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18085-97-7,MFCD01081948
Catalog No.:AA0022B2

18085-97-7 | Jaceosidin

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Purity
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1mg
99+%
in stock  
$48.00   $34.00
- +
5mg
99+%
in stock  
$121.00   $85.00
- +
10mg
99+%
in stock  
$158.00   $110.00
- +
25mg
99+%
in stock  
$206.00   $144.00
- +
50mg
99+%
in stock  
$268.00   $188.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0022B2
Chemical Name:
Jaceosidin
CAS Number:
18085-97-7
Molecular Formula:
C17H14O7
Molecular Weight:
330.2889
MDL Number:
MFCD01081948
SMILES:
COc1cc(ccc1O)c1cc(=O)c2c(o1)cc(c(c2O)OC)O
Properties
Properties
 
BP:
619°C at 760 mmHg  
Form:
Solid  
MP:
228 - 230°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
505  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
1.7  

Upstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2012,vol.22,#7,p.2534-2535

[1]BioorganicandMedicinalChemistryLetters,2012,vol.22,#7,p.2534-2535

[1]BioorganicandMedicinalChemistryLetters,2012,vol.22,#7,p.2534-2535

[1]Patent:JP5712580,2015,B2,

[1]Patent:JP5712580,2015,B2,

Downstream Synthesis Route

[1]Phytochemistry,1985,vol.24,p.1515-1520

[1]Phytochemistry,1983,vol.22,p.2057-2060

[1]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.2534-2535

Literature

Title: Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells.

Journal: Chemico-biological interactions 20161225

Title: Flavonoids from the Japanese monotypic genus, Nipponanthemum.

Journal: Natural product communications 20120801

Title: Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production.

Journal: Bioorganic & medicinal chemistry letters 20120401

Title: Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells.

Journal: Nutrition research and practice 20120401

Title: [Chemical constituents of Eupatorium lindleyanum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401

Title: A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M.

Journal: Natural product research 20120101

Title: Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31.

Journal: Journal of agricultural and food chemistry 20111228

Title: The relevance of higher plants in lead compound discovery programs.

Journal: Journal of natural products 20110624

Title: Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells.

Journal: European journal of pharmacology 20110125

Title: Neuropharmacological activity of Lippia nodiflora Linn.

Journal: Pharmacognosy research 20110101

Title: Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives.

Journal: Pharmacognosy reviews 20110101

Title: Jaceosidin induces p53-dependent G2/M phase arrest in U87 glioblastoma cells.

Journal: Asian Pacific journal of cancer prevention : APJCP 20110101

Title: Metabolism study of botanical drugs.

Journal: Archives of pharmacal research 20101201

Title: In vitro metabolism of jaceosidin and characterization of cytochrome P450 and UDP-glucuronosyltransferase enzymes in human liver microsomes.

Journal: Archives of pharmacal research 20101201

Title: Effects of eupatilin and jaceosidin on cytochrome p450 enzyme activities in human liver microsomes.

Journal: Molecules (Basel, Switzerland) 20100916

Title: A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.

Journal: Bioorganic & medicinal chemistry 20100201

Title: Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice.

Journal: Journal of ethnopharmacology 20090925

Title: Liquid chromatography-tandem mass spectrometry for the determination of jaceosidin in rat plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20090220

Title: Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita.

Journal: Journal of ethnopharmacology 20081030

Title: In vitro antioxidant and anti-inflammatory activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal.

Journal: Archives of pharmacal research 20080401

Title: Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway.

Journal: Journal of biomedicine & biotechnology 20080101

Title: Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity.

Journal: International immunopharmacology 20071215

Title: Anti-inflammatory activity of flavonoids from Eupatorium arnottianum.

Journal: Journal of ethnopharmacology 20070725

Title: Elemanolide sesquiterpenes and eudesmane sesquiterpene glycosides from Centaurea hierapolitana.

Journal: Phytochemistry 20070301

Title: Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells.

Journal: Annals of the New York Academy of Sciences 20070101

Title: Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species.

Journal: Annals of the New York Academy of Sciences 20070101

Title: Salicylic acid enhances Jaceosidin and Syringin production in cell cultures of Saussurea medusa.

Journal: Biotechnology letters 20060701

Title: Methyl jasmonate stimulates jaceosidin and hispidulin production in cell cultures of Saussurea medusa.

Journal: Applied biochemistry and biotechnology 20060701

Title: Flavonoids from Artemisia copa with anti-inflammatory activity.

Journal: Planta medica 20060101

Title: Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16.

Journal: Journal of ethnopharmacology 20050426

Title: Cellular aggregate size as the critical factor for flavonoid production by suspension cultures of Saussurea medusa.

Journal: Biotechnology letters 20050101

Title: Transformation of Saussurea medusa for hairy roots and jaceosidin production.

Journal: Plant cell reports 20041201

Title: Free radical scavengers and antioxidants from Baccharis grisebachii.

Journal: Journal of ethnopharmacology 20041201

Title: Active components from Artemisia iwayomogi displaying ONOO(-) scavenging activity.

Journal: Phytotherapy research : PTR 20040101

Title: [Study on the flavonoids of Eupatorium lindleyanum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040101

Title: Effect of aggregate size in cell cultures of Saussurea medusa on cell growth and jaceosidin production.

Journal: Plant cell reports 20030701

Title: Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.

Journal: Biological & pharmaceutical bulletin 20020701

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