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168626-94-6,MFCD00945712
Catalog No.:AA001Y3P

168626-94-6 | N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2(6),4,10,12-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide hydrochloride

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50mg
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100mg
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250mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001Y3P
Chemical Name:
N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2(6),4,10,12-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide hydrochloride
CAS Number:
168626-94-6
Molecular Formula:
C32H27ClN4O2
Molecular Weight:
535.0354
MDL Number:
MFCD00945712
SMILES:
Cc1[nH]c2c(n1)CCN(c1c2cccc1)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1.Cl
Properties
Computed Properties
 
Complexity:
820  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  

Downstream Synthesis Route

[1]Tsunoda,Takashi;Tanaka,Akihiro;Mase,Toshiyasu;Sakamoto,Shuichi[Heterocycles,2004,vol.63,#5,p.1113-1122]

[1]Tsunoda,Takashi;Tanaka,Akihiro;Mase,Toshiyasu;Sakamoto,Shuichi[Heterocycles,2004,vol.63,#5,p.1113-1122]

[1]Tsunoda,Takashi;Tanaka,Akihiro;Mase,Toshiyasu;Sakamoto,Shuichi[Heterocycles,2004,vol.63,#5,p.1113-1122]

24310-36-9   
conivaptanhydrochloride 

[1]Heterocycles,2004,vol.63,p.1113-1122

[2]OrganicProcessResearchandDevelopment,2005,vol.9,p.593-598

[1]Tsunoda,Takashi;Tanaka,Akihiro;Mase,Toshiyasu;Sakamoto,Shuichi[Heterocycles,2004,vol.63,#5,p.1113-1122]

[2]Tsunoda,Takashi;Yamazaki,Atsuki;Iwamoto,Hidenori;Sakamoto,Shuichi[OrganicProcessResearchandDevelopment,2003,vol.7,#6,p.883-887]

[3]Tsunoda,Takashi;Yamazaki,Atsuki;Iwamoto,Hidenori;Sakamoto,Shuichi[OrganicProcessResearchandDevelopment,2003,vol.7,#6,p.883-887]

Literature

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Title: Conivaptan therapy in an infant with severe hyponatremia and congestive heart failure.

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Title: Renal effects of conivaptan, furosemide, and the combination in patients with chronic heart failure.

Journal: Journal of cardiac failure 20111201

Title: Controlling the flood gates: vaptans, furosemide and the quest for a renal protective diuresis.

Journal: Journal of cardiac failure 20111201

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Journal: Current heart failure reports 20110901

Title: Vaptans are not the mainstay of treatment in hyponatremia: perhaps not yet.

Journal: Kidney international 20110901

Title: Use of intravenous conivaptan in neurosurgical patients with hyponatremia from syndrome of inappropriate antidiuretic hormone secretion.

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Title: Open-label randomized trial of the safety and efficacy of a single dose conivaptan to raise serum sodium in patients with traumatic brain injury.

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Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110401

Title: Hyponatremia: vasopressin antagonists in hyponatremia: more data needed.

Journal: Nature reviews. Nephrology 20110301

Title: A bolus of conivaptan lowers intracranial pressure in a patient with hyponatremia after traumatic brain injury.

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Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100615

Title: Sodium, potassium and glucose management in organ transplantation.

Journal: Current opinion in organ transplantation 20100601

Title: Intravenous conivaptan for the treatment of hyponatraemia caused by the syndrome of inappropriate secretion of antidiuretic hormone in hospitalized patients: a single-centre experience.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100501

Title: The vaptans: just landed. But how was the trip?

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100501

Title: The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists.

Journal: Journal of cardiac failure 20100501

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Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100501

Title: [Vasopressin receptor antagonists: the vaptans].

Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100501

Title: Vasopressin antagonists: Pharmacotherapy for the treatment of heart failure.

Journal: The Annals of pharmacotherapy 20100401

Title: Vasopressin receptor antagonist use in a neurologic rehabilitation center.

Journal: The journal of spinal cord medicine 20100201

Title: Hyponatremia: evaluation and management.

Journal: Hospital practice (1995) 20100201

Title: Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure.

Journal: Heart failure reviews 20100101

Title: Novel agents for the treatment of hyponatremia: a review of conivaptan and tolvaptan.

Journal: Cardiology in review 20100101

Title: Tolvaptan (Samsca) for hyponatremia.

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Journal: Therapeutische Umschau. Revue therapeutique 20091101

Title: Conivaptan increases serum sodium in hyponatremic patients with end-stage liver disease.

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Title: Conivaptan: promise of treatment in heart failure.

Journal: Expert opinion on pharmacotherapy 20090901

Title: Successful treatment of ifosfamide-induced hyponatremia with AVP receptor antagonist without interruption of hydration for prevention of hemorrhagic cystitis.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20090701

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Journal: Clinical therapeutics 20090701

Title: Pharmacology of vasopressin antagonists.

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Title: AVP receptor antagonists in patients with CHF.

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Journal: Neurocritical care 20090101

Title: Efficacy and safety of oral conivaptan, a vasopressin-receptor antagonist, evaluated in a randomized, controlled trial in patients with euvolemic or hypervolemic hyponatremia.

Journal: The American journal of the medical sciences 20090101

Title: Conivaptan bolus dosing for the correction of hyponatremia in the neurointensive care unit.

Journal: Neurocritical care 20090101

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Title: Vasopressin antagonists for the treatment of acute decompensated heart failure: when, for whom, for how long, and on what standard therapy?

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Title: Use of conivaptan to allow aggressive hydration to prevent tumor lysis syndrome in a pediatric patient with large-cell lymphoma and SIADH.

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Title: Vasopressin receptor antagonists.

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Title: Vasopressin receptor antagonists in heart failure.

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Title: Vasopressin excess and hyponatremia.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20060501

Title: Vaptans and the treatment of water-retaining disorders.

Journal: Seminars in nephrology 20060501

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Title: Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus.

Journal: Journal of the American Society of Nephrology : JASN 20060101

Title: Conivaptan: a selective vasopressin antagonist for the treatment of heart failure.

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Title: New drugs: rasagiline mesylate, conivaptan hydrochloride, and sunitinib malate.

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Title: Conivaptan Yamanouchi.

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Title: Intravenous administration of conivaptan hydrochloride improves cardiac hemodynamics in rats with myocardial infarction-induced congestive heart failure.

Journal: European journal of pharmacology 20050110

Title: Vasopressin antagonists in heart failure.

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Title: Vasopressin receptor antagonists in heart failure.

Journal: Current opinion in pharmacology 20031201

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Title: Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis.

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Title: Effect of the V1a/V2-AVP receptor antagonist, Conivaptan, on renal water metabolism and systemic hemodynamics in rats with cirrhosis and ascites.

Journal: Journal of hepatology 20030601

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Journal: Cardiovascular research 20020401

Title: Body compartment volumes and composition after giving a vasopressin antagonist: changes are revealed by a tonicity balance.

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Title: Conivaptan (Yamanouchi).

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Title: Molecular modeling of interactions of the non-peptide antagonist YM087 with the human vasopressin V1a, V2 receptors and with oxytocin receptors.

Journal: Journal of computer-aided molecular design 20011201

Title: Acute hemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure.

Journal: Circulation 20011113

Title: Long-term treatment of patients with inappropriate secretion of antidiuretic hormone by the vasopressin receptor antagonist conivaptan, urea, or furosemide.

Journal: The American journal of medicine 20010501

Title: Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells.

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Title: Pharmacological characterization of YM087, a potent, nonpeptide human vasopressin V1A and V2 receptor antagonist.

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Title: Wada K, et al. Intravenous administration of conivaptan hydrochloride improves cardiac hemodynamics in rats with myocardial infarction-induced congestive heart failure. Eur J Pharmacol. 2005 Jan 10;507(1-3):145-51. Epub 2005 Jan 1.

Title: Fernandez-Varo G, et al. Effect of the V1a/V2-AVP receptor antagonist, Conivaptan, on renal water metabolism and systemic hemodynamics in rats with cirrhosis and ascites. J Hepatol. 2003 Jun;38(6):755-61.

Title: Yatsu T, et al. Cardiovascular and renal effects of conivaptan hydrochloride (YM087), a vasopressin V1A and V2 receptor antagonist, in dogs with pacing-induced congestive heart failure. Eur J Pharmacol. 1999 Jul 9;376(3):239-46.

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Tags:168626-94-6 Molecular Formula|168626-94-6 MDL|168626-94-6 SMILES|168626-94-6 N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2(6),4,10,12-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide hydrochloride