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2257-09-2,MFCD00004821
Catalog No.:AA003HSN
2257-09-2 | 2-Phenylethyl isothiocyanate
Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%
in stock  
$22.00   $15.00
- +
5g
98%
in stock  
$50.00   $35.00
- +
25g
98%
in stock  
$122.00   $85.00
- +
100g
98%
in stock  
$366.00   $256.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003HSN
Chemical Name:
2-Phenylethyl isothiocyanate
CAS Number:
2257-09-2
Molecular Formula:
C9H9NS
Molecular Weight:
163.2395
MDL Number:
MFCD00004821
IUPAC Name:
2-isothiocyanatoethylbenzene
InChI:
InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2
InChI Key:
IZJDOKYDEWTZSO-UHFFFAOYSA-N
SMILES:
S=C=NCCc1ccccc1
EC Number:
218-855-5
UNII:
6U7TFK75KV
NSC Number:
87868
FEMA Number:
4014
Properties
Computed Properties
 
Complexity:
144  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
163.046g/mol
Formal Charge:
0
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
163.238g/mol
Monoisotopic Mass:
163.046g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
44.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.5  

Synonyms
 
2-phenylethyl isothiocyanate 
beta-phenylethyl isothiocyanate 
Phenylethyl isothiocyanate 
4-12-00-02476 (Beilstein Handbook Reference) 
A816267 
I01-3453 
I01-8790 
J-802164 
W-107466 
BRD-K56700933-001-02-1 
1-ISOTHIOCYANATO-2-PHENYLETHANE (1,1,2,2-D4) 
F0001-0795 
InChI=1/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 
(2-Isothiocyanatoethyl)benzene 
PEITC compound 
Phenylethylisothiocyanate 
beta-Phenethylisothiocyanat 
D07AOL 
ethyl-2-isothiocyanato acetate 
Phenylethyl isothiocyanate, 96% 
CID16741 
2-Phenethyl isothiocyanate, 96% - 25G 25g 
C058305 
Phenethyl mustard oil 
Phenylaethylsenfoel 
2-isothiocyanatoethylbenzene 
Benzene, (2-isothiocyanatoethyl)- 
PEITC 
Phenylethyl mustard oil 
2-phenylethylisothiocyanate 
PHENETHYLISOTHIOCYANATE 
PEITC 
2-phenethyl isothiocyanate 
ISOTHIOCYANIC ACID, PHENETHYL ESTER 
beta-Phenethyl isothiocyanate 
MFCD00004821 
beta-Phenylethyl isothiocyanate 
CHEBI:351346 
NSC 87868 
C9H9NS 
UNII-6U7TFK75KV 
Phenylaethylsenfoel [German] 
PEITC compound 
6U7TFK75KV 
CCRIS 3146 
CHEMBL151649 
.beta.-Phenethyl isothiocyanate 
1-Isothiocyanato-2-phenylethane 
.beta.-Phenylethyl isothiocyanate 
1-(2-isothiocyanatoethyl)benzene 
(2-Isothiocyanato-ethyl)-benzene 
IZJDOKYDEWTZSO-UHFFFAOYSA-N 
EINECS 218-855-5 
phenethyl isothiocyanate 
Isothiocyanic Acid 2-Phenylethyl Ester 
BRN 2084162 
2-phenylethanisothiocyanate 
phenethyl-isothiocyanate 
ACMC-1CLKQ 
2-phenethylisothiocyanate 
A-Phenethyl isothiocyanate 
DSSTox_CID_1120 
WLN: SCN2R 
beta-phenethylisothiocyanate 
phenethylisothiocyanate 
Epitope ID:138724 
b-phenylethyl isothiocyanate 
DSSTox_RID_75951 
DSSTox_GSID_21120 
2-phenyl ethyl isothiocyanate 
SCHEMBL156960 
Phenethyl isothiocyanate, 99% 
AC1L28L3 
DTXSID5021120 
CTK4E9755 
phenylethyl isothiocyanate 
IZJDOKYDEWTZSO-UHFFFAOYSA- 
(2-Isothiocyanatoethyl)benzene # 
2-Phenylethyl isothiocyanate, FG 
Benzene,(2-isothiocyanatoethyl)- 
HMS1783C17 
KS-00000YK1 
NSC87868 
ZERO/008133 
ZINC2022074 
Tox21_200100 
2-Phenylethyl isothiocyanate 
(2-Isothiocyanatoethyl)benzene, 9CI 
ANW-13714 
BBL009999 
BDBM50240850 
NSC-87868 
SBB002732 
STK397325 
AKOS000119469 
DB12695 
LS-7646 
Phenethyl isothiocyanate 
MCULE-7681211375 
NE22461 
Isothiocyanic acid beta-phenylethyl ester 
NCGC00248526-01 
NCGC00257654-01 
AC-12769 
AS-17373 
BP-12941 
NCI60_041942 
SC-75540 
2257-09-2 
U800 
CAS-2257-09-2 
AB1006056 
DB-045947 
Isothiocyanic acid .beta.-phenylethyl ester 
TC-102458 
FT-0604634 
P0986 
Phenethyl isothiocyanate, analytical standard 
ST50330661 
Literature

Title: Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells.

Journal: Environmental toxicology 20170101

Title: PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

Journal: Oncotarget 20161115

Title: Iron depletion in HCT116 cells diminishes the upregulatory effect of phenethyl isothiocyanate on heme oxygenase-1.

Journal: Toxicology and applied pharmacology 20160415

Title: Inhibition of crosstalk between Bcr-Abl and PKC signaling by PEITC, augments imatinib sensitivity in chronic myelogenous leukemia cells.

Journal: Chemico-biological interactions 20151205

Title: Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin.

Journal: Chemical research in toxicology 20141215

Title: Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.

Journal: Neoplasia (New York, N.Y.) 20140901

Title: Aberrant activation of M phase proteins by cell proliferation-evoking carcinogens after 28-day administration in rats.

Journal: Toxicology letters 20130607

Title: Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cells.

Journal: PloS one 20130101

Title: Time-related survival effects of two gluconasturtiin hydrolysis products on the terrestrial isopod Porcellio scaber.

Journal: Chemosphere 20121101

Title: Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells.

Journal: Analytical biochemistry 20121015

Title: miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein.

Journal: The Prostate 20121001

Title: Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121001

Title: Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent.

Journal: Cell stress & chaperones 20120901

Title: Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120901

Title: Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle.

Journal: Journal of medicinal food 20120901

Title: Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20120901

Title: Modulation of carcinogen metabolizing cytochromes P450 in rat liver and kidney by cabbage and sauerkraut juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate.

Journal: Phytotherapy research : PTR 20120801

Title: Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

Title: Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse model.

Journal: Journal of the National Cancer Institute 20120801

Title: Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo.

Journal: The Prostate 20120701

Title: β-Phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38.

Journal: Oral diseases 20120701

Title: Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2.

Journal: Journal of natural products 20120622

Title: Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile.

Journal: Journal of agricultural and food chemistry 20120606

Title: Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cells.

Journal: Molecular carcinogenesis 20120601

Title: Paclitaxel sensitivity of breast cancer cells requires efficient mitotic arrest and disruption of Bcl-xL/Bak interaction.

Journal: Breast cancer research and treatment 20120601

Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Journal: Journal of medicinal chemistry 20120524

Title: Molecular and life-history effects of a natural toxin on herbivorous and non-target soil arthropods.

Journal: Ecotoxicology (London, England) 20120501

Title: First study on antimicriobial activity and synergy between isothiocyanates and antibiotics against selected Gram-negative and Gram-positive pathogenic bacteria from clinical and animal source.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20120501

Title: Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment.

Journal: International journal of oncology 20120401

Title: Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde.

Journal: The Journal of biological chemistry 20120302

Title: Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor.

Journal: Molecular nutrition & food research 20120301

Title: Five decades with glutathione and the GSTome.

Journal: The Journal of biological chemistry 20120224

Title: Allyl isothiocyanate as a potential inducer of paraoxonase-1--studies in cultured hepatocytes and in mice.

Journal: IUBMB life 20120201

Title: Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Antimicrobial activities of phenethyl isothiocyanate isolated from horseradish.

Journal: Natural product research 20120101

Title: The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes.

Journal: Journal of oncology 20120101

Title: Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish.

Journal: PloS one 20120101

Title: A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer.

Journal: Journal of clinical bioinformatics 20120101

Title: Estrogen receptor-alpha 36 mediates mitogenic antiestrogen signaling in ER-negative breast cancer cells.

Journal: PloS one 20120101

Title: Astroglial pentose phosphate pathway rates in response to high-glucose environments.

Journal: ASN neuro 20120101

Title: Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death.

Journal: PloS one 20120101

Title: Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells.

Journal: PloS one 20120101

Title: Towards the understanding of microRNA and environmental factor interactions and their relationships to human diseases.

Journal: Scientific reports 20120101

Title: Modeling effective dosages in hormetic dose-response studies.

Journal: PloS one 20120101

Title: Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Current and future options for the management of phantom-limb pain.

Journal: Journal of pain research 20120101

Title: Cigarette smoke exposure-associated alterations to non-coding RNA.

Journal: Frontiers in genetics 20120101

Title: Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway.

Journal: PloS one 20120101

Title: Turning the 'mustard oil bomb' into a 'cyanide bomb': aromatic glucosinolate metabolism in a specialist insect herbivore.

Journal: PloS one 20120101

Title: Sulforaphane potentiates RNA damage induced by different xenobiotics.

Journal: PloS one 20120101

Title: A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications.

Journal: PloS one 20120101

Title: Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures.

Journal: Journal of ovarian research 20120101

Title: Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models.

Journal: BMC medicine 20120101

Title: Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model.

Journal: PloS one 20120101

Title: Effects of indole-3-carbinol and phenethyl isothiocyanate on bile and pancreatic juice excretion in rats.

Journal: The journal of medical investigation : JMI 20120101

Title: Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by β-phenethyl isothiocyanate: mechanisms for anti-leukemia activity.

Journal: Antioxidants & redox signaling 20111215

Title: Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung.

Journal: Mutation research 20111201

Title: Cancer chemoprevention by targeting the epigenome.

Journal: Current drug targets 20111201

Title: Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes.

Journal: International journal of obesity (2005) 20111201

Title: Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.

Journal: The British journal of nutrition 20111201

Title: NF-κB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death.

Journal: Oncogene 20111110

Title: Sulforaphane induces antioxidative and antiproliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells.

Journal: Journal of Korean medical science 20111101

Title: Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.

Journal: Clinical epigenetics 20111026

Title: Identification of potential protein targets of isothiocyanates by proteomics.

Journal: Chemical research in toxicology 20111017

Title: Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.

Journal: Molecular nutrition & food research 20111001

Title: Inorganic sulfur reduces the motility and invasion of MDA-MB-231 human breast cancer cells.

Journal: Nutrition research and practice 20111001

Title: Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.

Journal: The Journal of biological chemistry 20110923

Title: The expression of the pro-apoptotic gene Air is inducible in human pancreatic adenocarcinoma cells.

Journal: Journal of cellular physiology 20110901

Title: Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5.

Journal: Journal of agricultural and food chemistry 20110810

Title: Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality.

Journal: Archives of toxicology 20110801

Title: Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110801

Title: Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.

Journal: Bioorganic & medicinal chemistry letters 20110801

Title: Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma.

Journal: Haematologica 20110801

Title: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Journal: Nature 20110714

Title: In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.

Journal: Pest management science 20110701

Title: Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.

Journal: Biopharmaceutics & drug disposition 20110701

Title: Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells.

Journal: Anticancer research 20110501

Title: [Effect of phenethyl isothiocyanate given at different duration of gestation on the outcome of pregnancy in rats].

Journal: Wei sheng yan jiu = Journal of hygiene research 20110501

Title: Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

Journal: Journal of the National Cancer Institute 20110406

Title: Phenethyl isothiocyanate inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory responses in mouse skin.

Journal: Journal of medicinal food 20110401

Title: Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.

Journal: Cell death & disease 20110401

Title: Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate.

Journal: The British journal of nutrition 20110301

Title: Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts.

Journal: Pharmacological research 20110301

Title: Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.

Journal: Journal of medicinal chemistry 20110210

Title: Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells.

Journal: Carcinogenesis 20110201

Title: Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Exposure to isothiocyanates suppresses urinary mutagenicity in rats treated with heterocyclic amine IQ: lack of association with CYP1 activity.

Journal: Nutrition and cancer 20110101

Title: [Changes on neurobehavioral development of the offspring in rats prenataly exposed by phenethyl isothiocyanate].

Journal: Wei sheng yan jiu = Journal of hygiene research 20110101

Title: Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell death.

Journal: Molecular medicine reports 20110101

Title: NNK-Induced Lung Tumors: A Review of Animal Model.

Journal: Journal of oncology 20110101

Title: Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.

Journal: Molecular cancer 20110101

Title: The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.

Journal: PloS one 20110101

Title: Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3.

Journal: BMC cancer 20110101

Title: Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.

Journal: PloS one 20110101

Title: Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.

Journal: Chinese medicine 20110101

Title: Notch activation by phenethyl isothiocyanate attenuates its inhibitory effect on prostate cancer cell migration.

Journal: PloS one 20110101

Title: Mitochondrial peroxiredoxin III is a potential target for cancer therapy.

Journal: International journal of molecular sciences 20110101

Title: Selenium and lung cancer: a systematic review and meta analysis.

Journal: PloS one 20110101

Title: Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

Journal: Clinical epigenetics 20110101

Title: Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.

Journal: Molecular nutrition & food research 20101201

Title: Differential response of normal (PrEC) and cancerous human prostate cells (PC-3) to phenethyl isothiocyanate-mediated changes in expression of antioxidant defense genes.

Journal: Pharmaceutical research 20101201

Title: Determination of new biomarkers to monitor the dietary consumption of isothiocyanates.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20101201

Title: In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study.

Journal: The British journal of nutrition 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Loss of ERα and FOXA1 expression in a progression model of luminal type breast cancer: insights from PyMT transgenic mouse model.

Journal: Oncology reports 20101101

Title: Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate.

Journal: Blood 20101014

Title: Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450.

Journal: Archives of toxicology 20101001

Title: Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate.

Journal: Molecular nutrition & food research 20101001

Title: Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment.

Journal: PLoS medicine 20101001

Title: Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt-induced IFN-gamma secretion in LPS-activated peritoneal macrophages.

Journal: Molecular nutrition & food research 20100901

Title: Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review).

Journal: International journal of oncology 20100901

Title: Identification of biologically relevant compounds in aboveground and belowground induced volatile blends.

Journal: Journal of chemical ecology 20100901

Title: Multidirectional time-dependent effect of sinigrin and allyl isothiocyanate on metabolic parameters in rats.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20100901

Title: Evaluation of antibacterial activity of 3-butenyl, 4-pentenyl, 2-phenylethyl, and benzyl isothiocyanate in Brassica vegetables.

Journal: Journal of food science 20100901

Title: Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells.

Journal: The Journal of biological chemistry 20100820

Title: A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.

Journal: Journal of molecular biology 20100820

Title: Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates.

Journal: Chemical research in toxicology 20100816

Title: Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100801

Title: Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.

Journal: The Journal of nutrition 20100801

Title: Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

Journal: Journal of medicinal chemistry 20100722

Title: Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36.

Journal: Journal of cellular and molecular medicine 20100601

Title: Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

Title: Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways.

Journal: Anticancer research 20100601

Title: Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver.

Journal: Chemical research in toxicology 20100517

Title: Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM.

Journal: Carcinogenesis 20100501

Title: Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung.

Journal: Carcinogenesis 20100501

Title: Formation and distribution of NNK metabolites in an isolated perfused rat lung.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100501

Title: Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells.

Journal: International journal of food sciences and nutrition 20100501

Title: Antimicrobial activity of phenolics and glucosinolate hydrolysis products and their synergy with streptomycin against pathogenic bacteria.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20100501

Title: New biomarkers for monitoring the levels of isothiocyanates in humans.

Journal: Chemical research in toxicology 20100419

Title: Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.

Journal: Bioorganic & medicinal chemistry letters 20100415

Title: p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.

Journal: Cancer research 20100415

Title: Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivo.

Journal: Pharmaceutical research 20100401

Title: 6-Chloro-3-phenethyl-2-thioxo-2,3-di-hydro-quinazolin-4(1H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20100401

Title: Phytochemicals in cancer prevention and therapy: truth or dare?

Journal: Toxins 20100401

Title: Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables.

Journal: Toxins 20100401

Title: Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin.

Journal: FEBS letters 20100319

Title: Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine.

Journal: International journal of cancer 20100301

Title: Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats.

Journal: Molecular nutrition & food research 20100301

Title: Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention.

Journal: The AAPS journal 20100301

Title: Paradoxical roles for antioxidants in tumor prevention and eradication.

Journal: Cancer biology & therapy 20100301

Title: Pharmacological modulation of genome and proteome alterations in mice treated with the endocrine disruptor bisphenol A.

Journal: Current cancer drug targets 20100301

Title: Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables.

Journal: Toxicology 20100209

Title: Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs.

Journal: Cancer prevention research (Philadelphia, Pa.) 20100101

Title: A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.

Journal: Arthritis research & therapy 20100101

Title: Immunochemical detection of food-derived isothiocyanate as a lysine conjugate.

Journal: Bioscience, biotechnology, and biochemistry 20100101

Title: Oxidative stress in NSC-741909-induced apoptosis of cancer cells.

Journal: Journal of translational medicine 20100101

Title: Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages.

Journal: Mediators of inflammation 20100101

Title: Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study.

Journal: BMC cancer 20100101

Title: Dietary phenethylisothiocyanate attenuates bowel inflammation in mice.

Journal: BMC chemical biology 20100101

Title: Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.

Journal: BMC cancer 20100101

Title: Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.

Journal: PloS one 20100101

Title: Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.

Journal: Journal of molecular signaling 20100101

Title: Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.

Journal: PloS one 20100101

Title: Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling.

Journal: PloS one 20100101

Title: Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.

Journal: Chinese medicine 20100101

Title: Cigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells.

Journal: PloS one 20100101

Title: Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity.

Journal: PloS one 20100101

Title: Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin.

Journal: Journal of hematology & oncology 20100101

Title: Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment.

Journal: Toxins 20100101

Title: Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells.

Journal: European journal of nutrition 20091201

Title: Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates.

Journal: The Journal of biological chemistry 20091120

Title: Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery.

Journal: Biochemical and biophysical research communications 20091016

Title: Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells.

Journal: Molecular and cellular biochemistry 20091001

Title: Growth-inhibiting activities of phenethyl isothiocyanate and its derivatives against intestinal bacteria.

Journal: Journal of food science 20091001

Title: Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.

Journal: Biochemical pharmacology 20090801

Title: Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells.

Journal: Molecular nutrition & food research 20090701

Title: Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.

Journal: The Journal of biological chemistry 20090619

Title: Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090601

Title: Key residues controlling binding of diverse ligands to human cytochrome P450 2A enzymes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090601

Title: Initial in vitro evaluations of the antibacterial activities of glucosinolate enzymatic hydrolysis products against plant pathogenic bacteria.

Journal: Journal of applied microbiology 20090601

Title: Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice.

Journal: Cancer prevention research (Philadelphia, Pa.) 20090601

Title: Antimutagenic effect of phenethyl isothiocyanate.

Journal: Central European journal of public health 20090601

Title: Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling.

Journal: Chemico-biological interactions 20090515

Title: Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells.

Journal: Cancer research 20090415

Title: Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells.

Journal: Experimental biology and medicine (Maywood, N.J.) 20090301

Title: [Natural compounds in chemoprevention of esophageal squamous cell tumors--experimental studies].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20090201

Title: Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation.

Journal: Pharmaceutical research 20090101

Title: Phenethyl isothiocyanate induces cell cycle arrest and reduction of alpha- and beta-tubulin isotypes in human prostate cancer cells.

Journal: Cell biology international 20090101

Title: Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells.

Journal: Oncology reports 20090101

Title: Isothiocyanate profile and selective antibacterial activity of root, stem, and leaf extracts derived from Raphanus sativus L.

Journal: Foodborne pathogens and disease 20090101

Title: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells.

Journal: BMC gastroenterology 20090101

Title: Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response.

Journal: PloS one 20090101

Title: Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells.

Journal: Cancer cell international 20090101

Title: Differing mechanisms of simple nitrile formation on glucosinolate degradation in Lepidium sativum and Nasturtium officinale seeds.

Journal: Phytochemistry 20090101

Title: Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members.

Journal: PloS one 20090101

Title: Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosis.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20090101

Title: Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis.

Journal: British journal of cancer 20081209

Title: Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

Title: Budesonide and phenethyl isothiocyanate attenuate DNA damage in bronchoalveolar lavage cells of mice exposed to environmental cigarette smoke.

Journal: Current cancer drug targets 20081201

Title: Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells.

Journal: Archives of pharmacal research 20081201

Title: Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL.

Journal: Cancer letters 20081128

Title: Development of chitosan-SLN microparticles for chemotherapy: in vitro approach through efflux-transporter modulation.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20081112

Title: Acaricidal constituents isolated from Sinapis alba L. seeds and structure-activity relationships.

Journal: Journal of agricultural and food chemistry 20081112

Title: Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.

Journal: Journal of natural products 20081101

Title: [Effect of phenethyl isothiocyanate on expression of genes during differentiation process of mouse embryonic stem cells in vitro].

Journal: Wei sheng yan jiu = Journal of hygiene research 20081101

Title: Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.

Journal: Diabetes 20081001

Title: Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents.

Journal: Planta medica 20081001

Title: Genetic networks controlling structural outcome of glucosinolate activation across development.

Journal: PLoS genetics 20081001

Title: Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate.

Journal: Pharmaceutical research 20080901

Title: Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism.

Journal: Blood 20080901

Title: Cancer is a preventable disease that requires major lifestyle changes.

Journal: Pharmaceutical research 20080901

Title: Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates.

Journal: Free radical biology & medicine 20080815

Title: De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc.

Journal: International journal of oncology 20080801

Title: Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate.

Journal: Cancer research 20080801

Title: Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

Title: Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Journal: Journal of medicinal chemistry 20080612

Title: Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism.

Journal: Leukemia 20080601

Title: PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway.

Journal: The AAPS journal 20080601

Title: Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC).

Journal: Molecular carcinogenesis 20080501

Title: Cytochrome P450 2E1 in the substantia nigra: relevance for dopaminergic neurotransmission and free radical production.

Journal: Synapse (New York, N.Y.) 20080501

Title: Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

Journal: Journal of applied toxicology : JAT 20080301

Title: Herbal compounds and toxins modulating TRP channels.

Journal: Current neuropharmacology 20080301

Title: Barbarea vulgaris glucosinolate phenotypes differentially affect performance and preference of two different species of lepidopteran herbivores.

Journal: Journal of chemical ecology 20080201

Title: Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate.

Journal: PloS one 20080101

Title: Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.

Journal: Nutrition and cancer 20080101

Title: Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.

Journal: Chinese medicine 20080101

Title: Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context.

Journal: Molecular cancer 20080101

Title: Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents.

Journal: Biological chemistry 20071001

Title: The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.

Journal: Cancer research 20070701

Title: Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus.

Journal: Cancer research 20070701

Title: Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation.

Journal: The Prostate 20070601

Title: Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound.

Journal: Cancer biology & therapy 20070501

Title: Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.

Journal: Cancer research 20070415

Title: Kinetics of the stability of broccoli (Brassica oleracea Cv. Italica) myrosinase and isothiocyanates in broccoli juice during pressure/temperature treatments.

Journal: Journal of agricultural and food chemistry 20070321

Title: Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo.

Journal: Cancer research 20070301

Title: Does the consumption of green tea reduce the risk of lung cancer among smokers?

Journal: Evidence-based complementary and alternative medicine : eCAM 20070301

Title: Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer.

Journal: Molecular carcinogenesis 20070101

Title: Polymeric nanoparticle-encapsulated curcumin ('nanocurcumin'): a novel strategy for human cancer therapy.

Journal: Journal of nanobiotechnology 20070101

Title: Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate.

Journal: BMC cancer 20070101

Title: The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase.

Journal: BMC cancer 20070101

Title: CYP 2E1 mutant mice are resistant to DDC-induced enhancement of MPTP toxicity.

Journal: Journal of neural transmission. Supplementum 20070101

Title: Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages.

Journal: BioFactors (Oxford, England) 20070101

Title: Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation.

Journal: BioFactors (Oxford, England) 20070101

Title: Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cells.

Journal: The Journal of nutritional biochemistry 20061201

Title: Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations.

Journal: British journal of cancer 20061120

Title: Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.

Journal: Carcinogenesis 20061101

Title: Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray.

Journal: Life sciences 20061012

Title: Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation.

Journal: Gynecologic oncology 20061001

Title: Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate.

Journal: Carcinogenesis 20061001

Title: Enzymatic mechanisms of ethanol oxidation in the brain.

Journal: Alcoholism, clinical and experimental research 20060901

Title: Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

Journal: Cancer cell 20060901

Title: c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent.

Journal: Molecular carcinogenesis 20060801

Title: Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.

Journal: Molecular cancer therapeutics 20060801

Title: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae.

Journal: Mutation research 20060725

Title: Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2.

Journal: Cancer research 20060701

Title: Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G(1) cell cycle arrest.

Journal: International immunopharmacology 20060501

Title: Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.

Journal: Carcinogenesis 20060401

Title: In vitro and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate.

Journal: The Journal of pharmacology and experimental therapeutics 20060401

Title: Early loss of Fhit in the respiratory tract of rodents exposed to environmental cigarette smoke.

Journal: Cancer research 20060401

Title: Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells.

Journal: Journal of agricultural and food chemistry 20060308

Title: ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

Journal: Carcinogenesis 20060301

Title: Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.

Journal: Carcinogenesis 20060301

Title: The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells.

Journal: Anti-cancer drugs 20060301

Title: Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats.

Journal: Carcinogenesis 20060201

Title: Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.

Journal: Cancer research 20060115

Title: Current trends and perspectives in nutrition and cancer prevention.

Journal: Neoplasma 20060101

Title: Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene.

Journal: BMC cancer 20060101

Title: Modest induction of phase 2 enzyme activity in the F-344 rat prostate.

Journal: BMC cancer 20060101

Title: Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats.

Journal: Nutrition and cancer 20060101

Title: Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

Journal: Journal of applied toxicology : JAT 20060101

Title: Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada.

Journal: Journal of ethnobiology and ethnomedicine 20060101

Title: Cytochrome P450 and Parkinson's disease: protective role of neuronal CYP 2E1 from MPTP toxicity.

Journal: Journal of neural transmission. Supplementum 20060101

Title: Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

Journal: Journal of applied toxicology : JAT 20060101

Title: Modulation of multigene expression and proteome profiles by chemopreventive agents.

Journal: Mutation research 20051211

Title: Modulation of apoptosis by cancer chemopreventive agents.

Journal: Mutation research 20051211

Title: The time-dependent effect of gluconasturtiin and phenethyl isothiocyanate on metabolic and antioxidative parameters in rats.

Journal: Journal of animal physiology and animal nutrition 20051201

Title: Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats.

Journal: Toxicology 20051115

Title: Biofumigation: environmental impacts on the biological activity of diverse pure and plant-derived isothiocyanates.

Journal: Pest management science 20051101

Title: Pharmacokinetics of dietary phenethyl isothiocyanate in rats.

Journal: Pharmaceutical research 20051001

Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Journal: Current drug metabolism 20051001

Title: N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells.

Journal: Cancer research 20050915

Title: Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

Journal: Cancer research 20050915

Title: Chemoprevention of acrylamide toxicity by antioxidative agents in rats--effective suppression of testicular toxicity by phenylethyl isothiocyanate.

Journal: Archives of toxicology 20050901

Title: The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050901

Title: Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.

Journal: European journal of pharmacology 20050822

Title: Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein.

Journal: Biochemical pharmacology 20050815

Title: Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis.

Journal: World journal of gastroenterology 20050714

Title: Role of mitogen-activated protein kinases in phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.

Journal: Molecular carcinogenesis 20050701

Title: Induction of glutathione S-transferase and glutathione by toxic compounds and elicitors in reed canary grass.

Journal: Biotechnology letters 20050701

Title: Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

Journal: Oncogene 20050630

Title: Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages.

Journal: Nitric oxide : biology and chemistry 20050601

Title: Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050401

Title: Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion.

Journal: Toxicology letters 20050315

Title: Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model.

Journal: Cancer letters 20050310

Title: beta-Phenylethyl isothiocyanate mediated apoptosis: a proteomic investigation of early apoptotic protein changes.

Journal: Proteomics 20050301

Title: Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Journal: Archives of pharmacal research 20050301

Title: Beta-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway.

Journal: The international journal of biochemistry & cell biology 20050101

Title: Animal models and analytical approaches for understanding the relationships between wine and cancer.

Journal: Drugs under experimental and clinical research 20050101

Title: Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein).

Journal: Molecular pharmaceutics 20050101

Title: Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport.

Journal: Pharmaceutical research 20041201

Title: Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041001

Title: Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

Journal: Journal of neurochemistry 20041001

Title: Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.

Journal: Experimental biology and medicine (Maywood, N.J.) 20040901

Title: Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest.

Journal: Carcinogenesis 20040801

Title: Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport.

Journal: Journal of pharmaceutical sciences 20040701

Title: Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040701

Title: Potent chemopreventive agents against pancreatic cancer.

Journal: Current cancer drug targets 20040601

Title: Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells.

Journal: The Journal of pharmacology and experimental therapeutics 20040501

Title: The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis.

Journal: Carcinogenesis 20040501

Title: Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

Journal: Molecular cancer therapeutics 20040501

Title: Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line.

Journal: Pharmaceutical research 20040401

Title: Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway.

Journal: Pharmaceutical research 20040401

Title: Genetic and metabolic effects of gluconasturtiin, a glucosinolate derived from cruciferae.

Journal: Mutation research 20040112

Title: Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040101

Title: Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases.

Journal: Anticancer research 20040101

Title: Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3.

Journal: Nutrition and cancer 20040101

Title: Toxicological assessment of noxious inhalants.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20040101

Title: Phenethyl isothiocyanate inhibits nitrosamine carcinogenesis in a model for study of oral cancer chemoprevention.

Journal: Cancer letters 20031230

Title: Induction of GADD gene expression by phenethylisothiocyanate in human colon adenocarcinoma cells.

Journal: Journal of cellular biochemistry 20031215

Title: Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry.

Journal: Analytical biochemistry 20031201

Title: Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC).

Journal: Pharmaceutical research 20030901

Title: Quantitative evaluation of isothiocyanates as substrates and inhibitors of P-glycoprotein.

Journal: The Journal of pharmacy and pharmacology 20030901

Title: Ontogenic variations of ascorbic acid and phenethyl isothiocyanate concentrations in watercress (Nasturtium officinale R.Br.) leaves.

Journal: Journal of agricultural and food chemistry 20030827

Title: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

Journal: Carcinogenesis 20030801

Title: [Effects of ursolic acid on liver-protection and bile secretion].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030801

Title: beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells.

Journal: Cellular and molecular life sciences : CMLS 20030701

Title: Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.

Journal: Biochimica et biophysica acta 20030626

Title: Sensitivity of Meloidogyne javanica and Tylenchulus semipenetrans to Isothiocyanates in Laboratory Assays.

Journal: Phytopathology 20030601

Title: Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.

Journal: Carcinogenesis 20030301

Title: Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.

Journal: Carcinogenesis 20030301

Title: Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay.

Journal: Chemico-biological interactions 20030106

Title: Mechanism-based in vitro screening of potential cancer chemopreventive agents.

Journal: Mutation research 20030101

Title: Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis.

Journal: Mutation research 20030101

Title: Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats.

Journal: Toxicologic pathology 20030101

Title: An investigation of dopaminergic metabolites in the striatum and in the substantia nigra in vivo utilising radiolabelled L-DOPA and high performance liquid chromatography: a new approach in the search for transmitter metabolites.

Journal: Neuroscience 20030101

Title: Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes.

Journal: Nutrition and cancer 20030101

Title: Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.

Journal: The Journal of biological chemistry 20021018

Title: In vitro induction of benzo(a)pyrene cell-transforming activity by the glucosinolate gluconasturtiin found in cruciferous vegetables.

Journal: Cancer letters 20021008

Title: Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.

Journal: Pharmaceutical research 20021001

Title: Effect of nicotine, cotinine and phenethyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in the Syrian golden hamster.

Journal: Toxicology 20020930

Title: Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.

Journal: Carcinogenesis 20020901

Title: Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination.

Journal: Carcinogenesis 20020901

Title: Rapid in vivo assay for topical oral cancer chemopreventive agents.

Journal: International journal of oncology 20020701

Title: Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.

Journal: Cancer research 20020701

Title: The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.

Journal: Pharmaceutical research 20020701

Title: Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3.

Journal: The Journal of biological chemistry 20020510

Title: Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents.

Journal: Carcinogenesis 20020201

Title: [Determination of isothiocyanates and related compounds in mustard extract and horseradish extract used as natural food additives].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20020201

Title: Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators.

Journal: The Biochemical journal 20020115

Title: Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis.

Journal: Cancer research 20020101

Title: 4-(Methylthio)-3-butenyl isothiocyanate, a principal antimutagen in daikon (Raphanus sativus; Japanese white radish).

Journal: Journal of agricultural and food chemistry 20011201

Title: Barbarea verna as a source of 2-phenylethyl glucosinolate, precursor of cancer chemopreventive phenylethyl isothiocyanate.

Journal: Fitoterapia 20011101

Title: Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.

Journal: Chemical research in toxicology 20010901

Title: Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.

Journal: Cancer research 20010815

Title: Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010801

Title: Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents.

Journal: Mutation research 20010725

Title: Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A.

Journal: Archives of biochemistry and biophysics 20010701

Title: Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?

Journal: Synapse (New York, N.Y.) 20010615

Title: Cell-type specific differences in glutamate cysteine ligase transcriptional regulation demonstrate independent subunit control.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010601

Title: Consumption of watercress fails to alter coumarin metabolism in humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010601

Title: High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate.

Journal: Analytical biochemistry 20010415

Title: Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.

Journal: Cancer research 20010315

Title: Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK.

Journal: British journal of cancer 20010301

Title: Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats.

Journal: Carcinogenesis 20010301

Title: Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro.

Journal: Biochemical pharmacology 20010115

Title: Investigation of the enhancement of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis by 6-phenylhexyl isothiocyanate.

Journal: Cancer letters 20010110

Title: Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol.

Journal: Medical hypotheses 20010101

Title: Inhibition of carcinogenesis and toxicity by dietary constituents.

Journal: Advances in experimental medicine and biology 20010101

Title: Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

Journal: Drug metabolism reviews 20010101

Title: Comparative tissue-specific toxicities of 20 cancer preventive agents using cultured cells from 8 different normal human epithelia.

Journal: In vitro & molecular toxicology 20010101

Title: Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis.

Journal: Nutrition and cancer 20010101

Title: Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.

Journal: Biochemical pharmacology 20000715

Title: Metabolism of N-nitrosobenzylmethylamine by human cytochrome P-450 enzymes.

Journal: Journal of toxicology and environmental health. Part A 19991210

Title: Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.

Journal: Carcinogenesis 19981101

Title: Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

Journal: Cancer research 19980201

Title: Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism.

Journal: Carcinogenesis 19970901

Title: Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model.

Journal: International journal of cancer 19970703

Title: Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).

Journal: Carcinogenesis 19951201

Title: Phenethyl isothiocyanate, a new dietary liver aldehyde dehydrogenase inhibitor.

Journal: The Journal of pharmacology and experimental therapeutics 19951001

Title: Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions.

Journal: European journal of biochemistry 19950615

Title: Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases.

Journal: Biochemical and biophysical research communications 19950117

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