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21102-95-4,MFCD00153771
Catalog No.:AA002L2E

21102-95-4 | 8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:2)

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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA002L2E
Chemical Name:
8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:2)
CAS Number:
21102-95-4
Molecular Formula:
C22H33Cl2N3O3
Molecular Weight:
458.4217
MDL Number:
MFCD00153771
SMILES:
COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2.Cl.Cl
Properties
Computed Properties
 
Complexity:
547  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  

Literature

Title: Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat.

Journal: European journal of pharmacology 20120315

Title: Molecular and pharmacological characteristics of the gerbil α(1a)-adrenergic receptor.

Journal: Hearing research 20120101

Title: Effect of inter-renal aortic coarctation-induced hypertension on function and expression of vascular α(1A)- and α(1D)-adrenoceptors.

Journal: Canadian journal of physiology and pharmacology 20120101

Title: [Medical expulsive therapy facilitated by alpha 1 adrenoceptor antagonist].

Journal: Clinical calcium 20111001

Title: Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α₁-adrenoceptor subtypes.

Journal: European journal of medicinal chemistry 20110701

Title: Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion.

Journal: Investigative ophthalmology & visual science 20110701

Title: Vasopressor nerve responses in the pithed rat, previously identified as α2-adrenoceptor mediated, may be α1D-adrenoceptor mediated.

Journal: European journal of pharmacology 20110511

Title: Characterization of α1-adrenoceptor subtypes mediating contraction in human isolated ureters.

Journal: Urology 20110301

Title: α(1D)-Adrenoceptor regulates the vasopressor action of α(1A)-adrenoceptor in mesenteric vascular bed of α(1D)-adrenoceptor knockout mice.

Journal: Autonomic & autacoid pharmacology 20110101

Title: alpha(1)-Adrenergic receptor subtype function in fetal and adult cerebral arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20100601

Title: Gene expressions and mechanical functions of α1-adrenoceptor subtypes in mouse ureter.

Journal: World journal of urology 20091201

Title: Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats.

Journal: Acta pharmacologica Sinica 20090901

Title: Inhibitory effect of fentanyl on phenylephrine-induced contraction of the rat aorta.

Journal: Yonsei medical journal 20090630

Title: Serotonin1A-mediated amplification of light-induced phase advances of circadian rhythms in the Syrian hamster: post-light effects.

Journal: Brain research 20090123

Title: Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.

Journal: Autonomic & autacoid pharmacology 20090101

Title: Increased alpha1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats.

Journal: World journal of urology 20081201

Title: The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.

Journal: Molecular pharmacology 20081001

Title: Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension.

Journal: Acta pharmacologica Sinica 20080501

Title: Different affinities of native alpha1B-adrenoceptors for ketanserin between intact tissue segments and membrane preparations.

Journal: European journal of pharmacology 20080428

Title: Role of alpha1-adrenoceptor subtypes in the effects of methylenedioxy methamphetamine (MDMA) on body temperature in the mouse.

Journal: British journal of pharmacology 20080201

Title: Noradrenergic vasoconstriction of pig prostatic small arteries.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080201

Title: Characteristics of contractile activity in the renal artery of ovariectomized rats.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20080201

Title: Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats.

Journal: Autonomic & autacoid pharmacology 20080101

Title: Evidence of alpha1-adrenoceptor functional changes in omental arteries of patients with end-stage renal disease.

Journal: Autonomic & autacoid pharmacology 20080101

Title: Vascular alpha-1D-adrenoceptors are overexpressed in aorta of the aryl hydrocarbon receptor null mouse: role of increased angiotensin II.

Journal: Autonomic & autacoid pharmacology 20080101

Title: Alpha(1D)-adrenoceptors mediate nerve and agonist-evoked contractions in mouse vas deferens: evidence obtained from knockout technology.

Journal: Autonomic & autacoid pharmacology 20080101

Title: Ma huang and alpha subtype adrenoceptors in the cat pulmonary vascular bed.

Journal: Journal of dietary supplements 20080101

Title: Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter.

Journal: European journal of pharmacology 20071114

Title: Trophic effects induced by alpha1D-adrenoceptors on endothelial cells are potentiated by hypoxia.

Journal: American journal of physiology. Heart and circulatory physiology 20071001

Title: Influence of cisplatin-induced renal failure on the alpha(1)-adrenoceptor subtype causing vasoconstriction in the kidney of the rat.

Journal: European journal of pharmacology 20070813

Title: Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed.

Journal: Autonomic & autacoid pharmacology 20070701

Title: Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes.

Journal: Cardiovascular research 20070601

Title: Vascular alpha1-adrenoceptors in isolated perfused rat kidney: influence of ageing.

Journal: Autonomic & autacoid pharmacology 20070101

Title: Effect of alpha-adrenoceptor subtype-selective inverse agonists on non-pregnant and late-pregnant cervical resistance in vitro in the rat.

Journal: Clinical and experimental pharmacology & physiology 20070101

Title: Alpha(1A/L)-adrenoceptors mediate contraction of the circular smooth muscle of the pig urethra.

Journal: Autonomic & autacoid pharmacology 20061001

Title: Selective agonists reveal alpha(1A)- and alpha(1B)-adrenoceptor subtypes in caudal artery of the young rat.

Journal: Autonomic & autacoid pharmacology 20061001

Title: Potentiation of the resetting effects of light on circadian rhythms of hamsters using serotonin and neuropeptide Y receptor antagonists.

Journal: Neuroscience 20060901

Title: Alpha1D-adrenoceptor-induced relaxation on rat carotid artery is impaired during the endothelial dysfunction evoked in the early stages of hyperhomocysteinemia.

Journal: European journal of pharmacology 20060814

Title: Evidence against alpha-adrenoceptors mediating relaxation in rat thoracic aortae: alpha-agonists relaxation depends on interaction with alpha-adrenoceptors.

Journal: Fundamental & clinical pharmacology 20060801

Title: Heterodimers of alpha1B- and alpha1D-adrenergic receptors form a single functional entity.

Journal: Molecular pharmacology 20060101

Title: Captopril therapy decreases both expression and function of alpha-adrenoceptors in pre- hypertensive rat aorta.

Journal: Autonomic & autacoid pharmacology 20060101

Title: A two model receptor system of the alpha1D adrenergic receptor to describe interactions with epinephrine and BMY7378.

Journal: Journal of chemical information and modeling 20060101

Title: Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells.

Journal: European journal of pharmacology 20051219

Title: Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice.

Journal: British journal of pharmacology 20051001

Title: The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist.

Journal: Autonomic & autacoid pharmacology 20051001

Title: Chloroethylclonidine reveals that alpha (1 A)-adrenoceptors mediate contraction in aorta of alpha (1 D)-adrenoceptor knockout mice.

Journal: Autonomic & autacoid pharmacology 20051001

Title: Differential distribution of functional alph}1-adrenergic receptor subtypes along the rat tail artery.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: Nitric oxide and cGMP mediate alpha1D-adrenergic receptor-Stimulated protein secretion and p42/p44 MAPK activation in rat lacrimal gland.

Journal: Investigative ophthalmology & visual science 20050801

Title: Fentanyl attenuates alpha1B-adrenoceptor-mediated pulmonary artery contraction.

Journal: Anesthesiology 20050801

Title: Postjunctional alpha1-adrenoceptors in the vasculature of the pithed mouse are of the alpha1A-subtype.

Journal: Autonomic & autacoid pharmacology 20050701

Title: Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta.

Journal: European journal of pharmacology 20050131

Title: Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens.

Journal: British journal of pharmacology 20041101

Title: Effects of norepinephrine on alpha-subtype receptors in the feline pulmonary vascular bed.

Journal: Critical care medicine 20041101

Title: Pharmacological characterization of alpha1-adrenoceptors in mouse isolated femoral small arteries.

Journal: European journal of pharmacology 20041025

Title: Different roles of alpha1-adrenoceptor subtypes in mediating cardiomyocyte protein synthesis in neonatal rats.

Journal: Clinical and experimental pharmacology & physiology 20040901

Title: Effects of androgen manipulation on alpha1-adrenoceptor subtypes in the rat seminal vesicle.

Journal: Life sciences 20040806

Title: Alpha1-adrenoceptor subtype substitution in knockout mice.

Journal: British journal of pharmacology 20040701

Title: Hepatocytes from alpha1B-adrenoceptor knockout mice reveal compensatory adrenoceptor subtype substitution.

Journal: British journal of pharmacology 20040701

Title: Alpha-1D adrenoceptors are involved in reserpine-induced supersensitivity of rat tail artery.

Journal: British journal of pharmacology 20040601

Title: The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats.

Journal: British journal of pharmacology 20040601

Title: Human alpha1D-adrenoceptor phosphorylation and desensitization.

Journal: Biochemical pharmacology 20040515

Title: Evidence that alpha(1B)-adrenoceptors are involved in noradrenaline-induced contractions of rat tail artery.

Journal: European journal of pharmacology 20040319

Title: Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries.

Journal: British journal of pharmacology 20040301

Title: alpha1A-adrenergic receptor mediated pressor response to phenylephrine in anesthetized rat.

Journal: Science in China. Series C, Life sciences 20040201

Title: The hypotensive effect of BMY 7378 involves central 5-HT1A receptor stimulation in the adult but not in the young rat.

Journal: Archives of medical research 20040101

Title: Excitatory alpha1-adrenergic receptors predominate over inhibitory beta-receptors in rabbit dorsal detrusor.

Journal: The Journal of urology 20031201

Title: Effects of intravenous and infravesical administration of suramin, terazosin and BMY 7378 on bladder instability in conscious rats with bladder outlet obstruction.

Journal: BJU international 20030701

Title: Functional characterization of alpha-adrenoceptors mediating pupillary dilation in rats.

Journal: European journal of pharmacology 20030620

Title: Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens.

Journal: European journal of pharmacology 20030620

Title: Interaction between neuropeptide Y Y1 receptors and alpha1B-adrenoceptors in the neurovascular junction of canine splenic arteries.

Journal: European journal of pharmacology 20030418

Title: Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR.

Journal: American journal of physiology. Heart and circulatory physiology 20030401

Title: Functional alpha1-adrenergic receptor subtypes in human right gastroepiploic artery.

Journal: Acta pharmacologica Sinica 20030401

Title: Investigation of postjunctional alpha1- and alpha2-adrenoceptor subtypes in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice.

Journal: British journal of pharmacology 20030301

Title: Evidence for the role of alpha1D- and alpha1A-adrenoceptors in contraction of the rat mesenteric artery.

Journal: Vascular pharmacology 20030201

Title: Serotonergic serotonin (1A) mixed agonists/antagonists elicit large-magnitude phase shifts in hamster circadian wheel-running rhythms.

Journal: Neuroscience 20030101

Title: Pharmacological characterization of alpha1-adrenoceptor in mouse iliac artery.

Journal: European journal of pharmacology 20021205

Title: Alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo.

Journal: American journal of physiology. Heart and circulatory physiology 20021001

Title: Pharmacological characterization of alpha1-adrenoceptor subtypes in the bovine tail artery.

Journal: Journal of veterinary pharmacology and therapeutics 20021001

Title: Noradrenaline-induced contraction of human saphenous vein and human internal mammary artery: involvement of different alpha-adrenoceptor subtypes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020801

Title: (+/-)-Domesticine, a novel and selective alpha1D-adrenoceptor antagonist in animal tissues and human alpha 1-adrenoceptors.

Journal: European journal of pharmacology 20020607

Title: Adrenergic activation of cardiac phospholipase D: role of alpha(1)-adrenoceptor subtypes.

Journal: Cardiovascular research 20020401

Title: The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction.

Journal: The Journal of clinical investigation 20020315

Title: Modulatory role of a constitutively active population of alpha(1D)-adrenoceptors in conductance arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20020201

Title: Changes in alpha(1)-adrenergic vascular reactivity in monocrotaline-treated rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020201

Title: Existence of functional alpha1A- and alpha1D- but no alpha1B-adrenoceptor subtypes in rat common carotid arteries.

Journal: Japanese journal of pharmacology 20020201

Title: Pathological role of a constitutively active population of alpha(1D)-adrenoceptors in arteries of spontaneously hypertensive rats.

Journal: British journal of pharmacology 20020101

Title: The functional alpha-adrenoceptor in dog caudal vesical arteries is mainly an alpha1A subtype.

Journal: Autonomic & autacoid pharmacology 20020101

Title: The role of alpha1D-adrenoceptors in prostatic contraction examined using protection studies.

Journal: Autonomic & autacoid pharmacology 20020101

Title: A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity.

Journal: European journal of pharmacology 20011214

Title: Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes.

Journal: The Journal of biological chemistry 20011102

Title: alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta.

Journal: British journal of pharmacology 20011101

Title: Existence of alpha(1A)- and alpha(1B)-adrenoceptor subtypes in canine mandibular alveolar arteries.

Journal: Clinical and experimental pharmacology & physiology 20010901

Title: Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor.

Journal: European journal of pharmacology 20010831

Title: alpha(1D)-Adrenoceptors do not contribute to phosphoinositide hydrolysis in adult rat cardiac myocytes.

Journal: Archives of biochemistry and biophysics 20010801

Title: Characterization of alpha1-adrenoceptor-mediated contraction in the mouse thoracic aorta.

Journal: European journal of pharmacology 20010720

Title: Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists.

Journal: The Journal of biological chemistry 20010706

Title: Functional characterization of alpha(1)-adrenoceptor subtypes in human skeletal muscle resistance arteries.

Journal: British journal of pharmacology 20010701

Title: The alpha(1A)-adrenoceptor subtype mediates contraction in rat femoral resistance arteries.

Journal: European journal of pharmacology 20010622

Title: Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010501

Title: The role of several alpha(1)- and alpha(2)-adrenoceptor subtypes mediating vasoconstriction in the canine external carotid circulation.

Journal: British journal of pharmacology 20010301

Title: Inositolphosphate formation in thoracic and abdominal rat aorta following Gq/11-coupled receptor stimulation.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010301

Title: Alpha1-adrenoceptor subtypes mediating vasoconstriction in the carotid circulation of anaesthetized pigs: possible avenues for antimigraine drug development.

Journal: Cephalalgia : an international journal of headache 20010301

Title: The hypotensive effect of BMY 7378 is antagonized by a silent 5-HT(1A) receptor antagonist: comparison with 8-hydroxy-dipropylamino tetralin.

Journal: Archives of medical research 20010101

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Tags:21102-95-4 Molecular Formula|21102-95-4 MDL|21102-95-4 SMILES|21102-95-4 8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:2)