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1783-84-2,MFCD00065721
Catalog No.:AA0025U0

1783-84-2 | Cis-8,11,14-eicosatrienoic acid

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10mg
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50mg
≥98%
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$145.00   $101.00
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100mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0025U0
Chemical Name:
Cis-8,11,14-eicosatrienoic acid
CAS Number:
1783-84-2
Molecular Formula:
C20H34O2
Molecular Weight:
306.4828
MDL Number:
MFCD00065721
SMILES:
CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O
Properties
Properties
 
BP:
200°C(lit.)  
Form:
Liquid  
Refractive Index:
n20/D 1.478(lit.)  
Solubility:
chloroform: 50 mg/mL, clear, colorless  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
327  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
15  
XLogP3:
7.2  

Literature

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Journal: Journal of the American Academy of Dermatology 20180301

Title: Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.

Journal: Scientific reports 20180101

Title: Vascular hepoxilin and trioxilins mediate vasorelaxation through TP receptor inhibition in mouse arteries.

Journal: Acta physiologica (Oxford, England) 20170101

Title: Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids.

Journal: Archives of toxicology 20170101

Title: Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.

Journal: Journal of hypertension 20161001

Title: Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.

Journal: British journal of clinical pharmacology 20160501

Title: Pathophysiology of the hepoxilins.

Journal: Biochimica et biophysica acta 20150401

Title: A lipid mediator hepoxilin A3 is a natural inducer of neutrophil extracellular traps in human neutrophils.

Journal: Mediators of inflammation 20150101

Title: Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart.

Journal: Toxicology letters 20140407

Title: Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130801

Title: Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20130101

Title: Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20121115

Title: Upregulation of cytochrome P450 2J3/11,12-epoxyeicosatrienoic acid inhibits apoptosis in neonatal rat cardiomyocytes by a caspase-dependent pathway.

Journal: Cytokine 20121101

Title: The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture.

Journal: Neuroscience 20121025

Title: EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides.

Journal: Journal of lipid research 20121001

Title: Disturbed ratio of renal 20-HETE/EETs is involved in androgen-induced hypertension in cytochrome P450 4F2 transgenic mice.

Journal: Gene 20120901

Title: Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates.

Journal: American journal of physiology. Endocrinology and metabolism 20120901

Title: Genetic disruption of soluble epoxide hydrolase is protective against streptozotocin-induced diabetic nephropathy.

Journal: American journal of physiology. Endocrinology and metabolism 20120901

Title: High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance.

Journal: Nutrition research (New York, N.Y.) 20120901

Title: Soluble epoxide hydrolase: sex differences and role in endothelial cell survival.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20120801

Title: Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis.

Journal: Human gene therapy 20120701

Title: Role of PI3Kα and sarcolemmal ATP-sensitive potassium channels in epoxyeicosatrienoic acid mediated cardioprotection.

Journal: Journal of molecular and cellular cardiology 20120701

Title: Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults.

Journal: Lipids 20120601

Title: Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor κB signaling.

Journal: The Journal of pharmacology and experimental therapeutics 20120601

Title: Exogenous arachidonate restores the dimethoate-induced inhibition of steroidogenesis in rat interstitial cells.

Journal: Lipids 20120601

Title: Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells.

Journal: Journal of lipid research 20120601

Title: Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease.

Journal: Atherosclerosis 20120601

Title: Inhibitory effect of 5,8,11-eicosatrienoic acid on angiogenesis.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20120601

Title: 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120502

Title: Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).

Journal: European journal of clinical nutrition 20120501

Title: Pyramidal cells and cytochrome P450 epoxygenase products in the neurovascular coupling response to basal forebrain cholinergic input.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120501

Title: Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid.

Journal: Atherosclerosis 20120501

Title: 11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20120415

Title: Maintenance of arachidonic acid and evidence of Δ5 desaturation in cats fed γ-linolenic and linoleic acid enriched diets.

Journal: Lipids 20120401

Title: Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.

Journal: Circulation research 20120316

Title: Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation.

Journal: American journal of physiology. Heart and circulatory physiology 20120301

Title: Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury.

Journal: Journal of lipid research 20120301

Title: The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.

Journal: Cellular oncology (Dordrecht) 20120201

Title: Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.

Journal: The British journal of nutrition 20120201

Title: Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women.

Journal: Atherosclerosis 20120201

Title: A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels.

Journal: Pulmonary pharmacology & therapeutics 20120201

Title: 8R-Lipoxygenase-catalyzed synthesis of a prominent cis-epoxyalcohol from dihomo-γ-linolenic acid: a distinctive transformation compared with S-lipoxygenases.

Journal: Journal of lipid research 20120201

Title: Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications.

Journal: Prostaglandins & other lipid mediators 20120101

Title: Multiple roles of dihomo-γ-linolenic acid against proliferation diseases.

Journal: Lipids in health and disease 20120101

Title: 8,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice.

Journal: PloS one 20120101

Title: 11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction.

Journal: PloS one 20120101

Title: Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters.

Journal: Nutrition and cancer 20120101

Title: Sonodynamic and photodynamic mechanisms of action of the novel hypocrellin sonosensitizer, SL017: mitochondrial cell death is attenuated by 11, 12-epoxyeicosatrienoic acid.

Journal: Investigational new drugs 20111201

Title: Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men.

Journal: European journal of nutrition 20111201

Title: Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls.

Journal: Clinical science (London, England : 1979) 20111201

Title: Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts.

Journal: Cardiovascular drugs and therapy 20111201

Title: EET signaling in cancer.

Journal: Cancer metastasis reviews 20111201

Title: Effects of dynamic exercise on plasma arachidonic acid epoxides and diols in human volunteers.

Journal: International journal of sport nutrition and exercise metabolism 20111201

Title: Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice.

Journal: Prostaglandins & other lipid mediators 20111101

Title: Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes.

Journal: Prostaglandins & other lipid mediators 20111101

Title: Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi.

Journal: American journal of physiology. Lung cellular and molecular physiology 20111101

Title: Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide.

Journal: The Journal of pharmacology and experimental therapeutics 20111101

Title: Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception.

Journal: Prostaglandins & other lipid mediators 20111101

Title: 11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension.

Journal: Prostaglandins & other lipid mediators 20111101

Title: Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain.

Journal: Neuroscience 20111027

Title: Reversible controlled assembly of thermosensitive polymer-coated gold nanoparticles.

Journal: Langmuir : the ACS journal of surfaces and colloids 20111018

Title: Models of neurovascular coupling via potassium and EET signalling.

Journal: Journal of theoretical biology 20111007

Title: Regulation of forskolin-induced cAMP production by cytochrome P450 epoxygenase metabolites of arachidonic acid in HEK293 cells.

Journal: Cell biology and toxicology 20111001

Title: Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles.

Journal: American journal of physiology. Renal physiology 20111001

Title: P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20111001

Title: Terminal fatty-acyl-CoA desaturase involved in sex pheromone biosynthesis in the winter moth (Operophtera brumata).

Journal: Insect biochemistry and molecular biology 20110901

Title: Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC).

Journal: American journal of physiology. Renal physiology 20110901

Title: Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110901

Title: Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo.

Journal: American journal of physiology. Heart and circulatory physiology 20110801

Title: Increased myoendothelial gap junctions mediate the enhanced response to epoxyeicosatrienoic acid and acetylcholine in mesenteric arterial vessels of cirrhotic rats.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20110701

Title: Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats.

Journal: American journal of physiology. Heart and circulatory physiology 20110601

Title: Hepoxilin A(3) protects β-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid.

Journal: Biochimica et biophysica acta 20110601

Title: CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET).

Journal: The Journal of biological chemistry 20110520

Title: 20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor.

Journal: Biochemistry 20110510

Title: Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110501

Title: Characterization of free radicals formed from COX-catalyzed DGLA peroxidation.

Journal: Free radical biology & medicine 20110501

Title: Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors.

Journal: Analytical and bioanalytical chemistry 20110501

Title: Selection of a DGLA-producing mutant of the microalga Parietochloris incisa: I. Identification of mutation site and expression of VLC-PUFA biosynthesis genes.

Journal: Applied microbiology and biotechnology 20110401

Title: Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase.

Journal: Journal of lipid research 20110401

Title: Epoxyeicosatrienoic acids--novel mechanism and pharmacological therapy of chronic renocardiac syndrome.

Journal: Medical hypotheses 20110401

Title: Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20110301

Title: Cytochrome P450 eicosanoids and cerebral vascular function.

Journal: Expert reviews in molecular medicine 20110301

Title: Cytochrome P450-derived epoxyeicosatrienoic acids and pulmonary hypertension: central role of transient receptor potential C6 channels.

Journal: Journal of cardiovascular pharmacology 20110201

Title: Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury.

Journal: British journal of pharmacology 20110201

Title: Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes.

Journal: Prostaglandins & other lipid mediators 20110201

Title: Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20110201

Title: Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).

Journal: Prostaglandins & other lipid mediators 20110201

Title: Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs.

Journal: Hypertension (Dallas, Tex. : 1979) 20110201

Title: 14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries.

Journal: The Journal of pharmacology and experimental therapeutics 20110101

Title: Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.

Journal: Lipids 20110101

Title: Cytochrome P450 2J3/epoxyeicosatrienoic acids mediate the cardioprotection induced by ischaemic post-conditioning, but not preconditioning, in the rat.

Journal: Clinical and experimental pharmacology & physiology 20110101

Title: Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans.

Journal: BMC genetics 20110101

Title: Effects of perfluorinated fatty acids with different carbon chain length on fatty acid profiles of hepatic lipids in mice.

Journal: Biological & pharmaceutical bulletin 20110101

Title: Incorporation of n-3 PUFA and γ-linolenic acid in blood lipids and red blood cell lipids together with their influence on disease activity in patients with chronic inflammatory arthritis--a randomized controlled human intervention trial.

Journal: Lipids in health and disease 20110101

Title: Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation.

Journal: Molecular pain 20110101

Title: Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.

Journal: PloS one 20110101

Title: Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats.

Journal: American journal of respiratory cell and molecular biology 20101201

Title: Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARγ.

Journal: Stem cells and development 20101201

Title: Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists.

Journal: Cancer science 20101201

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

Journal: Rapid communications in mass spectrometry : RCM 20101130

Title: 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase.

Journal: American journal of respiratory cell and molecular biology 20101101

Title: Epoxyeicosatrienoates are the dominant eicosanoids in human lungs upon microbial challenge.

Journal: The European respiratory journal 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC.

Journal: Journal of the American Society of Nephrology : JASN 20101001

Title: Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.

Journal: The Journal of pharmacology and experimental therapeutics 20100901

Title: 14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery.

Journal: Prostaglandins & other lipid mediators 20100901

Title: Effects of DHLA-capped CdSe/ZnS quantum dots on the fibrillation of human serum albumin.

Journal: The journal of physical chemistry. B 20100826

Title: 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway.

Journal: Experimental cell research 20100815

Title: L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice.

Journal: Drug metabolism letters 20100801

Title: Development of a high throughput cell-based assay for soluble epoxide hydrolase using BacMam technology.

Journal: Molecular biotechnology 20100701

Title: Uptake of dihomo-gamma-linolenic acid by murine macrophages increases series-1 prostaglandin release following lipopolysaccharide treatment.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20100701

Title: Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20100601

Title: Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20100601

Title: Prevention of UV-induced skin damages by 11,14,17-eicosatrienoic acid in hairless mice in vivo.

Journal: Journal of Korean medical science 20100601

Title: Skin aging and photoaging alter fatty acids composition, including 11,14,17-eicosatrienoic acid, in the epidermis of human skin.

Journal: Journal of Korean medical science 20100601

Title: Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4.

Journal: Mucosal immunology 20100501

Title: Epoxyeicosatrienoic acids and endothelium-dependent responses.

Journal: Pflugers Archiv : European journal of physiology 20100501

Title: Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice.

Journal: Diabetes 20100401

Title: Pharmacological inhibition of the soluble epoxide hydrolase-from mouse to man.

Journal: Current opinion in pharmacology 20100401

Title: Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB.

Journal: Hypertension (Dallas, Tex. : 1979) 20100401

Title: Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.

Journal: Clinical science (London, England : 1979) 20100223

Title: A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo.

Journal: Cardiovascular research 20100201

Title: Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling.

Journal: American journal of physiology. Heart and circulatory physiology 20100201

Title: Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury.

Journal: Microcirculation (New York, N.Y. : 1994) 20100201

Title: Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20100101

Title: [The role of modification of fatty acid composition of erythrocyte lipids in pathogenesis of arterial hypertension].

Journal: Kardiologiia 20100101

Title: Vascular pharmacology of epoxyeicosatrienoic acids.

Journal: Advances in pharmacology (San Diego, Calif.) 20100101

Title: Serum cytokeratin 18 M30 antigen level and its correlation with nutritional parameters in middle-aged Japanese males with nonalcoholic fatty liver disease (NAFLD).

Journal: Journal of nutritional science and vitaminology 20100101

Title: Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice.

Journal: The Journal of pharmacology and experimental therapeutics 20091201

Title: 20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site.

Journal: The Journal of pharmacology and experimental therapeutics 20091201

Title: The role of neutrophils in the event of intestinal inflammation.

Journal: Current opinion in pharmacology 20091201

Title: Rapid, simultaneous quantitation of mono and dioxygenated metabolites of arachidonic acid in human CSF and rat brain.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091201

Title: Eicosapentaenoic acid increases cytochrome P-450 2J2 gene expression and epoxyeicosatrienoic acid production via peroxisome proliferator-activated receptor γ in endothelial cells.

Journal: Journal of cardiology 20091201

Title: Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries.

Journal: The Journal of biological chemistry 20091106

Title: The hepoxilins and some analogues: a review of their biology.

Journal: British journal of pharmacology 20091001

Title: Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090915

Title: Detection of EETs and HETE-generating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function.

Journal: American journal of physiology. Endocrinology and metabolism 20090901

Title: TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure.

Journal: American journal of physiology. Heart and circulatory physiology 20090901

Title: 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

Journal: Journal of medicinal chemistry 20090827

Title: Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090801

Title: Associations between term birth dimensions and prenatal exposure to essential and trans fatty acids.

Journal: Early human development 20090801

Title: Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone.

Journal: American journal of physiology. Heart and circulatory physiology 20090801

Title: Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.

Journal: Journal of atherosclerosis and thrombosis 20090801

Title: Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function.

Journal: Cardiovascular research 20090715

Title: Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog.

Journal: American journal of physiology. Heart and circulatory physiology 20090701

Title: Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis.

Journal: The British journal of nutrition 20090601

Title: An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3.

Journal: Journal of lipid research 20090601

Title: Subchronic (13-week) oral toxicity study of dihomo-gamma-linolenic acid (DGLA) oil in rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090601

Title: Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.

Journal: Journal of molecular and cellular cardiology 20090601

Title: Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels.

Journal: Journal of molecular and cellular cardiology 20090601

Title: 8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.

Journal: Prostaglandins & other lipid mediators 20090601

Title: Oral supplementation with dihomo-gamma-linolenic acid-enriched oil altered serum fatty acids in healthy men.

Journal: Bioscience, biotechnology, and biochemistry 20090601

Title: Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels.

Journal: American journal of physiology. Heart and circulatory physiology 20090501

Title: [Production of functional lipids by microorganisms: arachidonic acid and related polyunsaturated fatty acids].

Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090501

Title: A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist.

Journal: Molecular pharmacology 20090401

Title: Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression.

Journal: The Tohoku journal of experimental medicine 20090401

Title: Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20090401

Title: Epoxyeicosatrienoic acid activates BK channels in the cortical collecting duct.

Journal: Journal of the American Society of Nephrology : JASN 20090301

Title: Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20090301

Title: Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD.

Journal: American journal of physiology. Renal physiology 20090301

Title: Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy.

Journal: American journal of physiology. Renal physiology 20090301

Title: Associations between neonatal birth dimensions and maternal essential and trans fatty acid contents during pregnancy and at delivery.

Journal: The British journal of nutrition 20090201

Title: The depressive effects of 5,8,11-eicosatrienoic Acid (20:3n-9) on osteoblasts.

Journal: Lipids 20090201

Title: Possible mediators of connecting tubule glomerular feedback.

Journal: Hypertension (Dallas, Tex. : 1979) 20090201

Title: Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats.

Journal: Journal of hypertension 20090201

Title: Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation.

Journal: The Journal of pharmacology and experimental therapeutics 20090101

Title: Cytochrome P450 metabolites of arachidonic acid play a role in the enhanced cardiac dysfunction in diabetic rats following ischaemic reperfusion injury.

Journal: Autonomic & autacoid pharmacology 20090101

Title: Nutrition for the eye: different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation.

Journal: Ophthalmic research 20090101

Title: Optimal dose of preoperative enteral immunonutrition for patients with esophageal cancer.

Journal: Surgery today 20090101

Title: Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation.

Journal: Cardiovascular research 20081201

Title: Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081201

Title: CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi.

Journal: American journal of respiratory cell and molecular biology 20081201

Title: Inhibitory effects of epoxyeicosatrienoic acids on volume-activated chloride channels in rat mesenteric arterial smooth muscle.

Journal: Prostaglandins & other lipid mediators 20081201

Title: Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats.

Journal: American journal of physiology. Renal physiology 20081201

Title: Hypercholesterolemia enhances 15-lipoxygenase-mediated vasorelaxation and acetylcholine-induced hypotension.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20081201

Title: Determination of epoxyeicosatrienoic acids in human red blood cells and plasma by GC/MS in the NICI mode.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081201

Title: Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20081201

Title: Arachidonic acid metabolites inhibit the stimulatory effect of angiotensin II in renal proximal tubules.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20081201

Title: Cytochrome P-450 metabolites in renal circulation and excretion--interaction with the nitric oxide (NO) system.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20081201

Title: The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.

Journal: The Journal of pharmacology and experimental therapeutics 20081101

Title: Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.

Journal: Pharmacogenetics and genomics 20081101

Title: Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.

Journal: American journal of physiology. Cell physiology 20081101

Title: Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.

Journal: American journal of physiology. Heart and circulatory physiology 20081101

Title: Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo.

Journal: American journal of physiology. Heart and circulatory physiology 20081101

Title: [Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20081101

Title: Direct and simultaneous profiling of epoxyeicosatrienoic acid enantiomers by capillary tandem column chiral-phase liquid chromatography with dual online photodiode array and tandem mass spectrometric detection.

Journal: Analytical and bioanalytical chemistry 20081001

Title: Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080801

Title: Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.

Journal: The Journal of pharmacology and experimental therapeutics 20080801

Title: Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex.

Journal: American journal of physiology. Heart and circulatory physiology 20080801

Title: Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils.

Journal: Infection and immunity 20080801

Title: Atopic dermatitis: the quest for the silver bullet.

Journal: Veterinary journal (London, England : 1997) 20080801

Title: LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium.

Journal: The Journal of biological chemistry 20080711

Title: Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Journal: Stroke 20080701

Title: An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis.

Journal: Blood 20080615

Title: Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia.

Journal: Journal of cellular physiology 20080601

Title: Production of arachidonic acid and dihomo-gamma-linolenic acid from glycerol by oil-producing filamentous fungi, Mortierella in the ARS culture collection.

Journal: Journal of industrial microbiology & biotechnology 20080601

Title: Cytochrome P450 2C9-induced angiogenesis is dependent on EphB4.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20080601

Title: Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways.

Journal: American journal of physiology. Renal physiology 20080601

Title: Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

Journal: American journal of physiology. Heart and circulatory physiology 20080601

Title: Tone-dependent vascular responses to astrocyte-derived signals.

Journal: American journal of physiology. Heart and circulatory physiology 20080601

Title: [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases].

Journal: Annales de cardiologie et d'angeiologie 20080601

Title: Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids.

Journal: Cardiovascular research 20080501

Title: Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity.

Journal: The Journal of pharmacology and experimental therapeutics 20080501

Title: Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats.

Journal: Basic & clinical pharmacology & toxicology 20080501

Title: Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080501

Title: Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20080501

Title: Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease.

Journal: Hypertension (Dallas, Tex. : 1979) 20080501

Title: Fish oil prevents essential fatty acid deficiency and enhances growth: clinical and biochemical implications.

Journal: Metabolism: clinical and experimental 20080501

Title: Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta.

Journal: American journal of physiology. Heart and circulatory physiology 20080301

Title: 11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta.

Journal: American journal of physiology. Heart and circulatory physiology 20080301

Title: Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells.

Journal: Investigative ophthalmology & visual science 20080301

Title: [Protective effects of 11,12-epoxyeicosatrienoic acid preconditioning and postconditioning on myocardial ischemia/reperfusion injury in rats].

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20080225

Title: Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations.

Journal: The British journal of nutrition 20080201

Title: EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17.

Journal: American journal of respiratory cell and molecular biology 20080201

Title: Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration.

Journal: Clinical and experimental immunology 20080201

Title: Age-related decrease in 15-lipoxygenase contributes to reduced vasorelaxation in rabbit aorta.

Journal: American journal of physiology. Heart and circulatory physiology 20080201

Title: Influence of pancreatic status and sex on polyunsaturated fatty acid profiles in cystic fibrosis.

Journal: Clinical chemistry 20080201

Title: Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.

Journal: Microcirculation (New York, N.Y. : 1994) 20080201

Title: Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080101

Title: 11,12-Epoxyeicosatrienoic acid activates the L-arginine/nitric oxide pathway in human platelets.

Journal: Molecular and cellular biochemistry 20080101

Title: Oral administration of dihomo-gamma-linolenic acid prevents development of atopic dermatitis in NC/Nga mice.

Journal: Lipids 20080101

Title: Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080101

Title: Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20071201

Title: Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning.

Journal: Journal of cardiovascular pharmacology 20071201

Title: [Effects of 11, 12-epoxyeicosatrienoic acid preconditioning and postconditioning on Ca(2+)- handling proteins in myocardial ischemia/reperfusion injury in rats].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20071201

Title: Randomized clinical trial of the effects of perioperative use of immune-enhancing enteral formula on metabolic and immunological status in patients undergoing esophagectomy.

Journal: World journal of surgery 20071101

Title: Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice.

Journal: Molecular pharmacology 20071001

Title: Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ERalpha knockout mice: role of aromatase.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20070901

Title: Dynamic expression of epoxyeicosatrienoic acid synthesizing and metabolizing enzymes in the primate corpus luteum.

Journal: Molecular human reproduction 20070801

Title: Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070701

Title: Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats.

Journal: American journal of physiology. Renal physiology 20070701

Title: Epoxyeicosatrienoic acids affect electrolyte transport in renal tubular epithelial cells: dependence on cyclooxygenase and cell polarity.

Journal: American journal of physiology. Renal physiology 20070701

Title: Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator.

Journal: The FEBS journal 20070701

Title: A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat.

Journal: Experimental physiology 20070701

Title: Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha.

Journal: Lipids 20070601

Title: Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi.

Journal: American journal of respiratory cell and molecular biology 20070501

Title: Cyclooxygenase (COX)-1 and COX-2 participate in 5,6-epoxyeicosatrienoic acid-induced contraction of rabbit intralobar pulmonary arteries.

Journal: The Journal of pharmacology and experimental therapeutics 20070501

Title: Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides.

Journal: The Journal of pharmacology and experimental therapeutics 20070501

Title: Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4.

Journal: The Journal of biological chemistry 20070427

Title: Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070425

Title: Action of epoxyeicosatrienoic acids on cellular function.

Journal: American journal of physiology. Cell physiology 20070301

Title: Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.

Journal: Journal of molecular and cellular cardiology 20070301

Title: Adenoviral expression of 15-lipoxygenase-1 in rabbit aortic endothelium: role in arachidonic acid-induced relaxation.

Journal: American journal of physiology. Heart and circulatory physiology 20070201

Title: Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation.

Journal: Prostaglandins & other lipid mediators 20070201

Title: Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid.

Journal: Thrombosis and haemostasis 20070201

Title: Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system.

Journal: Trends in pharmacological sciences 20070101

Title: Erythrocyte-derived epoxyeicosatrienoic acids.

Journal: Prostaglandins & other lipid mediators 20070101

Title: Cyclic AMP-dependent modulation of cardiac L-type Ca2+ and transient outward K+ channel activities by epoxyeicosatrienoic acids.

Journal: Prostaglandins & other lipid mediators 20070101

Title: Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.

Journal: Prostaglandins & other lipid mediators 20070101

Title: Effects of 5-oxo-ETE and 14,15-EET on reactivity and Ca2+ sensitivity in guinea pig bronchi.

Journal: Prostaglandins & other lipid mediators 20070101

Title: Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).

Journal: Prostaglandins & other lipid mediators 20070101

Title: Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury.

Journal: Prostaglandins & other lipid mediators 20070101

Title: Epoxyeicosatrienoic acids, cell signaling and angiogenesis.

Journal: Prostaglandins & other lipid mediators 20070101

Title: 11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells.

Journal: Prostaglandins & other lipid mediators 20070101

Title: Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids.

Journal: Prostaglandins & other lipid mediators 20070101

Title: Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase.

Journal: Cell biochemistry and biophysics 20070101

Title: Hepoxilin analogs, PBT-3 and PBT-4, cause apoptosis of Gleevec-resistant K562 cells in vitro.

Journal: In vivo (Athens, Greece) 20070101

Title: Role of cytochrome P450 metabolites of arachidonic acid in regulation of corporal smooth muscle tone in diabetic and older rats.

Journal: Vascular pharmacology 20070101

Title: Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress?

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20070101

Title: Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC.

Journal: American journal of physiology. Renal physiology 20061201

Title: [Effect of 11, 12-epoxyeicosatrienoic acids on hypoxia/reoxygenation injury in the human umbilical vein endothelial cells].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20061201

Title: Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20061101

Title: Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase.

Journal: American journal of physiology. Heart and circulatory physiology 20061001

Title: High-calcium vs high-phosphate intake and small artery tone in advanced experimental renal insufficiency.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20061001

Title: From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling.

Journal: Pharmacology & therapeutics 20060901

Title: Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms.

Journal: The Journal of physiology 20060901

Title: Compartmental analyses of plasma 13C- and 2H-labeled n-6 fatty acids arising from oral administrations of 13C-U-18:2n-6 and 2H5-20:3n-6 in newborn infants.

Journal: Pediatric research 20060901

Title: Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids.

Journal: Biochimica et biophysica acta 20060901

Title: Distribution and metabolism of dihomo-gamma-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats.

Journal: Bioscience, biotechnology, and biochemistry 20060901

Title: The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression.

Journal: The Journal of endocrinology 20060901

Title: Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury.

Journal: American journal of physiology. Heart and circulatory physiology 20060801

Title: Having a heart attack? Avoid the 'HETE'!

Journal: American journal of physiology. Heart and circulatory physiology 20060801

Title: Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature.

Journal: American journal of physiology. Heart and circulatory physiology 20060801

Title: Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway.

Journal: American journal of physiology. Renal physiology 20060701

Title: Modulation of ACTH-induced cortisol release by polyunsaturated fatty acids in interrenal cells from gilthead seabream, Sparus aurata.

Journal: The Journal of endocrinology 20060701

Title: Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.

Journal: The Journal of pharmacy and pharmacology 20060601

Title: Allylic alcohol transposition by ortho ester-initiated carbonate extension. synthesis of the vasodilator 11(R),12(S),15(S)-trihydroxyeicosa- 5(Z),8(Z),13(E)-trienoic acid.

Journal: Organic letters 20060525

Title: Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites.

Journal: Analytical biochemistry 20060501

Title: Dietary manipulation implicates lipid signaling in the regulation of germ cell maintenance in C. elegans.

Journal: Developmental biology 20060415

Title: Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060401

Title: Endothelium-derived epoxyeicosatrienoic acids and vascular function.

Journal: Hypertension (Dallas, Tex. : 1979) 20060401

Title: Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid.

Journal: American journal of physiology. Heart and circulatory physiology 20060401

Title: Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315

Title: Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

Title: Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201

Title: A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets.

Journal: The Journal of physiology 20060115

Title: Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis.

Journal: The Journal of biological chemistry 20060113

Title: 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha.

Journal: American journal of physiology. Heart and circulatory physiology 20060101

Title: Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase.

Journal: American journal of physiology. Heart and circulatory physiology 20060101

Title: A biosynthetic pathway generating 12-hydroxy-5,8,14-eicosatrienoic acid from arachidonic acid is active in mouse skin microsomes.

Journal: The Journal of pharmacology and experimental therapeutics 20060101

Title: Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children.

Journal: The British journal of nutrition 20060101

Title: Hepoxilin analogs, potential new therapeutics in disease.

Journal: Current pharmaceutical design 20060101

Title: Effects of long-term continuous use of immune-enhancing enteral formula on nutritional and immunologic status in non-surgical patients.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20060101

Title: Capping of CdSe-ZnS quantum dots with DHLA and subsequent conjugation with proteins.

Journal: Nature protocols 20060101

Title: Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells.

Journal: Biochimica et biophysica acta 20051230

Title: PBT-3, a hepoxilin stable analog, causes long term inhibition of growth of K562 solid tumours in vivo.

Journal: Biochemical and biophysical research communications 20051209

Title: Hepoxilin A3 synthase.

Journal: Biochemical and biophysical research communications 20051209

Title: TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels.

Journal: Circulation research 20051209

Title: EDHF redux: EETs, TRPV4, and Ca2+ sparks.

Journal: Circulation research 20051209

Title: Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus.

Journal: American journal of physiology. Renal physiology 20051201

Title: Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis.

Journal: Journal of cell science 20051201

Title: [Arachidonic acid epoxygenases and their metabolites promote angiogenesis].

Journal: Zhonghua xin xue guan bing za zhi 20051201

Title: Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure.

Journal: American journal of respiratory and critical care medicine 20051101

Title: Glomerular cytochrome P-450 and cyclooxygenase metabolites regulate efferent arteriole resistance.

Journal: Hypertension (Dallas, Tex. : 1979) 20051101

Title: Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium.

Journal: Circulation research 20051028

Title: 5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20051001

Title: Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited.

Journal: Cardiovascular research 20051001

Title: Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels.

Journal: The Journal of pharmacology and experimental therapeutics 20051001

Title: Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved.

Journal: Science in China. Series C, Life sciences 20051001

Title: A linchpin approach to unsaturated fatty acids: 11,12-epoxyeicosatrienoic acid and 11S,12S-dihydroxyeicosatrienoic acid ethyl esters.

Journal: The Journal of organic chemistry 20050930

Title: Mediation of neurogenic ion transport by acetylcholine, prostanoids and 5-hydroxytryptamine in porcine ileum.

Journal: European journal of pharmacology 20050920

Title: Cytochrome P450/NADPH-dependent biosynthesis of 5,6-trans-epoxyeicosatrienoic acid from 5,6-trans-arachidonic acid.

Journal: The Biochemical journal 20050915

Title: Role of Ca2+-independent phospholipase A2 and cytochrome P-450 in store-operated calcium entry in 3T6 fibroblasts.

Journal: Biochemical pharmacology 20050901

Title: Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis.

Journal: Biological & pharmaceutical bulletin 20050901

Title: Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids.

Journal: American journal of physiology. Renal physiology 20050801

Title: Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).

Journal: The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 20050801

Title: [Effect of 11, 12-epoxyeicosatrienoic acid on nitric oxide synthase of ischemia-reperfusion myocardium in rats].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20050801

Title: Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids.

Journal: The Journal of biological chemistry 20050722

Title: Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20050701

Title: Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids.

Journal: British journal of pharmacology 20050701

Title: COX-2 inhibitors and metabolism of essential fatty acids.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20050701

Title: Stereospecific synthesis and mass spectrometry of 5,6-trans-epoxy-8Z,11Z,14Z-eicosatrienoic acid.

Journal: Bioorganic & medicinal chemistry letters 20050615

Title: Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.

Journal: Cancer research 20050601

Title: Molecular determinants of cardiac K(ATP) channel activation by epoxyeicosatrienoic acids.

Journal: The Journal of biological chemistry 20050513

Title: Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050401

Title: Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation.

Journal: Hypertension (Dallas, Tex. : 1979) 20050401

Title: 14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries.

Journal: Hypertension (Dallas, Tex. : 1979) 20050401

Title: Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20050301

Title: Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle.

Journal: Circulation research 20050218

Title: Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050201

Title: Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids.

Journal: Archives of biochemistry and biophysics 20050115

Title: Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid.

Journal: American journal of physiology. Heart and circulatory physiology 20050101

Title: Influence of testosterone on polyunsaturated fatty acid biosynthesis in Sertoli cells in culture.

Journal: Cell biochemistry and function 20050101

Title: Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.

Journal: Nature medicine 20050101

Title: Red blood cells: reservoirs of cis- and trans-epoxyeicosatrienoic acids.

Journal: Prostaglandins & other lipid mediators 20050101

Title: The hepoxilin analog, PBT-3, inhibits growth of K-562 CML solid tumours in vivo in nude mice.

Journal: In vivo (Athens, Greece) 20050101

Title: Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries.

Journal: European journal of pharmacology 20041215

Title: Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels.

Journal: American journal of physiology. Heart and circulatory physiology 20041201

Title: Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling.

Journal: Endocrinology 20041101

Title: Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20041101

Title: Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway.

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Title: Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.

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Title: Beating ischemia: a new feat of EETs?

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Title: Non-prostaglandin eicosanoids in fever and anapyrexia.

Journal: Frontiers in bioscience : a journal and virtual library 20040901

Title: Identification of 5,6-trans-epoxyeicosatrienoic acid in the phospholipids of red blood cells.

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Title: Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium.

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Title: 14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries.

Journal: Pharmacological research 20040601

Title: Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants.

Journal: Nature biotechnology 20040601

Title: Developmental changes in myoendothelial gap junction mediated vasodilator activity in the rat saphenous artery.

Journal: The Journal of physiology 20040501

Title: Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid.

Journal: Biochemical pharmacology 20040415

Title: Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040301

Title: Role of EETs in regulation of endothelial permeability in rat lung.

Journal: American journal of physiology. Lung cellular and molecular physiology 20040201

Title: Mediators of bradykinin-induced vasorelaxation in human coronary microarteries.

Journal: Hypertension (Dallas, Tex. : 1979) 20040201

Title: Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat preglomerular microvessels (PGMV) via A2A receptors.

Journal: British journal of pharmacology 20040201

Title: A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury.

Journal: The American journal of pathology 20040201

Title: Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?

Journal: Circulation research 20040109

Title: Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.

Journal: Progress in lipid research 20040101

Title: 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta.

Journal: American journal of physiology. Heart and circulatory physiology 20031201

Title: The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells.

Journal: The Journal of pharmacology and experimental therapeutics 20031201

Title: Effects of sesamin and capsaicin on the mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes.

Journal: Journal of nutritional science and vitaminology 20031201

Title: 11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.

Journal: Bioorganic & medicinal chemistry letters 20031117

Title: Role of epoxyeicosatrienoic acids in renal functional response to inhibition of NO production in the rat.

Journal: American journal of physiology. Renal physiology 20031101

Title: Nitric oxide-epoxygenase interactions and arachidonate-induced dilation of rat renal microvessels.

Journal: American journal of physiology. Heart and circulatory physiology 20031101

Title: Effect of 11,12-epoxyeicosatrienoic acid as an additive to St. Thomas' cardioplegia and University of Wisconsin solutions on endothelium-derived hyperpolarizing factor-mediated function in coronary microarteries: influence of temperature and time.

Journal: The Annals of thoracic surgery 20031101

Title: Dihomo-gamma-linolenic acid inhibits tumour necrosis factor-alpha production by human leucocytes independently of cyclooxygenase activity.

Journal: Immunology 20031101

Title: Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase.

Journal: Biochemistry 20031014

Title: To b'EET or not to b'EET? That is the question!

Journal: Clinical science (London, England : 1979) 20031001

Title: 5,6-epoxyeicosatrienoic acid mediates the enhanced renal vasodilation to arachidonic acid in the SHR.

Journal: Hypertension (Dallas, Tex. : 1979) 20031001

Title: 14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries.

Journal: Hypertension (Dallas, Tex. : 1979) 20031001

Title: Effect of dietary fat level and sesamin on the polyunsaturated fatty acid metabolism in rats.

Journal: Journal of nutritional science and vitaminology 20031001

Title: Plasma fatty acid composition and incidence of coronary heart disease in middle aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20031001

Title: [Effects of 11,12-epoxyeicosatrienoic acid on cardioplegia and reperfusion arrhythmias in the isolated immature rabbit hearts].

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20031001

Title: Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes.

Journal: The Journal of biological chemistry 20030912

Title: Hepoxilins and trioxilins in barnacles: an analysis of their potential roles in egg hatching and larval settlement.

Journal: The Journal of experimental biology 20030901

Title: 11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1.

Journal: The Journal of biological chemistry 20030808

Title: Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia.

Journal: American journal of physiology. Heart and circulatory physiology 20030701

Title: Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis.

Journal: Journal of the American Society of Nephrology : JASN 20030701

Title: 11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide.

Journal: Experimental biology and medicine (Maywood, N.J.) 20030701

Title: Effects of eicosatrienoic acid (20:3 n-9, Mead's acid) on some promalignant-related properties of three human cancer cell lines.

Journal: Prostaglandins & other lipid mediators 20030701

Title: Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta.

Journal: Biochimica et biophysica acta 20030620

Title: Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit.

Journal: American journal of physiology. Heart and circulatory physiology 20030601

Title: Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles.

Journal: Kidney international 20030601

Title: The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20030501

Title: Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401

Title: HETEs/EETs in renal glomerular and epithelial cell functions.

Journal: Current opinion in pharmacology 20030401

Title: Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells.

Journal: Prostaglandins & other lipid mediators 20030401

Title: The regulation of arachidonic acid metabolism in human first trimester trophoblast by cyclic AMP.

Journal: Prostaglandins & other lipid mediators 20030401

Title: Effect of DHLA on response of isolated rat urinary bladder to repetitive field stimulation.

Journal: Molecular and cellular biochemistry 20030401

Title: Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase.

Journal: Archives of biochemistry and biophysics 20030315

Title: Biosynthesis of hepoxilins: evidence for the presence of a hepoxilin synthase activity in rat insulinoma cells.

Journal: FEBS letters 20030313

Title: The nitric oxide- and prostaglandin-independent component of the renal vasodilator effect of thimerosal is mediated by epoxyeicosatrienoic acids.

Journal: The Journal of pharmacology and experimental therapeutics 20030301

Title: Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels.

Journal: Circulation 20030211

Title: Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation.

Journal: American journal of physiology. Heart and circulatory physiology 20030101

Title: Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells.

Journal: American journal of physiology. Heart and circulatory physiology 20030101

Title: Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells.

Journal: European journal of pharmacology 20030101

Title: A lipoxygenase product, hepoxilin A(3), enhances nerve growth factor-dependent neurite regeneration post-axotomy in rat superior cervical ganglion neurons in vitro.

Journal: Neuroscience 20030101

Title: Eicosanoid precursor polyenoic fatty acids modulate synaptic levels of dopamine in ex-vivo slices of rat brain striatum.

Journal: In vivo (Athens, Greece) 20030101

Title: Cytochrome P450-derived eicosanoids mediators of ocular surface inflammation. are.

Journal: Advances in experimental medicine and biology 20030101

Title: Beneficial effects of n-9 eicosatrienoic acid on experimental bowel lesions.

Journal: Surgery today 20030101

Title: The hepoxilin analog PBT-3 induces apoptosis in BCR-ABL-positive K562 leukemia cells.

Journal: Anticancer research 20030101

Title: The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100.

Journal: Thrombosis research 20030101

Title: Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide.

Journal: American journal of physiology. Heart and circulatory physiology 20021201

Title: Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid.

Journal: Stroke 20021201

Title: Modulation of microphthalmia-associated transcription factor gene expression alters skin pigmentation.

Journal: The Journal of investigative dermatology 20021201

Title: Capillary electrophoresis of cytochrome P-450 epoxygenase metabolites of arachidonic acid. 2. Resolution of stereoisomers.

Journal: Analytical chemistry 20021115

Title: Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle.

Journal: American journal of physiology. Heart and circulatory physiology 20021101

Title: Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors.

Journal: American journal of physiology. Heart and circulatory physiology 20021101

Title: Stereospecific activation of cardiac ATP-sensitive K(+) channels by epoxyeicosatrienoic acids: a structural determinant study.

Journal: Molecular pharmacology 20021101

Title: Production of 5,8,11-eicosatrienoic acid by a delta5 and delta6 desaturation activity-enhanced mutant derived from a delta12 desaturation activity-defective mutant of Mortierella alpina 1S-4.

Journal: Applied microbiology and biotechnology 20021101

Title: Assessment of essential fatty acid and omega3-fatty acid status by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20021101

Title: Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids.

Journal: Lipids 20021001

Title: Role of 5,6-epoxyeicosatrienoic acid in the regulation of newborn piglet pulmonary vascular tone.

Journal: American journal of physiology. Lung cellular and molecular physiology 20020801

Title: The production of progesterone and 5,6-epoxyeicosatrienoic acid by human granulosa cells.

Journal: The Journal of steroid biochemistry and molecular biology 20020801

Title: Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.

Journal: The Biochemical journal 20020715

Title: To move or not to move? Cytochrome P450 products and cell migration.

Journal: Circulation research 20020517

Title: Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.

Journal: Circulation research 20020517

Title: 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.

Journal: Circulation research 20020517

Title: Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells.

Journal: The Journal of biological chemistry 20020510

Title: Cytochrome P450 2C9-induced endothelial cell proliferation involves induction of mitogen-activated protein (MAP) kinase phosphatase-1, inhibition of the c-Jun N-terminal kinase, and up-regulation of cyclin D1.

Journal: The Journal of biological chemistry 20020503

Title: Polyunsaturated fatty acid biosynthesis from [1-14C]20:3 n-6 acid in rat cultured Sertoli cells. Linoleic acid effect.

Journal: The international journal of biochemistry & cell biology 20020501

Title: 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels.

Journal: American journal of physiology. Heart and circulatory physiology 20020501

Title: Hepoxilin analogs inhibit bleomycin-induced pulmonary fibrosis in the mouse.

Journal: The Journal of pharmacology and experimental therapeutics 20020501

Title: A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition.

Journal: The Journal of pharmacology and experimental therapeutics 20020501

Title: Effects of epoxyeicosatrienoic acids on polymorphonuclear leukocyte function.

Journal: Life sciences 20020421

Title: Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid.

Journal: Circulation research 20020419

Title: Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells.

Journal: American journal of physiology. Heart and circulatory physiology 20020401

Title: The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP.

Journal: FEBS letters 20020327

Title: Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle.

Journal: American journal of physiology. Cell physiology 20020301

Title: Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: new insights into the reaction of peroxynitrite with thiols.

Journal: Archives of biochemistry and biophysics 20020101

Title: P-450 metabolites of arachidonic acid in the control of cardiovascular function.

Journal: Physiological reviews 20020101

Title: Hepoxilin B3 and its enzymatically formed derivative trioxilin B3 are incorporated into phospholipids in psoriatic lesions.

Journal: The Journal of investigative dermatology 20020101

Title: Substrate down regulation of 12-lipoxygenase in human platelets.

Journal: Advances in experimental medicine and biology 20020101

Title: Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs.

Journal: Advances in experimental medicine and biology 20020101

Title: Activation of ATP-sensitive K(+) channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes.

Journal: The Journal of physiology 20011215

Title: Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase.

Journal: Hypertension (Dallas, Tex. : 1979) 20011201

Title: Epoxyeicosatrienoic acids (EET(11,12)) may partially restore endothelium-derived hyperpolarizing factor-mediated function in coronary microarteries.

Journal: The Annals of thoracic surgery 20011201

Title: Vicinal nitrohydroxyeicosatrienoic acids: vasodilator lipids formed by reaction of nitrogen dioxide with arachidonic acid.

Journal: The Journal of pharmacology and experimental therapeutics 20011101

Title: A critical review of the role of endothelial factors in the pathogenesis of hypertension.

Journal: Journal of cardiovascular pharmacology 20011101

Title: Cytochrome p450 and vascular homeostasis.

Journal: Circulation research 20011026

Title: Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance.

Journal: American journal of physiology. Heart and circulatory physiology 20011001

Title: Stereospecific synthesis of trans-arachidonic acids.

Journal: Bioorganic & medicinal chemistry letters 20010917

Title: Hypothalamic 11,12-epoxyeicosatrienoic acid attenuates fever induced by central interleukin-1beta in the rat.

Journal: Neuroscience letters 20010914

Title: Dihydroxyeicosatrienoic acids are potent activators of Ca(2+)-activated K(+) channels in isolated rat coronary arterial myocytes.

Journal: The Journal of physiology 20010801

Title: Nitric oxide synthase activity in neutrophils from patients with localized aggressive periodontitis.

Journal: Journal of periodontology 20010801

Title: Mediation of EDHF-induced reduction of smooth muscle [Ca(2+)](i) and arteriolar dilation by K(+) channels, 5,6-EET, and gap junctions.

Journal: Microcirculation (New York, N.Y. : 1994) 20010801

Title: Identifying endothelium-derived hyperpolarizing factor: recent approaches to assay the role of epoxyeicosatrienoic acids.

Journal: Japanese journal of pharmacology 20010801

Title: The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells.

Journal: Pflugers Archiv : European journal of physiology 20010701

Title: EET homologs potently dilate coronary microvessels and activate BK(Ca) channels.

Journal: American journal of physiology. Heart and circulatory physiology 20010601

Title: EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice.

Journal: American journal of physiology. Heart and circulatory physiology 20010601

Title: Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect.

Journal: American journal of physiology. Heart and circulatory physiology 20010601

Title: Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.

Journal: The Journal of biological chemistry 20010511

Title: Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries.

Journal: Biochemical and biophysical research communications 20010511

Title: Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition.

Journal: The Journal of biological chemistry 20010504

Title: EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010501

Title: Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs.

Journal: Analytical biochemistry 20010501

Title: Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid.

Journal: Journal of hypertension 20010501

Title: Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases.

Journal: The Journal of biological chemistry 20010330

Title: Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010301

Title: Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs.

Journal: American journal of physiology. Heart and circulatory physiology 20010301

Title: Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR.

Journal: Hypertension (Dallas, Tex. : 1979) 20010301

Title: Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways.

Journal: American journal of hypertension 20010301

Title: Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3.

Journal: Archives of biochemistry and biophysics 20010301

Title: Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population.

Journal: Cancer letters 20010226

Title: Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid.

Journal: Molecular and cellular biochemistry 20010201

Title: Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein.

Journal: Biochemistry 20010130

Title: Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries.

Journal: Circulation research 20010119

Title: Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism.

Journal: The Biochemical journal 20010101

Title: The lung HETEs (and EETs) up.

Journal: American journal of physiology. Heart and circulatory physiology 20010101

Title: Regulation of BK(Ca) channels expressed in human embryonic kidney 293 cells by epoxyeicosatrienoic acid.

Journal: Molecular pharmacology 20010101

Title: Epoxygenase metabolites contribute to nitric oxide-independent afferent arteriolar vasodilation in response to bradykinin.

Journal: Journal of vascular research 20010101

Title: Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids.

Journal: Trends in cardiovascular medicine 20010101

Title: Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy.

Journal: Journal of perinatal medicine 20010101

Title: Investigation of long-chain polyunsaturated fatty acid metabolism in lactating women by means of stable isotope techniques.

Journal: Advances in experimental medicine and biology 20010101

Title: Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland.

Journal: Nutrition and cancer 20010101

Title: Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.

Journal: Circulation research 20001124

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Tags:1783-84-2 Molecular Formula|1783-84-2 MDL|1783-84-2 SMILES|1783-84-2 Cis-8,11,14-eicosatrienoic acid