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2004-03-7,MFCD00083663
Catalog No.:AA002CO8

2004-03-7 | 6-Methyl-7h-purine

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250mg
98%
in stock  
$79.00   $55.00
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1g
98%
in stock  
$143.00   $100.00
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5g
98%
in stock  
$683.00   $478.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002CO8
Chemical Name:
6-Methyl-7h-purine
CAS Number:
2004-03-7
Molecular Formula:
C6H6N4
Molecular Weight:
134.1386
MDL Number:
MFCD00083663
SMILES:
Cc1ncnc2c1nc[nH]2
NSC Number:
407198
Properties
Computed Properties
 
Complexity:
127  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.5  

Literature

Title: Genetics Techniques for Thermococcus kodakarensis.

Journal: Frontiers in microbiology 20120101

Title: Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase.

Journal: Cancer gene therapy 20110601

Title: Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110527

Title: Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: a tangible union against chemoresistant cancer.

Journal: BMC cancer 20110101

Title: Promoters with cancer cell-specific activity for melanoma gene therapy.

Journal: Acta naturae 20110101

Title: Enzymatic synthesis of 2'-deoxyadenosine and 6-methylpurine-2'-deoxyriboside by Escherichia coli DH5alpha overexpressing nucleoside phosphorylases from Escherichia coli BL21.

Journal: Journal of bioscience and bioengineering 20100801

Title: Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer.

Journal: Nucleosides, nucleotides & nucleic acids 20090501

Title: Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy.

Journal: PloS one 20090101

Title: Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT.

Journal: Journal of experimental & clinical cancer research : CR 20090101

Title: A comparison of leaf and petal senescence in wallflower reveals common and distinct patterns of gene expression and physiology.

Journal: Plant physiology 20080801

Title: Synergistic antitumor efficacy of suicide/ePNP gene and 6-methylpurine 2'-deoxyriboside via Salmonella against murine tumors.

Journal: Cancer gene therapy 20080701

Title: Suicide gene/prodrug therapy using salmonella-mediated delivery of Escherichia coli purine nucleoside phosphorylase gene and 6-methoxypurine 2'-deoxyriboside in murine mammary carcinoma 4T1 model.

Journal: Cancer science 20080601

Title: Controlled aggregation of adenine by sugars: physicochemical studies, molecular modelling simulations of sugar-aromatic CH-pi stacking interactions, and biological significance.

Journal: Physical chemistry chemical physics : PCCP 20080521

Title: Prodrug converting enzyme gene delivery by L. monocytogenes.

Journal: BMC cancer 20080101

Title: hTERT-targeted E. coli purine nucleoside phosphorylase gene/6-methylpurine deoxyribose therapy for pancreatic cancer.

Journal: Chinese medical journal 20070805

Title: Induction of wall ingrowths of transfer cells occurs rapidly and depends upon gene expression in cotyledons of developing Vicia faba seeds.

Journal: Protoplasma 20070101

Title: [Killing effect of PNP/MeP-dR suicide gene system driven by an AFP promoter AF0.3 on AFP-positive hepatoma cells].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20061101

Title: Improved synthesis of beta-D-6-methylpurine riboside and antitumor effects of the beta-D- and alpha-D-anomers.

Journal: Molecules (Basel, Switzerland) 20050831

Title: Transcriptional tumor-selective promoter targeting of E. coli purine nucleoside phosphorylase for pancreatic cancer suicide gene therapy.

Journal: The journal of gene medicine 20050501

Title: Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy.

Journal: Human gene therapy 20050301

Title: Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: PNP anticancer gene therapy.

Journal: Current topics in medicinal chemistry 20050101

Title: Suicide gene/prodrug therapy for pancreatic adenocarcinoma by E. coli purine nucleoside phosphorylase and 6-methylpurine 2'-deoxyriboside.

Journal: Pancreas 20040301

Title: An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines.

Journal: The Journal of organic chemistry 20030711

Title: A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration.

Journal: The Journal of pharmacology and experimental therapeutics 20030301

Title: Selective metalation of 6-methylpurines: synthesis of 6-fluoromethylpurines and related nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Current progress in suicide gene therapy for cancer.

Journal: World journal of surgery 20020701

Title: Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange.

Journal: Journal of medicinal chemistry 20011220

Title: Synthesis, antiproliferative and antiviral activity of imidazo[4,5-d]isothiazole nucleosides as 5:5 fused analogs of nebularine and 6-methylpurine ribonucleoside.

Journal: Journal of medicinal chemistry 19970227

Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19951109

Title: A STUDY OF THE CROSS-REACTIVITY OF ANTIPURIN-6-OYL SERUM WITH DEOXYRIBONUCLEIC ACID (DNA).

Journal: The Journal of experimental medicine 19650101

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