Title: Molecular mechanism and inhibitory targets of dioscin in HepG2 cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20181001
Title: Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation.
Journal: Toxicology 20170301
Title: Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
Journal: Toxicology and applied pharmacology 20160815
Title: Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20151201
Title: Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.
Journal: Toxicology and applied pharmacology 20141201
Title: Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo.
Journal: Toxicology and applied pharmacology 20140601
Title: Protective effects of dioscin against alcohol-induced liver injury.
Journal: Archives of toxicology 20140301
Title: Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.
Journal: Journal of biomedical science 20140101
Title: Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways.
Journal: Journal of applied toxicology : JAT 20130801
Title: Dioscin's antiviral effect in vitro.
Journal: Virus research 20130301
Title: The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica.
Journal: Biochimica et biophysica acta 20130301
Title: Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
Journal: Toxicology letters 20121002
Title: Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china.
Journal: Food chemistry 20120915
Title: Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment.
Journal: Bioorganic & medicinal chemistry letters 20120715
Title: A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501
Title: New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides.
Journal: Bioorganic & medicinal chemistry 20120415
Title: Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.
Journal: Cancer biology & therapy 20120201
Title: Application of high-speed countercurrent chromatography-evaporative light scattering detection for the separation of seven steroidal saponins from Dioscorea villosa.
Journal: Phytochemical analysis : PCA 20120101
Title: Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells.
Journal: World journal of gastroenterology 20111021
Title: [Effects of organic solvents on proliferation of Hela cells line].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401
Title: Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells.
Journal: European journal of pharmacology 20110305
Title: Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CCl₄-induced liver damage in mice.
Journal: Planta medica 20110301
Title: Apoptosis of human ovarian cancer cells induced by Paris chinensis dioscin via a Ca(2+)-mediated mitochondrion pathway.
Journal: Asian Pacific journal of cancer prevention : APJCP 20110101
Title: Anthelmintic activity of steroidal saponins from Paris polyphylla.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201
Title: New dioscin-glycosidase hydrolyzing multi-glycosides of dioscin from Absidia strain.
Journal: Journal of microbiology and biotechnology 20100601
Title: Hemolytic mechanism of dioscin proposed by molecular dynamics simulations.
Journal: Journal of molecular modeling 20100101
Title: Synthesis and cytotoxicities of icogenin analogues with disaccharide residues.
Journal: Bioorganic & medicinal chemistry letters 20090515
Title: Preparative separation of dioscin derivatives from Dioscorea villosa by centrifugal partition chromatography coupled with evaporative light scattering detection.
Journal: Journal of separation science 20080701
Title: Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.
Journal: Carbohydrate research 20071228
Title: Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study.
Journal: Journal of proteome research 20071201
Title: Induction of growth hormone release by dioscin from Dioscorea batatas DECNE.
Journal: Journal of biochemistry and molecular biology 20071130
Title: Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.
Journal: Analytica chimica acta 20070905
Title: [Selection of the microorganism for dioscin hydrolyze].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070801
Title: Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins.
Journal: Bioorganic & medicinal chemistry 20070401
Title: Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.
Journal: Chemical & pharmaceutical bulletin 20070201
Title: Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation.
Journal: Vascular pharmacology 20070101
Title: Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues.
Journal: Bioorganic & medicinal chemistry letters 20061101
Title: [Study on steroidal compounds from Dioscorea zingiberensis].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061101
Title: [Study on steroidal saponins of Dioscorea septemloba thunb].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061101
Title: Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.
Journal: Organic letters 20060622
Title: Effect of ethanol extract of dried Chinese yam (Dioscorea batatas) flour containing dioscin on gastrointestinal function in rat model.
Journal: Archives of pharmacal research 20060501
Title: Proteomic approach to study the cytotoxicity of dioscin (saponin).
Journal: Proteomics 20060401
Title: Purification and characterization of dioscin-alpha-L-rhamnosidase from pig liver.
Journal: Chemical & pharmaceutical bulletin 20050801
Title: Characterization of the pharmacokinetics of dioscin in rat.
Journal: Steroids 20050701
Title: Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
Journal: Journal of natural products 20050501
Title: Determination of dioscin in rat plasma by liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325
Title: Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives.
Journal: Organic letters 20050217
Title: [Steroidal constituents from Dioscorea parviflora].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050201
Title: Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
Journal: Molecular diversity 20050101
Title: Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice.
Journal: Journal of neurochemistry 20040301
Title: A new steroidal saponin from Dioscorea zingiberensis Wright.
Journal: Natural product research 20030801
Title: [Apoptosis of human chronic myeloid leukemia k562 cell induced by prosapogenin B of dioscin (P.B) in vitro].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20030801
Title: Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents.
Journal: Bioscience, biotechnology, and biochemistry 20030701
Title: The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides.
Journal: Carbohydrate research 20030404
Title: Synthesis of monomethylated dioscin derivatives and their antitumor activities.
Journal: Carbohydrate research 20030120
Title: A facile approach to diosgenin and furostan type saponins bearing a 3beta-chacotriose moiety.
Journal: Carbohydrate research 20021119
Title: Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.
Journal: Journal of natural products 20020601
Title: Apoptosis induced by dioscin in Hela cells.
Journal: Biological & pharmaceutical bulletin 20020201
Title: Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.
Journal: Biological & pharmaceutical bulletin 20010201
Title: Chen J, et al. Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34(1):125-30.
Title: Qu X, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014 Jan 10;443(2):658-65.
Title: Qin J, et al. Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg). 2014 Jan;64(1):47-52.
