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171500-79-1,MFCD09837770
Catalog No.:AA00ABKT

171500-79-1 | Dalbavancin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95% (mixture of A0, A1, B0, B1, B2)
in stock  
$48.00   $33.00
- +
5mg
≥95% (mixture of A0, A1, B0, B1, B2)
in stock  
$119.00   $83.00
- +
10mg
≥95% (mixture of A0, A1, B0, B1, B2)
in stock  
$188.00   $131.00
- +
25mg
≥95% (mixture of A0, A1, B0, B1, B2)
in stock  
$409.00   $286.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABKT
Chemical Name:
Dalbavancin
CAS Number:
171500-79-1
Molecular Formula:
C88H100Cl2N10O28
Molecular Weight:
1816.6918
MDL Number:
MFCD09837770
SMILES:
OC[C@H]1O[C@H](Oc2cc(O)cc3c2c2cc(ccc2O)[C@H]2NC(=O)[C@@H]4NC(=O)[C@H]5NC(=O)[C@@H](Cc6ccc(Oc7cc4cc(Oc4ccc([C@H]([C@@H](C(=O)N[C@@H]3C(=O)NCCCN(C)C)NC2=O)O)cc4Cl)c7O[C@@H]2O[C@H](C(=O)O)[C@H]([C@@H]([C@H]2NC(=O)CCCCCCCCC(C)C)O)O)cc6)NC(=O)[C@H](NC)c2cc(Oc3cc5c(Cl)c(c3)O)c(O)cc2)[C@H]([C@H]([C@@H]1O)O)O
Properties
Computed Properties
 
Complexity:
3740  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
18  
Heavy Atom Count:
128  
Hydrogen Bond Acceptor Count:
30  
Hydrogen Bond Donor Count:
21  
Rotatable Bond Count:
22  
XLogP3:
3.8  

Literature

Title: Dalbavancin (BI-387) for the treatment of complicated skin and skin structure infection.

Journal: Expert review of anti-infective therapy 20150201

Title: [In vitro activity of linezolid and dalbavancin against vancomycin-resistant enterococci].

Journal: Mikrobiyoloji bulteni 20120701

Title: A carrier protein strategy yields the structure of dalbavancin.

Journal: Journal of the American Chemical Society 20120314

Title: MRSA new treatments on the horizon: current status.

Journal: Injury 20111201

Title: Susceptibility of molecularly characterized hospital-associated methicillin-resistant Staphylococcus aureus isolates to dalbavancin.

Journal: Journal of chemotherapy (Florence, Italy) 20111001

Title: Dalbavancin: Quantification in human plasma and urine by a new improved high performance liquid chromatography-tandem mass spectrometry method.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110901

Title: In vitro activity of dalbavancin and telavancin against staphylococci and streptococci isolated from patients in Canadian hospitals: results of the CANWARD 2007-2009 study.

Journal: Diagnostic microbiology and infectious disease 20110301

Title: Outpatient parenteral antimicrobial therapy: Recent developments and future prospects.

Journal: Current opinion in investigational drugs (London, England : 2000) 20100801

Title: Evaluation of dalbavancin as chiral selector for HPLC and comparison with teicoplanin-based chiral stationary phases.

Journal: Chirality 20100515

Title: New lipoglycopeptides: a comparative review of dalbavancin, oritavancin and telavancin.

Journal: Drugs 20100507

Title: [Update on antimicrobial chemotherapy].

Journal: Medecine et maladies infectieuses 20100301

Title: A comparative review of the lipoglycopeptides: oritavancin, dalbavancin, and telavancin.

Journal: Pharmacotherapy 20100101

Title: Modeled dalbavancin transmembrane clearance during intermittent and continuous renal replacement therapies.

Journal: Blood purification 20100101

Title: In vitro activity of dalbavancin against staphylococci isolated in Istanbul, Turkey.

Journal: Chemotherapy 20100101

Title: Antibiotics for gram-positive bacterial infections: vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinones, daptomycin, dalbavancin, and telavancin.

Journal: Infectious disease clinics of North America 20091201

Title: New antimicrobial agents for methicillin-resistant Staphylococcus aureus.

Journal: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20091201

Title: Microbiology of drugs for treating multiply drug-resistant Gram-positive bacteria.

Journal: The Journal of infection 20090901

Title: Antimicrobial development in the era of emerging resistance.

Journal: Mini reviews in medicinal chemistry 20090701

Title: Multicenter evaluation of the in vitro activity of dalbavancin tested against staphylococci and streptococci in 5 European countries: results from the DECIDE Surveillance Program (2007).

Journal: Diagnostic microbiology and infectious disease 20090601

Title: Pharmacokinetics of dalbavancin in patients with renal or hepatic impairment.

Journal: Journal of clinical pharmacology 20090401

Title: A single-dose combination therapy that both prevents and treats anthrax infection.

Journal: Vaccine 20090313

Title: New antibiotics for healthcare-associated pneumonia.

Journal: Seminars in respiratory and critical care medicine 20090201

Title: In vitro activity of dalbavancin against enterococci isolates from wild animals, pets, poultry and humans in Portugal.

Journal: Journal of basic microbiology 20081201

Title: Antimicrobial agents in treatment of MRSA infections.

Journal: Disease-a-month : DM 20081201

Title: Pharmacokinetic-pharmacodynamic modeling of dalbavancin, a novel glycopeptide antibiotic.

Journal: Journal of clinical pharmacology 20080901

Title: Dalbavancin: a lipoglycopeptide antibacterial for Gram-positive infections.

Journal: Expert opinion on pharmacotherapy 20080701

Title: Dalbavancin: a new lipoglycopeptide antibiotic.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080401

Title: Dalbavancin: a novel once-weekly lipoglycopeptide antibiotic.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080215

Title: Dalbavancin and telavancin: novel lipoglycopeptides for the treatment of Gram-positive infections.

Journal: Expert review of anti-infective therapy 20080201

Title: Review: dalbavancin--a novel lipoglycopeptide antimicrobial for gram positive pathogens.

Journal: Pakistan journal of pharmaceutical sciences 20080101

Title: Dalbavancin.

Journal: Drugs 20080101

Title: Update on prevalence and treatment of methicillin-resistant Staphylococcus aureus infections.

Journal: Expert review of anti-infective therapy 20071201

Title: Pharmacokinetics of dalbavancin in plasma and skin blister fluid.

Journal: The Journal of antimicrobial chemotherapy 20070901

Title: Dalbavancin, a long-acting lipoglycopeptide for the treatment of multidrug-resistant Gram-positive bacteria.

Journal: Expert review of anti-infective therapy 20070801

Title: Dalbavancin: a novel antimicrobial.

Journal: International journal of clinical practice 20070501

Title: Review of dalbavancin, a novel semisynthetic lipoglycopeptide.

Journal: Expert opinion on investigational drugs 20070501

Title: Dalbavancin: a review.

Journal: Drugs of today (Barcelona, Spain : 1998) 20070501

Title: Biotransformations of lipoglycopeptides to obtain novel antibiotics.

Journal: The Journal of antibiotics 20070401

Title: [Therapeutic perspectives of linezolid in the management of infections due to multiresistant Gram-positive pathogens].

Journal: Recenti progressi in medicina 20070301

Title: Pharmacodynamics of dalbavancin studied in an in vitro pharmacokinetic system.

Journal: The Journal of antimicrobial chemotherapy 20061001

Title: Effect of dalbavancin on the normal intestinal microflora.

Journal: The Journal of antimicrobial chemotherapy 20060901

Title: Glycopeptides and glycodepsipeptides in clinical development: a comparative review of their antibacterial spectrum, pharmacokinetics and clinical efficacy.

Journal: Current opinion in investigational drugs (London, England : 2000) 20060801

Title: Understanding and manipulating glycopeptide pathways: the example of the dalbavancin precursor A40926.

Journal: Journal of industrial microbiology & biotechnology 20060701

Title: Dalbavancin: a novel lipoglycopeptide antibacterial.

Journal: Pharmacotherapy 20060701

Title: Evaluation of dalbavancin in combination with nine antimicrobial agents to detect enhanced or antagonistic interactions.

Journal: International journal of antimicrobial agents 20060601

Title: Antibacterial drug discovery and development--SRI's 11th Annual Summit. Antibacterial trends and current research.

Journal: IDrugs : the investigational drugs journal 20060601

Title: Dalbavancin: a review for dermatologists.

Journal: Dermatology online journal 20060530

Title: Dalbavancin: a new option for the treatment of gram-positive infections.

Journal: The Annals of pharmacotherapy 20060301

Title: Spectrum and potency of dalbavancin tested against 3322 Gram-positive cocci isolated in the United States Surveillance Program (2004).

Journal: Diagnostic microbiology and infectious disease 20060201

Title: Microbiologic characterization of isolates from a dalbavancin clinical trial for catheter-related bloodstream infections.

Journal: Diagnostic microbiology and infectious disease 20060201

Title: Dalbavancin activity against selected populations of antimicrobial-resistant Gram-positive pathogens.

Journal: Diagnostic microbiology and infectious disease 20051201

Title: Antimicrobial spectrum and potency of dalbavancin tested against clinical isolates from Europe and North America (2003): initial results from an international surveillance protocol.

Journal: Journal of chemotherapy (Florence, Italy) 20051201

Title: Randomized, double-blind comparison of once-weekly dalbavancin versus twice-daily linezolid therapy for the treatment of complicated skin and skin structure infections.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20051115

Title: Population pharmacokinetic analysis of dalbavancin, a novel lipoglycopeptide.

Journal: Journal of clinical pharmacology 20051101

Title: New antibiotics for the treatment of severe staphylococcal infection in the critically ill patient.

Journal: Current opinion in critical care 20051001

Title: Acquisitions not a cure for anti-infectives.

Journal: Nature reviews. Drug discovery 20050901

Title: Dalbavancin compared with vancomycin for prevention of Staphylococcus aureus colonization of devices in vivo.

Journal: The Journal of infection 20050401

Title: Origin, structure, and activity in vitro and in vivo of dalbavancin.

Journal: The Journal of antimicrobial chemotherapy 20050301

Title: In vitro antistaphylococcal activity of dalbavancin, a novel glycopeptide.

Journal: The Journal of antimicrobial chemotherapy 20050301

Title: Human pharmacokinetics and rationale for once-weekly dosing of dalbavancin, a semi-synthetic glycopeptide.

Journal: The Journal of antimicrobial chemotherapy 20050301

Title: Pharmacokinetics and excretion of dalbavancin in the rat.

Journal: The Journal of antimicrobial chemotherapy 20050301

Title: Efficacy and safety of weekly dalbavancin therapy for catheter-related bloodstream infection caused by gram-positive pathogens.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050201

Title: Antimicrobial activity of dalbavancin tested against Gram-positive clinical isolates from Latin American medical centres.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20050201

Title: Dalbavancin: an investigational glycopeptide.

Journal: Expert review of anti-infective therapy 20041201

Title: Recent advances in the treatment of infections due to resistant Staphylococcus aureus.

Journal: Current opinion in infectious diseases 20041201

Title: Glycopeptides in clinical development: pharmacological profile and clinical perspectives.

Journal: Current opinion in pharmacology 20041001

Title: Activity of dalbavancin against staphylococci and streptococci, assessed by BSAC and NCCLS agar dilution methods.

Journal: The Journal of antimicrobial chemotherapy 20040901

Title: Current and new antimicrobial agents.

Journal: American heart journal 20040401

Title: Worldwide assessment of dalbavancin activity and spectrum against over 6,000 clinical isolates.

Journal: Diagnostic microbiology and infectious disease 20040201

Title: Validation of commercial dry-form broth microdilution panels and test reproducibility for susceptibility testing of dalbavancin, a new very long-acting glycopeptide.

Journal: International journal of antimicrobial agents 20040201

Title: Glycopeptide antibiotics: from conventional molecules to new derivatives.

Journal: Drugs 20040101

Title: Once-weekly dalbavancin versus standard-of-care antimicrobial regimens for treatment of skin and soft-tissue infections.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031115

Title: The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species.

Journal: Chemistry & biology 20030601

Title: Audiologic monitoring for potential ototoxicity in a phase I clinical trial of a new glycopeptide antibiotic.

Journal: Journal of the American Academy of Audiology 20030401

Title: Dalbavancin (Biosearch Italia/Versicor).

Journal: Current opinion in investigational drugs (London, England : 2000) 20020201

Title: Heine HS, et al. Activity of dalbavancin against Bacillus anthracis in vitro and in a mouse inhalation anthrax model. Antimicrob Agents Chemother. 2010 Mar;54(3):991-6.

Title: Bennett JW, et al. Dalbavancin in the treatment of complicated skin and soft-tissue infections: a review. Ther Clin Risk Manag. 2008 Feb;4(1):31-40.

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Tags:171500-79-1 Molecular Formula|171500-79-1 MDL|171500-79-1 SMILES|171500-79-1 Dalbavancin