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Home Amines 184475-71-6
184475-71-6,MFCD09908046
Catalog No.:AA0075CQ

184475-71-6 | 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
98%
in stock  
$13.00   $9.00
- +
250mg
98%
in stock  
$19.00   $14.00
- +
1g
98%
in stock  
$25.00   $18.00
- +
5g
98%
in stock  
$31.00   $22.00
- +
25g
98%
in stock  
$85.00   $60.00
- +
100g
98%
in stock  
$320.00   $224.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0075CQ
Chemical Name:
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
CAS Number:
184475-71-6
Molecular Formula:
C15H11ClFN3O2
Molecular Weight:
319.7181
MDL Number:
MFCD09908046
SMILES:
COc1cc2ncnc(c2cc1O)Nc1ccc(c(c1)Cl)F
Properties
Computed Properties
 
Complexity:
379  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.8  

Upstream Synthesis Route

[1]Patent:US5866572,1999,A,

[2]Patent:US5770599,1998,A,

[3]Patent:US5770603,1998,A,

[1]Patent:WO2013/71697,2013,A1,.Locationinpatent:Paragraph00197

[2]Patent:US2014/228361,2014,A1,.Locationinpatent:Paragraph0277-0278

[3]Patent:US2014/206664,2014,A1,.Locationinpatent:Paragraph0225;0229

[4]Patent:EP2796451,2014,A1,.Locationinpatent:Paragraph0082

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistry,2010,vol.18,p.870-879

[2]Patent:CN106045980,2016,A.Locationinpatent:Paragraph0027;0028;0029

[3]Patent:CN106432202,2017,A.Locationinpatent:Paragraph0012

[4]Patent:WO2013/71697,2013,A1.Locationinpatent:Paragraph00196

[5]Patent:US2014/228361,2014,A1.Locationinpatent:Paragraph0275-0276

[6]Patent:US2004/254205,2004,A1.Locationinpatent:Page19

[7]DaltonTransactions,2015,vol.44,p.13100-13111

[8]Patent:US2010/143295,2010,A1

[9]EuropeanJournalofMedicinalChemistry,2017,vol.127,p.442-458

[10]Patent:WO2018/119441,2018,A1.Locationinpatent:Paragraph00568-00570

[11]Patent:CN109721552,2019,A.Locationinpatent:Paragraph0116-0118

[12]Patent:CN108047209,2018,A.Locationinpatent:Paragraph0041;0049;0050

[13]JournalofMedicinalChemistry,2018,vol.61,p.11372-11383

[14]BioorganicandMedicinalChemistryLetters,2001,vol.11,p.1911-1914

[15]BioorganicandMedicinalChemistryLetters,2006,vol.16,p.4908-4912

[16]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.4745-4749

[17]Patent:US2014/206664,2014,A1.Locationinpatent:Paragraph0225

[18]Patent:EP2796451,2014,A1.Locationinpatent:Paragraph0079

[19]EuropeanJournalofMedicinalChemistry,2015,vol.89,p.826-834

[20]Patent:CN103570738,2016,B.Locationinpatent:Paragraph0319;0320;0326

[21]ChineseJournalofChemistry,2017,vol.35,p.1693-1700

[22]Patent:CN107417735,2017,A.Locationinpatent:Page/Pagecolumn8

[23]AngewandteChemie-InternationalEdition,2013,vol.52,p.8551-8556    Angew.Chem.,2013,vol.125,p.8713-8718,6

[1]Patent:KR101635724,2016,B1.Locationinpatent:Paragraph0064;0075;0076

[2]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2014,vol.53B,p.1269-1274

[3]Patent:CN105503748,2016,A.Locationinpatent:Paragraph0067;0068;0069;0070

[4]Patent:WO2015/188318,2015,A1.Locationinpatent:Paragraph0035;0038;0039

[5]Patent:CN109721552,2019,A.Locationinpatent:Paragraph0119-0122

[6]Patent:CN107698523,2018,A.Locationinpatent:Paragraph0096;0097;0098

[7]Molecules,2006,vol.11,p.286-297

[8]Patent:US2010/143295,2010,A1

[9]Patent:US5770599,1998,A

[10]Patent:WO2008/125867,2008,A2.Locationinpatent:Page/Pagecolumn27

[11]Patent:WO2013/180403,2013,A1.Locationinpatent:Paragraph96-99

[1]Molecules,2006,vol.11,p.286-297

[2]BioorganicandMedicinalChemistryLetters,2001,vol.11,p.1911-1914

[3]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.4745-4749

[4]Patent:WO2013/71697,2013,A1

[5]Patent:WO2013/180403,2013,A1

[6]Patent:US2014/206664,2014,A1

[7]Patent:US2014/228361,2014,A1

[8]Patent:EP2796451,2014,A1

[9]DaltonTransactions,2015,vol.44,p.13100-13111

[10]Patent:CN103570738,2016,B

[11]Patent:CN106045980,2016,A

[12]Patent:US2009/111772,2009,A1

[13]ChineseJournalofChemistry,2017,vol.35,p.1693-1700

[14]Patent:CN108047209,2018,A

[15]JournalofMedicinalChemistry,2018,vol.61,p.11372-11383

[16]Patent:CN109721552,2019,A

[17]AngewandteChemie-InternationalEdition,2013,vol.52,p.8551-8556    Angew.Chem.,2013,vol.125,p.8713-8718,6

[18]EuropeanJournalofMedicinalChemistry,2021,vol.216

[1]Knesl,Petr;Roeseling,Dirk;Jordis,Ulrich[Molecules,2006,vol.11,#4,p.286-297]

[2]Barker,AndrewJ.;Gibson,KeithH.;Grundy,Walter;Godfrey,AndrewA.;Barlow,JeffreyJ.;Healy,MarkP.;Woodburn,JamesR.;Ashton,SusanE.;Curry,BrendaJ.;Scarlett,Lynn;Henthorn,Lianne;Richards,Laura[BioorganicandMedicinalChemistryLetters,2001,vol.11,#14,p.1911-1914]

[3]Chen,Yurong;Feng,Man;Li,Shilei;Xu,Jingli;Ning,Hongyu;He,Yong;Wang,Xiao;Ding,Rui;Qi,Chuanmin[BioorganicandMedicinalChemistryLetters,2012,vol.22,#14,p.4745-4749]

[4]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-WO2013/71697,2013,A1

[5]CurrentPatentAssignee:Qian,Wei-US2014/206664,2014,A1

[6]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-US2014/228361,2014,A1

[7]CurrentPatentAssignee:Qian,Wei-EP2796451,2014,A1

[8]CurrentPatentAssignee:CHINESEACADEMYOFSCIENCES;ShanghaiInstituteofMateriaMedica(in:CAS)-CN103570738,2016,B

[9]CurrentPatentAssignee:CURISINC-US2009/111772,2009,A1

[10]Shi,Huiping;Lai,Bonan;Chen,Shizhen;Zhou,Xin;Nie,Jing;Ma,Jun-An[ChineseJournalofChemistry,2017,vol.35,#11,p.1693-1700]

[11]Li,Zhengqiu;Hao,Piliang;Li,Lin;Tan,ChelseaY.J.;Cheng,Xiamin;Chen,GraceY.J.;Sze,SiuKwan;Shen,Han-Ming;Yao,ShaoQ.[AngewandteChemie-InternationalEdition,2013,vol.52,#33,p.8551-8556][Angew.Chem.,2013,vol.125,#33,p.8713-8718,6]

[12]CurrentPatentAssignee:GUANGXINORMALUNIVERSITY-CN113264889,2021,A

[1]Molecules,2006,vol.11,p.286-297

[2]BioorganicandMedicinalChemistryLetters,2001,vol.11,p.1911-1914

[3]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.4745-4749

[4]Patent:WO2013/71697,2013,A1

[5]Patent:US2014/206664,2014,A1

[6]Patent:US2014/228361,2014,A1

[7]Patent:EP2796451,2014,A1

[8]Patent:CN103570738,2016,B

[9]Patent:CN106045980,2016,A

[10]Patent:US2009/111772,2009,A1

[11]ChineseJournalofChemistry,2017,vol.35,p.1693-1700

[12]Patent:CN108047209,2018,A

[13]JournalofMedicinalChemistry,2018,vol.61,p.11372-11383

[14]Patent:CN109721552,2019,A

[15]AngewandteChemie-InternationalEdition,2013,vol.52,p.8551-8556    Angew.Chem.,2013,vol.125,p.8713-8718,6

[16]EuropeanJournalofMedicinalChemistry,2021,vol.216

Literature
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