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216691-95-1,MFCD30536363
Catalog No.:AA00BBIT

216691-95-1 | 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98% by HPLC
in stock  
$148.00   $104.00
- +
10mg
98% by HPLC
in stock  
$206.00   $144.00
- +
25mg
98% by HPLC
in stock  
$364.00   $255.00
- +
50mg
98% by HPLC
in stock  
$575.00   $403.00
- +
100mg
98% by HPLC
in stock  
$949.00   $664.00
- +
500mg
98% by HPLC
in stock  
$2,920.00   $2,044.00
- +
1000mg
98% by HPLC
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BBIT
Chemical Name:
7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
CAS Number:
216691-95-1
Molecular Formula:
C27H21ClN2O2
Molecular Weight:
440.9208
MDL Number:
MFCD30536363
SMILES:
Clc1ccc2c(c1)C(=NC(C(=O)N2C)Cc1ccc2c(c1)cccc2)c1ccc(cc1)O
Properties
Computed Properties
 
Complexity:
704  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.6  

Literature

Title: Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423.

Journal: Chemistry & biology 20050401

Title: The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells.

Journal: Cancer research 20031015

Title: A comparison of the anticonvulsant effects of 1,4- and 1,5-benzodiazepines in the amygdala-kindled rat and their effects on motor function.

Journal: Epilepsy research 19890101

Title: Blatt NB, et al. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem Pharmacol. 2009 Oct 15;78(8):966-73.

Title: Blatt NB, et al. Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free Radic Biol Med. 2008 Nov 1;45(9):1232-42.

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SDS
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Tags:216691-95-1 Molecular Formula|216691-95-1 MDL|216691-95-1 SMILES|216691-95-1 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one