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1910124-24-1,MFCD30489734
Catalog No.:AA00ABPJ

1910124-24-1 | Gsk6853

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
5mg
98%
in stock  
$21.00   $15.00
- +
10mg
98%
in stock  
$29.00   $21.00
- +
25mg
98%
in stock  
$48.00   $34.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ABPJ
Chemical Name:
Gsk6853
CAS Number:
1910124-24-1
Molecular Formula:
C22H27N5O3
Molecular Weight:
409.4815
MDL Number:
MFCD30489734
SMILES:
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCNC[C@H]1C)n(c(=O)n2C)C
Properties
Computed Properties
 
Complexity:
646  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
1.6  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2016/62737,2016,A1

[2]Bamborough,Paul;Barnett,HeatherA.;Becher,Isabelle;Bird,MarkJ.;Chung,Chun-Wa;Craggs,PeterD.;Demont,EmmanuelH.;Diallo,Hawa;Fallon,DavidJ.;Gordon,LaurieJ.;Grandi,Paola;Hobbs,ClareI.;Hooper-Greenhill,Edward;Jones,EmmaJ.;Law,RobertP.;LeGall,Armelle;Lugo,David;Michon,Anne-Marie;Mitchell,DarrenJ.;Prinjha,RabK.;Sheppard,RobertJ.;Watson,AllanJ.B.;Watson,RobertJ.[ACSMedicinalChemistryLetters,2016,vol.7,#6,p.552-557]

[1]Bamborough,Paul;Barnett,HeatherA.;Becher,Isabelle;Bird,MarkJ.;Chung,Chun-Wa;Craggs,PeterD.;Demont,EmmanuelH.;Diallo,Hawa;Fallon,DavidJ.;Gordon,LaurieJ.;Grandi,Paola;Hobbs,ClareI.;Hooper-Greenhill,Edward;Jones,EmmaJ.;Law,RobertP.;LeGall,Armelle;Lugo,David;Michon,Anne-Marie;Mitchell,DarrenJ.;Prinjha,RabK.;Sheppard,RobertJ.;Watson,AllanJ.B.;Watson,RobertJ.[ACSMedicinalChemistryLetters,2016,vol.7,#6,p.552-557]

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2016/62737,2016,A1Locationinpatent:Page/Pagecolumn27-28

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2016/62737,2016,A1

[2]Bamborough,Paul;Barnett,HeatherA.;Becher,Isabelle;Bird,MarkJ.;Chung,Chun-Wa;Craggs,PeterD.;Demont,EmmanuelH.;Diallo,Hawa;Fallon,DavidJ.;Gordon,LaurieJ.;Grandi,Paola;Hobbs,ClareI.;Hooper-Greenhill,Edward;Jones,EmmaJ.;Law,RobertP.;LeGall,Armelle;Lugo,David;Michon,Anne-Marie;Mitchell,DarrenJ.;Prinjha,RabK.;Sheppard,RobertJ.;Watson,AllanJ.B.;Watson,RobertJ.[ACSMedicinalChemistryLetters,2016,vol.7,#6,p.552-557]

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2016/62737,2016,A1

[2]Bamborough,Paul;Barnett,HeatherA.;Becher,Isabelle;Bird,MarkJ.;Chung,Chun-Wa;Craggs,PeterD.;Demont,EmmanuelH.;Diallo,Hawa;Fallon,DavidJ.;Gordon,LaurieJ.;Grandi,Paola;Hobbs,ClareI.;Hooper-Greenhill,Edward;Jones,EmmaJ.;Law,RobertP.;LeGall,Armelle;Lugo,David;Michon,Anne-Marie;Mitchell,DarrenJ.;Prinjha,RabK.;Sheppard,RobertJ.;Watson,AllanJ.B.;Watson,RobertJ.[ACSMedicinalChemistryLetters,2016,vol.7,#6,p.552-557]

[1]Bamborough,Paul;Barnett,HeatherA.;Becher,Isabelle;Bird,MarkJ.;Chung,Chun-Wa;Craggs,PeterD.;Demont,EmmanuelH.;Diallo,Hawa;Fallon,DavidJ.;Gordon,LaurieJ.;Grandi,Paola;Hobbs,ClareI.;Hooper-Greenhill,Edward;Jones,EmmaJ.;Law,RobertP.;LeGall,Armelle;Lugo,David;Michon,Anne-Marie;Mitchell,DarrenJ.;Prinjha,RabK.;Sheppard,RobertJ.;Watson,AllanJ.B.;Watson,RobertJ.[ACSMedicinalChemistryLetters,2016,vol.7,#6,p.552-557]

Literature

Title: Bamborough P et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7.

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SDS
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