Home Amines 201943-63-7
201943-63-7,MFCD00949707
Catalog No.:AA0027UU

201943-63-7 | 9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$250.00   $175.00
- +
10mg
≥98%
in stock  
$262.00   $183.00
- +
50mg
≥98%
in stock  
$1,065.00   $745.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0027UU
Chemical Name:
9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)-
CAS Number:
201943-63-7
Molecular Formula:
C20H19NO5
Molecular Weight:
353.3686
MDL Number:
MFCD00949707
SMILES:
OC(=O)[C@H]1C[C@@H]1[C@](C(=O)O)(CC1c2ccccc2Oc2c1cccc2)N
Properties
Computed Properties
 
Complexity:
559  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
-0.2  

Literature

Title: Perinatal exposure to low-dose of bisphenol A causes anxiety-like alteration in adrenal axis regulation and behaviors of rat offspring: a potential role for metabotropic glutamate 2/3 receptors.

Journal: Journal of psychiatric research 20150501

Title: Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.

Journal: The Journal of pharmacology and experimental therapeutics 20130901

Title: Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor.

Journal: Synapse (New York, N.Y.) 20121201

Title: Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.

Journal: Journal of neurophysiology 20121101

Title: mTOR activation is required for the antidepressant effects of mGluR₂/₃ blockade.

Journal: The international journal of neuropsychopharmacology 20120501

Title: Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.

Journal: Scientific reports 20120101

Title: Development of GPCR modulation of GABAergic transmission in chicken nucleus laminaris neurons.

Journal: PloS one 20120101

Title: Group II metabotropic glutamate receptors depress synaptic transmission onto subicular burst firing neurons.

Journal: PloS one 20120101

Title: Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists.

Journal: Neuropharmacology 20111201

Title: Excitatory amino acid transporter 2 and excitatory amino acid transporter 1 negatively regulate calcium-dependent proliferation of hippocampal neural progenitor cells and are persistently upregulated after injury.

Journal: The European journal of neuroscience 20111201

Title: Estradiol attenuates the adenosine triphosphate-induced increase of intracellular calcium through group II metabotropic glutamate receptors in rat dorsal root ganglion neurons.

Journal: Journal of neuroscience research 20111101

Title: Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.

Journal: Neuroscience letters 20111024

Title: Blockade of GABA(B) receptors facilitates evoked neurotransmitter release at spinal dorsal horn synapse.

Journal: Neuroscience 20111013

Title: Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110907

Title: Functional coupling between metabotropic glutamate receptors and G-proteins in rat cerebral cortex assessed by guanosine-5'-O-(3-[(35)S]thio)triphosphate binding assay.

Journal: Basic & clinical pharmacology & toxicology 20110901

Title: The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20110801

Title: A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110706

Title: Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain.

Journal: Molecular pharmacology 20110701

Title: Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268.

Journal: Journal of neurochemistry 20110601

Title: Group II metabotropic glutamate receptors in the striatum of non-human primates: dysregulation following chronic cocaine self-administration.

Journal: Neuroscience letters 20110527

Title: Baclofen and adenosine inhibition of synaptic transmission at CA3-CA1 synapses display differential sensitivity to K+ channel blockade.

Journal: Cellular and molecular neurobiology 20110501

Title: Postsynaptic and presynaptic group II metabotropic glutamate receptor activation reduces neuronal excitability in rat midline paraventricular thalamic nucleus.

Journal: The Journal of pharmacology and experimental therapeutics 20110301

Title: Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective.

Journal: Molecular pharmacology 20110301

Title: Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust.

Journal: The European journal of neuroscience 20110201

Title: Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice.

Journal: Brain research 20110131

Title: AMPA receptor mediates mGlu 2/3 receptor antagonist-induced dopamine release in the rat nucleus accumbens shell.

Journal: Neurochemistry international 20101101

Title: Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats.

Journal: European journal of pharmacology 20100810

Title: Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice.

Journal: European journal of pharmacology 20100810

Title: Metabotropic glutamate receptors modulate glutamatergic and GABAergic synaptic transmission in the central nucleus of the inferior colliculus.

Journal: Brain research 20100414

Title: Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100317

Title: Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats.

Journal: European journal of pharmacology 20100210

Title: Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage.

Journal: Neuroscience bulletin 20100201

Title: Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism.

Journal: Journal of neurochemistry 20100101

Title: Extinction of cued fear memory involves a distinct form of depotentiation at cortical input synapses onto the lateral amygdala.

Journal: The European journal of neuroscience 20091203

Title: Involvement of Group II mGluRs in mossy fiber LTD.

Journal: Synapse (New York, N.Y.) 20091201

Title: Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia.

Journal: Neuroscience letters 20090925

Title: gamma-Aminobutyric acid-mediated regulation of the activity-dependent olfactory bulb dopaminergic phenotype.

Journal: Journal of neuroscience research 20090801

Title: Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

Journal: Molecular pharmacology 20090801

Title: Antinociceptive synergistic effect of spinal mGluR2/3 antagonist and glial cells inhibitor on peripheral inflammation-induced mechanical hypersensitivity.

Journal: Brain research bulletin 20090529

Title: A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090513

Title: Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain.

Journal: Molecular pharmacology 20090501

Title: Metabotropic glutamate receptor II in the brains of Parkinsonian patients.

Journal: Journal of neuropathology and experimental neurology 20090401

Title: The slow Ca2+ -dependent K+ -current facilitates synchronization of hyperexcitable pyramidal neurons.

Journal: Brain research 20090203

Title: Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.

Journal: Brain research 20090112

Title: Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells.

Journal: Journal of neurophysiology 20081201

Title: GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses.

Journal: Nature neuroscience 20081201

Title: AMPA silencing is a prerequisite for developmental long-term potentiation in the hippocampal CA1 region.

Journal: Journal of neurophysiology 20081101

Title: Repeated exposure to cocaine alters the modulation of mesocorticolimbic glutamate transmission by medial prefrontal cortex Group II metabotropic glutamate receptors.

Journal: Journal of neurochemistry 20081001

Title: Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression.

Journal: European journal of pharmacology 20080911

Title: Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells.

Journal: Neuropharmacology 20080901

Title: Blockade of group II metabotropic glutamate receptors produces hyper-locomotion in cocaine pre-exposed rats by interactions with dopamine receptors.

Journal: Neuropharmacology 20080901

Title: Conformational change of the transmembrane helices II and IV of metabotropic glutamate receptor involved in G protein activation.

Journal: Journal of neurochemistry 20080701

Title: Group II metabotropic glutamate receptor activation attenuates peripheral sensitization in inflammatory states.

Journal: Neuroscience 20080623

Title: Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080601

Title: Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor.

Journal: European journal of pharmacology 20080531

Title: Involvement of group I mGluRs in LTP induced by strong high frequency stimulation in the dentate gyrus in vitro.

Journal: Neuroscience letters 20080509

Title: Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist.

Journal: Bioorganic & medicinal chemistry 20080415

Title: A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors.

Journal: Molecular pharmacology 20080401

Title: Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated.

Journal: Neuropharmacology 20080401

Title: Distinct neural mechanisms mediate olfactory memory formation at different timescales.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20080301

Title: Basal ganglia group II metabotropic glutamate receptors specific binding in non-human primate model of L-Dopa-induced dyskinesias.

Journal: Neuropharmacology 20080201

Title: Glutamate spillover modulates GABAergic synaptic transmission in the rat midbrain periaqueductal grey via metabotropic glutamate receptors and endocannabinoid signaling.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080123

Title: Differential modulation of ethanol-induced sedation and hypnosis by metabotropic glutamate receptor antagonists in C57BL/6J mice.

Journal: Alcoholism, clinical and experimental research 20080101

Title: Dual GABAergic synaptic response of fast excitation and slow inhibition in the medial habenula of rat epithalamus.

Journal: Journal of neurophysiology 20070901

Title: A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.

Journal: Molecular pharmacology 20070801

Title: In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders.

Journal: Psychopharmacology 20070701

Title: A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20070701

Title: Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex.

Journal: Neuroscience 20070525

Title: The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task.

Journal: Neuropharmacology 20070301

Title: Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.

Journal: Experimental eye research 20070301

Title: Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hyperthermia test in singly housed mice.

Journal: Psychopharmacology 20070201

Title: Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs.

Journal: The Journal of pharmacology and experimental therapeutics 20070201

Title: Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.

Journal: Journal of neurophysiology 20070201

Title: Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats.

Journal: European journal of pharmacology 20070112

Title: Group III metabotropic glutamate receptor agonists selectively suppress excitatory synaptic currents in the rat prefrontal cortex induced by 5-hydroxytryptamine2A receptor activation.

Journal: The Journal of pharmacology and experimental therapeutics 20070101

Title: Participation of peripheral group I and II metabotropic glutamate receptors in the development or maintenance of IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats.

Journal: Neuroscience letters 20061206

Title: Blockade of group II metabotropic glutamate receptors in the nucleus accumbens produces hyperlocomotion in rats previously exposed to amphetamine.

Journal: Neuropharmacology 20061001

Title: Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.

Journal: Current biology : CB 20060822

Title: Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060816

Title: Unique presynaptic and postsynaptic roles of Group II metabotropic glutamate receptors in the modulation of thalamic network activity.

Journal: Neuroscience 20060811

Title: Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20060801

Title: Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20060701

Title: Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cells.

Journal: Journal of neurophysiology 20060401

Title: Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression.

Journal: Journal of neurophysiology 20060401

Title: Metabotropic glutamate receptor antagonists selectively enhance responses of slowly adapting type I mechanoreceptors.

Journal: Synapse (New York, N.Y.) 20060315

Title: A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20060301

Title: Antinociceptive effects and synergistic interaction with morphine of intrathecal metabotropic glutamate receptor 2/3 antagonist in the formalin test of rats.

Journal: Neuroscience letters 20060220

Title: Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes.

Journal: Journal of neurochemistry 20060201

Title: Long-term depression of NMDA receptor-mediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to long-term potentiation by low intracellular calcium buffering.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125

Title: Modulation of excitatory synaptic transmission by endogenous glutamate acting on presynaptic group II mGluRs in rat substantia nigra compacta.

Journal: Journal of neuroscience research 20051215

Title: Regulation of IPSP theta rhythm by muscarinic receptors and endocannabinoids in hippocampus.

Journal: Journal of neurophysiology 20051201

Title: Neuroprotective effect of N-acetyl-aspartyl-glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia.

Journal: Journal of neurochemistry 20051201

Title: 2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice.

Journal: Psychopharmacology 20051201

Title: Role of group II metabotropic glutamate receptors 2/3 and group I metabotropic glutamate receptor 5 in developing rat medial vestibular nuclei.

Journal: Neuroreport 20050822

Title: Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706

Title: Presynaptic inhibition of corticothalamic feedback by metabotropic glutamate receptors.

Journal: Journal of neurophysiology 20050701

Title: Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.

Journal: Neuro-oncology 20050701

Title: Neuropharmacological profiles of antagonists of group II metabotropic glutamate receptors.

Journal: Neuroscience letters 20050422

Title: A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.

Journal: The Journal of pharmacology and experimental therapeutics 20050401

Title: Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.

Journal: Psychopharmacology 20050401

Title: Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate.

Journal: Experimental neurology 20050401

Title: Developmental switch in synaptic mechanisms of hippocampal metabotropic glutamate receptor-dependent long-term depression.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050316

Title: The metabotropic glutamate (mGLU)2/3 receptor antagonist LY341495 [2S-2-amino-2-(1S,2S-2-carboxycyclopropyl-1-yl)-3-(xanth-9-yl)propanoic acid] stimulates waking and fast electroencephalogram power and blocks the effects of the mGLU2/3 receptor agonist ly379268 [(-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate] in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20050201

Title: Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus.

Journal: Neuropharmacology 20050101

Title: Group II and III mGluRs-mediated presynaptic inhibition of EPSCs recorded from hippocampal interneurons of CA1 stratum lacunosum moleculare.

Journal: Neuropharmacology 20050101

Title: Comparison of c-Fos induction in the brain by the mGlu2/3 receptor antagonist LY341495 and agonist LY354740: evidence for widespread endogenous tone at brain mGlu2/3 receptors in vivo.

Journal: Neuropharmacology 20050101

Title: The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy.

Journal: Neuropharmacology 20050101

Title: Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus.

Journal: The Journal of physiology 20041201

Title: Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat.

Journal: Brain research 20041119

Title: Glutamate-evoked alterations of glial and neuronal cell morphology in the guinea pig retina.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110

Title: Activation of Group II and Group III metabotropic glutamate receptors by endogenous ligand(s) and the modulation of synaptic transmission in the superficial superior colliculus.

Journal: Neuropharmacology 20041101

Title: Distinct properties of carbachol- and DHPG-induced network oscillations in hippocampal slices.

Journal: Neuropharmacology 20040901

Title: Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists.

Journal: Journal of medicinal chemistry 20040826

Title: Tonic activity of metabotropic glutamate receptors is involved in developmental modification of short-term plasticity in the neocortex.

Journal: Journal of neurophysiology 20040801

Title: Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model.

Journal: The European journal of neuroscience 20040701

Title: Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040630

Title: Modulation of glutamate mobility reveals the mechanism underlying slow-rising AMPAR EPSCs and the diffusion coefficient in the synaptic cleft.

Journal: Neuron 20040610

Title: Depression of GABAergic input to identified hippocampal neurons by group III metabotropic glutamate receptors in the rat.

Journal: The European journal of neuroscience 20040501

Title: Distinct properties of presynaptic group II and III metabotropic glutamate receptor-mediated inhibition of perforant pathway-CA1 EPSCs.

Journal: The European journal of neuroscience 20040501

Title: The selective mGlu2/3 receptor antagonist LY341495 exacerbates behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons.

Journal: Neuropharmacology 20040401

Title: Group II metabotropic glutamate receptors inhibit cAMP-dependent protein kinase-mediated enhancemednt of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons.

Journal: Neuroscience letters 20040311

Title: An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in vitro.

Journal: Neuropharmacology 20040301

Title: Selective transmission of single photon responses by saturation at the rod-to-rod bipolar synapse.

Journal: Neuron 20040205

Title: Inhibitory effects of group II mGluR-related drugs on memory performance in mice.

Journal: Physiology & behavior 20040201

Title: GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism.

Journal: Journal of neurophysiology 20040101

Title: The mGlu2/3 receptor agonist, LY354740, blocks immobilization-induced increases in noradrenaline and dopamine release in the rat medial prefrontal cortex.

Journal: Journal of neurochemistry 20040101

Title: Cannabinoids decrease corticostriatal synaptic transmission via an effect on glutamate uptake.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031203

Title: Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.

Journal: The Journal of physiology 20031201

Title: Protective effect of LY379268, a selective group II metabotropic glutamate receptor agonist, on dizocilpine-induced neuropathological changes in rat retrosplenial cortex.

Journal: Brain research 20031128

Title: Prefrontal group II metabotropic glutamate receptor activation decreases performance on a working memory task.

Journal: Annals of the New York Academy of Sciences 20031101

Title: Bidirectional modulation of cystine/glutamate exchanger activity in cultured cortical astrocytes.

Journal: Annals of the New York Academy of Sciences 20031101

Title: Group II metabotropic glutamate receptor antagonists LY341495 and LY366457 increase locomotor activity in mice.

Journal: Neuropharmacology 20031001

Title: Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

Journal: Molecular pharmacology 20031001

Title: Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030901

Title: Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

Journal: Neuropharmacology 20030801

Title: Actions of LY341495 on metabotropic glutamate receptor-mediated responses in the neonatal rat spinal cord.

Journal: British journal of pharmacology 20030501

Title: Reduction of excitatory postsynaptic responses by persistently active metabotropic glutamate receptors in the hippocampus.

Journal: Journal of neurophysiology 20030401

Title: Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells.

Journal: Journal of neurochemistry 20030301

Title: Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex.

Journal: Journal of neurophysiology 20030301

Title: Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands.

Journal: Bioorganic & medicinal chemistry 20030117

Title: Group II metabotropic glutamate receptor modulation of DOI-induced c-fos mRNA and excitatory responses in the cerebral cortex.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101

Title: Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats.

Journal: Neuroscience 20030101

Title: Effect of donepezil on group II mGlu receptor agonist- or antagonist-induced amnesia on passive avoidance in mice.

Journal: Neural plasticity 20030101

Title: Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei.

Journal: The Journal of physiology 20020915

Title: Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors.

Journal: Pharmacology, biochemistry, and behavior 20020901

Title: The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam.

Journal: Pharmacology, biochemistry, and behavior 20020901

Title: Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020801

Title: Group I metabotropic glutamate receptors (mGluRs) modulate visual responses in the superficial superior colliculus of the rat.

Journal: The Journal of physiology 20020615

Title: Role of p/q-Ca2+ channels in metabotropic glutamate receptor 2/3-dependent presynaptic long-term depression at nucleus accumbens synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020601

Title: Postsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region.

Journal: Journal of neurophysiology 20020301

Title: Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia.

Journal: European journal of pharmacology 20020222

Title: Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors.

Journal: Bioorganic & medicinal chemistry letters 20011217

Title: Internalization of ionotropic glutamate receptors in response to mGluR activation.

Journal: Nature neuroscience 20011101

Title: Modulation of primary afferent-mediated neurotransmission and Fos expression by glutamate uptake inhibition in rat spinal neurones in vitro.

Journal: Neuropharmacology 20011001

Title: Differential modulation of the D1-like- and D2-like dopamine receptor-induced locomotor responses by group II metabotropic glutamate receptors in the rat nucleus accumbens.

Journal: Neuropharmacology 20010901

Title: [3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain.

Journal: The Journal of pharmacology and experimental therapeutics 20010801

Title: Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.

Journal: Journal of neuroendocrinology 20010801

Title: Evidence that glutamate acting on presynaptic type-II metabotropic glutamate receptors alone does not fully account for the phenomenon of depolarisation-induced suppression of inhibition in cerebellar Purkinje cells.

Journal: Pflugers Archiv : European journal of physiology 20010601

Title: Activation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata.

Journal: Journal of neurophysiology 20010501

Title: Activity-dependent presynaptic autoinhibition by group II metabotropic glutamate receptors at the perforant path inputs to the dentate gyrus and CA1.

Journal: Neuropharmacology 20010101

Title: Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20001201

Title: Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors.

Journal: Neuropharmacology 20000724

Title: [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.

Journal: Neuropharmacology 19991001

Title: Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes.

Journal: British journal of pharmacology 19980201

Title: LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.

Journal: Neuropharmacology 19980101

Title: Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes.

Journal: Neuropharmacology 19950801

Title: Pitsikas N, et al. The metabotropic glutamate 2/3 receptor antagonist LY341495 differentially affects recognition memory in rats. Behav Brain Res. 2012 May 1;230(2):374-9.

Title: Sutton LP, et al. Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268.J Neurochem. 2011 Jun;117(6):973-83.

Title: Linden AM, et al. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology. 2009 Aug;57(2):172-82. Epub 2009 May 27.

Title: Li J, et al. N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases. Pain. 2016 Aug;157(8):1711-23.

Title: A E Kingston, et al. LY341495 Is a Nanomolar Potent and Selective Antagonist of Group II Metabotropic Glutamate Receptors.Neuropharmacology. 1998;37(1):1-12.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 201943-63-7
Tags:201943-63-7 Molecular Formula|201943-63-7 MDL|201943-63-7 SMILES|201943-63-7 9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)-