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202983-32-2,MFCD01861187
Catalog No.:AA01E3L3

202983-32-2 | NF279

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Purity
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1mg
98%
1 week  
$400.00   $280.00
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5mg
98%
1 week  
$828.00   $580.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E3L3
Chemical Name:
NF279
CAS Number:
202983-32-2
Molecular Formula:
C49H30N6Na6O23S6
Molecular Weight:
1401.1175
MDL Number:
MFCD01861187
SMILES:
O=C(Nc1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])Nc1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Properties
Computed Properties
 
Complexity:
2840  
Covalently-Bonded Unit Count:
7  
Heavy Atom Count:
90  
Hydrogen Bond Acceptor Count:
23  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
10  

Literature

Title: Modulation of purinergic neuromuscular transmission by phorbol dibutyrate is independent of protein kinase C in murine urinary bladder.

Journal: The Journal of pharmacology and experimental therapeutics 20120801

Title: Purinoreceptor-mediated current in myocytes from renal resistance arteries.

Journal: British journal of pharmacology 20100601

Title: Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists.

Journal: Biochemical pharmacology 20071115

Title: Desensitization masks nanomolar potency of ATP for the P2X1 receptor.

Journal: The Journal of biological chemistry 20040220

Title: Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior.

Journal: The Journal of clinical investigation 20031215

Title: P2X receptor-mediated excitatory synaptic currents in somatosensory cortex.

Journal: Molecular and cellular neurosciences 20031101

Title: NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010901

Title: Rettinger J, Schmalzing G, Damer S, Müller G, Nickel P, Lambrecht G. The suramin analogue NF279 is a novel and potent antagonist selective for the P2X(1) receptor. Neuropharmacology. 2000;39(11):2044-2053.

Title: Giroud C, et al. P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions. J Virol. 2015;89(18):9368-9382.

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