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222723-55-9,MFCD05865095
Catalog No.:AA00BBYK

222723-55-9 | NOLADIN ETHER

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BBYK
Chemical Name:
NOLADIN ETHER
CAS Number:
222723-55-9
Molecular Formula:
C23H40O3
Molecular Weight:
364.5619
MDL Number:
MFCD05865095
SMILES:
CCCCCC=CCC=CCC=CCC=CCCCCOC(CO)CO
Properties
Computed Properties
 
Complexity:
379  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
4  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
18  
XLogP3:
5.7  

Literature

Title: Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.

Journal: Journal of medicinal chemistry 20131114

Title: Stimulation of accumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.

Journal: Pharmacological research 20120901

Title: Noladin ether, a putative endocannabinoid, enhances motivation to eat after acute systemic administration in rats.

Journal: British journal of pharmacology 20120701

Title: NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120201

Title: Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor.

Journal: Journal of medicinal chemistry 20111222

Title: Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors.

Journal: Journal of medicinal chemistry 20110728

Title: Anti-proliferative effect of a putative endocannabinoid, 2-arachidonylglyceryl ether in prostate carcinoma cells.

Journal: Prostaglandins & other lipid mediators 20110201

Title: BDNF regulates neuronal sensitivity to endocannabinoids.

Journal: Neuroscience letters 20091225

Title: CB(2) cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB(2) receptor in pain.

Journal: Neurochemistry international 20081201

Title: Noladin ether, a putative endocannabinoid, inhibits mu-opioid receptor activation via CB2 cannabinoid receptors.

Journal: Neurochemistry international 20080101

Title: The orphan receptor GPR55 is a novel cannabinoid receptor.

Journal: British journal of pharmacology 20071201

Title: Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism.

Journal: British journal of pharmacology 20071101

Title: 2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling.

Journal: European journal of pharmacology 20070322

Title: Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.

Journal: British journal of pharmacology 20070301

Title: Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand.

Journal: Bioorganic & medicinal chemistry 20070115

Title: Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography-tandem electrospray ionization mass spectrometry.

Journal: Analytical biochemistry 20070115

Title: Noladin ether acts on trabecular meshwork cannabinoid (CB1) receptors to enhance aqueous humor outflow facility.

Journal: Investigative ophthalmology & visual science 20060501

Title: Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones.

Journal: The Journal of physiology 20051201

Title: Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20051101

Title: Hippocampal cannabinoid-1 receptor upregulation upon endothelin-B receptor deficiency: a neuroprotective substitution effect?

Journal: Neurochemical research 20051001

Title: Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050915

Title: Persistent anxiogenic effects of a single or repeated doses of cocaine and methamphetamine: interactions with endogenous cannabinoid receptor ligands.

Journal: Behavioural pharmacology 20050901

Title: The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.

Journal: Journal of medicinal chemistry 20050811

Title: The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: Differential effects of endocannabinoids on [(3)H]-GABA uptake in the rat globus pallidus.

Journal: Experimental neurology 20050701

Title: Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice.

Journal: Brain research bulletin 20050315

Title: Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 G(i/o) linked receptor.

Journal: British journal of pharmacology 20040601

Title: Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons.

Journal: Molecular pharmacology 20040301

Title: Ether-linked analogue of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species.

Journal: Journal of neurochemistry 20030601

Title: Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors.

Journal: Bioorganic & medicinal chemistry letters 20030106

Title: Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide.

Journal: Neuroscience letters 20021031

Title: Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid.

Journal: Investigative ophthalmology & visual science 20021001

Title: Acute neuronal injury, excitotoxicity, and the endocannabinoid system.

Journal: Molecular neurobiology 20020101

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