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17834-03-6,MFCD00272668
Catalog No.:AA0025W8

17834-03-6 | 2H-1-Benzopyran-2-one, 4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)-

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1mg
≥98%
in stock  
$209.00   $146.00
- +
5mg
95%
in stock  
$746.00   $522.00
- +
10mg
95%
in stock  
$1,260.00   $882.00
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25mg
95%
in stock  
$2,443.00   $1,710.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0025W8
Chemical Name:
2H-1-Benzopyran-2-one, 4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)-
CAS Number:
17834-03-6
Molecular Formula:
C19H16O5
Molecular Weight:
324.3273
MDL Number:
MFCD00272668
SMILES:
CC(=O)CC(c1c(=O)oc2c(c1O)ccc(c2)O)c1ccccc1
Properties
Computed Properties
 
Complexity:
532  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.3  

Literature

Title: Warfarin Metabolites in Patients Following Cardiac Valve Implantation: A Contribution of Clinical and Genetic Factors.

Journal: Cardiovascular drugs and therapy 20150601

Title: Warfarin is an effective modifier of multiple UDP-glucuronosyltransferase enzymes: evaluation of its potential to alter the pharmacokinetics of zidovudine.

Journal: Journal of pharmaceutical sciences 20150101

Title: Responsiveness to low-dose warfarin associated with genetic variants of VKORC1, CYP2C9, CYP2C19, and CYP4F2 in an Indonesian population.

Journal: European journal of clinical pharmacology 20130301

Title: Analysis of R- and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases.

Journal: The Journal of pharmacology and experimental therapeutics 20120101

Title: Simultaneous determination of warfarin and 7-hydroxywarfarin enantiomers by high-performance liquid chromatography with ultraviolet detection.

Journal: Therapeutic drug monitoring 20110201

Title: Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Journal: Chemical research in toxicology 20100517

Title: Effects of folic acid supplementation on the pharmacokinetics and anticoagulant effect of warfarin: an open-label, prospective study of long-term administration in adults.

Journal: Clinical therapeutics 20100201

Title: Determination of plasma warfarin concentrations in Korean patients and its potential for clinical application.

Journal: The Korean journal of laboratory medicine 20091201

Title: Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans.

Journal: Chemical research in toxicology 20090701

Title: R(+)XK469 inhibits hydroxylation of S-warfarin by CYP2C9.

Journal: European journal of cancer (Oxford, England : 1990) 20090701

Title: Prediction of human disposition toward S-3H-warfarin using chimeric mice with humanized liver.

Journal: Drug metabolism and pharmacokinetics 20090101

Title: CYP2C9-catalyzed metabolism of S-warfarin to 7-hydroxywarfarin in vivo and in vitro in chimeric mice with humanized liver.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20081201

Title: Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20081101

Title: The effect of CYP2C19 genotypes on the pharmacokinetics of warfarin enantiomers.

Journal: Journal of clinical pharmacy and therapeutics 20080201

Title: Simultaneous determination of warfarin enantiomers and its metabolite in human plasma by column-switching high-performance liquid chromatography with chiral separation.

Journal: Therapeutic drug monitoring 20070601

Title: Synthesis and structure-activity relationships of novel warfarin derivatives.

Journal: Bioorganic & medicinal chemistry 20070315

Title: Determination of warfarin enantiomers and hydroxylated metabolites in human blood plasma by liquid chromatography with achiral and chiral separation.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425

Title: Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.

Journal: British journal of clinical pharmacology 20040501

Title: mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030301

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SDS
Tags:17834-03-6 Molecular Formula|17834-03-6 MDL|17834-03-6 SMILES|17834-03-6 2H-1-Benzopyran-2-one, 4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)-