Home Imidazoles 224785-90-4
224785-90-4,MFCD07773094
Catalog No.:AA00I4D1

224785-90-4 | 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-propyl-1H,4H-imidazo[4,3-f][1,2,4]triazin-4-one hydrochloride

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1mg
98%
in stock  
$6.00   $4.00
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1g
97%
in stock  
$62.00   $44.00
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5g
97%
in stock  
$137.00   $96.00
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10g
97%
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$236.00   $166.00
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25g
97%
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$411.00   $288.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I4D1
Chemical Name:
2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-propyl-1H,4H-imidazo[4,3-f][1,2,4]triazin-4-one hydrochloride
CAS Number:
224785-90-4
Molecular Formula:
C23H33ClN6O4S
Molecular Weight:
525.0639
MDL Number:
MFCD07773094
SMILES:
CCOc1ccc(cc1c1nc(=O)c2n([nH]1)c(CCC)nc2C)S(=O)(=O)N1CCN(CC1)CC.Cl
Properties
Properties
 
BP:
692.2°C at 760 mmHg  
Form:
Solid  
Storage:
Room Temperature;Light sensitive;Inert atmosphere;  

Computed Properties
 
Complexity:
854  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
2.5  

Downstream Synthesis Route
224785-90-4   
1-3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo5,1-f1,2,4triazin-2-yl)-4-ethoxyphenylsulfonyl-4-ethylpiperazinedihydrochloridedihydrate 

[1]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-US2007/197535,2007,A1Locationinpatent:Page/Pagecolumn7

[1]Patent:US2007/197535,2007,A1.Locationinpatent:Page/Pagecolumn6

1-3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo5,1-f1,2,4triazin-2-yl)-4-ethoxyphenylsulfonyl-4-ethylpiperazinedihydrochloridedihydrate 
  224785-90-4   
1-3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo5,1-f1,2,4triazin-2-yl)-4-ethoxyphenylsulfonyl-4-ethylpiperazinedihydrochloridemonohydrate 

[1]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-US2007/197535,2007,A1Locationinpatent:Page/Pagecolumn7

1-3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo5,1-f1,2,4triazin-2-yl)-4-ethoxyphenylsulfonyl-4-ethylpiperazinedihydrochloridedihydrate 
  224785-90-4   
1-3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo5,1-f1,2,4triazin-2-yl)-4-ethoxyphenylsulfonyl-4-ethylpiperazinedihydrochloridetrihydrate 

[1]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-US2007/197535,2007,A1Locationinpatent:Page/Pagecolumn7

Literature

Title: Validation of an LC-ESI-MS/MS method for the quantitation of phosphodiesterase-5 inhibitors and their main metabolites in rat serum and brain tissue samples.

Journal: Journal of pharmaceutical and biomedical analysis 20121101

Title: Screening for multiple phosphodiesterase type 5 inhibitor drugs in dietary supplement materials by flow injection mass spectrometry and their quantification by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20121101

Title: Phosphodiesterase type 5 inhibition reverts prostate fibroblast-to-myofibroblast trans-differentiation.

Journal: Endocrinology 20121101

Title: A spontaneous, double-blind, double-dummy cross-over study on the effects of daily vardenafil on arterial stiffness in patients with vasculogenic erectile dysfunction.

Journal: International journal of cardiology 20121018

Title: Lifestyle illicit drug seizures: a routine ESI-LC-MS method for the identification of sildenafil and vardenafil.

Journal: Forensic science international 20121010

Title: Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks.

Journal: Journal of pharmaceutical and biomedical analysis 20121001

Title: Response to on-demand vardenafil was improved by its daily usage in hypertensive men.

Journal: Urology 20121001

Title: Examination of the effects of vardenafil on esophageal function using multichannel intraluminal impedance and manometry.

Journal: Journal of neurogastroenterology and motility 20121001

Title: Vardenafil for the treatment of raynaud phenomenon: a randomized, double-blind, placebo-controlled crossover study.

Journal: Archives of internal medicine 20120813

Title: Beneficial effect of vardenafil on aortic stiffness and wave reflections.

Journal: Journal of clinical pharmacology 20120801

Title: PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells.

Journal: Journal of cellular biochemistry 20120801

Title: PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter.

Journal: Cancer science 20120801

Title: Early alcohol exposure disrupts visual cortex plasticity in mice.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20120801

Title: Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction.

Journal: The Journal of urology 20120801

Title: Characterization of efflux transport of the PDE5 inhibitors, vardenafil and sildenafil.

Journal: The Journal of pharmacy and pharmacology 20120801

Title: Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice.

Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20120701

Title: Effects of chronic vardenafil treatment persist after end of treatment in rats with acute arteriogenic erectile dysfunction.

Journal: The journal of sexual medicine 20120701

Title: Current status of transrectal ultrasound techniques in prostate cancer.

Journal: Current opinion in urology 20120701

Title: Efficacy and satisfaction rates of oral PDE5is in the treatment of erectile dysfunction secondary to spinal cord injury: a review of literature.

Journal: The journal of spinal cord medicine 20120701

Title: Enhancement of myocardial and vascular function after phosphodiesterase-5 inhibition in a rat model.

Journal: The Thoracic and cardiovascular surgeon 20120601

Title: A randomized, placebo-controlled study to assess safety and efficacy of vardenafil 10 mg and tamsulosin 0.4 mg vs. tamsulosin 0.4 mg alone in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia.

Journal: The journal of sexual medicine 20120601

Title: Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study.

Journal: The Lancet. Oncology 20120601

Title: Anterior ischemic optic neuropathy associated with udenafil.

Journal: Korean journal of ophthalmology : KJO 20120601

Title: Identification of phototransformation products of sildenafil (Viagra) and its N-demethylated human metabolite under simulated sunlight.

Journal: Journal of mass spectrometry : JMS 20120601

Title: Effects of phosphodiesterase-5 inhibitor vardenafil on testicular androgen-binding protein secretion, the maintenance of foci of advanced spermatogenesis and the sperm fertilising capacity in azoospermic men.

Journal: Andrologia 20120501

Title: Effect of vardenafil on nitric oxide synthase expression in the paraventricular nucleus of rats without sexual stimulation.

Journal: Andrologia 20120501

Title: A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia.

Journal: European urology 20120501

Title: Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanisms.

Journal: Neurobiology of learning and memory 20120501

Title: Increasing the dose of vardenafil on a daily basis does not improve erectile function after unilateral nerve-sparing radical prostatectomy.

Journal: The journal of sexual medicine 20120501

Title: Re: time to onset of action of vardenafil: a retrospective analysis of the pivotal trials for the orodispersible and film-coated tablet formulations.

Journal: The Journal of urology 20120501

Title: Vardenafil ameliorates calcium mobilization in pulmonary artery smooth muscle cells from hypoxic pulmonary hypertensive mice.

Journal: Archives of medical research 20120501

Title: Nitric oxide synthases: regulation and function.

Journal: European heart journal 20120401

Title: Treating erectile dysfunction and central neurological diseases with oral phosphodiesterase type 5 inhibitors. Review of the literature.

Journal: The journal of sexual medicine 20120401

Title: How to interpret a functional or motility test - sphincter of oddi manometry.

Journal: Journal of neurogastroenterology and motility 20120401

Title: Benign prostatic hyperplasia: from bench to clinic.

Journal: Korean journal of urology 20120301

Title: Influences of neuroregulatory factors on the development of lower urinary tract symptoms/benign prostatic hyperplasia and erectile dysfunction in aging men.

Journal: The Urologic clinics of North America 20120201

Title: cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function.

Journal: Nature medicine 20120122

Title: 10-Year analysis of adverse event reports to the Food and Drug Administration for phosphodiesterase type-5 inhibitors.

Journal: The journal of sexual medicine 20120101

Title: Should central serous chorioretinopathy be added to the list of ocular side effects of phosphodiesterase 5 inhibitors?

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20120101

Title: A pilot study to evaluate the effects of vardenafil on sexual distress in men with obesity.

Journal: International journal of impotence research 20120101

Title: Vardenafil orodispersible tablet.

Journal: Drugs 20120101

Title: How to evaluate the efficacy of the phosphodiesterase type 5 inhibitors.

Journal: The journal of sexual medicine 20120101

Title: Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells.

Journal: Frontiers in pharmacology 20120101

Title: Penile methadone injection in suicidal intent: life-threatening and fatal for erectile function.

Journal: Journal of andrology 20120101

Title: Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa.

Journal: Journal of translational medicine 20120101

Title: Bilateral simultaneous nonarteritic anterior ischemic optic neuropathy after ingestion of sildenafil for erectile dysfunction.

Journal: Case reports in medicine 20120101

Title: Restenosis and therapy.

Journal: International journal of vascular medicine 20120101

Title: Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes.

Journal: International journal of vascular medicine 20120101

Title: Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats.

Journal: PloS one 20120101

Title: Public health concerns for anti-obesity medicines imported for personal use through the internet: a cross-sectional study.

Journal: BMJ open 20120101

Title: cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents.

Journal: PloS one 20120101

Title: Acute effects of vardenafil on pulmonary artery responsiveness in pulmonary hypertension.

Journal: TheScientificWorldJournal 20120101

Title: Erectile dysfunction and hypertension: impact on cardiovascular risk and treatment.

Journal: International journal of hypertension 20120101

Title: [Erectile dysfunction: conservative treatment and new approaches].

Journal: Revue medicale de Bruxelles 20120101

Title: PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis.

Journal: Frontiers in pharmacology 20120101

Title: Identification of novel sildenafil-analogues in an adulterated herbal food supplement.

Journal: Journal of pharmaceutical and biomedical analysis 20111205

Title: PDE5 inhibitors: targeting erectile dysfunction in diabetics.

Journal: Current opinion in pharmacology 20111201

Title: The disposition of three phosphodiesterase type 5 inhibitors, vardenafil, sildenafil, and udenafil, is differently influenced by the CYP3A5 genotype.

Journal: Pharmacogenetics and genomics 20111201

Title: Phosphodiesterase type 5 (PDE5) inhibitors in erectile dysfunction: the proper drug for the proper patient.

Journal: The journal of sexual medicine 20111201

Title: Phosphodiesterase type 5 inhibitors as adjunctive therapy in the management of systolic heart failure.

Journal: The Annals of pharmacotherapy 20111201

Title: [Efficacy and safety of vardenafil in the treatment of erectile dysfunction: a report of 700 cases].

Journal: Zhonghua nan ke xue = National journal of andrology 20111201

Title: Analysis of prescriptions of alpha-blockers and phosphodiesterase 5 inhibitors from the urology department and other departments.

Journal: International neurourology journal 20111201

Title: cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

Journal: Current neuropharmacology 20111201

Title: Long-term health outcomes in a British cohort of breast, colorectal and prostate cancer survivors: a database study.

Journal: British journal of cancer 20111108

Title: High-performance liquid chromatographic method with amperometric detection employing boron-doped diamond electrode for the determination of sildenafil, vardenafil and their main metabolites in plasma.

Journal: Journal of chromatography. A 20111104

Title: Determination of tadalafil and N-desmethylsibutramine in health and dietary supplements using ultra-performance liquid chromatography (UPLC) coupled with quadrupole-time-of-flight mass spectrometry (Q-TOF MS).

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20111101

Title: Combination of BAY 60-4552 and vardenafil exerts proerectile facilitator effects in rats with cavernous nerve injury: a proof of concept study for the treatment of phosphodiesterase type 5 inhibitor failure.

Journal: European urology 20111101

Title: Are we finally on the right track in treating 'difficult' erectile dysfunction patients?

Journal: European urology 20111101

Title: Focus on phosphodiesterase inhibitors for the treatment of erectile dysfunction in older men.

Journal: Clinical therapeutics 20111101

Title: Effects of type 5-phosphodiesterase inhibition on energy metabolism and mitochondrial biogenesis in human adipose tissue ex vivo.

Journal: Journal of endocrinological investigation 20111101

Title: Conformational conversion of PDE5 by incubation with sildenafil or metal ion is accompanied by stimulation of allosteric cGMP binding.

Journal: Cellular signalling 20111001

Title: Improvement in sexual quality of life of the female partner following vardenafil treatment of men with erectile dysfunction: a randomized, double-blind, placebo-controlled study.

Journal: The journal of sexual medicine 20111001

Title: Are phosphodiesterase type 5 inhibitors associated with vision-threatening adverse events? A critical analysis and review of the literature.

Journal: The journal of sexual medicine 20111001

Title: Efficacy and safety of vardenafil for the treatment of erectile dysfunction in men with metabolic syndrome: results of a randomized, placebo-controlled trial.

Journal: The journal of sexual medicine 20111001

Title: Time to onset of action of vardenafil: a retrospective analysis of the pivotal trials for the orodispersible and film-coated tablet formulations.

Journal: The journal of sexual medicine 20111001

Title: Novel phosphodiesterase type 5 modulators: a patent survey (2008 - 2010).

Journal: Expert opinion on therapeutic patents 20111001

Title: Late-onset hypogonadism syndrome and lower urinary tract symptoms.

Journal: Korean journal of urology 20111001

Title: Phosphodiesterase type 5 inhibitors in the management of non-neurogenic male lower urinary tract symptoms: critical analysis of current evidence.

Journal: European urology 20110901

Title: The use of beat-to-beat electrocardiogram analysis to distinguish QT/QTc interval changes caused by moxifloxacin from those caused by vardenafil.

Journal: Clinical pharmacology and therapeutics 20110901

Title: Brachial flow-mediated dilation correlates with vardenafil response in hypertensive men with vasculogenic erectile dysfunction.

Journal: Urology 20110801

Title: Phosphodiesterase (PDE) inhibitors in the treatment of lower urinary tract dysfunction.

Journal: British journal of clinical pharmacology 20110801

Title: Tadalafil: a long-acting phosphodiesterase-5 inhibitor for the treatment of pulmonary arterial hypertension.

Journal: Clinical therapeutics 20110801

Title: The controversial role of phosphodiesterase type 5 inhibitors in the treatment of premature ejaculation.

Journal: The journal of sexual medicine 20110801

Title: Editorial comment.

Journal: Urology 20110801

Title: [Effects and mechanisms of phosphodiesterase type 5 inhibitors on rats with overactive bladder].

Journal: Zhonghua yi xue za zhi 20110726

Title: Synthesis of core-shell magnetic molecularly imprinted polymers and detection of sildenafil and vardenafil in herbal dietary supplements.

Journal: Journal of hazardous materials 20110715

Title: Prevalence and medical management of erectile dysfunction in Asia.

Journal: Asian journal of andrology 20110701

Title: Vardenafil in pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled study.

Journal: American journal of respiratory and critical care medicine 20110615

Title: Recreational use of erectile dysfunction medications in undergraduate men in the United States: characteristics and associated risk factors.

Journal: Archives of sexual behavior 20110601

Title: Vardenafil, an inhibitor of phosphodiesterase-5, blocks advanced glycation end product (AGE)-induced up-regulation of monocyte chemoattractant protein-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression via elevation of cGMP.

Journal: Clinical and experimental medicine 20110601

Title: Results of vardenafil mediated power Doppler ultrasound, contrast enhanced ultrasound and systematic random biopsies to detect prostate cancer.

Journal: The Journal of urology 20110601

Title: A state of art review on vardenafil in men with erectile dysfunction and associated underlying diseases.

Journal: Expert opinion on pharmacotherapy 20110601

Title: Phosphodiesterase type 5 inhibitor abuse: a critical review.

Journal: Current drug abuse reviews 20110601

Title: [ED patients and their female partners prefer tadalafil].

Journal: Zhonghua nan ke xue = National journal of andrology 20110601

Title: Retinitis pigmentosa: genes and disease mechanisms.

Journal: Current genomics 20110601

Title: New perspectives for the treatment of pulmonary hypertension.

Journal: British journal of pharmacology 20110501

Title: Combination of testosterone and vardenafil increases female sexual functioning in sub-primed rats.

Journal: The journal of sexual medicine 20110401

Title: Vardenafil and resveratrol synergistically enhance the nitric oxide/cyclic guanosine monophosphate pathway in corpus cavernosal smooth muscle cells and its therapeutic potential for erectile dysfunction in the streptozotocin-induced diabetic rat: preliminary findings.

Journal: The journal of sexual medicine 20110401

Title: A novel approach to simultaneous screening and confirmation of regulated pharmaceutical compounds in dietary supplements by LC/MS/MS with an information-dependent acquisition method.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110401

Title: [Small-dose vardenafil restores erectile function after penile surgery].

Journal: Zhonghua nan ke xue = National journal of andrology 20110401

Title: The effects of three phosphodiesterase type 5 inhibitors on ejaculation latency time in lifelong premature ejaculators: a double-blind laboratory setting study.

Journal: BJU international 20110401

Title: Comparison of the first intake of vardenafil and tadalafil in patients with diabetic neuropathy and diabetic erectile dysfunction.

Journal: The journal of sexual medicine 20110301

Title: Chronic vardenafil treatment improves erectile function via structural maintenance of penile corpora cavernosa in rats with acute arteriogenic erectile dysfunction.

Journal: The journal of sexual medicine 20110301

Title: Vardenafil effect on ureteric smooth muscle: in vitro study in porcine model.

Journal: Journal of endourology 20110301

Title: The management of erectile dysfunction: innovations and future perspectives.

Journal: Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 20110301

Title: Separation and structural elucidation of a novel analogue of vardenafil included as an adulterant in a dietary supplement by liquid chromatography-electrospray ionization mass spectrometry, infrared spectroscopy and nuclear magnetic resonance spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20110220

Title: Vardenafil decreases bladder afferent nerve activity in unanesthetized, decerebrate, spinal cord-injured rats.

Journal: European urology 20110201

Title: [Cardiovascular complications of phosphodiesterase-5 inhibitors].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20110201

Title: The effects of phosphodiesterase type 5 inhibitors on penile rigidity variables during a period with no sexual stimulation: a laboratory setting double-blind study.

Journal: BJU international 20110101

Title: Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice.

Journal: The European respiratory journal 20110101

Title: Efficacy and safety of an orodispersible vardenafil formulation for the treatment of erectile dysfunction in elderly men and those with underlying conditions: an integrated analysis of two pivotal trials.

Journal: The journal of sexual medicine 20110101

Title: Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds.

Journal: Handbook of experimental pharmacology 20110101

Title: Pharmacokinetics of a new orodispersible tablet formulation of vardenafil: results of three clinical trials.

Journal: Clinical drug investigation 20110101

Title: Effects of vardenafil on testicular torsion/detorsion damage: an experimental study in pigs.

Journal: Urologia internationalis 20110101

Title: Stopwatch-assessed duration of erection: a new measure of the efficacy of erectile dysfunction treatments.

Journal: International journal of impotence research 20110101

Title: A fully validated method for the determination of vardenafil in blood using gas chromatography/mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20110101

Title: Patients' preference in the treatment of erectile dysfunction: a critical review of the literature.

Journal: International journal of impotence research 20110101

Title: The journey of a thousand miles.

Journal: The European respiratory journal 20110101

Title: Effects of sildenafil and vardenafil treatments on sleep quality and depression in hemodialysis patients with erectile dysfunction.

Journal: International journal of impotence research 20110101

Title: Incremental cost-effectiveness of various monthly doses of vardenafil.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20110101

Title: Cyclic nucleotide metabolism including nitric oxide and phosphodiesterase-related targets in the lower urinary tract.

Journal: Handbook of experimental pharmacology 20110101

Title: Phosphodiesterase 5 inhibitors attenuate renal tubular apoptosis after partial unilateral ureteral obstruction: an experimental study.

Journal: The Kaohsiung journal of medical sciences 20110101

Title: A high-performance liquid chromatography:chemiluminescence method for potential determination of vardenafil in dietary supplement.

Journal: Journal of automated methods & management in chemistry 20110101

Title: Comparative effects of verapamil, nicardipine, and nitroglycerin on myocardial ischemia/reperfusion injury.

Journal: Anesthesiology research and practice 20110101

Title: Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion.

Journal: Clinics (Sao Paulo, Brazil) 20110101

Title: Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic acid, and role of the invariant glutamine.

Journal: PloS one 20110101

Title: Priapism in sickle cell anemia: emerging mechanistic understanding and better preventative strategies.

Journal: Anemia 20110101

Title: The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.

Journal: PloS one 20110101

Title: Orally disintegrating vardenafil tablets for the treatment of erectile dysfunction: efficacy, safety, and patient acceptability.

Journal: Patient preference and adherence 20110101

Title: Tadalafil alters energy metabolism in C2C12 skeletal muscle cells.

Journal: Acta biochimica Polonica 20110101

Title: Erectile dysfunction.

Journal: BMJ clinical evidence 20110101

Title: The effect of simvastatin in penile erection: a randomized, double-blind, placebo-controlled clinical trial (Simvastatin treatment for erectile dysfunction-STED TRIAL).

Journal: International journal of impotence research 20110101

Title: Evaluation of liver transplant candidates: A pulmonary perspective.

Journal: Annals of thoracic medicine 20110101

Title: Bladder, bowel, and sexual dysfunction in Parkinson's disease.

Journal: Parkinson's disease 20110101

Title: [Is there a place for treatment with type 5 phosphodiesterase inhibitors in heart failure patients?].

Journal: Kardiologia polska 20110101

Title: Quality of online pharmacies and websites selling prescription drugs: a systematic review.

Journal: Journal of medical Internet research 20110101

Title: Market Access Agreements for pharmaceuticals in Europe: diversity of approaches and underlying concepts.

Journal: BMC health services research 20110101

Title: Valorising and creating access to innovative medicines in the European union.

Journal: Frontiers in pharmacology 20110101

Title: Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes: randomised crossover trial.

Journal: BMJ open 20110101

Title: Overview of current therapeutic approaches for pulmonary hypertension.

Journal: Pulmonary circulation 20110101

Title: Future prospects in the treatment of erectile dysfunction: focus on avanafil.

Journal: Drug design, development and therapy 20110101

Title: PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers: Current Status of Clinical Trials.

Journal: International journal of rheumatology 20110101

Title: Emerging new uses of phosphodiesterase-5 inhibitors in cardiovascular diseases.

Journal: Experimental and clinical cardiology 20110101

Title: Tadalafil.

Journal: Profiles of drug substances, excipients, and related methodology 20110101

Title: Systemic sclerosis 2011.

Journal: International journal of rheumatology 20110101

Title: In vitro measurement of ejaculation latency time (ELT) and the effects of vardenafil on ELT on lifelong premature ejaculators: placebo-controlled, double-blind, cross-over laboratory setting.

Journal: International urology and nephrology 20101201

Title: Key features for designing phosphodiesterase-5 inhibitors.

Journal: Journal of biomolecular structure & dynamics 20101201

Title: Probable interaction between warfarin and bee pollen.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101201

Title: Vardenafil Enhances Oxytocin Expression in the Paraventricular Nucleus without Sexual Stimulation.

Journal: International neurourology journal 20101201

Title: Spider-venom peptides as therapeutics.

Journal: Toxins 20101201

Title: Effects of sildenafil and vardenafil on erectile dysfunction and health-related quality of life in haemodialysis patients: a prospective randomized crossover study.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101101

Title: Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction.

Journal: Expert opinion on investigational drugs 20101101

Title: An update on new oral PDE5 inhibitors for the treatment of erectile dysfunction.

Journal: Nature reviews. Urology 20101101

Title: Haemodynamic and renal effects of tadalafil in patients with cirrhosis.

Journal: World journal of gastroenterology 20101021

Title: Counterfeit drugs detection by measurement of tablets and secondary packaging colour.

Journal: Journal of pharmaceutical and biomedical analysis 20101010

Title: Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial.

Journal: BJU international 20101001

Title: Anabolic, doping, and lifestyle drugs, and selected metabolites in wastewater--detection, quantification, and behaviour monitored by high-resolution MS and MS(n) before and after sewage treatment.

Journal: Analytical and bioanalytical chemistry 20101001

Title: Oral therapy for erectile dysfunction.

Journal: Archivos espanoles de urologia 20101001

Title: The future of erectile dysfunction (ED).

Journal: Archivos espanoles de urologia 20101001

Title: Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury.

Journal: American journal of physiology. Heart and circulatory physiology 20100901

Title: The Real-Life Safety and Efficacy of vardenafil (REALISE) study: results in men from Europe and overseas with erectile dysfunction and cardiovascular or metabolic conditions.

Journal: The journal of sexual medicine 20100901

Title: cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.

Journal: Pharmacological reviews 20100901

Title: [Phosphodiesterase type 5 inhibitors in the treatment of pulmonary arterial hypertension].

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20100901

Title: Efficacy and Safety of Tadalafil 5 mg Administered Once Daily in Korean Men with Erectile Dysfunction: A Prospective, Multicenter Study.

Journal: Korean journal of urology 20100901

Title: The effect of mirodenafil on the penile erection and corpus cavernosum in the rat model of cavernosal nerve injury.

Journal: International journal of impotence research 20100901

Title: [Clinical efficacy of vardenafil on ED patients with kidney-yang or -yin deficiency or liver-qi stasis].

Journal: Zhonghua nan ke xue = National journal of andrology 20100901

Title: Validated LC-MS/MS assay for the quantitative determination of vardenafil in human plasma and its application to a pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20100801

Title: Effect of vardenafil on cerebral vasospasm following experimental subarachnoid hemorrhage in rats.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100801

Title: Screening of Indian aphrodisiac ayurvedic/herbal healthcare products for adulteration with sildenafil, tadalafil and/or vardenafil using LC/PDA and extracted ion LC-MS/TOF.

Journal: Journal of pharmaceutical and biomedical analysis 20100708

Title: Drug interactions with phosphodiesterase-5 inhibitors used for the treatment of erectile dysfunction or pulmonary hypertension.

Journal: Circulation 20100706

Title: Effectiveness of initiating treatment with valsartan/hydrochlorothiazide in patients with stage-1 or stage-2 hypertension.

Journal: Journal of human hypertension 20100701

Title: A phosphodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1/vascular endothelial growth factor pathway.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20100701

Title: Simultaneous determination of yohimbine, sildenafil, vardenafil and tadalafil in dietary supplements using high-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of separation science 20100701

Title: Hemodynamic effects of single-dose vardenafil in subjects receiving maraviroc.

Journal: Journal of acquired immune deficiency syndromes (1999) 20100701

Title: Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial.

Journal: Lancet (London, England) 20100619

Title: A gas chromatography/mass spectrometry method for the determination of sildenafil, vardenafil and tadalafil and their metabolites in human urine.

Journal: Rapid communications in mass spectrometry : RCM 20100615

Title: Sildenafil promotes adipogenesis through a PKG pathway.

Journal: Biochemical and biophysical research communications 20100611

Title: Influence of serum testosterone on urinary continence and sexual activity in patients undergoing radical prostatectomy for clinically localized prostate cancer.

Journal: Prostate cancer and prostatic diseases 20100601

Title: The efficacy and safety of testosterone undecanoate (Nebido(®)) in testosterone deficiency syndrome in Korean: a multicenter prospective study.

Journal: The journal of sexual medicine 20100601

Title: Co-possession of phosphodiesterase type-5 inhibitors (PDE5-I) with nitrates.

Journal: Current medical research and opinion 20100601

Title: Expression of cyclic AMP-dependent protein kinase isoforms in human cavernous arteries: functional significance and relation to phosphodiesterase type 4.

Journal: The journal of sexual medicine 20100601

Title: Acute dysphonia secondary to vocal fold hemorrhage after vardenafil use.

Journal: Ear, nose, & throat journal 20100601

Title: Irrespective of stomach conditions.

Journal: International journal of clinical practice 20100601

Title: [Benefits of tadalafil in sexual activity-related time concerns].

Journal: Zhonghua nan ke xue = National journal of andrology 20100601

Title: Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.

Journal: Neurobiology of disease 20100501

Title: Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation.

Journal: European urology 20100501

Title: Efficacy of phosphodiesterase type 5 inhibitor treatment in men with erectile dysfunction and dyslipidemia: a post hoc analysis of the vardenafil statin study.

Journal: The journal of sexual medicine 20100501

Title: Phosphodiesterase type 5 inhibitor use and hearing impairment.

Journal: Archives of otolaryngology--head & neck surgery 20100501

Title: Update in women's health.

Journal: Journal of general internal medicine 20100401

Title: Virtual screening and drug design for PDE-5 receptor from traditional Chinese medicine database.

Journal: Journal of biomolecular structure & dynamics 20100401

Title: The POTENT I randomized trial: efficacy and safety of an orodispersible vardenafil formulation for the treatment of erectile dysfunction.

Journal: The journal of sexual medicine 20100401

Title: Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea.

Journal: Clinics (Sao Paulo, Brazil) 20100401

Title: The POTENT II randomised trial: efficacy and safety of an orodispersible vardenafil formulation for the treatment of erectile dysfunction.

Journal: International journal of clinical practice 20100401

Title: [Effectiveness and treatment satisfaction in patients with erectile dysfunction in Spain: EDOS study].

Journal: Actas urologicas espanolas 20100401

Title: Failure of PDE5 inhibitor use: a case of nonresponder? (CME).

Journal: The journal of sexual medicine 20100401

Title: [Expert testimony re phosphodiesterase 5 inhibitors].

Journal: Zentralblatt fur Chirurgie 20100401

Title: Systemic and metabolic effects of PDE5-inhibitor drugs.

Journal: World journal of diabetes 20100315

Title: Erectile dysfunction.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20100309

Title: Effects of phosphodiesterase inhibitors on the inflammatory response of endothelial cells stimulated by myeloperoxidase-modified low-density lipoprotein or tumor necrosis factor alpha.

Journal: European urology 20100301

Title: Chronic treatment with a PDE5 inhibitor increases contractile force of normal bladder in rats.

Journal: International urology and nephrology 20100301

Title: Chuanxiongzine relaxes isolated corpus cavernosum strips and raises intracavernous pressure in rabbits.

Journal: International journal of impotence research 20100301

Title: Phosphodiesterase type V inhibitors: Occurrence and fate in wastewater and sewage sludge.

Journal: Water research 20100301

Title: Counterfeit phosphodiesterase type 5 inhibitors pose significant safety risks.

Journal: International journal of clinical practice 20100301

Title: Validation of stopwatch measurements of erection duration against responses to the sexual encounter profile and international index of erectile Function in patients treated with a phosphodiesterase type 5 inhibitor.

Journal: The journal of sexual medicine 20100301

Title: [Therapy for male patients with sexual dysfunction].

Journal: Therapeutische Umschau. Revue therapeutique 20100301

Title: Identification of counterfeit medicines for erectile dysfunction from an illegal supply chain.

Journal: Arhiv za higijenu rada i toksikologiju 20100301

Title: Assessment of erectile and ejaculatory function after penile prosthesis implantation.

Journal: Korean journal of urology 20100301

Title: [Therapy of erectile dysfunction].

Journal: Orvosi hetilap 20100227

Title: Phosphodiesterase type 5 inhibitors and female sexual response: faulty protocols or paradigms?

Journal: The journal of sexual medicine 20100201

Title: Central serous chorioretinopathy and phosphodiesterase-5 inhibitors: a case-control postmarketing surveillance study.

Journal: Retina (Philadelphia, Pa.) 20100201

Title: Management of erectile dysfunction.

Journal: American family physician 20100201

Title: Development of an immunoassay for rapid screening of vardenafil and its potential analogues in herbal products based on a group specific monoclonal antibody.

Journal: Analytica chimica acta 20100125

Title: Vardenafil can improve continence recovery after bilateral nerve sparing prostatectomy: results of a randomized, double blind, placebo-controlled pilot study.

Journal: The journal of sexual medicine 20100101

Title: Characterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract.

Journal: The journal of sexual medicine 20100101

Title: Phosphodiesterase-5 inhibitors and benign prostatic hyperplasia.

Journal: Current opinion in urology 20100101

Title: Acute vardenafil administration improves bladder oxygenation in spontaneously hypertensive rats.

Journal: The journal of sexual medicine 20100101

Title: Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database.

Journal: International journal of clinical practice 20100101

Title: ACceptance of therapy in vardenafil-treated patients with Erectile dysfunction (ACTIVE): A noninterventional study in Germany.

Journal: International journal of impotence research 20100101

Title: Sudden sensorineural hearing loss associated with vardenafil.

Journal: Pharmacotherapy 20100101

Title: Pharmacotherapy for erectile dysfunction.

Journal: The journal of sexual medicine 20100101

Title: Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications.

Journal: The journal of sexual medicine 20100101

Title: Hemodynamics in pulmonary arterial hypertension (PAH): do they explain long-term clinical outcomes with PAH-specific therapy?

Journal: BMC cardiovascular disorders 20100101

Title: Recent advances in the treatment of premature ejaculation.

Journal: Drug design, development and therapy 20100101

Title: Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models.

Journal: PloS one 20100101

Title: Advances in the treatment of Raynaud's phenomenon.

Journal: Vascular health and risk management 20100101

Title: On call. I've read your comprehensive discussion of erectile dysfunction, but one aspect is not mentioned: at age 74 (with a new wife, age 70), I can have erections, both with and without Levitra, but I have increasing difficulty achieving difficulty achieving ejaculation. I assume this is related to ED and age, but wonder whether there is a solution. I don't drink or have diabetes. I do have high blood pressure, but it's controlled with Hyzaar and Plendil.

Journal: Harvard men's health watch 20100101

Title: The emergence of oral tadalafil as a once-daily treatment for pulmonary arterial hypertension.

Journal: Vascular health and risk management 20100101

Title: Nitric oxide and pulmonary hypertension.

Journal: Korean journal of anesthesiology 20100101

Title: Erectile dysfunction in aging male.

Journal: Acta bio-medica : Atenei Parmensis 20100101

Title: Update on the clinical utility of sildenafil in the treatment of pulmonary arterial hypertension.

Journal: Drug design, development and therapy 20100101

Title: [Are there counterfeit medicines in Croatia?].

Journal: Lijecnicki vjesnik 20100101

Title: Potentially fatal new trend in performance enhancement: a cautionary note on nitrite.

Journal: Journal of the International Society of Sports Nutrition 20100101

Title: Addressing and managing erectile dysfunction after prostatectomy for prostate cancer.

Journal: Urologic nursing 20100101

Title: A once-daily dose of tadalafil for erectile dysfunction: compliance and efficacy.

Journal: Drug design, development and therapy 20100101

Title: Modulation of TGF-β/BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model.

Journal: Cardiovascular diabetology 20100101

Title: Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review.

Journal: Critical care (London, England) 20100101

Title: Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization.

Journal: Vascular health and risk management 20100101

Title: Recent advances in management of bladder overactivity.

Journal: F1000 medicine reports 20100101

Title: [Choice of treatment of erectile dysfunction associated with hypogonadism].

Journal: Urologiia (Moscow, Russia : 1999) 20100101

Title: Vascular alterations and sexual function in systemic sclerosis.

Journal: International journal of rheumatology 20100101

Title: Penile involvement in Systemic Sclerosis: New Diagnostic and Therapeutic Aspects.

Journal: International journal of rheumatology 20100101

Title: Protein biomarkers in cystic fibrosis research: where next?

Journal: Genome medicine 20100101

Title: [Counterfeit phosphodiesterase type 5 inhibitors--growing safety risks for public health].

Journal: Roczniki Panstwowego Zakladu Higieny 20100101

Title: [Vardenafil (levitra): new aspects of clinical efficacy].

Journal: Urologiia (Moscow, Russia : 1999) 20100101

Title: Phosphodiesterase-5 inhibitors in management of pulmonary hypertension: safety, tolerability, and efficacy.

Journal: Drug, healthcare and patient safety 20100101

Title: Long-term treatment of patients with HIV-1: the role of atazanavir.

Journal: HIV/AIDS (Auckland, N.Z.) 20100101

Title: Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model.

Journal: European journal of pharmacology 20091210

Title: Follicle development and luteal cell morphology altered by phosphodiesterase-5 inhibitor.

Journal: Micron (Oxford, England : 1993) 20091201

Title: The usefulness of 2D DOSY and 3D DOSY-COSY 1H NMR for mixture analysis: application to genuine and fake formulations of sildenafil (Viagra).

Journal: Magnetic resonance in chemistry : MRC 20091201

Title: Vardenafil-induced relaxation and cyclic nucleotide levels in normal and obstructed rat urinary bladder.

Journal: BJU international 20091201

Title: Platelet cyclic guanosine monophosphate as a biomarker of phosphodiesterase type 5 inhibitor efficacy in the treatment of erectile dysfunction: a randomized placebo-controlled study.

Journal: European urology 20091201

Title: Sexual risk behaviors among men who have sex with men using erectile dysfunction medications.

Journal: AIDS patient care and STDs 20091201

Title: Vardenafil increases cell proliferation in the dentate gyrus through enhancement of serotonin expression in the rat dorsal raphe.

Journal: Journal of Korean medical science 20091201

Title: Identification of sildenafil, tadalafil and vardenafil by gas chromatography-mass spectrometry on short capillary column.

Journal: Journal of chromatography. A 20091120

Title: Diagnosis and treatment of erectile dysfunction--a practical update.

Journal: Journal of medicine and life 20091115

Title: Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitors.

Journal: The Journal of biological chemistry 20091113

Title: Hormonal testing and pharmacologic treatment of erectile dysfunction: a clinical practice guideline from the American College of Physicians.

Journal: Annals of internal medicine 20091103

Title: Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis.

Journal: Annals of internal medicine 20091103

Title: 2D and 3D DOSY 1H NMR, a useful tool for analysis of complex mixtures: application to herbal drugs or dietary supplements for erectile dysfunction.

Journal: Journal of pharmaceutical and biomedical analysis 20091101

Title: Microvascular complications in diabetic erectile dysfunction: do we need other alternatives?

Journal: Diabetes care 20091101

Title: Non-traumatic urologic emergencies in men: a clinical review.

Journal: The western journal of emergency medicine 20091101

Title: [Vardenafil for refractory erectile dysfunction: the latest advances].

Journal: Zhonghua nan ke xue = National journal of andrology 20091101

Title: Mitigation of indomethacin-induced gastric mucosal lesions by a potent specific type V phosphodiesterase inhibitor.

Journal: World journal of gastroenterology 20091028

Title: High performance liquid chromatography-diode array and electrospray-mass spectrometry analysis of vardenafil, sildenafil, tadalafil, testosterone and local anesthetics in cosmetic creams sold on the Internet web sites.

Journal: Journal of pharmaceutical and biomedical analysis 20091015

Title: Vardenafil protects against myocardial and endothelial injuries after cardiopulmonary bypass.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20091001

Title: Phosphodiesterase type 5 inhibitors facilitate noncontact erections in male rats: site of action in the brain and mechanism of action.

Journal: The journal of sexual medicine 20091001

Title: Vardenafil allows successful intercourse initiated rapidly after dosing in Japanese patients with diabetes mellitus and erectile dysfunction.

Journal: The journal of sexual medicine 20091001

Title: Pharmacotherapy of the overactive bladder.

Journal: Discovery medicine 20091001

Title: Hair analysis to demonstrate administration of sildenafil to a woman in a case of drug-facilitated sexual assault.

Journal: Journal of analytical toxicology 20091001

Title: Effect of vardenafil on endothelial progenitor cells in hypogonadotrophic hypogonadal patients: role of testosterone treatment.

Journal: Clinical endocrinology 20090901

Title: Vardenafil treatment for patients with pulmonary arterial hypertension: a multicentre, open-label study.

Journal: Heart (British Cardiac Society) 20090901

Title: The ENDOTRIAL study: a spontaneous, open-label, randomized, multicenter, crossover study on the efficacy of sildenafil, tadalafil, and vardenafil in the treatment of erectile dysfunction.

Journal: The journal of sexual medicine 20090901

Title: Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes.

Journal: Current medical research and opinion 20090901

Title: Patterns of treatment with PDE5 inhibitors in the clinical practice in Italy: longitudinal data from the Erectile Dysfunction Observational Study.

Journal: Asian journal of andrology 20090901

Title: 2009 update on phosphodiesterase type 5 inhibitor therapy part 2: updates on optimal utilization for sexual concerns and rare toxicities in this class.

Journal: The journal of sexual medicine 20090901

Title: Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension.

Journal: Advances in therapy 20090901

Title: Is there a rationale for the chronic use of phosphodiesterase-5 inhibitors for lower urinary tract symptoms secondary to benign prostatic hyperplasia?

Journal: BJU international 20090801

Title: Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta.

Journal: European journal of pharmacology 20090801

Title: The burden and extent of comorbid conditions in patients with erectile dysfunction.

Journal: International journal of clinical practice 20090801

Title: Toward a new 'EPOCH': optimising treatment outcomes with phosphodiesterase type 5 inhibitors for erectile dysfunction.

Journal: International journal of clinical practice 20090801

Title: Five-year experience with tadalafil in the UK: an effective treatment for erectile dysfunction.

Journal: International journal of clinical practice 20090801

Title: Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats.

Journal: Amino acids 20090701

Title: Effect of phosphodiesterase-5 inhibitor on hearing.

Journal: The Journal of laryngology and otology 20090701

Title: Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090701

Title: Development of a method for the determination of vardenafil in human plasma by high performance liquid chromatography with UV detection.

Journal: Biomedical chromatography : BMC 20090701

Title: [Significance of phosphodiesterase isoenzymes in the control of human detrusor smooth muscle function. An immunohistochemical and functional study].

Journal: Der Urologe. Ausg. A 20090701

Title: Comparative relaxing effects of sildenafil, vardenafil, and tadalafil in human corpus cavernosum: contribution of endogenous nitric oxide release.

Journal: Urology 20090701

Title: 2009 update on phosphodiesterase type 5 inhibitor therapy part 1: Recent studies on routine dosing for penile rehabilitation, lower urinary tract symptoms, and other indications (CME).

Journal: The journal of sexual medicine 20090701

Title: Vardenafil reduces testicular damage following ischemia/reperfusion injury in rats.

Journal: The Kaohsiung journal of medical sciences 20090701

Title: Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue.

Journal: Urology 20090601

Title: Safety and efficacy of vardenafil versus sertraline in the treatment of premature ejaculation: a randomised, prospective and crossover study.

Journal: Andrologia 20090601

Title: Sexual functions of men with obstructive sleep apnoea syndrome and hypogonadism may improve upon testosterone administration: a pilot study.

Journal: Andrologia 20090601

Title: Selective phosphodiesterase-5 inhibition reduces neointimal hyperplasia in rat carotid arteries after surgical endarterectomy.

Journal: The Journal of thoracic and cardiovascular surgery 20090601

Title: Vardenafil modulates bladder contractility through cGMP-mediated inhibition of RhoA/Rho kinase signaling pathway in spontaneously hypertensive rats.

Journal: The journal of sexual medicine 20090601

Title: By the way, doctor. Finasteride has been prescribed for my BPH. I think that the most frequent side effect is erectile dysfunction or loss of sexual desire. Would Levita or a similar drug (like Viagra or Cialis) overcome the side effects of finasteride?

Journal: Harvard health letter 20090601

Title: Prospective pharmacologic therapies for the overactive bladder.

Journal: Therapeutic advances in urology 20090601

Title: Combined use of phosphodiesterase-5 inhibitors and selective serotonin reuptake inhibitors for temporary ejaculation failure in couple undergoing assisted reproductive technologies.

Journal: Fertility and sterility 20090501

Title: Re: Francesco Montorsi, Gerald Brock, Jay Lee, et al. Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy. Eur Urol 2008;54:924-31.

Journal: European urology 20090501

Title: Tadalafil and vardenafil vs sildenafil: a review of patient-preference studies.

Journal: BJU international 20090501

Title: Differences in side-effect duration and related bother levels between phosphodiesterase type 5 inhibitors.

Journal: BJU international 20090501

Title: Ten years of phosphodiesterase type 5 inhibitors in spinal cord injured patients.

Journal: The journal of sexual medicine 20090501

Title: Effects of vardenafil, a phosphodiesterase type-5 inhibitor, on sphincter of Oddi motility in patients with suspected biliary sphincter of Oddi dysfunction.

Journal: Gastrointestinal endoscopy 20090501

Title: Erectile dysfunction and heart failure: the role of phosphodiesterase type 5 inhibitors.

Journal: International journal of impotence research 20090501

Title: Levitra for sphincter of Oddi dysfunction? Are you kidding?

Journal: Gastrointestinal endoscopy 20090501

Title: Vardenafil: efficacy, tolerability and future directions.

Journal: Expert opinion on drug metabolism & toxicology 20090501

Title: Effects of the PDE5-inhibitor vardenafil in a mouse stroke model.

Journal: Brain research 20090410

Title: Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20090405

Title: Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: functional and biochemical aspects.

Journal: Clinical and experimental pharmacology & physiology 20090401

Title: Effects of chronic treatment with vardenafil, a phosphodiesterase 5 inhibitor, on female rat bladder in a partial bladder outlet obstruction model.

Journal: BJU international 20090401

Title: Management of erectile dysfunction in general practice.

Journal: The journal of sexual medicine 20090401

Title: Cardiovascular effects of phosphodiesterase type 5 inhibitors.

Journal: The journal of sexual medicine 20090301

Title: The influence of testosterone combined with a PDE5-inhibitor on cognitive, affective, and physiological sexual functioning in women suffering from sexual dysfunction.

Journal: The journal of sexual medicine 20090301

Title: The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus.

Journal: British journal of pharmacology 20090301

Title: Beneficial and adverse effects of bosentan treatment in korean patients with pulmonary artery hypertension.

Journal: Korean circulation journal 20090301

Title: Effects of phosphodiesterase inhibitors on the contractile responses of isolated human seminal vesicle tissue to adrenergic stimulation.

Journal: The journal of sexual medicine 20090201

Title: Childhood sexual abuse, selective attention for sexual cues and the effects of testosterone with or without vardenafil on physiological sexual arousal in women with sexual dysfunction: a pilot study.

Journal: The journal of sexual medicine 20090201

Title: Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat.

Journal: Journal of neurochemistry 20090201

Title: [Phosphodiesterase 5 inhibition in erectile dysfunction. Long-term administration without therapeutic advantage].

Journal: MMW Fortschritte der Medizin 20090115

Title: Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

Journal: Psychopharmacology 20090101

Title: A placebo-controlled study of sildenafil effects on cognition in schizophrenia.

Journal: Psychopharmacology 20090101

Title: Liquid chromatography/tandem mass spectrometry method for the simultaneous determination of vardenafil and its major metabolite, N-desethylvardenafil, in human plasma: application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090101

Title: Phosphodiesterase 5 inhibitors in the management of benign prostatic hyperplasia and erectile dysfunction: the best of both worlds.

Journal: Current opinion in urology 20090101

Title: Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts.

Journal: Acta pharmacologica Sinica 20090101

Title: Does on-demand vardenafil improve erectile function recovery after radical prostatectomy?

Journal: Nature clinical practice. Urology 20090101

Title: Improvement in duration of erection following phosphodiesterase type 5 inhibitor therapy with vardenafil in men with erectile dysfunction: the ENDURANCE study.

Journal: International journal of clinical practice 20090101

Title: Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date.

Journal: Drug safety 20090101

Title: Modulators of arginine metabolism support cancer immunosurveillance.

Journal: BMC immunology 20090101

Title: In vitro and in vivo effects of vardenafil (a PDE-5 Inhibitor) on corpus cavernosal smooth muscle relaxation in diabetic rabbits.

Journal: Urologia internationalis 20090101

Title: [Comparative study for the treatment of erectile dysfunction with sildenafil and vardenafil--multi-centric research in Nagano City].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20090101

Title: Evaluation of vardenafil for the treatment of subjective tinnitus: a controlled pilot study.

Journal: Journal of negative results in biomedicine 20090101

Title: Penile rehabilitation therapy with PDE-V inhibitors following radical prostatectomy: proceed with caution.

Journal: Advances in urology 20090101

Title: Role of atazanavir in the treatment of HIV infection.

Journal: Therapeutics and clinical risk management 20090101

Title: Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation.

Journal: International journal of impotence research 20090101

Title: Twelve years' experience with direct-to-consumer advertising of prescription drugs in Canada: a cautionary tale.

Journal: PloS one 20090101

Title: Treatment of pediatric pulmonary hypertension.

Journal: Vascular health and risk management 20090101

Title: Emerging treatments for premature ejaculation: focus on dapoxetine.

Journal: Neuropsychiatric disease and treatment 20090101

Title: Efficacy and safety of bilateral continuous theta burst stimulation (cTBS) for the treatment of chronic tinnitus: design of a three-armed randomized controlled trial.

Journal: Trials 20090101

Title: Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir.

Journal: Therapeutics and clinical risk management 20090101

Title: Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver.

Journal: BMC gastroenterology 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: The effect of phosphodiesterase isoenzyme 5 inhibitors on ureteropelvic junction obstruction in rabbits.

Journal: Urologia internationalis 20090101

Title: PDE5 inhibitors: in vitro and in vivo pharmacological profile.

Journal: Current pharmaceutical design 20090101

Title: Phosphodiesterase type 5 inhibitors: unmet needs.

Journal: Current pharmaceutical design 20090101

Title: Phosphodiesterase type 5 inhibitors for the management of erectile dysfunction: preference and adherence to treatment.

Journal: Current pharmaceutical design 20090101

Title: Patient preference and satisfaction in erectile dysfunction therapy: a comparison of the three phosphodiesterase-5 inhibitors sildenafil, vardenafil and tadalafil.

Journal: Patient preference and adherence 20090101

Title: Tadalafil once daily in the management of erectile dysfunction: patient and partner perspectives.

Journal: Patient preference and adherence 20090101

Title: Quality of life three years after diagnosis of localised prostate cancer: population based cohort study.

Journal: BMJ (Clinical research ed.) 20090101

Title: [Influence of regular use of vardenafil on endothelial and erectile functions in patients with arteriogenic erectile dysfunction].

Journal: Terapevticheskii arkhiv 20090101

Title: Sildenafil or vardenafil nonresponders' erectile response to tadalafil.

Journal: Urology journal 20090101

Title: Vardenafil for the treatment of erectile dysfunction: an overview of the clinical evidence.

Journal: Clinical interventions in aging 20090101

Title: Rehabilitation challenges in multiple sclerosis.

Journal: Annals of Indian Academy of Neurology 20090101

Title: Evaluation of therapeutic response of patients with erectile dysfunction.

Journal: Medicinski arhiv 20090101

Title: Quantitative analysis of sildenafil and desmethylsildenafil in human serum by liquid chromatography-mass spectrometry with minimal sample pretreatment.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081215

Title: Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion.

Journal: European journal of pharmacology 20081214

Title: The nitric oxide pathway in the human prostate: clinical implications in men with lower urinary tract symptoms.

Journal: World journal of urology 20081201

Title: [The basics of phosphodiesterase type 5 (PDE5) inhibition in urology].

Journal: Der Urologe. Ausg. A 20081201

Title: The role of combination medical therapy in benign prostatic hyperplasia.

Journal: International journal of impotence research 20081201

Title: Salvage therapy trial for erectile dysfunction using phosphodiesterase type 5 inhibitors and vitamin E: preliminary report.

Journal: The aging male : the official journal of the International Society for the Study of the Aging Male 20081201

Title: ABCD of the phosphodiesterase family: interaction and differential activity in COPD.

Journal: International journal of chronic obstructive pulmonary disease 20081201

Title: Tadalafil in the treatment of erectile dysfunction.

Journal: Therapeutics and clinical risk management 20081201

Title: Effects of selective phosphodiesterase-5-inhibition on myocardial contractility and reperfusion injury after heart transplantation.

Journal: Transplantation 20081127

Title: PDE-5 inhibition impedes TSP-1 expression, TGF-beta activation and matrix accumulation in experimental glomerulonephritis.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081101

Title: Oral phosphodiesterase type 5 inhibitors: nonerectogenic beneficial uses.

Journal: The journal of sexual medicine 20081101

Title: [Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20081101

Title: Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.

Journal: The Journal of biological chemistry 20081031

Title: Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy.

Journal: European urology 20081001

Title: Should vardenafil be used for the treatment of lower urinary tract symptoms associated with BPH?

Journal: Nature clinical practice. Urology 20081001

Title: Use of phosphodiesterase-5 inhibitors by college students.

Journal: Revista de saude publica 20081001

Title: Global experiences with vardenafil in men with erectile dysfunction and underlying conditions.

Journal: International journal of clinical practice 20081001

Title: [Efficacy and safety of vardenafil for kidney transplant recipients with erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20081001

Title: PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model.

Journal: Brain research 20080916

Title: How many drugs for LUTS due to BPH are too many?

Journal: The Journal of urology 20080901

Title: Effect of vardenafil on blood pressure profile of patients with erectile dysfunction concomitantly treated with doxazosin gastrointestinal therapeutic system for benign prostatic hyperplasia.

Journal: The Journal of urology 20080901

Title: [Impact of the pharmacokinetic properties of PDE5 inhibitors on the dose/sexual intercourse interval].

Journal: Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 20080901

Title: From Lydia Pinkham to Queen Levitra: direct-to-consumer advertising and medicalisation.

Journal: Sociology of health & illness 20080901

Title: Medical therapy options for aging men with benign prostatic hyperplasia: focus on alfuzosin 10 mg once daily.

Journal: Clinical interventions in aging 20080901

Title: The use of phosphodiesterase 5 inhibitors with concomitant medications.

Journal: Journal of endocrinological investigation 20080901

Title: [Tadalafil for erectile dysfunction: outstanding efficacy for 36 hours].

Journal: Zhonghua nan ke xue = National journal of andrology 20080901

Title: [Pulmonary arterial hypertension in Health District 11: a patient-oriented drug utilization analysis].

Journal: Recenti progressi in medicina 20080901

Title: In silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil.

Journal: Bioorganic & medicinal chemistry 20080815

Title: Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-[3',4':1,2]pyridin[3,4-b]indol-2-substituted acetates: synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilators.

Journal: Journal of medicinal chemistry 20080814

Title: Lower urinary-tract symptoms and testosterone in elderly men.

Journal: World journal of urology 20080801

Title: [Vardenafil significantly alleviates erectile dysfunction in aged men with diabetes].

Journal: Zhonghua nan ke xue = National journal of andrology 20080801

Title: The role of PDE5 inhibitors in heme oxygenase-cGMP relationship in rat cavernous tissues.

Journal: The journal of sexual medicine 20080701

Title: Is vardenafil 'noninferior' or superior to sildenafil in the management of erectile dysfunction? Revisiting the biochemical, physiological, and clinical evidence.

Journal: The journal of sexual medicine 20080701

Title: Nitric oxide synthesis leads to vascular endothelial growth factor synthesis via the NO/cyclic guanosine 3',5'-monophosphate (cGMP) pathway in human corpus cavernosal smooth muscle cells.

Journal: The journal of sexual medicine 20080701

Title: Endothelial rehabilitation: the impact of chronic PDE5 inhibitors on erectile function and protein alterations in cavernous tissue of diabetic rats.

Journal: European urology 20080701

Title: Comparable efficacy of once-daily versus on-demand vardenafil in men with mild-to-moderate erectile dysfunction: findings of the RESTORE study.

Journal: European urology 20080701

Title: Editorial comment on: comparable efficacy of once-daily versus on-demand vardenafil in men with mild-to-moderate erectile dysfunction: findings of the RESTORE study.

Journal: European urology 20080701

Title: Can Viagra really cause hearing and vision loss? If so, is this a reason to avoid using it?

Journal: Mayo Clinic health letter (English ed.) 20080701

Title: Vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia.

Journal: Current urology reports 20080701

Title: A randomised, placebo-controlled study to assess the efficacy of twice-daily vardenafil in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia.

Journal: European urology 20080601

Title: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080601

Title: Vardenafil in men with stable statin therapy and dyslipidemia.

Journal: The journal of sexual medicine 20080601

Title: PDE5 inhibitors for cystic fibrosis: can they also enhance chloride transport? Evaluation of: Lubamba B, Lecourt H, Lebacq J, et al. Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis. Am J Respir Crit Care Med 2008;177(5):506-15.

Journal: Expert opinion on investigational drugs 20080601

Title: Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets.

Journal: British journal of pharmacology 20080601

Title: Vardenafil demonstrates first-dose success and reliability of penetration and maintenance of erection in men with erectile dysfunction - RELY-II.

Journal: Canadian Urological Association journal = Journal de l'Association des urologues du Canada 20080601

Title: Zebrafish: An in vivo model for the study of neurological diseases.

Journal: Neuropsychiatric disease and treatment 20080601

Title: Mechanisms of the relaxant effect of vardenafil in rat penile arteries.

Journal: European journal of pharmacology 20080531

Title: Designer drugs in herbal aphrodisiacs.

Journal: Forensic science international 20080520

Title: Analysis of illegally manufactured formulations of tadalafil (Cialis) by 1H NMR, 2D DOSY 1H NMR and Raman spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20080512

Title: Long-term treatment of erectile dysfunction with a phosphodiesterase-5 inhibitor and dose optimization based on nocturnal penile tumescence.

Journal: BJU international 20080501

Title: The triad of erectile dysfunction, hypogonadism and the metabolic syndrome.

Journal: International journal of clinical practice 20080501

Title: Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG.

Journal: British journal of pharmacology 20080501

Title: Efficacy and tolerability of vardenafil in Asian men with erectile dysfunction.

Journal: Asian journal of andrology 20080501

Title: Effect of testosterone on potassium channel opening in human corporal smooth muscle cells.

Journal: The journal of sexual medicine 20080401

Title: Vardenafil improves ejaculation success rates and self-confidence in men with erectile dysfunction due to spinal cord injury.

Journal: Spine 20080401

Title: Role of phosphodiesterase 5 in synaptic plasticity and memory.

Journal: Neuropsychiatric disease and treatment 20080401

Title: Identification of a novel vardenafil analogue in herbal product.

Journal: Journal of pharmaceutical and biomedical analysis 20080313

Title: Acceptance of and discontinuation rate from erectile dysfunction oral treatment in patients following bilateral nerve-sparing radical prostatectomy.

Journal: European urology 20080301

Title: Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis.

Journal: American journal of respiratory and critical care medicine 20080301

Title: Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques.

Journal: Psychopharmacology 20080301

Title: Daily vardenafil for 6 months has no detrimental effects on semen characteristics or reproductive hormones in men with normal baseline levels.

Journal: The Journal of urology 20080301

Title: Phosphodiesterase 5 inhibitors and cystic fibrosis: correcting chloride channel dysfunction.

Journal: American journal of respiratory and critical care medicine 20080301

Title: The effect of physician and patient education when combined with vardenafil treatment in Canadian males with erectile dysfunction: an open-label, factorial-designed, cluster-randomized clinical trial.

Journal: The journal of sexual medicine 20080301

Title: Inflatable penile prostheses for the treatment of erectile dysfunction: an update.

Journal: Expert review of medical devices 20080301

Title: Effects of phosphodiesterase inhibitors on tension induced by norepinephrine and accumulation of cyclic nucleotides in isolated human prostatic tissue.

Journal: Urology 20080301

Title: Effect of phospodiesterase 5 inhibitors on apoptosis and nitric oxide synthases in testis torsion: an experimental study.

Journal: Pediatric surgery international 20080201

Title: cDNA microarray analysis of differentially expressed genes in penile tissue after treatment with tadalafil.

Journal: BJU international 20080201

Title: Giving patients with erectile dysfunction the opportunity to try all three available phosphodiesterase type 5 inhibitors contributes to better long-term treatment compliance.

Journal: The journal of sexual medicine 20080201

Title: Vardenafil in the treatment of erectile dysfunction in outpatients with chronic schizophrenia: a flexible-dose, open-label study.

Journal: The Journal of clinical psychiatry 20080201

Title: Phosphodiesterase 5 inhibition in essential hypertension.

Journal: Current hypertension reports 20080201

Title: The impact of formulary replacement of sildenafil by vardenafil at a local VA hospital.

Journal: International journal of impotence research 20080101

Title: Long-term continuous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats.

Journal: International journal of impotence research 20080101

Title: Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction that occurs after cavernosal nerve resection.

Journal: BJU international 20080101

Title: Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health.

Journal: Journal of andrology 20080101

Title: Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.

Journal: Molecular pharmacology 20080101

Title: The application of quantitative methods for identifying and exploring the presence of bias in systematic reviews: PDE-5 inhibitors for erectile dysfunction.

Journal: International journal of impotence research 20080101

Title: Effects of phosphodiesterase-5 inhibitors on sperm parameters and fertilizing capacity.

Journal: Asian journal of andrology 20080101

Title: Phosphodiesterase-5 inhibitors for lower urinary tract symptoms in men.

Journal: The Annals of pharmacotherapy 20080101

Title: Looking to the future for erectile dysfunction therapies.

Journal: Drugs 20080101

Title: Inhibition of hyaluronan export reduces collagen degradation in interleukin-1 treated cartilage.

Journal: Arthritis research & therapy 20080101

Title: Visual field defect as a presenting sign for hemorrhagic stroke caused by sildenafil.

Journal: Indian journal of ophthalmology 20080101

Title: Discovery of NO in the penis.

Journal: International journal of impotence research 20080101

Title: Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function.

Journal: International journal of impotence research 20080101

Title: An overview of harms associated with beta-lactam antimicrobials: where do the carbapenems fit in?

Journal: Critical care (London, England) 20080101

Title: Sublingual application of liquid nitrendipine does not result in critical hypotension in healthy volunteers under phosphodiesterase-5 inhibition.

Journal: Clinical hemorheology and microcirculation 20080101

Title: Drugs used to treat erectile dysfunction.

Journal: Orthopedic nursing 20080101

Title: Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry.

Journal: Journal of AOAC International 20080101

Title: A double-blind, placebo-controlled, randomized clinical study of the effects of vardenafil on human nasal patency.

Journal: American journal of rhinology 20080101

Title: Preclinical evidence for the benefits of penile rehabilitation therapy following nerve-sparing radical prostatectomy.

Journal: Advances in urology 20080101

Title: Structure -activity relationships of PDE5 inhibitors.

Journal: Current medicinal chemistry 20080101

Title: Intravenous tezosentan and vardenafil attenuate acute hypoxic pulmonary hypertension.

Journal: High altitude medicine & biology 20080101

Title: The relationship between erectile dysfunction and cardiovascular disease. Part II: The role of PDE-5 inhibition in sexual dysfunction and cardiovascular disease.

Journal: Reviews in cardiovascular medicine 20080101

Title: [Levitra (wardenafil) effects on endothelial function of brachial and cavernous arteries].

Journal: Urologiia (Moscow, Russia : 1999) 20080101

Title: Sickle cell trait and priapism: a case report and review of the literature.

Journal: Cases journal 20080101

Title: Phosphodiesterase type-5 inhibitor and oxidative stress.

Journal: International journal of immunopathology and pharmacology 20080101

Title: [Effects of different treatments on endothelial function in patients with erectile dysfunction and hypogonadism].

Journal: Terapevticheskii arkhiv 20080101

Title: [Wardenafil in combined treatment of patients with chronic bacterial prostatitis].

Journal: Urologiia (Moscow, Russia : 1999) 20080101

Title: Loss of digits after trauma in a patient with systemic lupus erythematosus.

Journal: The western journal of emergency medicine 20080101

Title: Preference for and adherence to oral phosphodiesterase-5 inhibitors in the treatment of erectile dysfunction.

Journal: Patient preference and adherence 20080101

Title: Drug therapy: Sildenafil for post-operative pulmonary hypertension and Eisenmenger syndrome - A brief review of literature and survey of expert opinion.

Journal: Annals of pediatric cardiology 20080101

Title: Management of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy.

Journal: Current oncology (Toronto, Ont.) 20071201

Title: Novel phosphodiesterase-5 inhibitors: current indications and future directions.

Journal: Indian journal of medical sciences 20071201

Title: Treating COPD with PDE 4 inhibitors.

Journal: International journal of chronic obstructive pulmonary disease 20071201

Title: Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors.

Journal: Biochemistry 20071127

Title: Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: Patterns of switching phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction: results from the Erectile Dysfunction Observational Study.

Journal: International journal of clinical practice 20071101

Title: Responsiveness and minimum important differences for the erection quality scale.

Journal: The Journal of urology 20071101

Title: Vardenafil improves urodynamic parameters in men with spinal cord injury: results from a single dose, pilot study.

Journal: The Journal of urology 20071101

Title: Efficacy of vardenafil for the treatment of erectile dysfunction in men with hypertension: a meta-analysis of clinical trial data.

Journal: Current medical research and opinion 20071001

Title: Analogues of erectile dysfunction drugs: an under-recognised threat.

Journal: Hong Kong medical journal = Xianggang yi xue za zhi 20071001

Title: N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization.

Journal: Biochemistry 20070911

Title: [PDE5 inhibitors. A new option in the treatment of ureteral colic?].

Journal: Der Urologe. Ausg. A 20070901

Title: [PDE5 inhibitors in treatment of benign prostatic syndrome].

Journal: Der Urologe. Ausg. A 20070901

Title: Therapeutic challenges for systemic sclerosis: facts and future targets.

Journal: Annals of the New York Academy of Sciences 20070901

Title: [Novel indications for phosphodiesterase type 5 inhibitors].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20070815

Title: Radical prostatectomy for clinical T3 disease: expanding indications while optimizing cancer control and quality of life.

Journal: Nature clinical practice. Urology 20070801

Title: Improvement in erectile function on vardenafil treatment correlates with treatment satisfaction in both patients and their partners.

Journal: BJU international 20070701

Title: The Treatment Satisfaction Scale (TSS) is a sensitive measure of treatment effectiveness for both patients and partners: results of a randomized controlled trial with vardenafil.

Journal: The journal of sexual medicine 20070701

Title: Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors.

Journal: Urology 20070701

Title: [A clinical study of sertraline and vardenafil in the treatment of premature ejaculation complicated by erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20070701

Title: Development and validation of a high-performance liquid chromatographic method using fluorescence detection for the determination of vardenafil in small volumes of rat plasma and bile.

Journal: Journal of chromatography. A 20070622

Title: Effects of vardenafil on intraocular pressure and orbital hemodynamics.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601

Title: [Efficacy of tadalafil for erectile dysfunction: an updated review].

Journal: Zhonghua nan ke xue = National journal of andrology 20070601

Title: Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation.

Journal: Therapeutics and clinical risk management 20070601

Title: Relationship between vascular damage degrees and endothelial progenitor cells in patients with erectile dysfunction: effect of vardenafil administration and PDE5 expression in the bone marrow.

Journal: European urology 20070501

Title: Pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via CYP3A1 and/or 3A2 by DA-8159, an erectogenic, in rats.

Journal: British journal of pharmacology 20070501

Title: Vardenafil: a selective inhibitor of phosphodiesterase-5 for the treatment of erectile dysfunction.

Journal: Expert opinion on pharmacotherapy 20070501

Title: The efficacy and safety of vardenafil in East Asian men with erectile dysfunction.

Journal: The journal of sexual medicine 20070501

Title: The future of the oral pharmacotherapy of male erectile dysfunction: things to come.

Journal: Expert opinion on emerging drugs 20070501

Title: The COUPLES-project: a pooled analysis of patient and partner treatment satisfaction scale (TSS) outcomes following vardenafil treatment.

Journal: BJU international 20070401

Title: Factors that predict changing the type of phosphodiesterase type 5 inhibitor medication among men in the UK.

Journal: BJU international 20070401

Title: Oral phosphodiesterase-5 inhibitors: effect of heme oxygenase inhibition on cGMP signalling in rat cavernous tissue.

Journal: Andrologia 20070401

Title: [Effects of Huafenqinutang and vardenafil for treatment of chronic prostatitis/chronic pelvic pain syndrome with concomitant erectile dysfunction].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070401

Title: Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors.

Journal: European journal of pharmacology 20070308

Title: Vardenafil increases coronary flow response to hypercapnic acidosis in isolated guinea pig heart.

Journal: Basic research in cardiology 20070301

Title: Real-life safety and efficacy of vardenafil in the treatment of erectile dysfunction-results from 30,010 U.S. patients.

Journal: The journal of sexual medicine 20070301

Title: Characterization and functional role of androgen-dependent PDE5 activity in the bladder.

Journal: Endocrinology 20070301

Title: Cardiovascular protection with sildenafil following chronic inhibition of nitric oxide synthase.

Journal: British journal of pharmacology 20070301

Title: Quality of life in HIV clinical trials: why sexual health must not be ignored.

Journal: PLoS clinical trials 20070301

Title: Efficacy of vardenafil and influence on self-esteem and self-confidence in patients with severe erectile dysfunction.

Journal: The journal of sexual medicine 20070301

Title: Erectile dysfunction: monitoring response to treatment in clinical practice--recommendations of an international study panel.

Journal: The journal of sexual medicine 20070301

Title: [Experience of using three phosphodiesterase type 5 inhibitors in the same period for the treatment of erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20070301

Title: Phosphodiesterase inhibitors in the treatment of erectile dysfunction in spinal cord-injured men.

Journal: Spinal cord 20070201

Title: Therapeutic effectiveness and patient satisfaction after 6 months of treatment with tadalafil, sildenafil, and vardenafil: results from the erectile dysfunction observational study (EDOS).

Journal: European urology 20070201

Title: In vitro effects of PDE5 inhibitors sildenafil, vardenafil and tadalafil on isolated human ureteral smooth muscle: a basic research approach.

Journal: Urological research 20070201

Title: Sildenafil and vardenafil but not nitroglycerin limit myocardial infarction through opening of mitochondrial K(ATP) channels when administered at reperfusion following ischemia in rabbits.

Journal: Journal of molecular and cellular cardiology 20070201

Title: Inhibitors of phosphodiesterase 5 (PDE 5) inhibit the nerve-induced release of nitric oxide from the rabbit corpus cavernosum.

Journal: British journal of pharmacology 20070201

Title: Vardenafil and weaning from inhaled nitric oxide: effect on pulmonary hypertension in ARDS.

Journal: Anaesthesia and intensive care 20070201

Title: Structure determination of new analogues of vardenafil and sildenafil in dietary supplements.

Journal: Food additives and contaminants 20070201

Title: Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus.

Journal: The Cochrane database of systematic reviews 20070124

Title: Phosphodiesterase type 5 inhibitors' extended duration of response as a variable in the treatment of erectile dysfunction.

Journal: International journal of impotence research 20070101

Title: The effects of chronic phosphodiesterase-5 inhibitor use on different organ systems.

Journal: International journal of impotence research 20070101

Title: Gene therapy and erectile dysfunction: the current status.

Journal: Asian journal of andrology 20070101

Title: Phosphodiesterase type 5 inhibitors: the day after.

Journal: European urology 20070101

Title: The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy.

Journal: International journal of impotence research 20070101

Title: Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil.

Journal: Frontiers in bioscience : a journal and virtual library 20070101

Title: Anti-ischemic effects of sildenafil, vardenafil and tadalafil in heart.

Journal: International journal of impotence research 20070101

Title: Do vardenafil and tadalafil have advantages over sildenafil in the treatment of erectile dysfunction?

Journal: International journal of impotence research 20070101

Title: Vardenafil restores erectile function to normal range in men with erectile dysfunction.

Journal: The journal of sexual medicine 20070101

Title: Post-marketing surveillance study of the efficacy and safety of vardenafil among patients with erectile dysfunction in primary care.

Journal: International journal of impotence research 20070101

Title: Mechanism of Phosphodiesterase 5 inhibitor relief of prostatitis symptoms.

Journal: Medical hypotheses 20070101

Title: Type 5 phosphodiesterase inhibitors in the treatment of erectile dysfunction and cardiovascular disease.

Journal: Cardiology in review 20070101

Title: The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels.

Journal: Current topics in medicinal chemistry 20070101

Title: The real-life safety and efficacy of vardenafil: an international post-marketing surveillance study of 2824 patients from the Middle East.

Journal: Clinical drug investigation 20070101

Title: [Therapeutic efficacy of a course administration of vardenafil--inhibitor of phosphodiesterase-5--in erectile dysfunction].

Journal: Urologiia (Moscow, Russia : 1999) 20070101

Title: Phosphodiesterase 5 inhibitors lower both portal and pulmonary pressure in portopulmonary hypertension: a case report.

Journal: Journal of medical case reports 20070101

Title: PDE5 inhibitors beyond erectile dysfunction.

Journal: International journal of impotence research 20070101

Title: The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development.

Journal: Current medicinal chemistry 20070101

Title: [Drug counterfeiting--the risk to the public health].

Journal: Przeglad lekarski 20070101

Title: The postmortem distribution of vardenafil (Levitra) in an aviation accident victim with an unusually high blood concentration.

Journal: Journal of analytical toxicology 20070101

Title: [The role of testosterone drugs in combined therapy of erectile dysfunction in patients with metabolic syndrome].

Journal: Urologiia (Moscow, Russia : 1999) 20070101

Title: The effect of vardenafil (a PDE type 5 inhibitor) on renal function in the diabetic rabbit: a pilot study.

Journal: In vivo (Athens, Greece) 20070101

Title: [Pulmonary hypertension and right ventricular failure. Part XII. Nitrous oxide and phosphodiesterase inhibitors in the treatment of primary pulmonary arterial hypertension].

Journal: Kardiologiia 20070101

Title: Premature ejaculation.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20070101

Title: Tadalafil: the evidence for its clinical potential in the treatment of pulmonary arterial hypertension.

Journal: Core evidence 20070101

Title: Endothelial dysfunction, erectile dysfunction and phosphodiesterase 5 inhibitors. An update of the current data and future perspectives.

Journal: Drug target insights 20070101

Title: [Treatment of pulmonary arterial hypertension: phosphodiesterase-5 inhibitors].

Journal: Deutsche medizinische Wochenschrift (1946) 20061208

Title: [Short history of erectile dysfunction treatment].

Journal: Revue medicale suisse 20061206

Title: Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future.

Journal: European urology 20061201

Title: Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms.

Journal: BJU international 20061201

Title: [Tadalafil and patients preference in the treatment of erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20061201

Title: Comorbid LUTS and erectile dysfunction: optimizing their management.

Journal: Current medical research and opinion 20061201

Title: Sexual function in hypertensive patients receiving treatment.

Journal: Vascular health and risk management 20061201

Title: Tadalafil in the treatment of erectile dysfunction; an overview of the clinical evidence.

Journal: Clinical interventions in aging 20061201

Title: [Viagra -- patients stand by their treatment].

Journal: Praxis 20061122

Title: Extended duration of efficacy of vardenafil when taken 8 hours before intercourse: a randomized, double-blind, placebo-controlled study.

Journal: European urology 20061101

Title: A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.

Journal: Molecular pharmacology 20061101

Title: Vardenafil duration of action.

Journal: European urology 20061101

Title: Combining testosterone and PDE5 inhibitors in erectile dysfunction: basic rationale and clinical evidences.

Journal: European urology 20061101

Title: Does the clinical efficacy of vardenafil correlate with its effect on the endothelial function of cavernosal arteries? A pilot study.

Journal: BJU international 20061101

Title: First-dose success with vardenafil in men with erectile dysfunction and associated comorbidities: RELY-I.

Journal: International journal of clinical practice 20061101

Title: Up-titration of vardena fi l dose from 10 mg to 20 mg improved erectile function in men with spinal cord injury.

Journal: International journal of urology : official journal of the Japanese Urological Association 20061101

Title: Antidepressant-induced inhibition of genital vascular responses is reversed by vardenafil in female rabbits.

Journal: The journal of sexual medicine 20061101

Title: Vardenafil improves sexual function and treatment satisfaction in couples affected by erectile dysfunction (ED): a randomized, double-blind, placebo-controlled trial in PDE5 inhibitor-naïve men with ED and their partners.

Journal: The journal of sexual medicine 20061101

Title: Comparing vardenafil and sildenafil in the treatment of men with erectile dysfunction and risk factors for cardiovascular disease: a randomized, double-blind, pooled crossover study.

Journal: The journal of sexual medicine 20061101

Title: The economic effect of switching from sildenafil to another phosphodiesterase type 5 inhibitor.

Journal: Managed care interface 20061101

Title: Epileptic seizures can follow high doses of oral vardenafil.

Journal: BMJ (Clinical research ed.) 20061014

Title: Phosphodiesterase 5 inhibitors in the treatment of premature ejaculation.

Journal: International journal of andrology 20061001

Title: An epidemiological and knowledge, attitudes, beliefs and practices study of sexually transmitted infections in older men.

Journal: Singapore medical journal 20061001

Title: Review of time of onset and duration of clinical efficacy of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction.

Journal: Urology 20061001

Title: Non-arteritic anterior ischemic optic neuropathy (NAION) and phosphodiesterase type-5 inhibitors.

Journal: The Canadian journal of urology 20061001

Title: [Efficacy and safety of vardenafil in the treatment of erectile dysfunction in men with hypertension].

Journal: Zhonghua nan ke xue = National journal of andrology 20061001

Title: Phosphodiesterase-5 isoforms: differential cyclic guanyl monophosphate binding and cyclic guanyl monophosphate catalytic activities, and inhibitory effects of sildenafil and vardenafil.

Journal: The Journal of urology 20060901

Title: Efficacy and safety of flexible-dose vardenafil in men with type 1 diabetes and erectile dysfunction.

Journal: The journal of sexual medicine 20060901

Title: Vardenafil improved erectile function in a 'real-life' broad population study of men with moderate to severe erectile dysfunction in Australia and New Zealand.

Journal: The journal of sexual medicine 20060901

Title: Prospective, randomized, open-label, fixed-dose, crossover study to establish preference of patients with erectile dysfunction after taking the three PDE-5 inhibitors.

Journal: The journal of sexual medicine 20060901

Title: Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use.

Journal: Pharmacological reviews 20060901

Title: [Safety and tolerability of Vardenafil].

Journal: Zhonghua nan ke xue = National journal of andrology 20060901

Title: Use of liquid chromatography-mass spectrometry and a hydrolytic technique for the detection and structure elucidation of a novel synthetic vardenafil designer drug added illegally to a 'natural' herbal dietary supplement.

Journal: Journal of chromatography. A 20060825

Title: Visual loss with erectile dysfunction medications.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060815

Title: Phosphodiesterase 5 in the female pig and human urethra: morphological and functional aspects.

Journal: BJU international 20060801

Title: Comparison of phosphodiesterase type 5 (PDE5) inhibitors.

Journal: International journal of clinical practice 20060801

Title: Vardenafil improves comorbid erectile dysfunction and mild depression.

Journal: Evidence-based mental health 20060801

Title: Depression-related improvement with vardenafil for erectile response.

Journal: The American journal of psychiatry 20060801

Title: Phosphodiesterases in the CNS: targets for drug development.

Journal: Nature reviews. Drug discovery 20060801

Title: Phosphodiesterase-5 inhibitors and their hemodynamic effects.

Journal: Current hypertension reports 20060801

Title: Vardenafil 20-mg demonstrated superior efficacy to 10-mg in Japanese men with diabetes mellitus suffering from erectile dysfunction.

Journal: International journal of urology : official journal of the Japanese Urological Association 20060801

Title: Vardenafil rescue rates of sildenafil nonresponders: objective assessment of 327 patients with erectile dysfunction.

Journal: Urology 20060801

Title: Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat.

Journal: Urology 20060801

Title: Erectile dysfunction.

Journal: Harvard men's health watch 20060801

Title: Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development.

Journal: The Journal of biological chemistry 20060728

Title: [Phosphodiesterase inhibitors: effectiveness and new applications].

Journal: Nederlands tijdschrift voor geneeskunde 20060722

Title: Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum.

Journal: European journal of pharmacology 20060717

Title: Treatment strategy for 'non-responders' to tadalafil and vardenafil: a real-life study.

Journal: European urology 20060701

Title: [Evidence-based therapy of Raynaud's syndrome].

Journal: Zeitschrift fur Rheumatologie 20060701

Title: Efficacy of tadalafil in Egyptian and Turkish men with erectile dysfunction.

Journal: International journal of clinical practice 20060701

Title: [Reliable efficacy of vardenafil for treatment of erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20060701

Title: Advertising in medical journals: should current practices change?

Journal: PLoS medicine 20060601

Title: Efficacy and safety of vardenafil in renal transplant recipients with erectile dysfunction.

Journal: Transplantation proceedings 20060601

Title: Erectile dysfunction.

Journal: Clinical evidence 20060601

Title: Prescribing all phosphodiesterase 5 inhibitors to a patient with erectile dysfunction--a realistic and feasible option in everyday clinical practice--outcomes of a simple treatment regime.

Journal: European urology 20060501

Title: [Epileptic seizures and vardenafil].

Journal: Revue neurologique 20060501

Title: Simultaneous administration of vardenafil and alcohol does not result in a pharmacodynamic or pharmacokinetic interaction in healthy male subjects.

Journal: International journal of clinical pharmacology and therapeutics 20060501

Title: [Role of female partners in the diagnosis and treatment of erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20060501

Title: Sildenafil citrate use and the incidence of nonarteritic anterior ischemic optic neuropathy.

Journal: International journal of clinical practice 20060401

Title: [Treatment of erectile dysfunction with PDE-5 inhibitors. Difficult for the physician to choose between the preparations--the patient should be given the opportunity to try out all three].

Journal: Lakartidningen 20060401

Title: [Efficacy and safety of vardenafil in difficult-to-treat erectile dysfunction men].

Journal: Zhonghua nan ke xue = National journal of andrology 20060401

Title: Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity.

Journal: The Journal of biological chemistry 20060303

Title: Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie's disease.

Journal: BJU international 20060301

Title: Vardenafil: a novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits.

Journal: Journal of molecular and cellular cardiology 20060301

Title: The effect of ovariectomy on rat vaginal tissue contractility and histomorphology.

Journal: The journal of sexual medicine 20060301

Title: Ophthalmic aspects of erectile dysfunction drugs.

Journal: American journal of ophthalmology 20060301

Title: Simultaneous determination of synthetic phosphodiesterase-5 inhibitors found in a dietary supplement and pre-mixed bulk powders for dietary supplements using high-performance liquid chromatography with diode array detection and liquid chromatography-electrospray ionization tandem mass spectrometry.

Journal: Journal of chromatography. A 20060203

Title: Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta.

Journal: The Journal of pharmacology and experimental therapeutics 20060201

Title: Can erectile dysfunction drug use lead to ischaemic optic neuropathy?

Journal: The British journal of ophthalmology 20060201

Title: PDE5 inhibitors: are there differences?

Journal: The Canadian journal of urology 20060201

Title: Long-term vardenafil therapy improves hemodynamics in patients with pulmonary hypertension.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20060201

Title: Efficacy and safety of vardenafil in men with erectile dysfunction caused by spinal cord injury.

Journal: Neurology 20060124

Title: Visual field defect and intracerebral hemorrhage associated with use of vardenafil (Levitra).

Journal: Neurology 20060124

Title: Phosphodiesterase type 5 inhibition is a novel therapeutic option in Raynaud disease.

Journal: Archives of internal medicine 20060123

Title: Efficacy of PDE-5-inhibitors for erectile dysfunction. A comparative meta-analysis of fixed-dose regimen randomized controlled trials administering the International Index of Erectile Function in broad-spectrum populations.

Journal: International journal of impotence research 20060101

Title: Evaluating preference trials of oral phosphodiesterase 5 inhibitors for erectile dysfunction.

Journal: European urology 20060101

Title: Tyrosine-612 in PDE5 contributes to higher affinity for vardenafil over sildenafil.

Journal: International journal of impotence research 20060101

Title: Differential effects of phosphodiesterase-5 inhibitors on hypoxic pulmonary vasoconstriction and pulmonary artery cytokine expression.

Journal: The Annals of thoracic surgery 20060101

Title: Efficacy and tolerability of vardenafil in men with mild depression and erectile dysfunction: the depression-related improvement with vardenafil for erectile response study.

Journal: The American journal of psychiatry 20060101

Title: Effect of vardenafil, an inhibitor of phosphodiesterase-5, on portal haemodynamics in normal and cirrhotic liver -- results of a pilot study.

Journal: Alimentary pharmacology & therapeutics 20060101

Title: How new drugs help treat erectile dysfunction.

Journal: Nursing 20060101

Title: The second Princeton consensus on sexual dysfunction and cardiac risk: new guidelines for sexual medicine.

Journal: The journal of sexual medicine 20060101

Title: Beyond Viagra. What are your options?

Journal: Mayo Clinic health letter (English ed.) 20060101

Title: The effect of vardenafil on endothelial function of brachial and cavernous arteries.

Journal: International journal of impotence research 20060101

Title: Erectile dysfunction following radical retropubic prostatectomy: epidemiology, pathophysiology and pharmacological management.

Journal: Drugs & aging 20060101

Title: A comparative review of apomorphine formulations for erectile dysfunction : recommendations for use in the elderly.

Journal: Drugs & aging 20060101

Title: Accurate mass measurement using Fourier transform ion cyclotron resonance mass spectrometry for structure elucidation of designer drug analogs of tadalafil, vardenafil and sildenafil in herbal and pharmaceutical matrices.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Phosphodiesterase inhibitors in Raynaud's phenomenon.

Journal: The Annals of pharmacotherapy 20060101

Title: Phosphodiesterase 5 inhibitors--drug design and differentiation based on selectivity, pharmacokinetic and efficacy profiles.

Journal: Current pharmaceutical design 20060101

Title: Cardiovascular effects of phosphodiesterase 5 inhibitors.

Journal: Current pharmaceutical design 20060101

Title: [Prediction of clinical efficacy of levitra (vardenafil) in patients with arteriogenic erectile dysfunction].

Journal: Urologiia (Moscow, Russia : 1999) 20060101

Title: [Levitra in the treatment of patients with chronic prostatitis associated with sexual dysfunction].

Journal: Urologiia (Moscow, Russia : 1999) 20060101

Title: Angioneurotic oedema with tadalafil: A rare case report.

Journal: Indian journal of psychiatry 20060101

Title: Hemodynamic and exercise effects of phosphodiesterase 5 inhibitors.

Journal: The American journal of cardiology 20051226

Title: Cardiac safety in clinical trials of phosphodiesterase 5 inhibitors.

Journal: The American journal of cardiology 20051226

Title: Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions.

Journal: The American journal of cardiology 20051226

Title: Phosphodiesterase 5 inhibition in chronic heart failure and pulmonary hypertension.

Journal: The American journal of cardiology 20051226

Title: Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference).

Journal: The American journal of cardiology 20051226

Title: The therapeutic dilemma: how to use tadalafil.

Journal: International journal of andrology 20051201

Title: Phosphodiesterase inhibitors in female sexual dysfunction.

Journal: World journal of urology 20051201

Title: Clinical update on phosphodiesterase type-5 inhibitors for erectile dysfunction.

Journal: World journal of urology 20051201

Title: Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors.

Journal: World journal of urology 20051201

Title: In vitro functional responses of isolated human vaginal tissue to selective phosphodiesterase inhibitors.

Journal: World journal of urology 20051201

Title: [Unreasonable advertising campaign from Bayer].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20051201

Title: Erectile dysfunction drugs and non-arteritic anterior ischemic optic neuropathy: is there a cause and effect relationship?

Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20051201

Title: Successful use of phosphodiesterase type 5 inhibitors to control symptomatic esophageal hypercontractility: a case report.

Journal: Digestive diseases and sciences 20051101

Title: Atrial fibrillation after vardenafil therapy.

Journal: Emergency medicine journal : EMJ 20051101

Title: PDE-5 inhibitors: current status and future trends.

Journal: The Urologic clinics of North America 20051101

Title: Women's sexual function improves when partners are administered vardenafil for erectile dysfunction: a prospective, randomized, double-blind, placebo-controlled trial.

Journal: The journal of sexual medicine 20051101

Title: Flexible-dose vardenafil in a community-based population of men affected by erectile dysfunction: a 12-week open-label, multicenter trial.

Journal: The journal of sexual medicine 20051101

Title: Medication utilization behavior in patients receiving phosphodiesterase type 5 inhibitors for erectile dysfunction.

Journal: The journal of sexual medicine 20051101

Title: Safety and efficacy of vardenafil, a selective phosphodiesterase 5 inhibitor, in patients with erectile dysfunction and arterial hypertension treated with multiple antihypertensives.

Journal: The journal of sexual medicine 20051101

Title: [Efficacy and safety of treatment of erectile dysfunction with Vardenafil under routine conditions].

Journal: MMW Fortschritte der Medizin 20051027

Title: [Therapy for organic erectile dysfunction].

Journal: Der Urologe. Ausg. A 20051001

Title: Sustained efficacy and safety of vardenafil for treatment of erectile dysfunction: a randomized, double-blind, placebo-controlled study.

Journal: Mayo Clinic proceedings 20051001

Title: High lung PDE5: a strong basis for treating pulmonary hypertension with PDE5 inhibitors.

Journal: Biochemical and biophysical research communications 20050902

Title: A novel method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)-ones.

Journal: The Journal of organic chemistry 20050902

Title: The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction.

Journal: Journal of clinical pharmacology 20050901

Title: Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.

Journal: Investigative ophthalmology & visual science 20050901

Title: [Treatment of erectile dysfunction after radical retropubic prostatectomy with PDE5 inhibitor].

Journal: Zhonghua nan ke xue = National journal of andrology 20050901

Title: [Evaluating the treatment satisfaction of vardenafil in men with erectile dysfunction and female partners by the Treatment Satisfaction Scale].

Journal: Zhonghua nan ke xue = National journal of andrology 20050901

Title: Erectile response to vardenafil in men with a history of nonresponse to sildenafil: a time-from-dosing descriptive analysis.

Journal: Clinical therapeutics 20050901

Title: Improving the sexual quality of life of couples affected by erectile dysfunction: a double-blind, randomized, placebo-controlled trial of vardenafil.

Journal: The journal of sexual medicine 20050901

Title: Drug firms back-pedal on direct advertising.

Journal: Nature 20050818

Title: Re: Montorsi F, Salonia A, Briganti A, Barbieri L, Zanni G, Surdi N, Cestari A, Montorsi P, Rigatti P. Vardenafil for the treatment of erectile dysfunction: a critical review of the literature based on personal clinical experience. Eur Urol 2005;47:612-21.

Journal: European urology 20050801

Title: Evidence for contamination of herbal erectile dysfunction products with phosphodiesterase type 5 inhibitors.

Journal: The Journal of urology 20050801

Title: Phosphodiesterase type 5 inhibitors for erectile dysfunction.

Journal: BJU international 20050801

Title: [Instructions for the combination of PDE5 inhibitors with alpha-blockers].

Journal: Zhonghua nan ke xue = National journal of andrology 20050801

Title: On call. I am 66 years old and have had angina for nearly 5 years. I take aspirin and Zocor, but I haven't needed nitroglycerin for at least 3 years, even though I ride my bike quite hard at least 4 days a week. I've started having trouble with my erections, and now I want to try Viagra. My doctor gave me a prescription, but my wife won't let me fill it. Is Viagra safe for me?

Journal: Harvard men's health watch 20050801

Title: Potency and selectivity of vardenafil: a phosphodiesterase Type 5 inhibitor.

Journal: Expert opinion on drug metabolism & toxicology 20050801

Title: Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference).

Journal: The American journal of cardiology 20050715

Title: From bedside to bed. Recovery of sexual function after prostate cancer.

Journal: Canadian family physician Medecin de famille canadien 20050710

Title: [Quality assurance in the urologist's practice. Erectile dysfunction as an example of a multicenter approach to documenting treatment results].

Journal: Der Urologe. Ausg. A 20050701

Title: In vivo and in vitro response of corpus cavernosum to phosphodiesterase-5 inhibition in the hypercholesterolaemic rabbit.

Journal: BJU international 20050701

Title: [Efficacy and safety of vardenafil in men with erectile dysfunction in general clinical practice].

Journal: Zhonghua nan ke xue = National journal of andrology 20050701

Title: [Determination of sildenafil and vardenafil in human plasma by high performance liquid chromatography coupled with liquid-liquid-liquid microextraction].

Journal: Se pu = Chinese journal of chromatography 20050701

Title: Vardenafil improved patient satisfaction with erectile hardness, orgasmic function and sexual experience in men with erectile dysfunction following nerve sparing radical prostatectomy.

Journal: The Journal of urology 20050601

Title: [Effects of food and alcohol on the pharmacokinetics of vardenafil].

Journal: Zhonghua nan ke xue = National journal of andrology 20050601

Title: [Erectile dysfunction (ED) and diabetes mellitus].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050601

Title: Penetration and maintenance of erection with vardenafil: a time-from-dosing analysis.

Journal: The Canadian journal of urology 20050601

Title: [Efficacy and tolerability of vardenafil within the time window of 6 hours after administration and beyond].

Journal: MMW Fortschritte der Medizin 20050505

Title: Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.

Journal: Bioorganic & medicinal chemistry letters 20050502

Title: Vardenafil for the treatment of erectile dysfunction: a critical review of the literature based on personal clinical experience.

Journal: European urology 20050501

Title: Viagra and anterior ischemic optic neuropathy.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20050501

Title: [Molecular studies of vardenafil].

Journal: Zhonghua nan ke xue = National journal of andrology 20050501

Title: Pharmacotherapy of erectile dysfunction: focus on cardiovascular safety.

Journal: Expert opinion on drug safety 20050501

Title: Inflatable penile prostheses for the treatment of erectile dysfunction.

Journal: Expert review of medical devices 20050501

Title: Drug Insight: oral phosphodiesterase type 5 inhibitors for erectile dysfunction.

Journal: Nature clinical practice. Urology 20050501

Title: [Efficacy and tolerability of vardenafil within the time window of 6 hours after administration and beyond. Results of a clinical study carried out in 233 urological offices].

Journal: MMW Fortschritte der Medizin 20050407

Title: Use of combined intracorporal injection and a phosphodiesterase-5 inhibitor therapy for men with a suboptimal response to sildenafil and/or vardenafil monotherapy after radical retropubic prostatectomy.

Journal: BJU international 20050401

Title: Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response.

Journal: Urology 20050401

Title: Viagra, Levitra, and Cialis: what's the difference?

Journal: South Dakota journal of medicine 20050401

Title: Erectile dysfunction: the Viagra revolution.

Journal: Harvard men's health watch 20050401

Title: Visual field defect and intracerebral hemorrhage associated with use of vardenafil (Levitra).

Journal: Neurology 20050322

Title: Clinical monograph for drug formulary review: erectile dysfunction agents.

Journal: Journal of managed care pharmacy : JMCP 20050301

Title: ED drugs covered, but managed care unmoved.

Journal: Managed care (Langhorne, Pa.) 20050301

Title: Simultaneous determination of sildenafil, vardenafil and tadalafil as forbidden components in natural dietary supplements for male sexual potency by high-performance liquid chromatography-electrospray ionization mass spectrometry.

Journal: Journal of chromatography. A 20050225

Title: Patient education series. Erectile dysfunction.

Journal: Nursing 20050201

Title: High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients.

Journal: International journal of impotence research 20050101

Title: Vardenafil is effective and well-tolerated for treating erectile dysfunction in a broad population of men, irrespective of age.

Journal: BJU international 20050101

Title: From aspiration to achievement: assessment and noninvasive treatment of erectile dysfunction in aging men.

Journal: Journal of the American Geriatrics Society 20050101

Title: [Vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy].

Journal: Zhonghua nan ke xue = National journal of andrology 20050101

Title: Editorial comment on the manuscript entitled 'Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction'.

Journal: Expert opinion on pharmacotherapy 20050101

Title: Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction.

Journal: Expert opinion on pharmacotherapy 20050101

Title: Recreational use and misuse of phosphodiesterase 5 inhibitors.

Journal: Journal of the American Pharmacists Association : JAPhA 20050101

Title: [Levitra-test in diagnosis of vasculogenic erectile dysfunction].

Journal: Urologiia (Moscow, Russia : 1999) 20050101

Title: PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans.

Journal: International journal of impotence research 20050101

Title: Recovery of erection after pelvic urologic surgery: our experience.

Journal: International journal of impotence research 20050101

Title: The real-life safety and efficacy of vardenafil: an international post-marketing surveillance study--results from 29 358 German patients.

Journal: The Journal of international medical research 20050101

Title: Phosphodiesterase 5 inhibitors for erectile dysfunction.

Journal: The Annals of pharmacotherapy 20050101

Title: Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11.

Journal: Methods in molecular biology (Clifton, N.J.) 20050101

Title: [Systemic approach to investigation of levitra efficacy in patients with chronic prostatitis with erectile dysfunction].

Journal: Urologiia (Moscow, Russia : 1999) 20050101

Title: Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.

Journal: Respiratory research 20050101

Title: Effectiveness of vardenafil versus papaverine in penile Doppler ultrasonography.

Journal: Urologia internationalis 20050101

Title: New achievement and novel therapeutic applications of PDE5 inhibithors in older males.

Journal: Journal of endocrinological investigation 20050101

Title: A comparative review of the options for treatment of erectile dysfunction: which treatment for which patient?

Journal: Drugs 20050101

Title: Vardenafil in patients with erectile dysfunction: achieving treatment optimization.

Journal: Journal of andrology 20050101

Title: [Causes of erectile dysfunction after transurethral resection of hyperplastic prostate and its prophylaxis].

Journal: Urologiia (Moscow, Russia : 1999) 20050101

Title: Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report.

Journal: Cardiovascular ultrasound 20050101

Title: Available and future treatments for erectile dysfunction.

Journal: Clinical cornerstone 20050101

Title: The efficacy and safety of PDE5 inhibitors.

Journal: Clinical cornerstone 20050101

Title: Patient preferences in treatment of erectile dysfunction: the continuing importance of patient education.

Journal: Clinical cornerstone 20050101

Title: Aetiology and management of male erectile dysfunction and female sexual dysfunction in patients with cardiovascular disease.

Journal: Drugs & aging 20050101

Title: Treatment for erectile dysfunction based on patient-reported outcomes: to every man the PDE5 inhibitor that he finds superior.

Journal: Drugs 20050101

Title: [Vardenafil: long-term and continuous treatment of severe erectile disorders].

Journal: Urologiia (Moscow, Russia : 1999) 20050101

Title: Hypnosis-associated blue-tinted vision: a case report.

Journal: BMC ophthalmology 20050101

Title: Indirect comparison of interventions using published randomised trials: systematic review of PDE-5 inhibitors for erectile dysfunction.

Journal: BMC urology 20050101

Title: Phosphodiesterase type 5 inhibitors: molecular pharmacology and interactions with other phosphodiesterases.

Journal: Current pharmaceutical design 20050101

Title: FDA updates labeling for erectile dysfunction drugs.

Journal: FDA consumer 20050101

Title: Vardenafil improves satisfaction rates, depressive symptomatology, and self-confidence in a broad population of men with erectile dysfunction.

Journal: The journal of sexual medicine 20050101

Title: There have been inadequate warnings that erectile dysfunction drugs can cause blindness.

Journal: MedGenMed : Medscape general medicine 20050101

Title: PDE-5 Inhibitor Therapy for Erectile Dysfunction Secondary to Nerve-Sparing Radical Retropubic Prostatectomy.

Journal: Reviews in urology 20050101

Title: Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports.

Journal: International journal of impotence research 20041201

Title: Phosphodiesterase-5 inhibitors: clinical market and basic science comparative studies.

Journal: Current urology reports 20041201

Title: Erectile dysfunction secondary to nerve-sparing radical retropubic prostatectomy: comparative phosphodiesterase-5 inhibitor efficacy for therapy and novel prevention strategies.

Journal: Current urology reports 20041201

Title: Vardenafil provides reliable efficacy over time in men with erectile dysfunction.

Journal: Urology 20041201

Title: Erectile response with vardenafil in sildenafil nonresponders: a multicentre, double-blind, 12-week, flexible-dose, placebo-controlled erectile dysfunction clinical trial.

Journal: BJU international 20041201

Title: [Efficacy and safety of oral vardenafil in the treatment of erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20041201

Title: Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects.

Journal: Methods and findings in experimental and clinical pharmacology 20041201

Title: Premature ejaculation. 3. Therapy.

Journal: Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 20041201

Title: Development of a Micellar electrokinetic capillary chromatography method for the determination of three drugs employed in the erectile dysfunction therapy.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041125

Title: Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC-ESI-MS and LC-UV.

Journal: Journal of pharmaceutical and biomedical analysis 20041115

Title: Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction.

Journal: Circulation 20041109

Title: Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5).

Journal: Neurochemistry international 20041101

Title: New phosphodiesterase inhibitors in the treatment of erectile dysfunction.

Journal: Expert opinion on pharmacotherapy 20041101

Title: Vardenafil reversal of female anorgasmia.

Journal: The American journal of psychiatry 20041101

Title: Simultaneous administration of vardenafil and tamsulosin does not induce clinically significant hypotension in patients with benign prostatic hyperplasia.

Journal: Urology 20041101

Title: Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men.

Journal: The Journal of urology 20041101

Title: [Efficacy and safety of vardenafil in men with erectile dysfunction and depression].

Journal: Zhonghua nan ke xue = National journal of andrology 20041101

Title: Vardenafil improves erectile function in men with erectile dysfunction irrespective of disease severity and disease classification.

Journal: The journal of sexual medicine 20041101

Title: Review of phosphodiesterases in the urogenital system: new directions for therapeutic intervention.

Journal: The journal of sexual medicine 20041101

Title: Absence of clinically important HERG channel blockade by three compounds that inhibit phosphodiesterase 5--sildenafil, tadalafil, and vardenafil.

Journal: European journal of pharmacology 20041019

Title: Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study.

Journal: Journal of the American College of Cardiology 20041006

Title: Vardenafil-induced generalized urticaria.

Journal: Journal of clinical pharmacy and therapeutics 20041001

Title: Specific aspects of erectile dysfunction in spinal cord injury.

Journal: International journal of impotence research 20041001

Title: Erectile dysfunction.

Journal: RN 20041001

Title: [Cardiovascular safety of vardenafil].

Journal: Zhonghua nan ke xue = National journal of andrology 20041001

Title: [Vardenafil for the treatment of erectile dysfunction in men with diabetes].

Journal: Zhonghua nan ke xue = National journal of andrology 20041001

Title: [Efficacy and safety of vardenafil for men with erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20040901

Title: [Pharmacodynamics and pharmacokinetics of vardenafil in patients with erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20040901

Title: Antidepressant-induced sexual dysfunction treated with vardenafil.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20040901

Title: Earliest time to onset of action leading to successful intercourse with vardenafil determined in an at-home setting: a randomized, double-blind, placebo-controlled trial.

Journal: The journal of sexual medicine 20040901

Title: Vardenafil improves patient satisfaction with erection hardness, orgasmic function, and overall sexual experience, while improving quality of life in men with erectile dysfunction.

Journal: The journal of sexual medicine 20040901

Title: Structure elucidation of sildenafil analogues in herbal products.

Journal: Food additives and contaminants 20040801

Title: Vardenafil: a new oral treatment for erectile dysfunction.

Journal: International journal of clinical practice 20040801

Title: [Birthday of a 'potency pill'. Helmut Newton celebrates posthumously likewise].

Journal: MMW Fortschritte der Medizin 20040722

Title: Efficacy of vardenafil in men with erectile dysfunction: a flexible-dose community practice study.

Journal: European urology 20040701

Title: [Erectile dysfunction. New drugs with special consideration of the PDE 5 inhibitors].

Journal: Der Urologe. Ausg. A 20040701

Title: Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation.

Journal: Molecular pharmacology 20040701

Title: Safety and efficacy of vardenafil in patients with erectile dysfunction: result of a bridging study in Japan.

Journal: International journal of urology : official journal of the Japanese Urological Association 20040701

Title: New oral drugs for erectile dysfunction.

Journal: Drug and therapeutics bulletin 20040701

Title: Evaluation of vardenafil and sildenafil on cardiac repolarization.

Journal: The American journal of cardiology 20040601

Title: A consumer's guide to impotence drugs.

Journal: The Johns Hopkins medical letter health after 50 20040601

Title: Potency, selectivity, and consequences of nonselectivity of PDE inhibition.

Journal: International journal of impotence research 20040601

Title: Vardenafil preclinical trial data: potency, pharmacodynamics, pharmacokinetics, and adverse events.

Journal: International journal of impotence research 20040601

Title: [Erectile function disorders. Epidemiology, physiology, etiology, diagnosis and therapy].

Journal: Der Nervenarzt 20040601

Title: [New options in the treatment of various forms of diabetic neuropathy].

Journal: MMW Fortschritte der Medizin 20040520

Title: The efficacy and safety of flexible-dose vardenafil (levitra) in a broad population of European men.

Journal: European urology 20040501

Title: Emerging oral drugs for erectile dysfunction.

Journal: Expert opinion on emerging drugs 20040501

Title: Erectile dysfunction: management update.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20040427

Title: Treatment of erectile dysfunction.

Journal: International journal of STD & AIDS 20040401

Title: Pills for erectile dysfunction: now there are three.

Journal: Harvard men's health watch 20040401

Title: Vardenafil: a novel type 5 phosphodiesterase inhibitor for the treatment of erectile dysfunction.

Journal: Expert opinion on pharmacotherapy 20040401

Title: Role of the cardiologist: clinical aspects of managing erectile dysfunction.

Journal: Clinical cardiology 20040401

Title: Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles.

Journal: Clinical cardiology 20040401

Title: Novel phosphodiesterase type 5 inhibitors: assessing hemodynamic effects and safety parameters.

Journal: Clinical cardiology 20040401

Title: Tadalafil and vardenafil.

Journal: Nature reviews. Drug discovery 20040401

Title: [Comparison of efficacy and safety of phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction].

Journal: Zhonghua nan ke xue = National journal of andrology 20040401

Title: Sexual dysfunction and diabetes.

Journal: International journal of clinical practice 20040401

Title: Atazanavir (Reyataz): new recommendations if combined with tenofovir (Viread) -- and warning on Viagra, Cialis, and Levitra.

Journal: AIDS treatment news 20040326

Title: Therapeutic options for patients returning to sexual activity.

Journal: The Journal of the American Osteopathic Association 20040301

Title: Pharmacokinetics, pharmacodynamics, and efficacy of phosphodiesterase type 5 inhibitors.

Journal: The Journal of the American Osteopathic Association 20040301

Title: Vardenafil--PDE5 inhibitor number 3.

Journal: International journal of clinical practice 20040301

Title: Sustained efficacy and tolerability with vardenafil over 2 years of treatment in men with erectile dysfunction.

Journal: International journal of clinical practice 20040301

Title: [Treatment of erectile dysfunction].

Journal: Orvosi hetilap 20040227

Title: Cialis is here. The soft sell.

Journal: Newsweek 20040202

Title: Cardioprotection with phosphodiesterase-5 inhibition--a novel preconditioning strategy.

Journal: Journal of molecular and cellular cardiology 20040201

Title: Drug approval highlights for 2003.

Journal: The Nurse practitioner 20040201

Title: [Erectile dysfunction. Epidemiology, physiology, etiology, diagnosis and therapy].

Journal: Der Urologe. Ausg. A 20040201

Title: Tadalafil (Cialis) and vardenafil (Levitra) recently approved drugs for erectile dysfunction.

Journal: Urologic nursing 20040201

Title: Are they better than Viagra? Two new drugs for erectile dysfunction work like Viagra and carry similar risks and benefits. Their subtle differences, however, may make a difference for some men.

Journal: Harvard health letter 20040101

Title: Vardenafil treatment for erectile dysfunction.

Journal: The Annals of pharmacotherapy 20040101

Title: Spotlight on vardenafil in erectile dysfunction.

Journal: Drugs & aging 20040101

Title: Therapy of ED: PDE-5 Inhibitors.

Journal: Endocrine 20040101

Title: [Effective and safe use of Levitra (Vardenafil) for treatment of erectile dysfunction].

Journal: Urologiia (Moscow, Russia : 1999) 20040101

Title: Cardiovascular parameter changes in patients with erectile dysfunction using pde-5 inhibitors: a study with sildenafil and vardenafil.

Journal: Journal of andrology 20040101

Title: Future options for combination therapy in the management of erectile dysfunction in older men.

Journal: Drugs & aging 20040101

Title: [Levitra in a hardness test].

Journal: Krankenpflege Journal 20040101

Title: [Levitra (vardenafil)--a new PDE 5 inhibitor for the treatment of erectile dysfunction].

Journal: Akusherstvo i ginekologiia 20040101

Title: Interactions between grapefruit juice and cardiovascular drugs.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20040101

Title: New treatment options for erectile dysfunction in patients with diabetes mellitus.

Journal: Drugs 20040101

Title: Pharmacologic update: treatment of erectile dysfunction in the elderly with phosphodiesterase type 5 inhibitors: cardiovascular implications.

Journal: The American journal of geriatric cardiology 20040101

Title: [Influence of gender on clinical research].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101

Title: [Efficacy and safety of vardenafil in patients with erectile dysfunction. Results of the Mexican Multicentric Study].

Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20040101

Title: Erectile dysfunction.

Journal: Le Journal medical libanais. The Lebanese medical journal 20040101

Title: Pharmacotherapy of sexual dysfunctions : current status.

Journal: Indian journal of psychiatry 20040101

Title: Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists.

Journal: Current urology reports 20031201

Title: Vardenafil: a new approach to the treatment of erectile dysfunction.

Journal: Current urology reports 20031201

Title: Pro-erectile effect of vardenafil: in vitro experiments in rabbits and in vivo comparison with sildenafil in rats.

Journal: European urology 20031201

Title: Oral drug treatment of erectile dysfunction.

Journal: International journal of impotence research 20031201

Title: Overview of phosphodiesterase 5 inhibition in erectile dysfunction.

Journal: The American journal of cardiology 20031106

Title: Switching patients with erectile dysfunction from sildenafil citrate to tadalafil: results of a European multicenter, open-label study of patient preference.

Journal: Clinical therapeutics 20031101

Title: Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy.

Journal: The Journal of urology 20031001

Title: New drugs and dosage forms.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031001

Title: Phosphodiesterase type 5 inhibitors: a biochemical and clinical correlation survey.

Journal: International journal of impotence research 20031001

Title: [Drug therapy of erectile dysfunction--the current status].

Journal: Der Urologe. Ausg. A 20031001

Title: Vardenafil (levitra) for erectile dysfunction.

Journal: The Medical letter on drugs and therapeutics 20030929

Title: Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules.

Journal: Nature 20030904

Title: Phosphodiesterase 5 inhibitors in male sexual dysfunction.

Journal: Current opinion in urology 20030901

Title: Efficacy and tolerability of vardenafil for treatment of erectile dysfunction in patient subgroups.

Journal: Urology 20030901

Title: [Medication of the month. Vardenafil (Levitra)].

Journal: Revue medicale de Liege 20030901

Title: US advertising campaign begins for alternative to sildenafil.

Journal: BMJ (Clinical research ed.) 20030830

Title: Erectile dysfunction in the cardiac patient: how common and should we treat?

Journal: The Journal of urology 20030801

Title: Hypogonadism and erectile dysfunction: the role for testosterone therapy.

Journal: International journal of impotence research 20030801

Title: [New PDE-5 inhibitor for treatment of impotence. 9 out of 10 have erections again].

Journal: MMW Fortschritte der Medizin 20030626

Title: Proceedings of the 99th meeting of the Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee. May 29th and 30th, 2003.

Journal: Circulation 20030617

Title: [New treatment options for erectile dysfunction. Pharmacologic and nonpharmacologic options].

Journal: Herz 20030601

Title: [Conservative treatment of erectile dysfunction].

Journal: Orvosi hetilap 20030601

Title: New phosphodiesterase type 5 inhibitors in the management of erectile dysfunction.

Journal: The journal of the Royal Society for the Promotion of Health 20030601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20030501

Title: The phosphodiesterase inhibitor 'war'.

Journal: BJU international 20030401

Title: Sustained efficacy and tolerability of vardenafil, a highly potent selective phosphodiesterase type 5 inhibitor, in men with erectile dysfunction: results of a randomized, double-blind, 26-week placebo-controlled pivotal trial.

Journal: Urology 20030401

Title: [How effective are PDE-5 inhibitors?].

Journal: Der Urologe. Ausg. A 20030401

Title: Vardenafil reverses erectile dysfunction induced by paroxetine in rats.

Journal: International journal of impotence research 20030401

Title: Vardenafil enhances clitoral and vaginal blood flow responses to pelvic nerve stimulation in female dogs.

Journal: International journal of impotence research 20030401

Title: Pharmacological management of erectile dysfunction.

Journal: BJU international 20030301

Title: Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study.

Journal: Diabetes care 20030301

Title: Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction.

Journal: Journal of clinical pharmacology 20030301

Title: Gateways to clinical trials. March 2003.

Journal: Methods and findings in experimental and clinical pharmacology 20030301

Title: Pharmacology of phosphodiesterase 5 inhibitors.

Journal: The Canadian journal of urology 20030201

Title: [New potency pill. Treating (vascular) bed failure].

Journal: MMW Fortschritte der Medizin 20030130

Title: Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells.

Journal: Blood 20030101

Title: Effective treatment of erectile dysfunction with vardenafil.

Journal: Drugs of today (Barcelona, Spain : 1998) 20030101

Title: Effects of medical or surgical castration on erectile function in an animal model.

Journal: Journal of andrology 20030101

Title: Vardenafil: a review of its use in erectile dysfunction.

Journal: Drugs 20030101

Title: Novel PDE5 inhibitors for the treatment of male erectile dysfunction.

Journal: Reproductive biomedicine online 20030101

Title: FDA approves new drug for treatment of erectile dysfunction in men.

Journal: FDA consumer 20030101

Title: New tools 2003.

Journal: Diabetes self-management 20030101

Title: The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease.

Journal: Journal of the American College of Cardiology 20021204

Title: Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus.

Journal: International journal of impotence research 20021201

Title: Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil--review of the literature.

Journal: European journal of medical research 20021029

Title: Vardenafil.

Journal: Expert opinion on investigational drugs 20021001

Title: [Erectile dysfunction].

Journal: Actas urologicas espanolas 20021001

Title: Phosphodiesterase 5 inhibitors: current status and potential applications.

Journal: Nature reviews. Drug discovery 20020901

Title: Erectile dysfunction: oral pharmacotherapy options.

Journal: International journal of clinical pharmacology and therapeutics 20020901

Title: Gateways to Clinical Trials.

Journal: Methods and findings in experimental and clinical pharmacology 20020901

Title: [New medications for treatment of erectile dysfunction].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020601

Title: Tadalafil (Cialis) for men with erectile dysfunction.

Journal: International journal of clinical practice 20020501

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20020501

Title: Vardenafil Bayer Yakuhin.

Journal: Current opinion in investigational drugs (London, England : 2000) 20020401

Title: Coming together.

Journal: Diabetes, obesity & metabolism 20020301

Title: [Erectile dysfunction. New therapy options ante portas].

Journal: MMW Fortschritte der Medizin 20020214

Title: [Therapy of erectile dysfunction. New, highly selective PDE-5 inhibitor].

Journal: MMW Fortschritte der Medizin 20020214

Title: Vardenafil: update on clinical experience.

Journal: International journal of impotence research 20020201

Title: Efficacy of vardenafil and sildenafil in facilitating penile erection in an animal model.

Journal: Journal of andrology 20020101

Title: Vardenafil.

Journal: Drugs & aging 20020101

Title: Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat.

Journal: Neuroscience 20020101

Title: Pharmacology of phosphodiesterase-5 inhibitors.

Journal: International journal of clinical practice 20020101

Title: Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial.

Journal: Journal of andrology 20020101

Title: PDE-5 inhibition and sexual response: pharmacological mechanisms and clinical outcomes.

Journal: Annual review of sex research 20020101

Title: Towards optimal ED management: educational forum - II.

Journal: The Canadian journal of urology 20011201

Title: Study shows patients taking vardenafil consistently completed sexual intercourse.

Journal: Urologic nursing 20011201

Title: Current treatments and emerging therapeutic approaches in male erectile dysfunction.

Journal: BJU international 20011001

Title: The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil.

Journal: International journal of impotence research 20011001

Title: Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor.

Journal: Life sciences 20010928

Title: The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial.

Journal: International journal of impotence research 20010801

Title: A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erection.

Journal: International journal of impotence research 20010801

Title: Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose.

Journal: European urology 20010801

Title: Rabbits as models for impotence research.

Journal: International journal of impotence research 20010601

Title: Oral drug therapy for erectile dysfunction.

Journal: The Urologic clinics of North America 20010501

Title: The oral efficacy of vardenafil hydrochloride for inducing penile erection in a conscious rabbit model.

Journal: The Journal of urology 20010401

Title: Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: a RigiScan and pharmacokinetic study.

Journal: World journal of urology 20010201

Title: Saenz de Tejada I, et al. The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res. 2001;13(5):282-290.

Title: Ashour AE, et al. Vardenafil dihydrochloride. Profiles Drug Subst Excip Relat Methodol. 2014;39:515-544.

Title: Gresser U, et al. Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil--review of the literature. Eur J Med Res. 2002 Oct 29. 7(10):435-46.

Title: Oudot A, et al. Combination of BAY 60-4552 and vardenafil exerts proerectile facilitator effects in rats with cavernous nerve injury: a proof of concept study for the treatment of phosphodiesterase type 5 inhibitor failure. Eur Urol. 2011 Nov. 60(5):1020-6.

Title: Ahmed N, et al. Hepatoprotective role of vardenafil against experimentally induced hepatitis in mice. J Biochem Mol Toxicol. 2017 Mar. 31(3).

Title: Bódi B, et al. Long-Term PDE-5A Inhibition Improves Myofilament Function in Left and Right Ventricular Cardiomyocytes through Partially Different Mechanisms in Diabetic Rat Hearts. Antioxidants (Basel). 2021 Nov 6. 10(11):1776.

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Tags:224785-90-4 Molecular Formula|224785-90-4 MDL|224785-90-4 SMILES|224785-90-4 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-propyl-1H,4H-imidazo[4,3-f][1,2,4]triazin-4-one hydrochloride