Home Amines 223673-61-8
223673-61-8,MFCD11100356
Catalog No.:AA0037Q2

223673-61-8 | 2-(2-amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)phenyl]acetamide

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5mg
>98%(HPLC)powder
in stock  
$48.00   $34.00
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25mg
>98%(HPLC)powder
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$66.00   $46.00
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100mg
>98%(HPLC)powder
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$156.00   $109.00
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1g
98%
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$162.00   $113.00
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5g
98%
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$502.00   $352.00
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10g
98%
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$843.00   $590.00
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25g
98%
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$1,640.00   $1,148.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0037Q2
Chemical Name:
2-(2-amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)phenyl]acetamide
CAS Number:
223673-61-8
Molecular Formula:
C21H24N4O2S
Molecular Weight:
396.5059
MDL Number:
MFCD11100356
SMILES:
O=C(Cc1csc(n1)N)Nc1ccc(cc1)CCNC[C@@H](c1ccccc1)O
Properties
Computed Properties
 
Complexity:
467  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  
XLogP3:
2.1  

Literature

Title: Mirabegron: potential off target effects and uses beyond the bladder.

Journal: British journal of pharmacology 20181101

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology 20150518

Title: The pharmacokinetic evaluation of mirabegron as an overactive bladder therapy option.

Journal: Expert opinion on drug metabolism & toxicology 20130501

Title: Single dose pharmacokinetics and absolute bioavailability of mirabegron, a β₃-adrenoceptor agonist for treatment of overactive bladder.

Journal: International journal of clinical pharmacology and therapeutics 20121101

Title: Use of mirabegron in treating overactive bladder.

Journal: International urogynecology journal 20121001

Title: Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonist.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20121001

Title: Pharmacokinetic properties of mirabegron, a β3-adrenoceptor agonist: results from two phase I, randomized, multiple-dose studies in healthy young and elderly men and women.

Journal: Clinical therapeutics 20121001

Title: Emerging therapies: what's new is old and what's old is new.

Journal: The Canadian journal of urology 20121001

Title: An aryloxypropanolamine hβ3-adrenoceptor agonist as bladder smooth muscle relaxant.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120815

Title: Overactive bladder, under scrutiny, gets a new treatment.

Journal: Nature medicine 20120801

Title: Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonist mirabegron in conscious rats with partial outflow obstruction.

Journal: BJU international 20120701

Title: Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonist mirabegron in conscious rats with partial outflow obstruction.

Journal: BJU international 20120701

Title: [Pharmacological and clinical profile of mirabegron (Betanis(®)): a new therapeutic agent for overactive bladder].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20120501

Title: Treatment of overactive bladder symptoms beyond antimuscarinics: current and future therapies.

Journal: Postgraduate medicine 20120501

Title: Stress urinary incontinence and overactive bladder syndrome: current options and new targets for management.

Journal: Postgraduate medicine 20120501

Title: Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective β(3)-adrenoceptor agonist, after oral administration to healthy male volunteers.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120401

Title: Development and validation of LC-MS/MS methods for the determination of mirabegron and its metabolites in human plasma and their application to a clinical pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301

Title: Mirabegron for the treatment of overactive bladder.

Journal: Drugs of today (Barcelona, Spain : 1998) 20120101

Title: Mirabegron: a safety review.

Journal: Expert opinion on drug safety 20110301

Title: Beta3-adrenoceptor agonists: possible role in the treatment of overactive bladder.

Journal: Korean journal of urology 20101201

Title: Mirabegron, a β₃-adrenoceptor agonist for the potential treatment of urinary frequency, urinary incontinence or urgency associated with overactive bladder.

Journal: IDrugs : the investigational drugs journal 20101001

Title: Tissue functions mediated by beta(3)-adrenoceptors-findings and challenges.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100801

Title: Effect of pre-contraction on β-adrenoceptor-mediated relaxation of rat urinary bladder.

Journal: World journal of urology 20091201

Title: Pharmacotherapy of the overactive bladder.

Journal: Discovery medicine 20091001

Title: Editorial comment on: Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study.

Journal: European urology 20090701

Title: Do gene polymorphisms alone or in combination affect the function of human beta3-adrenoceptors?

Journal: British journal of pharmacology 20090101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080601

Title: Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function.

Journal: The Journal of pharmacology and experimental therapeutics 20070501

Title: Relaxation of human detrusor muscle by selective beta-2 and beta-3 agonists and endogenous catecholamines.

Journal: Urology 20070401

Title: A quantitative analysis of mRNA expression of alpha 1 and beta-adrenoceptor subtypes and their functional roles in human normal and obstructed bladders.

Journal: The Journal of urology 20030801

Title: Beta3-adrenoceptors in human detrusor muscle.

Journal: Urology 20020501

Title: Takasu T, et al. Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)aminoethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function. J Pharmacol Exp Ther. 2007 May;321(2):642-7.

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Tags:223673-61-8 Molecular Formula|223673-61-8 MDL|223673-61-8 SMILES|223673-61-8 2-(2-amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)phenyl]acetamide