Home Other Building Blocks 197855-65-5
197855-65-5,MFCD02684535
Catalog No.:AA002B0X

197855-65-5 | Z-FA-FMK

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Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$54.00   $38.00
- +
5mg
99+%
in stock  
$167.00   $117.00
- +
10mg
99+%
in stock  
$249.00   $174.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002B0X
Chemical Name:
Z-FA-FMK
CAS Number:
197855-65-5
Molecular Formula:
C21H23FN2O4
Molecular Weight:
386.4167
MDL Number:
MFCD02684535
SMILES:
FCC(=O)C(NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C
Properties
Computed Properties
 
Complexity:
517  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.3  

Literature

Title: Z-FA.FMK activates duodenal epithelial cell proliferation through oxidative stress, NF-kappaB and IL-1beta in D-GalN/TNF-alpha-administered mice.

Journal: Cell biology international 20100408

Title: Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo.

Journal: Antiviral therapy 20100101

Title: Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol.

Journal: Current eye research 20080901

Title: Effects of Z-FA.FMK on D-galactosamine/tumor necrosis factor-alpha-induced kidney injury and oxidative stress in mice : effects of Z-FA.FMK on TNF-alpha-mediated kidney injury.

Journal: Molecular and cellular biochemistry 20080201

Title: The effect of Z-FA.FMK on D-galactosamine/TNF-alpha-induced liver injury in mice.

Journal: Cell biochemistry and function 20070101

Title: The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060915

Title: Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum.

Journal: Brain research 20060203

Title: Role of lysosomal cathepsins in naphthazarin- and Fas-induced apoptosis in oral squamous cell carcinoma cells.

Journal: Acta oto-laryngologica 20060101

Title: Incorporation of branched-chain fatty acid into cellular lipids and caspase-independent apoptosis in human breast cancer cell line, SKBR-3.

Journal: Lipids in health and disease 20050101

Title: Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells.

Journal: Archives of dermatological research 20040701

Title: Caspase activity is essential for long-term potentiation.

Journal: Journal of neuroscience research 20030915

Title: Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway.

Journal: Molecular cancer therapeutics 20030301

Title: A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury.

Journal: European journal of pharmacology 20021205

Title: The hepatitis C virus core protein interacts with NS5A and activates its caspase-mediated proteolytic cleavage.

Journal: Virology 20011125

Title: Cuticular collagen synthesis by Ascaris suum during development from the third to fourth larval stage: identification of a potential chemotherapeutic agent with a novel mechanism of action.

Journal: The Journal of parasitology 20011001

Title: The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide.

Journal: The Journal of biological chemistry 20010615

Title: Comparative histochemical, biochemical and immunocytochemical studies of cathepsin B in human gingiva.

Journal: Journal of periodontal research 19940501

Title: Usman Bacha, et al. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem Biol Drug Des. 2008 Jul;72(1):34-49.

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