Home Amines 169205-78-1
169205-78-1,MFCD09908082
Catalog No.:AA001YHF

169205-78-1 | N4-(3-Bromophenyl)quinazoline-4,6-diamine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
>98.0%(HPLC)
in stock  
$56.00   $40.00
- +
250mg
95%
in stock  
$95.00   $67.00
- +
1g
95%
in stock  
$207.00   $145.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001YHF
Chemical Name:
N4-(3-Bromophenyl)quinazoline-4,6-diamine
CAS Number:
169205-78-1
Molecular Formula:
C14H11BrN4
Molecular Weight:
315.1679
MDL Number:
MFCD09908082
SMILES:
Brc1cccc(c1)Nc1ncnc2c1cc(N)cc2
Properties
Computed Properties
 
Complexity:
301  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
3.4  

Literature

Title: Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides.

Journal: Journal of medicinal chemistry 20120308

Title: Synthesis and biological evaluation of quinazoline and quinoline bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors and EPR bio-probe agents.

Journal: European journal of medicinal chemistry 20120301

Title: The combination of 4-anilinoquinazoline and cinnamic acid: a novel mode of binding to the epidermal growth factor receptor tyrosine kinase.

Journal: Bioorganic & medicinal chemistry 20110815

Title: The combi-targeting concept: selective targeting of the epidermal growth factor receptor- and Her2-expressing cancer cells by the complex combi-molecule RB24.

Journal: The Journal of pharmacology and experimental therapeutics 20100701

Title: Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion.

Journal: Journal of medicinal chemistry 20100311

Title: N-(3-Bromo-phen-yl)quinazoline-4,6-diamine.

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: Synthesis and characterization of rhenium and technetium-99m tricarbonyl complexes bearing the 4-[3-bromophenyl]quinazoline moiety as a biomarker for EGFR-TK imaging.

Journal: European journal of medicinal chemistry 20091001

Title: Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.

Journal: Nature chemical biology 20070401

Title: The combi-targeting concept: synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR).

Journal: Journal of medicinal chemistry 20060615

Title: Synthesis of a prodrug designed to release multiple inhibitors of the epidermal growth factor receptor tyrosine kinase and an alkylating agent: a novel tumor targeting concept.

Journal: Journal of medicinal chemistry 20031204

Title: The combi-targeting concept: chemical dissection of the dual targeting properties of a series of 'combi-triazenes'.

Journal: Journal of medicinal chemistry 20030925

Title: 6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity.

Journal: Journal of medicinal chemistry 20010816

Title: Tyrosine kinase inhibitors. 12. Synthesis and structure-activity relationships for 6-substituted 4-(phenylamino)pyrimido[5,4-d]pyrimidines designed as inhibitors of the epidermal growth factor receptor.

Journal: Journal of medicinal chemistry 19970606

Title: Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.

Journal: Journal of medicinal chemistry 19960105

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:169205-78-1 Molecular Formula|169205-78-1 MDL|169205-78-1 SMILES|169205-78-1 N4-(3-Bromophenyl)quinazoline-4,6-diamine