[1]Lien,Jin-Cherng;Lee,Fang-Yu;Huang,Li-Jiau;Pan,Shiow-Lin;Guh,Jih-Hwa;Teng,Che-Ming;Kuo,Sheng-Chu[JournalofMedicinalChemistry,2002,vol.45,#23,p.4947-4949]
[2]CurrentPatentAssignee:YUNG-SHINPHARMAIND.,CO.LTD.-EP1512401,2005,A1Locationinpatent:Page/Pagecolumn4-5
[3]CurrentPatentAssignee:YUNG-SHINPHARMAIND.,CO.LTD.-EP1576954,2005,A1Locationinpatent:Page/Pagecolumn6
[4]CurrentPatentAssignee:YUNG-SHINPHARMAIND.,CO.LTD.;CARLSBADTECHNOLOGY-EP1723954,2006,A1Locationinpatent:Page/Pagecolumn6
[5]CurrentPatentAssignee:YUNG-SHINPHARMAIND.,CO.LTD.-EP1800676,2007,A1Locationinpatent:Page/Pagecolumn6-7
[6]CurrentPatentAssignee:YUNG-SHINPHARMAIND.,CO.LTD.-US2005/119278,2005,A1
[7]CurrentPatentAssignee:YUNG-SHINPHARMAIND.,CO.LTD.-US2005/215612,2005,A1Locationinpatent:Page/Pagecolumn3-4;6
[8]Locationinpatent:experimentalpartHattori,Keika;Yamaguchi,Kazuya;Yamaguchi,Junichiro;Itami,Kenichiro[Tetrahedron,2012,vol.68,#37,p.7605-7612]
[9]Gordon,DavidW.[Synlett,1998,#10,p.1065-1066]
[10]Fernandez,PatriciaA.;Bellamy,Tom;Kling,Marcel;Madge,DavidJ.;Selwood,DavidL.[Heterocycles,2001,vol.55,#9,p.1813-1816]
[11]Le;Lien;Huang;Huang;Tsai;Teng;Wu;Cheng;Kuo[JournalofMedicinalChemistry,2001,vol.44,#22,p.3746-3749]
[1]Xiao,Juan;Jin,Chunmei;Liu,Zhixue;Guo,Shujing;Zhang,Xiaochuan;Zhou,Xin;Wu,Xue[OrganicandBiomolecularChemistry,2015,vol.13,#26,p.7257-7264]
[2]Collot,Valerie;Dallemagne,Patrick;Bovy,PhilippeR.;Rault,Sylvain[Tetrahedron,1999,vol.55,#22,p.6917-6922]
[3]CurrentPatentAssignee:SCHNELLBIOPHARMACEUTICALSINC.;HIFBIO-WO2005/30121,2005,A2Locationinpatent:Figure13
[4]Tang,Meng;Kong,Yuanfang;Chu,Bingjie;Feng,Dan[AdvancedSynthesisandCatalysis,2016,vol.358,#6,p.926-939]
[5]CurrentPatentAssignee:LANZHOUUNIVERSITY-CN106316958,2017,ALocationinpatent:Paragraph0179;0180;0187;0201;0202
[6]Yu,Jingbo;Yang,Xinjie;Wu,Chongyang;Su,Weike[JournalofOrganicChemistry,2020,vol.85,#2,p.1009-1021]
[7]Locationinpatent:schemeortableAn,Hongchan;Kim,Nam-Jung;Jung,Jong-Wha;Jang,Hannah;Park,Jong-Wan;Suh,Young-Ger[BioorganicandMedicinalChemistryLetters,2011,vol.21,#21,p.6297-6300]
[8]Zhao,Jian;Li,Wanchun;Gou,Shaohua;Li,Shuang;Lin,Shengqiu;Wei,Qianhui;Xu,Gang[InorganicChemistry,2018,vol.57,#14,p.8396-8403]
[1]Le;Lien;Huang;Huang;Tsai;Teng;Wu;Cheng;Kuo[JournalofMedicinalChemistry,2001,vol.44,#22,p.3746-3749]
[2]Lien,Jin-Cherng;Lee,Fang-Yu;Huang,Li-Jiau;Pan,Shiow-Lin;Guh,Jih-Hwa;Teng,Che-Ming;Kuo,Sheng-Chu[JournalofMedicinalChemistry,2002,vol.45,#23,p.4947-4949]
[1]Lien,Jin-Cherng;Lee,Fang-Yu;Huang,Li-Jiau;Pan,Shiow-Lin;Guh,Jih-Hwa;Teng,Che-Ming;Kuo,Sheng-Chu[JournalofMedicinalChemistry,2002,vol.45,#23,p.4947-4949]
[2]Le;Lien;Huang;Huang;Tsai;Teng;Wu;Cheng;Kuo[JournalofMedicinalChemistry,2001,vol.44,#22,p.3746-3749]
[3]Kuo,Ting-Hao;Lin,Tzu-Hung;Yang,Rong-Sen;Kuo,Sheng-Chu;Fu,Wen-Mei;Hung,Hsin-Yi[JournalofMedicinalChemistry,2015,vol.58,#12,p.4954-4963]
[1]Hering,KirkW.;Artz,JenniferD.;Pearson,WilliamH.;Marletta,MichaelA.[BioorganicandMedicinalChemistryLetters,2006,vol.16,#3,p.618-621]
Title: Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors.
Journal: Dalton transactions (Cambridge, England : 2003) 20140407
Title: Dysfunctional nitric oxide signalling increases risk of myocardial infarction.
Journal: Nature 20131219
Title: MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells.
Journal: Archives of toxicology 20130301
Title: The effect of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) on cell viability under hypoxia.
Journal: Molecular vision 20130101
Title: Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1α.
Journal: PloS one 20130101
Title: Nitric oxide, can it be only good? Increasing the antioxidant properties of nitric oxide in hepatocytes by YC-1 compound.
Journal: Nitric oxide : biology and chemistry 20121201
Title: YC-1, a potent antithrombotic agent, induces lipolysis through the PKA pathway in rat visceral fat cells.
Journal: European journal of pharmacology 20120815
Title: Lipopolysaccharide and hypoxia-induced HIF-1 activation in human gingival fibroblasts.
Journal: Journal of periodontology 20120601
Title: Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways.
Journal: European journal of pharmacology 20120515
Title: Inhibition of hypoxia inducible factor-1α ameliorates lung injury induced by trauma and hemorrhagic shock in rats.
Journal: Acta pharmacologica Sinica 20120501
Title: YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition.
Journal: Chinese journal of cancer 20120501
Title: YC-1 potentiates cAMP-induced CREB activation and nitric oxide production in alveolar macrophages.
Journal: Toxicology and applied pharmacology 20120415
Title: HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120301
Title: Mechanisms underlying somatostatin receptor 2 down-regulation of vascular endothelial growth factor expression in response to hypoxia in mouse retinal explants.
Journal: The Journal of pathology 20120201
Title: Hypoxia inducible factor-1α contributes to UV radiation-induced inflammation, epidermal hyperplasia and immunosuppression in mice.
Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120201
Title: Hypoxia-derived oxidative stress mediates epigenetic repression of PKCε gene in foetal rat hearts.
Journal: Cardiovascular research 20120201
Title: HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells.
Journal: Cellular and molecular life sciences : CMLS 20120101
Title: Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells.
Journal: Urologia internationalis 20120101
Title: HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast.
Journal: BMC cancer 20120101
Title: Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells.
Journal: Journal of experimental & clinical cancer research : CR 20120101
Title: Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity.
Journal: ASN neuro 20120101
Title: Insufficient radiofrequency ablation promotes angiogenesis of residual hepatocellular carcinoma via HIF-1α/VEGFA.
Journal: PloS one 20120101
Title: YC-1 targeting of hypoxia-inducible factor-1α reduces RGC-5 cell viability and inhibits cell proliferation.
Journal: Molecular vision 20120101
Title: YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway.
Journal: Investigational new drugs 20111201
Title: Blockade of hypoxia-inducible factor-1α by YC-1 attenuates interferon-γ and tumor necrosis factor-α-induced intestinal epithelial barrier dysfunction.
Journal: Cytokine 20111201
Title: YC-1 attenuates hypoxia-induced pulmonary arterial hypertension in mice.
Journal: Pulmonary pharmacology & therapeutics 20111201
Title: Hypoxia-inducible factor-1α is essential for hypoxia-induced mesenchymal stem cell mobilization into the peripheral blood.
Journal: Stem cells and development 20111101
Title: Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.
Journal: Journal of cellular physiology 20111101
Title: Acidic triazoles as soluble guanylate cyclase stimulators.
Journal: Bioorganic & medicinal chemistry letters 20111101
Title: Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20111101
Title: Guanylate cyclase activator YC-1 enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells via activation of apoptosis-related proteins.
Journal: Basic & clinical pharmacology & toxicology 20111001
Title: Impact of hypoxia on the metastatic potential of human prostate cancer cells.
Journal: International journal of radiation oncology, biology, physics 20111001
Title: Endothelium-dependent vasoconstriction in isolated vessel grafts: a novel mechanism of vasospasm?
Journal: The Annals of thoracic surgery 20111001
Title: The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.
Journal: The Journal of pharmacology and experimental therapeutics 20110901
Title: Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction.
Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20110805
Title: Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II.
Journal: Archivum immunologiae et therapiae experimentalis 20110801
Title: Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.
Journal: Biochemistry 20110524
Title: Protective effects of YC-1 against glutamate induced PC12 cell apoptosis.
Journal: Cellular and molecular neurobiology 20110301
Title: Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).
Journal: Expert opinion on therapeutic patents 20110201
Title: The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine.
Journal: Canadian journal of physiology and pharmacology 20110201
Title: Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy.
Journal: PloS one 20110101
Title: Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice.
Journal: Environmental toxicology and pharmacology 20110101
Title: [Inhibition of no-dependent soluble human platelet guanylate cyclase by isatin].
Journal: Biomeditsinskaia khimiia 20110101
Title: Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke.
Journal: PloS one 20110101
Title: Involvement of YC-1 in extracellular signal-regulated kinase action in rat cremasteric muscle.
Journal: The Journal of pharmacy and pharmacology 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Efficient two-step sequence for the synthesis of 2,5-disubstituted furan derivatives from functionalized nitroalkanes: successive Amberlyst A21- and Amberlyst 15-catalyzed processes.
Journal: Chemical communications (Cambridge, England) 20100907
Title: Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation.
Journal: Biochemical and biophysical research communications 20100702
Title: Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia.
Journal: Journal of neuroscience research 20100701
Title: Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence.
Journal: Biochemistry 20100615
Title: Insulin promotes proliferative vitality and invasive capability of pancreatic cancer cells via hypoxia-inducible factor 1alpha pathway.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20100601
Title: Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.
Journal: Biochemistry 20100511
Title: Preconditioning protects against oxidative injury involving hypoxia-inducible factor-1 and vascular endothelial growth factor in cultured astrocytes.
Journal: European journal of pharmacology 20100510
Title: Development of nitrergic neurons in the nervous system of the locust embryo.
Journal: The Journal of comparative neurology 20100415
Title: YC-1 enhances natural killer cell differentiation from hematopoietic stem cells.
Journal: International immunopharmacology 20100401
Title: Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1.
Journal: Biochemical pharmacology 20100315
Title: Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy.
Journal: Molecular pharmacology 20100301
Title: The effect of hypoxia-inducible factor 1-alpha on hypoxia-induced apoptosis in primary neonatal rat ventricular myocytes.
Journal: Cardiovascular journal of Africa 20100201
Title: HIF-1alpha and cancer therapy.
Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20100101
Title: The guanylyl cyclase activator YC-1 directly inhibits the voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.
Journal: Journal of pharmacological sciences 20100101
Title: Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis.
Journal: Experimental eye research 20091101
Title: Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells.
Journal: Toxicology and applied pharmacology 20091101
Title: Presence of cyclic nucleotide-gated channels in the rat urethra and their involvement in nerve-mediated nitrergic relaxation.
Journal: American journal of physiology. Renal physiology 20091101
Title: Combined application of camptothecin and the guanylate cyclase activator YC-1: Impact on cell death and apoptosis-related proteins in ovarian carcinoma cell lines.
Journal: Chemico-biological interactions 20091007
Title: Using YC-1 to overcome the radioresistance of hypoxic cancer cells.
Journal: Oral oncology 20091001
Title: Involvement of Ras/Raf-1/p44/42 MAPK in YC-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells.
Journal: Pharmacological research 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms.
Journal: The Journal of biological chemistry 20090925
Title: Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.
Journal: Journal of molecular and cellular cardiology 20090801
Title: L-DOPA inhibits nitric oxide-dependent vasorelaxation via production of reactive oxygen species in rat aorta.
Journal: The journal of medical investigation : JMI 20090801
Title: Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.
Journal: Investigative ophthalmology & visual science 20090701
Title: 1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1alpha inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090615
Title: The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects.
Journal: Journal of cardiovascular pharmacology and therapeutics 20090601
Title: [Effect of YC-1 on HIF-1 alpha and VEGF expression in human hepatocarcinoma cell lines].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090401
Title: Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy.
Journal: British journal of cancer 20090310
Title: YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells.
Journal: Molecular pharmacology 20090101
Title: Effect of nitric oxide/cyclic guanosine mono-phosphate pathway on gallbladder relaxant response in bile duct-ligated guinea pigs.
Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20090101
Title: [Potentiation of nitric oxide-dependent activation of soluble guanylate cyclase by levomycetin, tetracycline, and oxolin].
Journal: Biomeditsinskaia khimiia 20090101
Title: The effect of heme oxygenase inhibition on visual evoked potentials.
Journal: The International journal of neuroscience 20090101
Title: A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.
Journal: Molecular cancer therapeutics 20081201
Title: Binding of YC-1 or BAY 41-2272 to soluble guanylyl cyclase induces a geminate phase in CO photolysis.
Journal: Journal of the American Chemical Society 20081126
Title: Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20081101
Title: YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway.
Journal: British journal of pharmacology 20081001
Title: Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.
Journal: American journal of physiology. Renal physiology 20081001
Title: YC-1 induces heat shock protein 70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells.
Journal: Shock (Augusta, Ga.) 20080901
Title: An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase.
Journal: The Journal of biological chemistry 20080704
Title: Design and synthesis of novel furoquinoline based inhibitors of multiple targets in the PI3K/Akt-mTOR pathway.
Journal: Bioorganic & medicinal chemistry letters 20080615
Title: [Recent progress in the study on antitumor drugs targeting hypoxia-inducible factor-1].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080601
Title: ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIalpha.
Journal: Biochemical and biophysical research communications 20080418
Title: YC-1 attenuates homotypic human neutrophil aggregation through inhibition of phosphodiesterase activity.
Journal: European journal of pharmacology 20080128
Title: Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226.
Journal: Biochemical pharmacology 20080115
Title: Inhibitory effect of YC-1, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole, on experimental choroidal neovascularization in rat.
Journal: Ophthalmic research 20080101
Title: Novel therapies for cyclic GMP control of vascular smooth muscle growth.
Journal: American journal of therapeutics 20080101
Title: [YC-1-like potentiation of nitric oxide-dependent activation of soluble guanylyl cyclase by adrenochrome].
Journal: Biomeditsinskaia khimiia 20080101
Title: Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma.
Journal: Cancer biology & therapy 20071201
Title: SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule-disrupting agents.
Journal: Cancer biology & therapy 20071201
Title: Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.
Journal: Cardiovascular research 20071001
Title: Modulation of human monocyte-derived dendritic cells maturation by a soluble guanylate cyclase activator, YC-1, in a cyclic nucleotide independent manner.
Journal: International immunopharmacology 20071001
Title: Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading.
Journal: Cancer letters 20070918
Title: Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.
Journal: Bioorganic & medicinal chemistry letters 20070901
Title: Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression.
Journal: Molecular pharmacology 20070801
Title: Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions.
Journal: The Journal of pharmacology and experimental therapeutics 20070801
Title: YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.
Journal: Oncogene 20070607
Title: Regulation of soluble guanylyl cyclase activity by oestradiol and progesterone in the hypothalamus but not hippocampus of female rats.
Journal: Journal of neuroendocrinology 20070601
Title: YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia.
Journal: British journal of pharmacology 20070601
Title: Guanylate cyclase activators influence reactivity of human mesenteric superior arteries retrieved and preserved in the same conditions as transplanted kidneys.
Journal: Transplantation proceedings 20070601
Title: Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.
Journal: Cancer research 20070501
Title: Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft.
Journal: Canadian journal of physiology and pharmacology 20070501
Title: Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction?
Journal: Clinical and experimental pharmacology & physiology 20070401
Title: Effects of YC-1 on hypoxia-inducible factor 1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells.
Journal: Pancreas 20070301
Title: Synthesis of furopyrazole analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-leukemia agents.
Journal: Bioorganic & medicinal chemistry 20070215
Title: Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.
Journal: The Journal of biological chemistry 20070202
Title: Contractile performance of adult ventricular rat cardiomyocytes is not directly jeopardized by NO/cGMP-dependent induction of pro-apoptotic pathways.
Journal: Journal of molecular and cellular cardiology 20070201
Title: Nitric oxide regulates cell survival in purified cultures of avian retinal neurons: involvement of multiple transduction pathways.
Journal: Journal of neurochemistry 20070101
Title: Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture.
Journal: Arthritis research & therapy 20070101
Title: [Nitric oxide. Potentiation of NO-dependent activation of soluble guanylate cyclase--(patho)physiological and pharmacotherapeutical significance].
Journal: Biomeditsinskaia khimiia 20070101
Title: Suppression of hypoxia inducible factor-1alpha (HIF-1alpha) by YC-1 is dependent on murine double minute 2 (Mdm2).
Journal: Biochemical and biophysical research communications 20061006
Title: Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells.
Journal: Molecular cancer therapeutics 20060901
Title: Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase.
Journal: Cardiovascular research 20060715
Title: A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent.
Journal: International journal of oncology 20060701
Title: [Inhibitory effect of YC-1 on induction of VEGF and GPI genes in hypoxic human pancreatic cancer cells].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20060701
Title: YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases.
Journal: Cancer research 20060615
Title: Penile erection requires association of soluble guanylyl cyclase with endothelial caveolin-1 in rat corpus cavernosum.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine] and YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl Indazole].
Journal: The Journal of pharmacology and experimental therapeutics 20060401
Title: YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX.
Journal: Biochemistry. Biokhimiia 20060301
Title: Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways.
Journal: Molecular cancer therapeutics 20060301
Title: The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase.
Journal: Bioorganic & medicinal chemistry letters 20060201
Title: YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9.
Journal: The Journal of pharmacology and experimental therapeutics 20060101
Title: Relaxant effects of the soluble guanylate cyclase activator and NO sensitizer YC-1 in piglet pulmonary arteries.
Journal: Biology of the neonate 20060101
Title: Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi.
Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20060101
Title: BAY 41-2272, a potent activator of soluble guanylyl cyclase, stimulates calcium elevation and calcium-activated potassium current in pituitary GH cells.
Journal: Clinical and experimental pharmacology & physiology 20051201
Title: Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition.
Journal: Journal of cardiovascular pharmacology 20051001
Title: YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells.
Journal: Molecular cancer therapeutics 20051001
Title: Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.
Journal: Cancer research 20050915
Title: Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction.
Journal: European journal of pharmacology 20050905
Title: Enhanced responsiveness to nitric oxide, nitroxyl anions, and nitrergic transmitter by 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole in the rat anococcygeus muscle.
Journal: Nitric oxide : biology and chemistry 20050901
Title: Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050901
Title: New drugs target hypoxia response in tumors.
Journal: Journal of the National Cancer Institute 20050803
Title: Nitric oxide/cyclic guanosine monophosphate signaling in the central complex of the grasshopper brain inhibits singing behavior.
Journal: The Journal of comparative neurology 20050725
Title: Comparative relaxant effects of YC-1 and DETA/NO on spontaneous contractions and the levels of cGMP of isolated pregnant rat myometrium.
Journal: European journal of pharmacology 20050711
Title: YC-1-inhibited proliferation of rat mesangial cells through suppression of cyclin D1-independent of cGMP pathway and partially reversed by p38 MAPK inhibitor.
Journal: European journal of pharmacology 20050704
Title: Dynamic association of nitric oxide downstream signaling molecules with endothelial caveolin-1 in rat aorta.
Journal: The Journal of pharmacology and experimental therapeutics 20050701
Title: YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models.
Journal: The Journal of pharmacology and experimental therapeutics 20050701
Title: Nitric oxide upregulates induction of PDGF receptor-alpha expression in rat renal mesangial cells and in anti-Thy-1 glomerulonephritis.
Journal: Journal of the American Society of Nephrology : JASN 20050701
Title: The nitric oxide donor sodium nitroprusside stimulates the Na+-K+ pump in isolated rabbit cardiac myocytes.
Journal: The Journal of physiology 20050615
Title: Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase.
Journal: Journal of the American Chemical Society 20050406
Title: Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC-1.
Journal: The European journal of neuroscience 20050301
Title: CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050201
Title: [Hypoxia-inducible factor 1: regulation, involvement in carcinogenesis and target for anticancer therapy].
Journal: Bulletin du cancer 20050201
Title: Soluble guanylyl cyclase during postnatal porcine pulmonary maturation.
Journal: American journal of physiology. Lung cellular and molecular physiology 20050101
Title: Nerve-induced release of nitric oxide from the rabbit corpus cavernosum is modulated by cyclic guanosine 3',5'-monophosphate.
Journal: Neuroscience 20050101
Title: cAMP modulates cGMP-mediated cerebral arteriolar relaxation in vivo.
Journal: American journal of physiology. Heart and circulatory physiology 20041201
Title: The blockade of cyclopiazonic acid-induced store-operated Ca2+ entry pathway by YC-1 in neutrophils.
Journal: Biochemical pharmacology 20041115
Title: Salutary properties of YC-1 in the cardiovascular and hematological systems.
Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20041001
Title: Activation of soluble guanylyl cyclase inhibits estradiol production and cyclic AMP accumulation from cultured rat granulosa cells.
Journal: Fertility and sterility 20041001
Title: New anticancer strategies targeting HIF-1.
Journal: Biochemical pharmacology 20040915
Title: Soluble guanylyl cyclase is localised in the acinar cells and participates in amylase secretion in rat parotid gland.
Journal: Archives of oral biology 20040901
Title: YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells.
Journal: Molecular pharmacology 20040901
Title: An evolutionarily conserved mechanism for sensitization of soluble guanylyl cyclase reveals extensive nitric oxide-mediated upregulation of cyclic GMP in insect brain.
Journal: The European journal of neuroscience 20040901
Title: Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells.
Journal: American journal of physiology. Cell physiology 20040701
Title: Resonance Raman study on synergistic activation of soluble guanylate cyclase by imidazole, YC-1 and GTP.
Journal: Journal of inorganic biochemistry 20040501
Title: Versatile pharmacological actions of YC-1: anti-platelet to anticancer.
Journal: Cancer letters 20040415
Title: Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272.
Journal: Circulation 20040413
Title: Inhibitory mechanisms of YC-1 and PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages.
Journal: Biochemical pharmacology 20040401
Title: Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1.
Journal: The Journal of biological chemistry 20040326
Title: Functional characterization of nitric oxide and YC-1 activation of soluble guanylyl cyclase: structural implication for the YC-1 binding site?
Journal: Biochemistry 20040323
Title: The inhibitory mechanism of YC-1, a benzyl indazole, on smooth muscle cell proliferation: an in vitro and in vivo study.
Journal: Journal of pharmacological sciences 20040301
Title: Antiaggregating and antithrombotic activities of new 1, 2, 3-triazolecarboxamides.
Journal: Archiv der Pharmazie 20040301
Title: Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells.
Journal: FEBS letters 20040213
Title: Contribution of cGMP but not peroxynitrite to negative feedback regulation of penile erection elicited by nitric oxide in the hippocampal formation of the rat.
Journal: Neuropharmacology 20040101
Title: YC-1 prevents sodium nitroprusside-mediated apoptosis in vascular smooth muscle cells.
Journal: Cardiovascular research 20040101
Title: YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits the spontaneous contractions of isolated pregnant rat myometrium.
Journal: Journal of pharmacological sciences 20040101
Title: Mechanism of the positive contractile effect of nitric oxide on rat ventricular cardiomyocytes with positive force/frequency relationship.
Journal: Pflugers Archiv : European journal of physiology 20031201
Title: Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway.
Journal: Molecular pharmacology 20031201
Title: The NO signaling pathway differentially regulates KCC3a and KCC3b mRNA expression.
Journal: Nitric oxide : biology and chemistry 20031101
Title: Preparation of heme-free soluble guanylate cyclase.
Journal: Protein expression and purification 20030901
Title: YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway.
Journal: Biochemical pharmacology 20030715
Title: Potentiation of tumor necrosis factor-alpha expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway.
Journal: Biochemical pharmacology 20030701
Title: Nitric oxide signaling in brain: potentiating the gain with YC-1.
Journal: Molecular pharmacology 20030601
Title: Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.
Journal: Molecular pharmacology 20030601
Title: A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding.
Journal: The Journal of biological chemistry 20030404
Title: Is HIF-1 alpha a valid therapeutic target?
Journal: Journal of the National Cancer Institute 20030402
Title: YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.
Journal: Journal of the National Cancer Institute 20030402
Title: YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase.
Journal: The Journal of biological chemistry 20030328
Title: Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle.
Journal: European journal of pharmacology 20030221
Title: Nitric oxide-mediated arachidonic acid release from perifused Venus verrucosa oocytes.
Journal: General and comparative endocrinology 20030215
Title: Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aorta.
Journal: The Journal of biological chemistry 20030124
Title: A-350619: a novel activator of soluble guanylyl cyclase.
Journal: Life sciences 20030117
Title: YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
Journal: European journal of pharmacology 20030101
Title: Analysis of nitric oxide-sensitive guanylyl cyclase in human platelets before and after aggregation.
Journal: Platelets 20030101
Title: Investigation of the potential modulatory effect of biliverdin, carbon monoxide and bilirubin on nitrergic neurotransmission in the pig gastric fundus.
Journal: European journal of pharmacology 20021220
Title: Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.
Journal: British journal of pharmacology 20021201
Title: 1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.
Journal: Journal of medicinal chemistry 20021107
Title: Selective regulation of blood pressure by heme oxygenase-1 in hypertension.
Journal: Hypertension (Dallas, Tex. : 1979) 20020901
Title: Nitric oxide potently inhibits the rate-limiting enzymatic step in steroidogenesis.
Journal: Molecular and cellular endocrinology 20020830
Title: Inhibition of deactivation of NO-sensitive guanylyl cyclase accounts for the sensitizing effect of YC-1.
Journal: The Journal of biological chemistry 20020712
Title: Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels.
Journal: The Journal of pharmacology and experimental therapeutics 20020601
Title: YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells.
Journal: British journal of pharmacology 20020601
Title: Nitric oxide independent activation of guanylate cyclase by YC-1 causes erectile responses in the rat.
Journal: The Journal of urology 20020501
Title: Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
Journal: British journal of pharmacology 20020501
Title: The nitric oxide donor NOC12 protects cultured astrocytes against apoptosis via a cGMP-dependent mechanism.
Journal: Japanese journal of pharmacology 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase.
Journal: Biochemical and biophysical research communications 20020412
Title: Carbon monoxide relaxes the female pig urethra as effectively as nitric oxide in the presence of YC-1.
Journal: The Journal of urology 20020401
Title: Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1.
Journal: International journal of impotence research 20020401
Title: YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function.
Journal: Biochemical and biophysical research communications 20020308
Title: Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules.
Journal: American journal of physiology. Heart and circulatory physiology 20020301
Title: Insulin increases NADH/NAD+ redox state, which stimulates guanylate cyclase in vascular smooth muscle.
Journal: American journal of hypertension 20020301
Title: Inhibition of superoxide anion generation by YC-1 in rat neutrophils through cyclic GMP-dependent and -independent mechanisms.
Journal: Biochemical pharmacology 20020215
Title: Comparison of nitric oxide donors in lowering intraocular pressure in rabbits: role of cyclic GMP.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020201
Title: Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction.
Journal: International journal of impotence research 20020201
Title: Soluble guanylyl cyclase activator YC-1 protects white matter axons from nitric oxide toxicity and metabolic stress, probably through Na(+) channel inhibition.
Journal: Molecular pharmacology 20020101
Title: Carbon monoxide decreases perfusion pressure in isolated human placenta.
Journal: Placenta 20020101
Title: Effect of nitric oxide on arachidonic acid release from human amnion-like WISH cells.
Journal: Placenta 20020101
Title: Role of conformational changes in the heme-dependent regulation of human soluble guanylate cyclase.
Journal: Journal of inorganic biochemistry 20011215
Title: Prolonged exposure to YC-1 induces apoptosis in adrenomedullary endothelial and chromaffin cells through a cGMP-independent mechanism.
Journal: Neuropharmacology 20011201
Title: Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.
Journal: The Journal of pharmacology and experimental therapeutics 20011101
Title: Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents.
Journal: Journal of medicinal chemistry 20011025
Title: Organic phosphates as a new class of soluble guanylate cyclase inhibitors.
Journal: FEBS letters 20011019
Title: Inhibition of extracellular Ca(2+) entry by YC-1, an activator of soluble guanylyl cyclase, through a cyclic GMP-independent pathway in rat neutrophils.
Journal: Biochemical pharmacology 20010915
Title: Inhibition of glucose transport by cyclic GMP in cardiomyocytes.
Journal: Life sciences 20010810
Title: In vitro activation of soluble guanylyl cyclase and nitric oxide release: a comparison of NO donors and NO mimetics.
Journal: Biochemistry 20010807
Title: Synergism between nitric oxide and hydrogen peroxide in the inhibition of platelet function: the roles of soluble guanylyl cyclase and vasodilator-stimulated phosphoprotein.
Journal: Nitric oxide : biology and chemistry 20010601
Title: Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.
Journal: Biochemical pharmacology 20010415
Title: Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells.
Journal: Biochemical pharmacology 20010401
Title: NO-independent stimulators of soluble guanylate cyclase.
Journal: Bioorganic & medicinal chemistry letters 20010326
Title: NO-independent regulatory site on soluble guanylate cyclase.
Journal: Nature 20010308
Title: Molecular mechanisms involved in the synergistic activation of soluble guanylyl cyclase by YC-1 and nitric oxide in endothelial cells.
Journal: Molecular pharmacology 20010201
Title: Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase.
Journal: Journal of medicinal chemistry 20010104
Title: YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate.
Journal: Canadian journal of physiology and pharmacology 20010101
Title: Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis.
Journal: Neuroscience 20010101
Title: NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272.
Journal: BMC pharmacology 20010101
Title: Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20001001
Title: Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.
Journal: The Biochemical journal 19981001
Title: Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme.
Journal: The EMBO journal 19961216
Title: YC-1, a novel activator of platelet guanylate cyclase.
Journal: Blood 19941215
Title: Purohit R, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53(1):101-14.
Title: Kong J, et al. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7.
Title: Chang LC, et al. YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171(17):4010-25.
Title: Komsuoglu Celikyurt I, et al. Effects of YC-1 on Learning and Memory Functions of Aged Rats. Med Sci Monit Basic Res. 2014 Aug 21;20:130-7.
