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2215-21-6,MFCD00008884
Catalog No.:AA003IKV

2215-21-6 | 3,5-Diisopropylsalicylic acid

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Purity
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1g
98%(HPLC)
in stock  
$24.00   $17.00
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5g
98%(HPLC)
in stock  
$34.00   $24.00
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25g
95%
in stock  
$62.00   $43.00
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100g
95%
in stock  
$245.00   $171.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003IKV
Chemical Name:
3,5-Diisopropylsalicylic acid
CAS Number:
2215-21-6
Molecular Formula:
C13H18O3
Molecular Weight:
222.2802
MDL Number:
MFCD00008884
SMILES:
CC(c1cc(C(C)C)c(c(c1)C(=O)O)O)C
Properties
Properties
 
BP:
303.46°C (rough estimate)  
Form:
Solid  
MP:
113-115 °C(lit.)  
Refractive Index:
1.4740 (estimate)  
Solubility:
Soluble in organic solvents.  
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
248  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
5.5  

Downstream Synthesis Route

[1]Patent:US6759546,2004,B1.Locationinpatent:Pagecolumn10

[2]Synthesis,1990,p.827-833

[3]JournaloftheAmericanChemicalSociety,1934,vol.56,p.2054    JournalofOrganicChemistry,1937,vol.2,p.253,255

[1]Pfister,JuergR.[JournalofHeterocyclicChemistry,1982,vol.19,p.1255-1256]

[1]Michellys;Ardecky;Chen;Crombie;Etgen;Faul;Faulkner;Grese;Heyman;Karanewsky;Klausing;Leibowitz;Liu;Mais;Mapes;Marschke;Reifel-Miller;Ogilvie;Rungta;Thompson;Tyhonas;Boehm[JournalofMedicinalChemistry,2003,vol.46,#13,p.2683-2696]

2215-21-6    124-68-5   
2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-4,6-diisopropylphenol 

[1]Bott,RobynK.J.;Hammond,Max;Horton,PeterN.;Lancaster,SimonJ.;Bochmann,Manfred;Scott,Peter[DaltonTransactions,2005,#22,p.3611-3613]

[1]Jendralla,Heiner;Chen,Li-Jian[Synthesis,1990,#9,p.827-833]

Literature

Title: Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines.

Journal: Journal of medicinal chemistry 20120308

Title: Irbesartan inhibits advanced glycation end product (AGE)-induced up-regulation of vascular cell adhesion molecule-1 (VCAM-1) mRNA levels in glomerular endothelial cells.

Journal: Microvascular research 20110501

Title: Fabrication and mechanical properties of PLLA/PCL/HA composites via a biomimetic, dip coating, and hot compression procedure.

Journal: Journal of materials science. Materials in medicine 20100601

Title: Fluorescence labelling of DNA by carboxylic polypyridyl-Ru complexes containing bpy and DIP ligands: a study revisited.

Journal: Journal of fluorescence 20100501

Title: Bis(2,2'-bipyridyl-κN,N')bis-(2-hydroxy-benzoato)-κO;κO,O-cadmium(II) methanol solvate.

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: Deoxyribonuclease I is essential for DNA fragmentation induced by gamma radiation in mice.

Journal: Radiation research 20091001

Title: Synthesis and anticancer activity of lipophilic platinum(II) complexes of 3,5-diisopropylsalicylate.

Journal: European journal of medicinal chemistry 20080701

Title: Copper(II) interaction with 3,5-diisopropylsalicylic acid (Dips): new insights on its role as a potential *OH inactivating ligand.

Journal: Journal of inorganic biochemistry 20070401

Title: Redox-dependent effects of nitric oxide on microvascular integrity in oxygen-induced retinopathy.

Journal: Free radical biology & medicine 20041201

Title: Pharmacokinetic distribution of 67Cu(II)2[3,5-diisopropyl(carboxy-14C)salicylate]4 among murine tissues.

Journal: Current medicinal chemistry 20041101

Title: Pharmacological and haematological results of rat skin burn injury treatment with Cu(II)2(3,5-diisopropylsalicylate)4.

Journal: Inflammopharmacology 20040101

Title: Ultraviolet-B-induced oxidative DNA base damage in primary normal human epidermal keratinocytes and inhibition by a hydroxyl radical scavenger.

Journal: The Journal of investigative dermatology 20030701

Title: Activation of calcium-dependent calmodulin by calcium(II)3(3,5-diisopropylsalicylate)6(H2O)6 decreases thrombin receptor activating peptide-induced P-selectin expression.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030201

Title: Protection against cisplatin-induced nephrotoxicity by Cu(II)2(3,5-diisopropylsalicylate)4.

Journal: Redox report : communications in free radical research 20030101

Title: Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis.

Journal: The Journal of rheumatology 20021201

Title: [Crystallochemistry of copper (II) and zinc (II) chelates by nonsteroidal antiinflammatory drugs].

Journal: Annales pharmaceutiques francaises 20020301

Title: Nitric oxide (NO) and cartilage metabolism: NO effects are modulated by superoxide in response to IL-1.

Journal: Biorheology 20020101

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