Home Amines 202466-68-0
202466-68-0,MFCD05662301
Catalog No.:AA00285W

202466-68-0 | Benzenesulfonamide, 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-

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5mg
≥98%(HPLC)
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10mg
≥98%(HPLC)
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$295.00   $207.00
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25mg
≥98%(HPLC)
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$590.00   $413.00
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50mg
≥98%(HPLC)
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$1,022.00   $715.00
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100mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00285W
Chemical Name:
Benzenesulfonamide, 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-
CAS Number:
202466-68-0
Molecular Formula:
C12H16N6O2S
Molecular Weight:
308.3594
MDL Number:
MFCD05662301
SMILES:
CNc1nc(NC)nc(c1)NS(=O)(=O)c1ccc(cc1)N
Properties
Computed Properties
 
Complexity:
418  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
1.7  

Literature

Title: Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

Journal: Journal of medicinal chemistry 20140911

Title: 1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.

Journal: Bioorganic & medicinal chemistry letters 20110115

Title: 5-HT6 antagonism attenuates cue-induced relapse to cocaine seeking without affecting cocaine reinforcement.

Journal: The international journal of neuropsychopharmacology 20100801

Title: Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.

Journal: Bioorganic & medicinal chemistry letters 20090615

Title: Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.

Journal: Journal of medicinal chemistry 20090212

Title: Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task.

Journal: Psychopharmacology 20090101

Title: The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801.

Journal: Behavioural brain research 20080409

Title: Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20080115

Title: A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

Journal: Journal of medicinal chemistry 20050630

Title: Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.

Journal: Journal of medicinal chemistry 20050324

Title: 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation--an effect sensitive to NMDA receptor antagonism.

Journal: Neuropharmacology 20040801

Title: Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790.

Journal: Psychopharmacology 20031201

Title: Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.

Journal: Journal of medicinal chemistry 20031106

Title: An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning.

Journal: The Journal of pharmacology and experimental therapeutics 20031101

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry 20030703

Title: Effect of the 5-HT6 receptor antagonists Ro04-6790 and Ro65-7199 on latent inhibition and prepulse inhibition in the rat: comparison to clozapine.

Journal: Pharmacology, biochemistry, and behavior 20030501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: DARPP-32 mediates serotonergic neurotransmission in the forebrain.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20020305

Title: A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze.

Journal: Neuropharmacology 20010801

Title: 5-HT(6) receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides.

Journal: European journal of medicinal chemistry 20010201

Title: Effects of the 5-HT(6) receptor antagonist Ro 04-6790 on learning consolidation.

Journal: Behavioural brain research 20010108

Title: 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.

Journal: Journal of medicinal chemistry 19990128

Title: Involvement of 5-HT6 receptors in nigro-striatal function in rodents.

Journal: British journal of pharmacology 19981201

Title: The 5-hydroxytryptamine6 receptor-selective radioligand [3H]Ro 63-0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum.

Journal: Molecular pharmacology 19980901

Title: Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors.

Journal: British journal of pharmacology 19980601

Title: A J Sleight, et al. Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. Br J Pharmacol. 1998 Jun;124(3):556-62.

Title: Sudabeh Shirazi-Southall, et al. Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology. 2002 May;26(5):583-94.

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