Home Other Building Blocks 189232-42-6
189232-42-6,MFCD04974145
Catalog No.:AA002I0T

189232-42-6 | Bohemine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$70.00   $49.00
- +
5mg
98%
in stock  
$85.00   $59.00
- +
25mg
98%
in stock  
$164.00   $115.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002I0T
Chemical Name:
Bohemine
CAS Number:
189232-42-6
Molecular Formula:
C18H24N6O
Molecular Weight:
340.4228
MDL Number:
MFCD04974145
SMILES:
OCCCNc1nc(NCc2ccccc2)c2c(n1)n(cn2)C(C)C
Properties
Computed Properties
 
Complexity:
390  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
3.1  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Human galectin-3 interacts with two anticancer drugs.

Journal: Proteomics 20100501

Title: The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors.

Journal: Neoplasma 20100101

Title: Inhibition of human immunodeficiency virus type-1 by cdk inhibitors.

Journal: AIDS research and therapy 20100101

Title: Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro.

Journal: Pharmaceutical research 20090201

Title: Hydrolytic cleavage of N6-substituted adenine derivatives by eukaryotic adenine and adenosine deaminases.

Journal: Bioscience reports 20081201

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Zinc(II) complexes with potent cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: synthesis, characterization, X-ray structures and biological activity.

Journal: Journal of inorganic biochemistry 20060201

Title: In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050701

Title: Meiotic inhibition with different cyclin-dependent kinase inhibitors in bovine oocytes and its effects on maturation and embryo development.

Journal: Zygote (Cambridge, England) 20040801

Title: Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis.

Journal: Molecular cancer therapeutics 20040301

Title: Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH+-N7)Cl(3)].9/5H2O [Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine].

Journal: Journal of inorganic biochemistry 20030401

Title: Synthesis and biological activity of olomoucine II.

Journal: Bioorganic & medicinal chemistry letters 20021118

Title: In vitro biotransformation of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine by mouse liver microsomes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20021101

Title: Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines.

Journal: Molecular pathology : MP 20020801

Title: Application of proteomics in the search for novel proteins associated with the anti-cancer effect of the synthetic cyclin-dependent kinases inhibitor, bohemine.

Journal: Technology in cancer research & treatment 20020801

Title: Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases.

Journal: Leukemia 20020301

Title: Comparison of the TUNEL, lamin B and annexin V methods for the detection of apoptosis by flow cytometry.

Journal: Acta histochemica 20020101

Title: Remodeling of donor nuclei, DNA-synthesis, and ploidy of bovine cumulus cell nuclear transfer embryos: effect of activation protocol.

Journal: Molecular reproduction and development 20010801

Title: In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010301

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:189232-42-6 Molecular Formula|189232-42-6 MDL|189232-42-6 SMILES|189232-42-6 Bohemine