of polymethoxylated 4-heteroarylcoumarins as tubulin assembly inhibitor.
Journal: Bioorganic & medicinal chemistry 20081001
Title: Tumour vascular disrupting agents: combating treatment resistance.
Journal: The British journal of radiology 20081001
Title: Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20080915
Title: 1,2,3,4-tetrahydro-2-thioxopyrimidine analogs of combretastatin-A4.
Journal: European journal of medicinal chemistry 20080901
Title: Antineoplastic agents. 552. Oxidation of combretastatin A-1: trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug.
Journal: Journal of natural products 20080901
Title: Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study.
Journal: British journal of cancer 20080722
Title: Antivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRI.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080701
Title: Synthesis and antitumor activity of benzils related to combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20080601
Title: The tubulin-depolymerising agent combretastatin-4 induces ectopic aster assembly and mitotic catastrophe in lung cancer cells H460.
Journal: Apoptosis : an international journal on programmed cell death 20080501
Title: 1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.
Journal: Bioorganic & medicinal chemistry 20080501
Title: Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
Journal: Bioorganic & medicinal chemistry letters 20080501
Title: p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.
Journal: International journal of cancer 20080415
Title: Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors.
Journal: Cancer research 20080401
Title: Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice.
Journal: Pharmacological research 20080401
Title: Preclinical studies to predict efficacy of vascular changes induced by combretastatin a-4 disodium phosphate in patients.
Journal: International journal of radiation oncology, biology, physics 20080301
Title: Efficacy of selected natural products as therapeutic agents against cancer.
Journal: Journal of natural products 20080301
Title: Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
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Title: The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
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Journal: Acta oncologica (Stockholm, Sweden) 20080101
Title: Solution-phase parallel synthesis and biological evaluation of combretatriazoles.
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Title: The effect of combretastatin A4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on water diffusion and blood perfusion in tumours.
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Title: In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071201
Title: Mechanism of retinoblastoma tumor cell death after focal chemotherapy, radiation, and vascular targeting therapy in a mouse model.
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Title: Combretastatin a-4 analogs as anticancer agents.
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Title: Assessment of tumor response to the vascular disrupting agents 5,6-dimethylxanthenone-4-acetic acid or combretastatin-A4-phosphate by intrinsic susceptibility magnetic resonance imaging.
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Title: Design, synthesis, and biological testing of pyrazoline derivatives of combretastatin-A4.
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Journal: Expert opinion on therapeutic targets 20071101
Title: Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells.
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Title: Combination chemotherapy including combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model.
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Title: The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4.
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Title: Characterizing the tumor response to treatment with combretastatin A4 phosphate.
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Title: A Ramberg-Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212.
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Title: Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer.
Journal: International journal of radiation oncology, biology, physics 20070401
Title: N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?
Journal: Bioorganic & medicinal chemistry letters 20070401
Title: Evaluation of the vascular targeting agent combretastatin a-4 prodrug on retinal neovascularization in the galactose-fed dog.
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Title: Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
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Title: Early effects of combretastatin-A4 disodium phosphate on tumor perfusion and interstitial fluid pressure.
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Title: Low-dose combretastatin A4 phosphate enhances the immune response of tumor hosts to experimental colon carcinoma.
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Title: 4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: synthesis and evaluation as anti-mitotic and cytotoxic agents.
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Title: A tumor vasculature targeted liposome delivery system for combretastatin A4: design, characterization, and in vitro evaluation.
Journal: AAPS PharmSciTech 20060407
Title: C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties.
Journal: Bioorganic & medicinal chemistry letters 20060101
Title: NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent.
Journal: Anti-cancer drugs 20060101
Title: In vivo antitumour effect of combretastatin A-4 phosphate added to fractionated irradiation.
Journal: Anticancer research 20060101
Title: The effects of the vascular disrupting agents combretastatin A-4 disodium phosphate, 5,6-dimethylxanthenone-4-acetic acid and ZD6126 in a murine tumour: a comparative assessment using MRI and MRS.
Journal: Acta oncologica (Stockholm, Sweden) 20060101
Title: Macular degeneration: the latest in current medical management.
Journal: Retina (Philadelphia, Pa.) 20060101
Title: Combretastatin A-1 phosphate potentiates the antitumor activity of carboplatin and paclitaxel in a severe combined immunodeficiency disease (SCID) mouse model of human ovarian carcinoma.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101
Title: A targeted liposome delivery system for combretastatin A4: formulation optimization through drug loading and in vitro release studies.
Journal: PDA journal of pharmaceutical science and technology 20060101
Title: Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression.
Journal: BMC cancer 20060101
Title: Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Journal: Bioorganic & medicinal chemistry letters 20051215
Title: Plant-based anticancer molecules: a chemical and biological profile of some important leads.
Journal: Bioorganic & medicinal chemistry 20051101
Title: Effect of vascular targeting agent in rat tumor model: dynamic contrast-enhanced versus diffusion-weighted MR imaging.
Journal: Radiology 20051101
Title: Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling.
Journal: The Journal of clinical investigation 20051101
Title: Antineoplastic strategy: irreversible tumor blood flow stasis induced by the combretastatin A-4 derivative AVE8062 (AC7700).
Journal: Chemotherapy 20051001
Title: Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
Journal: Journal of natural products 20051001
Title: A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.
Journal: Journal of medicinal chemistry 20050922
Title: Taking down tumors: vascular disrupting agents entering clinical trials.
Journal: Journal of the National Cancer Institute 20050907
Title: Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
Journal: Chemistry & biology 20050901
Title: Stilbenophane analogues of deoxycombretastatin A-4.
Journal: The Journal of organic chemistry 20050805
Title: Diffusion-weighted magnetic resonance imaging allows noninvasive in vivo monitoring of the effects of combretastatin a-4 phosphate after repeated administration.
Journal: Neoplasia (New York, N.Y.) 20050801
Title: Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives.
Journal: Organic & biomolecular chemistry 20050721
Title: Tumor physiologic response to combretastatin A4 phosphate assessed by MRI.
Journal: International journal of radiation oncology, biology, physics 20050701
Title: Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment.
Journal: Cancer research 20050701
Title: Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.
Journal: Journal of medicinal chemistry 20050616
Title: New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation.
Journal: Bioorganic & medicinal chemistry 20050601
Title: Novel vascular targeting/disrupting agents: combretastatin A4 phosphate and related compounds.
Journal: Current oncology reports 20050301
Title: Tumour parameters affected by combretastatin A-4 phosphate therapy in a human colorectal xenograft model in nude mice.
Journal: European journal of cancer (Oxford, England : 1990) 20050301
Title: Phase I trial of combretastatin a-4 phosphate with carboplatin.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050215
Title: Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines.
Journal: Journal of medicinal chemistry 20050210
Title: Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.
Journal: Journal of medicinal chemistry 20050127
Title: Combretastatin A-4 prodrug in the treatment of a murine model of retinoblastoma.
Journal: Investigative ophthalmology & visual science 20050101
Title: Evaluation of anti-vascular therapy with texture analysis.
Journal: Anticancer research 20050101
Title: Combretastatin A-4 resistance in H460 human lung carcinoma demonstrates distinctive alterations in beta-tubulin isotype expression.
Journal: Anticancer research 20050101
Title: The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death.
Journal: The American journal of pathology 20041001
Title: Combretastatin A4 phosphate: background and current clinical status.
Journal: Expert opinion on investigational drugs 20040901
Title: Consideration of QT/QTc interval data in a phase I study in patients with advanced cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040901
Title: Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.
Journal: Journal of medicinal chemistry 20040812
Title: A new family of quinoline and quinoxaline analogues of combretastatins.
Journal: Bioorganic & medicinal chemistry letters 20040716
Title: Vascular-targeting therapies for treatment of malignant disease.
Journal: Cancer 20040615
Title: Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.
Journal: Bioorganic & medicinal chemistry letters 20040503
Title: Combretastatin A4 phosphate.
Journal: Anti-cancer drugs 20040301
Title: Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040215
Title: Induction of tumour blood flow stasis and necrosis: a new function for epinephrine similar to that of combretastatin A-4 derivative AVE8062 (AC7700).
Journal: British journal of cancer 20040126
Title: Vascular targeting agents as cancer therapeutics.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040115
Title: Combretastatin A-4 phosphate enhances CPT-11 activity independently of the administration sequence.
Journal: European journal of cancer (Oxford, England : 1990) 20040101
Title: Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose phase I study in patients with advanced cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040101
Title: Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice.
Journal: Anticancer research 20040101
Title: Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins.
Journal: Journal of medicinal chemistry 20031204
Title: Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031201
Title: Thrombosis and Hemostasis Issues in Cancer - Second International Conference. 19-21 September, 2003, Bergamo, Italy.
Journal: IDrugs : the investigational drugs journal 20031101
Title: Combretastatin A-4 analogues as antimitotic antitumor agents.
Journal: Current medicinal chemistry 20030901
Title: Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo.
Journal: Cancer science 20030901
Title: Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030801
Title: Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030801
Title: Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization.
Journal: Investigative ophthalmology & visual science 20030801
Title: (E)-1-(2-Hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene.
Journal: Acta crystallographica. Section C, Crystal structure communications 20030701
Title: Vascular targeting effect of combretastatin A-4 phosphate dominates the inherent angiogenesis inhibitory activity.
Journal: International journal of cancer 20030520
Title: Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20030505
Title: Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin.
Journal: Cell biochemistry and biophysics 20030101
Title: Vascular targeting: a potential additional anti-cancer treatment.
Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20030101
Title: Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate.
Journal: Anticancer research 20030101
Title: The vascular targeting agent combretastatin A-4-phosphate induces neutrophil recruitment to endothelial cells in vitro.
Journal: Anticancer research 20030101
Title: Drug based approaches for targeting tumor vasculature: development of combretastatin A4 phosphate.
Journal: Pathophysiology of haemostasis and thrombosis 20030101
Title: The development of combretastatin A4 phosphate as a vascular targeting agent.
Journal: International journal of radiation oncology, biology, physics 20021201
Title: Combination of vascular targeting agents with thermal or radiation therapy.
Journal: International journal of radiation oncology, biology, physics 20021201
Title: Enhancement of vascular targeting by inhibitors of nitric oxide synthase.
Journal: International journal of radiation oncology, biology, physics 20021201
Title: Combretastatin A4 phosphate has primary antineoplastic activity against human anaplastic thyroid carcinoma cell lines and xenograft tumors.
Journal: Thyroid : official journal of the American Thyroid Association 20021201
Title: Schedule dependence of combretastatin A4 phosphate in transplanted and spontaneous tumour models.
Journal: International journal of cancer 20021101
Title: The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses.
Journal: International journal of oncology 20021001
Title: Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020801
Title: A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer.
Journal: Cancer research 20020615
Title: Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy.
Journal: International journal of cancer 20020501
Title: Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy.
Journal: Neoplasia (New York, N.Y.) 20020501
Title: The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas.
Journal: Cancer letters 20020425
Title: Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
Journal: Journal of medicinal chemistry 20020411
Title: Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS.
Journal: NMR in biomedicine 20020401
Title: Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.
Journal: The American journal of pathology 20020301
Title: The biology of the combretastatins as tumour vascular targeting agents.
Journal: International journal of experimental pathology 20020201
Title: Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma.
Journal: Acta oncologica (Stockholm, Sweden) 20020101
Title: Activity of the vascular targeting agent combretastatin A-4 disodium phosphate in a xenograft model of AIDS-associated Kaposi's sarcoma.
Journal: Acta oncologica (Stockholm, Sweden) 20020101
Title: Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate.
Journal: Anticancer research 20020101
Title: Critical assessment of angiogenesis inhibitors in clinical trials.
Journal: I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.] 20020101
Title: Tumor vasculature is targeted by the combination of combretastatin A-4 and hyperthermia.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20011201
Title: Novel syntheses of cis and trans isomers of combretastatin A-4.
Journal: The Journal of organic chemistry 20011130
Title: Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy.
Journal: International journal of radiation oncology, biology, physics 20011115
Title: Potent anti-metastatic activity of combretastatin-A4.
Journal: International journal of oncology 20011001
Title: The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability.
Journal: Cancer research 20010915
Title: The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.
Journal: Bioorganic & medicinal chemistry letters 20010903
Title: Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.
Journal: Cancer research 20010901
Title: Combretastatin A-4 and hyperthermia;a potent combination for the treatment of solid tumors.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010801
Title: Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010801
Title: Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate.
Journal: Cancer research 20010615
Title: Combretastatin A-4 prodrug inhibits growth of human non-small cell lung cancer in a murine xenotransplant model.
Journal: The Annals of thoracic surgery 20010501
Title: Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.
Journal: Bioorganic & medicinal chemistry letters 20010409
Title: Combretastatin A4 prodrug study of effect on the growth and the microvasculature of colorectal liver metastases in a murine model.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010401
Title: Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum.
Journal: Cancer gene therapy 20010401
Title: Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue.
Journal: British journal of cancer 20010301
Title: Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas.
Journal: FEMS immunology and medical microbiology 20010201
Title: In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment.
Journal: International journal of radiation oncology, biology, physics 20010201
Title: Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues.
Journal: International journal of radiation biology 20010201
Title: Targeting tumour vasculature: the development of combretastatin A4.
Journal: The Lancet. Oncology 20010201
Title: Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Journal: Bioorganic & medicinal chemistry letters 20010108
Title: Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma.
Journal: Oncology reports 20010101
Title: Stoppage of blood flow in 3-methylcholanthrene-induced autochthonous primary tumor due to a novel combretastatin A-4 derivative, AC7700, and its antitumor effect.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101
Title: Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy.
Journal: Anti-cancer drugs 20010101
Title: Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo.
Journal: Anticancer research 20010101
Title: Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.
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