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Home Amines 178307-42-1
178307-42-1,MFCD09955384
Catalog No.:AA0025UK

178307-42-1 | 2-Pyrimidinamine, 4-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-, hydrochloride (1:1)

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Purity
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Price(USD)
Quantity
  
5mg
98%
in stock  
$109.00   $77.00
- +
25mg
98%
in stock  
$216.00   $152.00
- +
100mg
98%
in stock  
$445.00   $312.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0025UK
Chemical Name:
2-Pyrimidinamine, 4-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-, hydrochloride (1:1)
CAS Number:
178307-42-1
Molecular Formula:
C22H24ClFN4
Molecular Weight:
398.9042
MDL Number:
MFCD09955384
SMILES:
Fc1ccc(cc1)Nc1nc(c(c(n1)C)C)N1CCc2c(C1C)cccc2.Cl
Properties
Computed Properties
 
Complexity:
481  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Bioavailability and tolerability of combination treatment with revaprazan 200 mg + itopride 150 mg: a randomized crossover study in healthy male Korean volunteers.

Journal: Clinical therapeutics 20120901

Title: Mitigating endoplasmic reticulum stress with revaprazan ameliorates stress-related mucosal disease.

Journal: Journal of gastroenterology and hepatology 20120101

Title: In vitro and in vivo protection against indomethacin-induced small intestinal injury by proton pump inhibitors, acid pump antagonists, or indomethacin-phosphatidylcholine.

Journal: Digestion 20120101

Title: The potential inhibitory effect of revaprazan, an acid pump antagonist, on anticoagulation with warfarin.

Journal: The Tohoku journal of experimental medicine 20110801

Title: Acid pump antagonist-provoked HSP27 dephosphorylation and accentuation rescues stomach from indomethacin-induced damages.

Journal: Journal of digestive diseases 20110401

Title: [Effect of acid pump antagonist (Revaprazan, Revanex(R)) on the result of 13C urea breath test in the patients with Helicobacter pylori associated peptic ulcer disease].

Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20110101

Title: [Effect of acid pump antagonist (Revaprazan, Revanex(R)) on result of 13C urea breath test in patients with Helicobacter pylori associated peptic ulcer disease].

Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20110101

Title: Novel pyrimidines as acid pump antagonists (APAs).

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: The transport of a reversible proton pump antagonist, 5, 6-dimethyl-2-(4-Fluorophenylamino)-4-(1-methyl-1,2,3, 4-tetrahydroisoquinoline-2-yl) pyrimidine hydrochloride (YH1885), across caco-2 cell monolayers.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010101

Title: Lee JS, et al. Revaprazan, a novel acid pump antagonist, exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling. J Clin Biochem Nutr. 2012 Sep;51(2):77-83.

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Tags:178307-42-1 Molecular Formula|178307-42-1 MDL|178307-42-1 SMILES|178307-42-1 2-Pyrimidinamine, 4-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-, hydrochloride (1:1)