Home Amines 172854-55-6
172854-55-6,MFCD01861177
Catalog No.:AA003HYW

172854-55-6 | 3-(3-(Dimethylamino)propyl)-4-hydroxy-N-(4-(pyridin-4-yl)phenyl)benzamide dihydrochloride

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003HYW
Chemical Name:
3-(3-(Dimethylamino)propyl)-4-hydroxy-N-(4-(pyridin-4-yl)phenyl)benzamide dihydrochloride
CAS Number:
172854-55-6
Molecular Formula:
C23H27Cl2N3O2
Molecular Weight:
448.3854
MDL Number:
MFCD01861177
SMILES:
CN(CCCc1cc(ccc1O)C(=O)Nc1ccc(cc1)c1ccncc1)C.Cl.Cl
Properties
Properties
 
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
471  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
7  

Literature

Title: Preservation of serotonin-mediated contractility in adult sheep pulmonary arteries following long-term high-altitude hypoxia.

Journal: High altitude medicine & biology 20111001

Title: Functional characterization of contractions to tegaserod in human isolated proximal and distal coronary arteries.

Journal: European journal of pharmacology 20091001

Title: Chronic treatment of hydroxytryptamine type 2a receptor antagonist sarpogrelate hydrochloride modulates the vasoreactivity of serotonin in experimental rabbit vein grafts.

Journal: Journal of vascular surgery 20090901

Title: Involvement of local serotonin-2A but not serotonin-1B receptors in the reinforcing effects of ethanol within the posterior ventral tegmental area of female Wistar rats.

Journal: Psychopharmacology 20090601

Title: 5-HT(1A) and 5-HT(1B) receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats.

Journal: Journal of oral science 20081201

Title: Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses.

Journal: American journal of veterinary research 20080201

Title: Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system.

Journal: Pharmacology, biochemistry, and behavior 20070501

Title: Activation of 5-HT1B and 5-HT1D receptors in the rat nucleus tractus solitarius: opposing action on neurones that receive an excitatory vagal C-fibre afferent input.

Journal: British journal of pharmacology 20070401

Title: 5-Hydroxytryptamine as a potent migration enhancer of human aortic endothelial cells.

Journal: FEBS letters 20051219

Title: Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin.

Journal: Circulation research 20040917

Title: Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040501

Title: Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors.

Journal: Psychopharmacology 20021201

Title: Effects of 5-HT(1B) receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

Title: Effects of serotonin (5-HT)(1B) receptor ligands, microinjected into accumbens subregions, on cocaine discrimination in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020901

Title: Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20020901

Title: Effect of intra-tegmental microinjections of 5-HT1B receptor ligands on the amphetamine-induced locomotor hyperactivity in rats.

Journal: Polish journal of pharmacology 20020101

Title: Enhanced contraction to 5-hydroxytryptamine is not due to 'unmasking' of 5-hydroxytryptamine(1b) receptors in the mesenteric artery of the deoxycorticosterone acetate-salt rat.

Journal: Hypertension (Dallas, Tex. : 1979) 20011001

Title: Selective up-regulation of 5-HT(1B/1D) receptors during organ culture of cerebral arteries.

Journal: Neuroreport 20010613

Title: Relaxation induced by serotonin and sumatriptan in isolated guinea pig gallbladder strips.

Journal: Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 20010301

Title: Serotonin1B receptor ligands in the nucleus accumbens shell do not affect the discriminative stimulus effects of amphetamine in rats.

Journal: Polish journal of pharmacology 20010101

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Tags:172854-55-6 Molecular Formula|172854-55-6 MDL|172854-55-6 SMILES|172854-55-6 3-(3-(Dimethylamino)propyl)-4-hydroxy-N-(4-(pyridin-4-yl)phenyl)benzamide dihydrochloride