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16881-39-3,MFCD00051777
Catalog No.:AA001Y92

16881-39-3 | N-Carbobenzoxy-l-proline tert-butyl ester

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1g
95%
in stock  
$45.00   $32.00
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5g
≥ 99.5% (Chiral HPLC)
in stock  
$126.00   $88.00
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25g
≥ 99.5% (Chiral HPLC)
in stock  
$354.00   $248.00
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100g
≥ 99.5% (Chiral HPLC)
in stock  
$926.00   $649.00
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250g
≥ 99.5% (Chiral HPLC)
in stock  
$1,722.00   $1,205.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001Y92
Chemical Name:
N-Carbobenzoxy-l-proline tert-butyl ester
CAS Number:
16881-39-3
Molecular Formula:
C17H23NO4
Molecular Weight:
305.3688
MDL Number:
MFCD00051777
SMILES:
O=C([C@@H]1CCCN1C(=O)OCc1ccccc1)OC(C)(C)C
Properties
Properties
 
BP:
51 °C / 1mmHg  
Form:
Solid  
MP:
45 °C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
396  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
3  

Downstream Synthesis Route

[1]Long,Bohua;Zhang,Jingzhao;Tang,Xudong;Wu,Zhengzhi[OrganicandBiomolecularChemistry,2016,vol.14,#41,p.9712-9715]

[2]Murata,Makoto;Hara,Takayoshi;Mori,Kohsuke;Ooe,Masahiko;Mizugaki,Tomoo;Ebitani,Kohki;Kaneda,Kiyotomi[TetrahedronLetters,2003,vol.44,#27,p.4981-4984]

[3]Kawasaki;Kawasaki;Tsuda;etal.[ChemicalandPharmaceuticalBulletin,1980,vol.28,#9,p.2692-2698]

[4]Wakimasu;Kitada;Fujino[ChemicalandPharmaceuticalBulletin,1981,vol.29,#9,p.2592-2597]

[5]Wakimasu,Mitsuhiro;Kitada,Chieko;Fujino,Masahiko[Chemicalandpharmaceuticalbulletin,1982,vol.30,#8,p.2766-2779]

[6]Miyazawa,Toshifumi;Hiramatsu,Shin'ichi;Tsuboi,Yasuhiro;Yamada,Takashi;Kuwata,Shigeru[BulletinoftheChemicalSocietyofJapan,1985,vol.58,#7,p.1976-1982]

[7]Munegumi,Toratane;Fujita,Manabu;Maruyama,Tetsuya;Shiono,Shozo;Takasaki,Michiaki;Harada,Kaoru[BulletinoftheChemicalSocietyofJapan,1987,vol.60,#1,p.249-254]

[8]Baures;Ojala;Gleason;Mishra;Johnson[JournalofMedicinalChemistry,1994,vol.37,#22,p.3677-3683]

[9]Baures,PaulW.;Ojalar,WilliamH.;Costain,WillardJ.;Ott,MichaelC.;Pradhan,Ashish;Gleason,WilliamB.;Mishra,RamK.;Johnson,RodneyL.[JournalofMedicinalChemistry,1997,vol.40,#22,p.3594-3600]

[10]Tayama,Eiji;Nanbara,Shintaro;Nakai,Takeshi[ChemistryLetters,2006,vol.35,#5,p.478-479]

[11]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US4105776,1978,ACurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US4046889,1977,A

[12]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US4052511,1977,A

[13]Locationinpatent:experimentalpartLibendi,SamuelShikuku;Demizu,Yosuke;Onomura,Osamu[OrganicandBiomolecularChemistry,2009,vol.7,#2,p.351-356]

[14]Tayama,Eiji;Watanabe,Kazutoshi;Matano,Yoshihiro[EuropeanJournalofOrganicChemistry,2016,vol.2016,#21,p.3631-3641]

[15]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US4154937,1979,A

[16]Gorges,Jan;Panter,Fabian;Kjaerulff,Louise;Hoffmann,Thomas;Kazmaier,Uli;Müller,Rolf[AngewandteChemie-InternationalEdition,2018,vol.57,#43,p.14270-14275][Angew.Chem.,2018,vol.130,p.14466-14471,6]

[1]Zeggaf,Choukri;Poncet,Joel;Jouin,Patrick;Dufour,Marie-Noelle;Castro,Bertrand[Tetrahedron,1989,vol.45,#16,p.5039-5050]

[2]Jouin,P.;Castro,B.;Zeggaf,C.;Pantaloni,A.;Senet,J.P.;et.al[TetrahedronLetters,1987,vol.28,#15,p.1661-1664]

[3]Dhaon,MadhupK.;Olsen,RichardK.;Ramasamy,K.[JournalofOrganicChemistry,1982,vol.47,#10,p.1962-1965]

[4]Held;VonDenHoff;Stephenson;Zipse[AdvancedSynthesisandCatalysis,2008,vol.350,#11-12,p.1891-1900]

[5]Long,Bohua;Zhang,Jingzhao;Tang,Xudong;Wu,Zhengzhi[OrganicandBiomolecularChemistry,2016,vol.14,#41,p.9712-9715]

[6]Locationinpatent:experimentalpartLibendi,SamuelShikuku;Demizu,Yosuke;Onomura,Osamu[OrganicandBiomolecularChemistry,2009,vol.7,#2,p.351-356]

[1]ChemistryLetters,1996,p.621-622

Literature
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