Home Amines 19036-73-8
19036-73-8,MFCD00671675
Catalog No.:AA002EFR

19036-73-8 | Benzeneethanamine, α-methyl-3-(trifluoromethyl)-, (αS)-

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002EFR
Chemical Name:
Benzeneethanamine, α-methyl-3-(trifluoromethyl)-, (αS)-
CAS Number:
19036-73-8
Molecular Formula:
C10H12F3N
Molecular Weight:
203.2042
MDL Number:
MFCD00671675
SMILES:
C[C@@H](Cc1cccc(c1)C(F)(F)F)N
Properties
Computed Properties
 
Complexity:
179  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2.5  

Literature

Title: [Letter on the article: 'benfluorex and valvular heart disease'].

Journal: Presse medicale (Paris, France : 1983) 20120301

Title: Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.

Journal: Bioorganic & medicinal chemistry 20111201

Title: [Benfluorex and valvular heart disease].

Journal: Presse medicale (Paris, France : 1983) 20111101

Title: Pharmacokinetic properties of N-nitrosofenfluramine after its administration to rats.

Journal: Biomedical chromatography : BMC 20110501

Title: Organ culture as a tool to identify early mechanisms of serotonergic valve disease.

Journal: The Journal of heart valve disease 20100901

Title: Appetite suppressants, cardiac valve disease and combination pharmacotherapy.

Journal: American journal of therapeutics 20090101

Title: Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080901

Title: Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Journal: Journal of medicinal chemistry 20080124

Title: The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine.

Journal: Bioorganic & medicinal chemistry 20071101

Title: The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension.

Journal: The Journal of pharmacology and experimental therapeutics 20070501

Title: Elevated childhood serotonergic function protects against adolescent aggression in disruptive boys.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry 20060701

Title: Serotonin 5-ht2c receptor agonists: potential for the treatment of obesity.

Journal: Molecular interventions 20051001

Title: (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter.

Journal: The Journal of pharmacology and experimental therapeutics 20050901

Title: Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor.

Journal: Molecular pharmacology 20050701

Title: Hair analysis for fenfluramine and norfenfluramine as biomarkers for N-nitrosofenfluramine ingestion.

Journal: Forensic science international 20041110

Title: The fenfluramine metabolite (+)-norfenfluramine is vasoactive.

Journal: The Journal of pharmacology and experimental therapeutics 20040501

Title: Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine.

Journal: American journal of physiology. Lung cellular and molecular physiology 20040301

Title: Relationship between anorexia and loss of serotonin uptake sites in brain of mice and rats receiving d-norfenfluramine or d-fenfluramine.

Journal: Pharmacology, biochemistry, and behavior 20040301

Title: The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux.

Journal: Journal of thrombosis and haemostasis : JTH 20031201

Title: (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.

Journal: Molecular pharmacology 20030601

Title: Effect of a 5-HT(2C) serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in guinea pigs.

Journal: Brain research 20020927

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Saccadic peak velocity and EEG as end-points for a serotonergic challenge test.

Journal: Human psychopharmacology 20020301

Title: Fluorometric determination of DL-fenfluramine, DL-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011105

Title: Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors.

Journal: Neuropharmacology 20010801

Title: Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.

Journal: Circulation 20001205

Title: Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.

Journal: Molecular pharmacology 20000101

Title: Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential.

Journal: Pharmacology, biochemistry, and behavior 19980301

Title: d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.

Journal: European journal of pharmacology 19930921

Title: Fenfluramine treatment of twenty children with autism.

Journal: Journal of autism and developmental disorders 19891201

Title: Long-term efficacy of fenfluramine in treatment of obesity.

Journal: Lancet (London, England) 19830219

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Tags:19036-73-8 Molecular Formula|19036-73-8 MDL|19036-73-8 SMILES|19036-73-8 Benzeneethanamine, α-methyl-3-(trifluoromethyl)-, (αS)-