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216450-65-6,MFCD30534403
Catalog No.:AA00BFPJ

216450-65-6 | sophoflavescenol

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Purity
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Price(USD)
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1mg
98%
1 week  
$368.00   $258.00
- +
5mg
98%
1 week  
$1,003.00   $702.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BFPJ
Chemical Name:
sophoflavescenol
CAS Number:
216450-65-6
Molecular Formula:
C21H20O6
Molecular Weight:
368.3799
MDL Number:
MFCD30534403
SMILES:
COc1cc(O)c(c2c1c(=O)c(O)c(o2)c1ccc(cc1)O)CC=C(C)C
Properties
Computed Properties
 
Complexity:
612  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
4.2  

Literature

Title: Kinetics and molecular docking studies of kaempferol and its prenylated derivatives as aldose reductase inhibitors.

Journal: Chemico-biological interactions 20120530

Title: Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo.

Journal: Archives of pharmacal research 20111201

Title: Antidiabetic complications and anti-Alzheimer activities of sophoflavescenol, a prenylated flavonol from Sophora flavescens, and its structure-activity relationship.

Journal: Phytotherapy research : PTR 20110501

Title: 8-Prenylkaempferol Suppresses Influenza A Virus-Induced RANTES Production in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-κB and IRF3.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.

Journal: Bioorganic & medicinal chemistry letters 20090515

Title: Prenylated flavonoids as tyrosinase inhibitors.

Journal: Archives of pharmacal research 20041101

Title: A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.

Journal: Bioorganic & medicinal chemistry letters 20020902

Title: Jung HA, et al. Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo. Arch Pharm Res. 2011 Dec;34(12):2087-99

Title: Jung HA, et al. Antidiabetic complications and anti-Alzheimer activities of sophoflavescenol, a prenylated flavonol from Sophora flavescens, and its structure-activity relationship. Phytother Res. 2011 May;25(5):709-15.

Title: Shin HJ, et al. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.

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