Home Amines 2217-40-5
2217-40-5,MFCD00001740
Catalog No.:AA003D77

2217-40-5 | 1,2,3,4-Tetrahydro-1-naphthylamine

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1g
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$8.00   $6.00
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25g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003D77
Chemical Name:
1,2,3,4-Tetrahydro-1-naphthylamine
CAS Number:
2217-40-5
Molecular Formula:
C10H13N
Molecular Weight:
147.2169
MDL Number:
MFCD00001740
SMILES:
NC1CCCc2c1cccc2
NSC Number:
30349
Properties
Properties
 
BP:
249.6°C at 760 mmHg  
Form:
Liquid  
Refractive Index:
n20/D 1.562(lit.)  
Stability:
Air Sensitive  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
133  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.6  

Literature

Title: Regioisomerism in the synthesis of a chiral aminotetralin drug compound: unraveling mechanistic details and diastereomer-specific in-depth NMR investigations.

Journal: The Journal of organic chemistry 20120706

Title: Computational modeling of capillary electrophoretic behavior of primary amines using dual system of 18-crown-6 and β-cyclodextrin.

Journal: Journal of chromatography. A 20110805

Title: Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014.

Journal: Bioorganic & medicinal chemistry letters 20110501

Title: Practical asymmetric synthesis of bioactive aminotetralins from a racemic precursor using a regiodivergent resolution.

Journal: Organic letters 20101203

Title: Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Separation of chiral primary amino compounds by forming a sandwiched complex in reversed-phase high performance liquid chromatography.

Journal: Journal of chromatography. A 20100723

Title: Synthesis and evaluation of dimeric 1,2,3,4-tetrahydro-naphthalenylamine and indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity.

Journal: European journal of medicinal chemistry 20100101

Title: Intelligent chiral sensing based on supramolecular and interfacial concepts.

Journal: Sensors (Basel, Switzerland) 20100101

Title: 2-Amino-nonyl-6-methoxyl-tetralin muriate inhibits sterol C-14 reductase in the ergosterol biosynthetic pathway.

Journal: Acta pharmacologica Sinica 20091201

Title: Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions.

Journal: Bioorganic & medicinal chemistry letters 20090215

Title: A chemoenzymatic approach to enantiomerically pure amines using dynamic kinetic resolution: application to the synthesis of norsertraline.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

Title: Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model.

Journal: Journal of medicinal chemistry 20081225

Title: 4-Methyl-2-[(E)-phen-yl(1,2,3,4-tetra-hydro-1-naphthyl-imino)meth-yl]phenol.

Journal: Acta crystallographica. Section E, Structure reports online 20081001

Title: Antileukemic activity of aminoparthenolide analogs.

Journal: Bioorganic & medicinal chemistry letters 20080715

Title: Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.

Journal: Journal of medicinal chemistry 20080214

Title: Preparation of alpha-aminobenzylphosphonic acids with a stereogenic quaternary carbon atom via microscopically configurationally stable alpha-aminobenzyllithiums.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

Title: 5-HT1A receptors mediate (+)8-OH-DPAT-stimulation of extracellular signal-regulated kinase (MAP kinase) in vivo in rat hypothalamus: time dependence and regional differences.

Journal: Brain research 20071205

Title: The prediction of (1)H chemical shifts in amines: a semiempirical and ab initio investigation.

Journal: Magnetic resonance in chemistry : MRC 20070901

Title: Rotigotine transdermal system: a short review.

Journal: Neuropsychiatric disease and treatment 20061201

Title: Iodine monochloride-amine complexes: an experimental and computational approach to new chiral electrophiles.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20050919

Title: Chiral metal architectures in aminopyridinato complexes of zirconium.

Journal: Dalton transactions (Cambridge, England : 2003) 20041207

Title: Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore.

Journal: Journal of medicinal chemistry 20041007

Title: Synthesis and biological characterization of novel hybrid 7-[[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors.

Journal: Bioorganic & medicinal chemistry 20040815

Title: Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants.

Journal: Bioorganic & medicinal chemistry 20040801

Title: Schizophrenia: from dopamine to glutamate and back.

Journal: Current medicinal chemistry 20040201

Title: The aminotetraline derivative (+/-)-(R,S)-5,6-dihydroxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene hydrochloride (CHF-1024) displays cardioprotection in postischemic ventricular dysfunction of the rat heart.

Journal: The Journal of pharmacology and experimental therapeutics 20031101

Title: Synthesis and structure--activity relationship of novel aminotetralin derivatives with high micro selective opioid affinity.

Journal: Bioorganic & medicinal chemistry letters 20021104

Title: The preparation and intra- and intermolecular addition reactions of acyclic N-acylimines: application to the synthesis of (+/-)-sertraline.

Journal: The Journal of organic chemistry 20011019

Title: Kinetic resolution of chiral amines with omega-transaminase using an enzyme-membrane reactor.

Journal: Biotechnology and bioengineering 20010505

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Tags:2217-40-5 Molecular Formula|2217-40-5 MDL|2217-40-5 SMILES|2217-40-5 1,2,3,4-Tetrahydro-1-naphthylamine |Organic_Building_Blocks