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22316-55-8,MFCD00871860
Catalog No.:AA00BO3X

22316-55-8 | 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BO3X
Chemical Name:
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
CAS Number:
22316-55-8
Molecular Formula:
C15H11ClN2O2
Molecular Weight:
286.7130
MDL Number:
MFCD00871860
SMILES:
O=C1CC(=O)N(c2c(N1)ccc(c2)Cl)c1ccccc1
Properties
Properties
 
BP:
601.8°C at 760 mmHg  
MP:
>219°C (dec.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
395  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.9  

Literature

Title: The Use of Human Liver Cell Model and Cytochrome P450 Substrate-Inhibitor Panel for Studies of Dasatinib and Warfarin Interactions.

Journal: Bulletin of experimental biology and medicine 20170201

Title: The metabolites N-desmethylclozapine and N-desmethylolanzapine produce cross-tolerance to the discriminative stimulus of the atypical antipsychotic clozapine in C57BL/6 mice.

Journal: Behavioural pharmacology 20110901

Title: Blood concentrations of clobazam and norclobazam in a lethal case involving clobazam, meprobamate and clorazepate.

Journal: Legal medicine (Tokyo, Japan) 20101101

Title: Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB.

Journal: Journal of the neurological sciences 20071215

Title: Eye rolling as a manifestation of clobazam toxicity in a child with epilepsy.

Journal: Developmental medicine and child neurology 20060701

Title: Simultaneous determination of clobazam and its major metabolite in human plasma by a rapid HPLC method.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050905

Title: 5-Hydroxytryptamine action in the rat olfactory bulb: in vitro electrophysiological patch-clamp recordings of juxtaglomerular and mitral cells.

Journal: Neuroscience 20050101

Title: A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam.

Journal: Brain & development 20041201

Title: Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.

Journal: Brain & development 20040101

Title: Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam.

Journal: Therapeutic drug monitoring 20021201

Title: Simple and sensitive high-performance liquid chromatographic method for the determination of 1,5-benzodiazepine clobazam and its active metabolite N-desmethylclobazam in human serum and urine with application to 1,4-benzodiazepines analysis.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010105

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Tags:22316-55-8 Molecular Formula|22316-55-8 MDL|22316-55-8 SMILES|22316-55-8 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione