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195514-63-7,MFCD25976784
Catalog No.:AA00ABFT

195514-63-7 | Ap1903

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Purity
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1mg
≥90%
in stock  
$112.00   $78.00
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5mg
≥90%
in stock  
$416.00   $291.00
- +
10mg
≥90%
in stock  
$610.00   $427.00
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25mg
≥98%(HPLC)
in stock  
$1,361.00   $953.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ABFT
Chemical Name:
Ap1903
CAS Number:
195514-63-7
Molecular Formula:
C78H98N4O20
Molecular Weight:
1411.6275
MDL Number:
MFCD25976784
SMILES:
CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@@H](c1cccc(c1)OCC(=O)NCCNC(=O)COc1cccc(c1)[C@H](OC(=O)[C@@H]1CCCCN1C(=O)[C@H](c1cc(OC)c(c(c1)OC)OC)CC)CCc1ccc(c(c1)OC)OC)CCc1ccc(c(c1)OC)OC)c1cc(OC)c(c(c1)OC)OC
Properties
Computed Properties
 
Complexity:
2330  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
102  
Hydrogen Bond Acceptor Count:
20  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
39  
XLogP3:
11.9  

Downstream Synthesis Route

[1]CurrentPatentAssignee:DUCHUANGSHANGHAIMEDICINETECH-CN109734655,2019,ALocationinpatent:Paragraph0030;0054-0056

Literature

Title: Inducible apoptosis as a safety switch for adoptive cell therapy.

Journal: The New England journal of medicine 20111103

Title: Eliminating cells gone astray.

Journal: The New England journal of medicine 20111103

Title: Long-term regulation of genetically modified primary hematopoietic cells in dogs.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20110701

Title: A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy.

Journal: The Journal of clinical investigation 20110401

Title: Using gene transfer to circumvent off-target effects.

Journal: Gene therapy 20080501

Title: Regulation of gene expression by synthetic dimerizers with novel specificity.

Journal: Bioorganic & medicinal chemistry letters 20031006

Title: A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease.

Journal: Blood 20010301

Title: Clackson T, et al. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42.

Title: Thomis DC, et al. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood. 2001 Mar 1;97(5):1249-57.

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SDS
Tags:195514-63-7 Molecular Formula|195514-63-7 MDL|195514-63-7 SMILES|195514-63-7 Ap1903