Title: Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite.
Journal: Toxicology 20171201
Title: Dexrazoxane Averts Idarubicin-Evoked Genomic Damage by Regulating Gene Expression Profiling Associated With the DNA Damage-Signaling Pathway in BALB/c Mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20171101
Title: Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice.
Journal: Toxicology and applied pharmacology 20160315
Title: Early and delayed cardioprotective intervention with dexrazoxane each show different potential for prevention of chronic anthracycline cardiotoxicity in rabbits.
Journal: Toxicology 20130915
Title: Response-dependent and reduced treatment in lower risk Hodgkin lymphoma in children and adolescents, results of P9426: a report from the Children's Oncology Group.
Journal: Pediatric blood & cancer 20121215
Title: Use of the cardioprotectants thymosin β4 and dexrazoxane during congenital heart surgery: proposal for a randomized, double-blind, clinical trial.
Journal: Annals of the New York Academy of Sciences 20121001
Title: BET 3: emergency management of anthracycline extravasation.
Journal: Emergency medicine journal : EMJ 20120901
Title: Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts.
Journal: Canadian journal of physiology and pharmacology 20120901
Title: Dexrazoxane for the prevention of cardiac toxicity and treatment of extravasation injury from the anthracycline antibiotics.
Journal: Current pharmaceutical biotechnology 20120801
Title: Dexrazoxane does not affect treatment outcome in non-Hodgkin's lymphoma patients.
Journal: American journal of hematology 20120801
Title: Effects of MnDPDP and ICRF-187 on Doxorubicin-Induced Cardiotoxicity and Anticancer Activity.
Journal: Translational oncology 20120801
Title: Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120710
Title: Cardiotoxicity in childhood cancer survivors: strategies for prevention and management.
Journal: Future cardiology 20120701
Title: Chemotherapy-induced cardiotoxicity.
Journal: Current heart failure reports 20120601
Title: Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training.
Journal: American journal of physiology. Heart and circulatory physiology 20120515
Title: Savene® (dexrazoxane) use in clinical practice.
Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120501
Title: Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120401
Title: Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity.
Journal: Canadian journal of physiology and pharmacology 20120401
Title: Dexrazoxane ameliorates doxorubicin-induced injury in mouse ovarian cells.
Journal: Biology of reproduction 20120301
Title: Clinical and genetic determinants of anthracycline-induced cardiac iron accumulation.
Journal: International journal of cardiology 20120209
Title: Treatment of experimental extravasation of amrubicin, liposomal doxorubicin, and mitoxantrone with dexrazoxane.
Journal: Cancer chemotherapy and pharmacology 20120201
Title: Dexrazoxane treatment of doxorubicin extravasation injury in four dogs.
Journal: Journal of the American Veterinary Medical Association 20120201
Title: Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.
Journal: Nature 20120112
Title: Recovery of symptomatic extravasation of liposomal doxorubicin after dexrazoxane treatment.
Journal: Anti-cancer drugs 20120101
Title: Mitochondria death/survival signaling pathways in cardiotoxicity induced by anthracyclines and anticancer-targeted therapies.
Journal: Biochemistry research international 20120101
Title: Strain echocardiography in early detection of Doxorubicin-induced left ventricular dysfunction in children with acute lymphoblastic leukemia.
Journal: ISRN pediatrics 20120101
Title: Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats.
Journal: Indian journal of pharmacology 20120101
Title: Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma.
Journal: Clinical sarcoma research 20120101
Title: Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats.
Journal: Oxidative medicine and cellular longevity 20120101
Title: A low dose of doxorubicin improves antioxidant defence system and modulates anaerobic metabolism during the development of lymphoma.
Journal: Indian journal of pharmacology 20120101
Title: Targeted therapies in sarcomas: challenging the challenge.
Journal: Sarcoma 20120101
Title: Sensitivity to TOP2 targeting chemotherapeutics is regulated by Oct1 and FILIP1L.
Journal: PloS one 20120101
Title: Prevention and treatment of doxorubicin-induced cardiotoxicity by dexrazoxane and schisandrin B in rabbits.
Journal: International journal of toxicology 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity.
Journal: Toxicology 20111118
Title: Moving forward with new data and approaches: a fresh look at anthracyclines in non-Hodgkin's lymphoma.
Journal: Hematology reports 20111028
Title: Anthracyclines: a cornerstone in the management of non-Hodgkin's lymphoma.
Journal: Hematology reports 20111028
Title: SIOG (International Society of Geriatric Oncology) recommendations for anthracycline use in the elderly.
Journal: Hematology reports 20111028
Title: Cardioprotective effect of dexrazoxane in a rat model of myocardial infarction: anti-apoptosis and promoting angiogenesis.
Journal: International journal of cardiology 20111020
Title: Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity.
Journal: Cell death & disease 20110801
Title: Salubrious effects of dexrazoxane against teniposide-induced DNA damage and programmed cell death in murine marrow cells.
Journal: Mutagenesis 20110701
Title: Cardioprotective interventions for cancer patients receiving anthracyclines.
Journal: The Cochrane database of systematic reviews 20110615
Title: The low incidence of secondary acute myelogenous leukaemia in children and adolescents treated with dexrazoxane for acute lymphoblastic leukaemia: a report from the Dana-Farber Cancer Institute ALL Consortium.
Journal: European journal of cancer (Oxford, England : 1990) 20110601
Title: Mechanisms and management of doxorubicin cardiotoxicity.
Journal: Herz 20110601
Title: Pharmacokinetics of dexrazoxane in subjects with impaired kidney function.
Journal: Journal of clinical pharmacology 20110501
Title: Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity.
Journal: British journal of pharmacology 20110501
Title: Anthracycline-associated cardiotoxicity in survivors of childhood cancer.
Journal: Pediatric cardiology 20110301
Title: [Extravasation of cytostatic drugs].
Journal: Magyar onkologia 20110301
Title: Extravasation management: clinical update.
Journal: Seminars in oncology nursing 20110201
Title: Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites--the cardioprotectant dexrazoxane as a model case.
Journal: Journal of chromatography. A 20110121
Title: Should anthracyclines and dexrazoxane be used for children with cancer?
Journal: The Lancet. Oncology 20110101
Title: Cardiac function in long-term survivors of childhood lymphoma.
Journal: Cardiology research and practice 20110101
Title: Cardiovascular effects in childhood cancer survivors treated with anthracyclines.
Journal: Cardiology research and practice 20110101
Title: A multicenter prospective phase II randomized trial of epirubicin/vinorelbine versus pegylated liposomal doxorubicin/vinorelbine as first-line treatment in advanced breast cancer. A GOIM study.
Journal: Journal of experimental & clinical cancer research : CR 20110101
Title: Review of cardiotoxicity in pediatric cancer patients: during and after therapy.
Journal: Cardiology research and practice 20110101
Title: Cardiomyocyte specific ablation of p53 is not sufficient to block doxorubicin induced cardiac fibrosis and associated cytoskeletal changes.
Journal: PloS one 20110101
Title: An in vitro comparison of the effects of the iron-chelating agents, CP94 and dexrazoxane, on protoporphyrin IX accumulation for photodynamic therapy and/or fluorescence guided resection.
Journal: Photochemistry and photobiology 20110101
Title: An integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase II.
Journal: PloS one 20110101
Title: Assessment of anti-cytogenotoxic effects of quercetin in animals treated with topotecan.
Journal: Oxidative medicine and cellular longevity 20110101
Title: Evaluation of chromosomal instability in diabetic rats treated with naringin.
Journal: Oxidative medicine and cellular longevity 20110101
Title: Flavaglines alleviate doxorubicin cardiotoxicity: implication of Hsp27.
Journal: PloS one 20110101
Title: [Cardiotoxicity of conservative treatment of solid tumors].
Journal: Likars'ka sprava 20110101
Title: Safety of concurrent administration of dexrazoxane and doxorubicin in the canine cancer patient.
Journal: Veterinary and comparative oncology 20101201
Title: Can anthracycline therapy for pediatric malignancies be less cardiotoxic?
Journal: Current oncology reports 20101101
Title: Dexrazoxane as a cardioprotectant in children receiving anthracyclines.
Journal: The oncologist 20101101
Title: Scavenging effects of dexrazoxane on free radicals.
Journal: Journal of clinical biochemistry and nutrition 20101101
Title: Comparison of doxorubicin cardiotoxicity in pediatric sarcoma patients when given with dexrazoxane versus as continuous infusion.
Journal: Pediatric hematology and oncology 20101001
Title: Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial.
Journal: The Lancet. Oncology 20101001
Title: Cardiac side-effects of cancer chemotherapy.
Journal: International journal of cardiology 20100924
Title: Successful dexrazoxane treatment of a potentially severe extravasation of concentrated doxorubicin.
Journal: Anti-cancer drugs 20100901
Title: Dexrazoxane for preventing anthracycline cardiotoxicity in children with solid tumors.
Journal: Journal of Korean medical science 20100901
Title: Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats.
Journal: Cancer chemotherapy and pharmacology 20100701
Title: Successful experience utilizing dexrazoxane treatment for an anthracycline extravasation.
Journal: The Annals of pharmacotherapy 20100501
Title: The effect of dexrazoxane for clinical and subclinical cardiotoxicity in children with acute myeloid leukemia.
Journal: Journal of pediatric hematology/oncology 20100501
Title: In vitro and in vivo study on the antioxidant activity of dexrazoxane.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100401
Title: Mechanisms of myocyte cytotoxicity induced by the multikinase inhibitor sorafenib.
Journal: Cardiovascular toxicology 20100301
Title: [Extra- and paravasation of cytotoxic drugs. Pathomechanisms and current preventive measures].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20100301
Title: A murine experimental anthracycline extravasation model: pathology and study of the involvement of topoisomerase II alpha and iron in the mechanism of tissue damage.
Journal: Toxicology 20100227
Title: Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000).
Journal: Leukemia 20100201
Title: Naproxen aggravates doxorubicin-induced cardiomyopathy in rats.
Journal: Indian journal of pharmacology 20100201
Title: Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention.
Journal: Journal of the National Cancer Institute 20100106
Title: Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I(Ks).
Journal: British journal of pharmacology 20100101
Title: Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane.
Journal: The Journal of pharmacology and experimental therapeutics 20100101
Title: Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro.
Journal: Oncology reports 20100101
Title: Antimuscarinic action of doxorubicin does not involve free-radical formation in isolated guinea pig hearts.
Journal: Canadian journal of physiology and pharmacology 20100101
Title: Drugs and pharmaceuticals: management of intoxication and antidotes.
Journal: EXS 20100101
Title: [Schisandrin B prevents doxorubicin-induced cardiotoxicity in rabbits].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100101
Title: Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors.
Journal: Molecular cancer 20100101
Title: Long-term efficiency and toxicity of adjuvant dose-dense sequential adriamycin-Paclitaxel-cyclophosphamide chemotherapy in high-risk breast cancer.
Journal: Oncology 20100101
Title: Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials.
Journal: BMC cancer 20100101
Title: [Dexrazoxane in anthracycline induced cardiotoxicity and extravasation].
Journal: Nederlands tijdschrift voor geneeskunde 20100101
Title: Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?
Journal: Progress in cardiovascular diseases 20100101
Title: Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.
Journal: PloS one 20100101
Title: Chemotherapy in Ewing's sarcoma.
Journal: Indian journal of orthopaedics 20100101
Title: Clinical trials and progress with paclitaxel in ovarian cancer.
Journal: International journal of women's health 20100101
Title: Good clinical and cost outcomes using dexrazoxane to treat accidental epirubicin extravasation.
Journal: Journal of cancer research and therapeutics 20100101
Title: Treatment of cancer in the older aged person.
Journal: Mediterranean journal of hematology and infectious diseases 20100101
Title: Serial Assessment of Cardiac Function during and following Mitoxantrone Infusion in 30 Consecutive Patients with Multiple Sclerosis.
Journal: Multiple sclerosis international 20100101
Title: Induction of thrombospondin-1 partially mediates the anti-angiogenic activity of dexrazoxane.
Journal: British journal of cancer 20090915
Title: Protection of mouse bone marrow from etoposide-induced genomic damage by dexrazoxane.
Journal: Cancer chemotherapy and pharmacology 20090901
Title: Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death.
Journal: British journal of cancer 20090901
Title: Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090701
Title: The iron chelator Dp44mT does not protect myocytes against doxorubicin.
Journal: Journal of inorganic biochemistry 20090701
Title: Cardiac lesions induced by testosterone: protective effects of dexrazoxane and trimetazidine.
Journal: Cardiovascular toxicology 20090601
Title: Topoisomerase II{alpha}-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin.
Journal: Molecular cancer therapeutics 20090501
Title: Chemotherapy induced cardiomyopathy: pathogenesis, monitoring and management.
Journal: Journal of clinical medicine research 20090401
Title: Dexrazoxane: new indication. Anthracycline extravasation: continue using dimethyl sulfoxide.
Journal: Prescrire international 20090201
Title: Dexrazoxane protects against doxorubicin-induced cardiomyopathy: upregulation of Akt and Erk phosphorylation in a rat model.
Journal: Cancer chemotherapy and pharmacology 20090101
Title: American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090101
Title: Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.
Journal: BMC medical genomics 20090101
Title: Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron.
Journal: Pharmacological reports : PR 20090101
Title: N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes.
Journal: BMC pharmacology 20090101
Title: Primary Adult Renal Ewing's Sarcoma: A Rare Entity.
Journal: Sarcoma 20090101
Title: Anthracycline extravasation injuries: management with dexrazoxane.
Journal: Therapeutics and clinical risk management 20090101
Title: Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort.
Journal: BMJ (Clinical research ed.) 20090101
Title: In vitro viability and cytotoxicity testing and same-well multi-parametric combinations for high throughput screening.
Journal: Current chemical genomics 20090101
Title: QTc prolongation assessment in anticancer drug development: clinical and methodological issues.
Journal: Ecancermedicalscience 20090101
Title: Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib.
Journal: Molecular pharmacology 20081201
Title: Optimal treatment strategies in postmenopausal women with hormone-receptor-positive and HER2-negative metastatic breast cancer.
Journal: Breast cancer research and treatment 20081201
Title: A novel mutation in the GATA1 gene associated with acute megakaryoblastic leukemia in a Korean Down syndrome patient.
Journal: Journal of Korean medical science 20081201
Title: Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity.
Journal: Expert review of cardiovascular therapy 20081101
Title: Dexrazoxane treatment for intrathoracic anthracycline extravasation.
Journal: Onkologie 20081101
Title: Dexrazoxane: a second look. Prevention of anthracycline cardiotoxicity: useful for some patients.
Journal: Prescrire international 20081001
Title: The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080901
Title: Asbestos induces doxorubicin resistance in MM98 mesothelioma cells via HIF-1alpha.
Journal: The European respiratory journal 20080801
Title: Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo.
Journal: The Journal of pharmacology and experimental therapeutics 20080701
Title: Systemic treatments for mesothelioma: standard and novel.
Journal: Current treatment options in oncology 20080601
Title: Cardioprotective interventions for cancer patients receiving anthracyclines.
Journal: The Cochrane database of systematic reviews 20080416
Title: Dexrazoxane (Totect): FDA review and approval for the treatment of accidental extravasation following intravenous anthracycline chemotherapy.
Journal: The oncologist 20080401
Title: Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking.
Journal: Molecular pharmacology 20080301
Title: Absence of secondary malignant neoplasms in children with high-risk acute lymphoblastic leukemia treated with dexrazoxane.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080301
Title: [The significance of extravasation in oncological care].
Journal: Magyar onkologia 20080301
Title: The use of dexrazoxane for the prevention of anthracycline extravasation injury.
Journal: Expert opinion on investigational drugs 20080201
Title: Matters of the heart: cardiac toxicity of adjuvant systemic therapy for early-stage breast cancer.
Journal: Current oncology (Toronto, Ont.) 20080101
Title: Chelators controlling metal metabolism and toxicity pathways: applications in cancer prevention, diagnosis and treatment.
Journal: Hemoglobin 20080101
Title: Outpatient and home chemotherapy with novel local control strategies in desmoplastic small round cell tumor.
Journal: Sarcoma 20080101
Title: Cardioprotective effect of dexrazoxane in patients with breast cancer treated with anthracyclines in adjuvant setting: a 10-year single institution experience.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101
Title: Aqueous fish extract increases survival in the mouse model of cytostatic toxicity.
Journal: Journal of experimental & clinical cancer research : CR 20080101
Title: Effect of dexrazoxane and amifostine on the vertebral bone quality of Doxorubicin treated male rats.
Journal: The open orthopaedics journal 20080101
Title: Extravasational side effects of cytotoxic drugs: A preventable catastrophe.
Journal: Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India 20080101
Title: Effects of dexrazoxane and amifostine on evolution of Doxorubicin cardiomyopathy in vivo.
Journal: Experimental biology and medicine (Maywood, N.J.) 20071201
Title: Anthracycline-induced cardiotoxicity and the cardiac-sparing effect of liposomal formulation.
Journal: International journal of nanomedicine 20071201
Title: Subacute cardiotoxicity caused by anthracycline therapy in children: can dexrazoxane prevent this effect?
Journal: European journal of pediatrics 20071101
Title: The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II study.
Journal: British journal of cancer 20071022
Title: Re: Totect: a new agent for treating anthracycline extravasation.
Journal: Clinical journal of oncology nursing 20071001
Title: Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane.
Journal: Cancer research 20070915
Title: Use of cardiac markers to assess the toxic effects of anthracyclines given to children with cancer: a systematic review.
Journal: European journal of cancer (Oxford, England : 1990) 20070901
Title: Do antioxidants interfere with radiation therapy for cancer?
Journal: Integrative cancer therapies 20070901
Title: Extravasation management.
Journal: Seminars in oncology nursing 20070801
Title: Dexrazoxane for anthracycline extravasation.
Journal: Expert review of anticancer therapy 20070801
Title: [Chemotherapeutics-induced heart failure].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20070715
Title: Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats.
Journal: British journal of pharmacology 20070701
Title: Management of anthracycline extravasation injuries.
Journal: The Annals of pharmacotherapy 20070701
Title: Cardioprotection against the toxic effects of anthracyclines given to children with cancer: a systematic review.
Journal: Health technology assessment (Winchester, England) 20070701
Title: Anticancer prodrugs of butyric acid and formaldehyde protect against doxorubicin-induced cardiotoxicity.
Journal: British journal of cancer 20070604
Title: Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management.
Journal: Expert opinion on pharmacotherapy 20070601
Title: Totect: a new agent for treating anthracycline extravasation.
Journal: Clinical journal of oncology nursing 20070601
Title: Nanoparticles in modern medicine: state of the art and future challenges.
Journal: International journal of nanomedicine 20070601
Title: Prevention of anthracycline-induced cardiotoxicity in children: the evidence.
Journal: European journal of cancer (Oxford, England : 1990) 20070501
Title: Phase I Trial of G3139, a bcl-2 antisense oligonucleotide, combined with doxorubicin and cyclophosphamide in children with relapsed solid tumors: a Children's Oncology Group Study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070420
Title: Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070301
Title: Caspase-dependent and -independent suppression of apoptosis by monoHER in Doxorubicin treated cells.
Journal: British journal of cancer 20070212
Title: Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin's disease.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070210
Title: Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia.
Journal: Blood 20070201
Title: Long-term effects of treatments for childhood cancers.
Journal: Current opinion in pediatrics 20070201
Title: Clinical and cost-effectiveness of cardioprotection against the toxic effects of anthracyclines given to children with cancer: a systematic review.
Journal: British journal of cancer 20070129
Title: Preclinical assessment of anthracycline cardiotoxicity in laboratory animals: predictiveness and pitfalls.
Journal: Cell biology and toxicology 20070101
Title: Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1.
Journal: Alternative therapies in health and medicine 20070101
Title: Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, Part 2.
Journal: Alternative therapies in health and medicine 20070101
Title: Evaluation of ECG time intervals in a rabbit model of anthracycline-induced cardiomyopathy: a useful tool for assessment of cardioprotective agents.
Journal: Physiological research 20070101
Title: Molecular and cellular mechanisms of anthracycline cardiotoxicity.
Journal: Cardiovascular toxicology 20070101
Title: Anthracycline cardiotoxicity in long-term survivors of childhood cancer.
Journal: Cardiovascular toxicology 20070101
Title: Long-term and short-term models for studying anthracycline cardiotoxicity and protectors.
Journal: Cardiovascular toxicology 20070101
Title: Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?
Journal: Cardiovascular toxicology 20070101
Title: Other uses of dexrazoxane: Savene, the first proven antidote against anthracycline extravasation injuries.
Journal: Cardiovascular toxicology 20070101
Title: Treatment of doxorubicin extravasation with intravenous dexrazoxane in a cat.
Journal: Journal of veterinary internal medicine 20070101
Title: Anthracycline antibiotics induce acute renal tubular toxicity in children with cancer.
Journal: Pathology oncology research : POR 20070101
Title: Antivasoconstrictor effect of the neuroprotective agent dexrazoxane in rat aorta.
Journal: Life sciences 20061214
Title: Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.
Journal: British journal of pharmacology 20061201
Title: Intrapleural extravasation of epirubicin, 5-fluouracil, and cyclophosphamide, treated with dexrazoxane.
Journal: International journal of clinical oncology 20061201
Title: Left ventricular systolic function assessed by echocardiography in children and adolescents with osteosarcoma treated with doxorubicin alone or in combination with dexrazoxane.
Journal: Arquivos brasileiros de cardiologia 20061201
Title: Anthracycline cardiotoxicity.
Journal: Expert opinion on drug safety 20061101
Title: Prevention of chronic anthracycline cardiotoxicity in the adult Fischer 344 rat by dexrazoxane and effects on iron metabolism.
Journal: Cancer chemotherapy and pharmacology 20061001
Title: Dexrazoxane prevents myocardial ischemia/reperfusion-induced oxidative stress in the rat heart.
Journal: Cardiovascular drugs and therapy 20061001
Title: A phase I study of intravenous liposomal daunorubicin (DaunoXome) in paediatric patients with relapsed or resistant solid tumours.
Journal: British journal of cancer 20060904
Title: Feasibility of radiotherapy after high-dose dense chemotherapy with epirubicin, preceded by dexrazoxane, and paclitaxel for patients with high-risk Stage II-III breast cancer.
Journal: International journal of radiation oncology, biology, physics 20060715
Title: Treatment of anthracycline extravasation with dexrazoxane -- clinical experience.
Journal: Onkologie 20060701
Title: Exposure to anthracyclines during childhood causes cardiac injury.
Journal: Seminars in oncology 20060601
Title: Cardiotoxic consequences of anthracycline-containing therapy in patients with breast cancer.
Journal: Seminars in oncology 20060601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060601
Title: Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin.
Journal: Circulation 20060509
Title: Multicenter randomized phase III study of the cardioprotective effect of dexrazoxane (Cardioxane) in advanced/metastatic breast cancer patients treated with anthracycline-based chemotherapy.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060401
Title: Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase.
Journal: Cardiovascular research 20060215
Title: Experimental study of dexrazoxane-anthracycline combinations using the model of isolated perfused rat heart.
Journal: Toxicology letters 20060208
Title: Late anthracycline cardiotoxicity protection by dexrazoxane (ICRF-187) in pediatric patients: echocardiographic follow-up.
Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060201
Title: Altered responsiveness of the guinea-pig isolated ileum to smooth muscle stimulants and to electrical stimulation after in situ ischemia.
Journal: British journal of pharmacology 20060201
Title: Anticancer agents and cardiotoxicity.
Journal: Seminars in oncology 20060201
Title: Extravasation of chemotherapeutic agents: prevention and treatment.
Journal: Seminars in oncology 20060201
Title: Dexrazoxane use in the prevention of anthracycline extravasation injury.
Journal: Future oncology (London, England) 20060201
Title: Treatment of anthracycline extravasation in mice with dexrazoxane with or without DMSO and hydrocortisone.
Journal: Cancer chemotherapy and pharmacology 20060101
Title: Suppression of mitoxantrone cardiotoxicity in multiple sclerosis patients by dexrazoxane.
Journal: Annals of neurology 20060101
Title: [Subacute cardiotoxicity caused by anthracycline therapy in children: can dexrazoxane prevent this effect?].
Journal: Magyar onkologia 20060101
Title: Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma.
Journal: BMC cancer 20060101
Title: The radiation response of sarcomas by histologic subtypes: a review with special emphasis given to results achieved with razoxane.
Journal: Sarcoma 20060101
Title: [Dexrazoxane (ICRF-187)--a cardioprotectant and modulator of action of some anticancer drugs].
Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20060101
Title: Cardioprotective effect of dexrazoxane during treatment with doxorubicin: a study using low-dose dobutamine stress echocardiography.
Journal: Pediatric blood & cancer 20051201
Title: Effect of epirubicin-based chemotherapy and dexrazoxane supplementation on QT dispersion in non-Hodgkin lymphoma patients.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20051201
Title: Long-term serial echocardiographic examination of late anthracycline cardiotoxicity and its prevention by dexrazoxane in paediatric patients.
Journal: European journal of pediatrics 20051101
Title: Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051001
Title: Combining etoposide and dexrazoxane synergizes with radiotherapy and improves survival in mice with central nervous system tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050915
Title: Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050901
Title: Amifostine and dexrazoxane enhance the rapid loss of bone mass and further deterioration of vertebrae architecture in female rats.
Journal: Calcified tissue international 20050901
Title: Molecular pharmacology of the interaction of anthracyclines with iron.
Journal: Molecular pharmacology 20050801
Title: CD95/Apo-1/Fas: independent cell death induced by doxorubicin in normal cultured cardiomyocytes.
Journal: Cancer immunology, immunotherapy : CII 20050701
Title: Monitoring cardiac function in patients receiving doxorubicin.
Journal: Seminars in nuclear medicine 20050701
Title: Dexrazoxane for the prevention of cardiomyopathy in anthracycline treated pediatric cancer patients.
Journal: Pediatric blood & cancer 20050615
Title: Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050601
Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.
Journal: Chemical research in toxicology 20050601
Title: Dexrazoxane protects against myelosuppression from the DNA cleavage-enhancing drugs etoposide and daunorubicin but not doxorubicin.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050515
Title: Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits.
Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20050401
Title: Gender-dependent reductions in vertebrae length, bone mineral density and content by doxorubicin are not reduced by dexrazoxane in young rats: effect on growth plate and intervertebral discs.
Journal: Calcified tissue international 20050301
Title: Cardioprotective interventions for cancer patients receiving anthracyclines.
Journal: The Cochrane database of systematic reviews 20050125
Title: The antitumor anthracyclines doxorubicin and daunorubicin do not inhibit cell growth through the formation of iron-mediated reactive oxygen species.
Journal: Anti-cancer drugs 20050101
Title: Anthracycline-induced cardiotoxicity in children with cancer: strategies for prevention and management.
Journal: Paediatric drugs 20050101
Title: Dexrazoxane : a review of its use for cardioprotection during anthracycline chemotherapy.
Journal: Drugs 20050101
Title: The prevention and management of cardiovascular complications of chemotherapy in patients with cancer.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101
Title: Clinical nurse specialist and evidence-based practice: managing anthracycline extravasation.
Journal: Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 20050101
Title: Cost Effectiveness of Cardioprotective Strategies in Patients with Aggressive Non-Hodgkin's Lymphoma.
Journal: Clinical drug investigation 20050101
Title: Mitoxantrone treatment of multiple sclerosis: safety considerations.
Journal: Neurology 20041228
Title: The iron chelating cardioprotective prodrug dexrazoxane does not affect the cell growth inhibitory effects of bleomycin.
Journal: Journal of inorganic biochemistry 20041101
Title: Evaluating the role of dexrazoxane as a cardioprotectant in cancer patients receiving anthracyclines.
Journal: Cancer treatment reviews 20041101
Title: [Cardiac prevention: the oncologic point of view].
Journal: Bulletin du cancer 20041101
Title: Can dexrazoxane reduce myocardial injury in anthracycline-treated children with acute lymphoblastic leukemia?
Journal: Nature clinical practice. Oncology 20041101
Title: Accelerated approval of oncology products: a decade of experience.
Journal: Journal of the National Cancer Institute 20041020
Title: Concurrent therapies that protect against doxorubicin-induced cardiomyopathy.
Journal: Clinical journal of oncology nursing 20041001
Title: Feasibility and pharmacokinetic study of infusional dexrazoxane and dose-intensive doxorubicin administered concurrently over 96 h for the treatment of advanced malignancies.
Journal: Cancer chemotherapy and pharmacology 20040901
Title: The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia.
Journal: The New England journal of medicine 20040708
Title: Rabbit model for in vivo study of anthracycline-induced heart failure and for the evaluation of protective agents.
Journal: European journal of heart failure 20040601
Title: [Dexrazoxane and cardiotoxicity in repeatedly treated patients].
Journal: Vnitrni lekarstvi 20040601
Title: [Dexrazoxane in patients with B-lymphomas or acute leukemias in the 2nd complete remission enables further therapy with cardiotoxic anthracyclines over recommended cumulative doses].
Journal: Vnitrni lekarstvi 20040601
Title: Dexrazoxane for anthracycline extravasation and GM-CSF for skin ulceration and wound healing.
Journal: The Lancet. Oncology 20040501
Title: Cardiotoxicity of cytotoxic drugs.
Journal: Cancer treatment reviews 20040401
Title: Synthesis and characterization of the biological activity of the cisplatin analogs, cis-PtCl(2)(dexrazoxane) and cis-PtCl(2)(levrazoxane), of the topoisomerase II inhibitors dexrazoxane (ICRF-187) and levrazoxane (ICRF-186).
Journal: Journal of inorganic biochemistry 20040401
Title: Anaphylaxis to dexrazoxane (ICRF-187) following three previous uncomplicated infusions.
Journal: Allergy 20040201
Title: The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: expert panel review.
Journal: Journal of cancer research and clinical oncology 20040101
Title: Pharmacokinetics of etoposide in cancer patients treated with high-dose etoposide and with dexrazoxane (ICRF-187) as a rescue agent.
Journal: Cancer chemotherapy and pharmacology 20040101
Title: The cardioprotector dexrazoxane augments therapeutic efficacy of mitoxantrone in experimental autoimmune encephalomyelitis.
Journal: Clinical and experimental immunology 20040101
Title: Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells.
Journal: BMC pharmacology 20040101
Title: Iron chelators in cancer chemotherapy.
Journal: Current topics in medicinal chemistry 20040101
Title: Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo.
Journal: BMC pharmacology 20040101
Title: The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin.
Journal: Free radical biology & medicine 20031201
Title: Supportive care of the older cancer patient.
Journal: Critical reviews in oncology/hematology 20031015
Title: The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity.
Journal: Molecular pharmacology 20030901
Title: Protein profiling in daunorubicin-induced cardiomyopathy.
Journal: General physiology and biophysics 20030901
Title: Analysis of bisdioxopiperazine dexrazoxane binding to human DNA topoisomerase II alpha: decreased binding as a mechanism of drug resistance.
Journal: Biochemistry 20030819
Title: Dexrazoxane does not protect against doxorubicin-induced damage in young rats.
Journal: American journal of physiology. Heart and circulatory physiology 20030801
Title: Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide.
Journal: Cancer chemotherapy and pharmacology 20030801
Title: High-dose epirubicin, preceded by dexrazoxane, given in combination with paclitaxel plus filgrastim provides an effective mobilizing regimen to support three courses of high-dose dense chemotherapy in patients with high-risk stage II-IIIA breast cancer.
Journal: Bone marrow transplantation 20030801
Title: Dexrazoxane in combination with anthracyclines lead to a synergistic cytotoxic response in acute myelogenous leukemia cell lines.
Journal: Leukemia research 20030701
Title: Iron chelator research: past, present, and future.
Journal: Current medicinal chemistry 20030601
Title: Cardiac toxicity of antineoplastic anthracyclines.
Journal: Current medicinal chemistry. Anti-cancer agents 20030301
Title: Effect of dexrazoxane on doxorubicin pharmacokinetics in young and old rats.
Journal: Cancer chemotherapy and pharmacology 20030201
Title: Myocardial cytoprotection by trimetazidine against anthracycline-induced cardiotoxicity in anticancer chemotherapy.
Journal: Angiology 20030101
Title: Dexrazoxane-a promising antidote in the treatment of accidental extravasation of anthracyclines.
Journal: Scandinavian journal of plastic and reconstructive surgery and hand surgery 20030101
Title: Dexrazoxane (ICRF-187) protects cardiac myocytes against doxorubicin by preventing damage to mitochondria.
Journal: Cardiovascular toxicology 20030101
Title: Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF-alpha expression.
Journal: BMC pharmacology 20030101
Title: Dihydroorotase catalyzes the ring opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187).
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201
Title: The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925.
Journal: Cancer chemotherapy and pharmacology 20021201
Title: Deferiprone protects against doxorubicin-induced myocyte cytotoxicity.
Journal: Free radical biology & medicine 20020715
Title: Effect of dexrazoxane on homocysteine-induced endothelial dysfunction in normal subjects.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20020701
Title: In vitro search for synergy and antagonism: evaluation of docetaxel combinations in breast cancer cell lines.
Journal: Breast cancer research and treatment 20020701
Title: [Cardiac toxicity in cancer therapy].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020701
Title: Early decline in left ventricular ejection fraction predicts doxorubicin cardiotoxicity in lymphoma patients.
Journal: British journal of cancer 20020605
Title: Dexrazoxane has no impact on sensitivity of childhood leukemic blasts to daunorubicin.
Journal: Leukemia 20020501
Title: Dexrazoxane pre-treatment protects skinned rat cardiac trabeculae against delayed doxorubicin-induced impairment of crossbridge kinetics.
Journal: British journal of pharmacology 20020401
Title: Gateways to Clinical Trials.
Journal: Methods and findings in experimental and clinical pharmacology 20020401
Title: The doxorubicin cardioprotective agent dexrazoxane (ICRF-187) induces endopolyploidy in rat neonatal myocytes through inhibition of DNA topoisomerase II.
Journal: Anti-cancer drugs 20020301
Title: Troponins in experimental studies.
Journal: Acta medica (Hradec Kralove) 20020101
Title: Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage.
Journal: Cardiovascular toxicology 20020101
Title: Multiple myeloma and its treatment.
Journal: Clinical journal of oncology nursing 20020101
Title: Minimising the long-term adverse effects of childhood leukaemia therapy.
Journal: Drug safety 20020101
Title: Effect of sodium 2,3-dimercaptopropane-1-sulphonate (DMPS) on chronic daunorubicin toxicity in rabbits: comparison with dexrazoxane.
Journal: Acta medica (Hradec Kralove) 20020101
Title: Recent advances in the prevention of anthracycline cardiotoxicity in childhood.
Journal: Current medicinal chemistry 20011101
Title: High-dose doxorubicin, dexrazoxane, and GM-CSF in malignant mesothelioma: a phase II study-Cancer and Leukemia Group B 9631.
Journal: Lung cancer (Amsterdam, Netherlands) 20011101
Title: Cytotoxic signalling by inhibitors of DNA topoisomerase II.
Journal: Biochemical Society transactions 20011101
Title: In vitro effects of dexrazoxane (Zinecard) and classical acute leukemia therapy: time to consider expanded clinical trials?
Journal: Leukemia 20011001
Title: In vitro prevention of the emergence of multidrug resistance in a pediatric rhabdomyosarcoma cell line.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011001
Title: The use of serum levels of cardiac troponin T to compare the protective activity of dexrazoxane against doxorubicin- and mitoxantrone-induced cardiotoxicity.
Journal: Cancer chemotherapy and pharmacology 20011001
Title: The effect of the catalytic topoisomerase II inhibitor dexrazoxane (ICRF-187) on CC9C10 hybridoma viability and productivity.
Journal: Cytotechnology 20011001
Title: Anthracycline-induced cardiomyopathy.
Journal: Seminars in oncology 20010801
Title: Phase I trial of 96-hour continuous infusion of dexrazoxane in patients with advanced malignancies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010601
Title: Diminished molecular response to doxorubicin and loss of cardioprotective effect of dexrazoxane in Egr-1 deficient female mice.
Journal: Canadian journal of physiology and pharmacology 20010601
Title: Dexrazoxane significantly impairs the induction of doxorubicin resistance in the human leukaemia line, K562.
Journal: British journal of cancer 20010401
Title: The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.
Journal: Molecular pharmacology 20010301
Title: Dexrazoxane is a potent and specific inhibitor of anthracycline induced subcutaneous lesions in mice.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010301
Title: [Cardiotoxicity of antineoplastic anthracycline antibiotics and prevention by cardioxane (Dexrazoxane) in clinical practice].
Journal: Voprosy onkologii 20010101
Title: Signal-averaged electrocardiography in survivors of Hodgkin's disease treated with and without dexrazoxane.
Journal: Neoplasma 20010101
Title: A new conservative approach to extravasation of anthracyclines with dimethylsulfoxide and dexrazoxane.
Journal: Acta oncologica (Stockholm, Sweden) 20010101
Title: Acute dosage with dexrazoxane, but not doxorubicin, is associated with increased rates of hepatic protein synthesis in vivo.
Journal: Toxicologic pathology 20010101
Title: [Exercise tolerance in patients after acute lymphoblastic leukemia treatment in childhood].
Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20010101
Title: Cardiovascular considerations with anthracycline use in patients with cancer.
Journal: Heart disease (Hagerstown, Md.) 20010101
Title: Dexrazoxane (ICRF-187).
Journal: General pharmacology 19990101
Title: Jones, R.L., Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther, 2008. 6(10): p. 1311-7.
Title: Loyevsky, M., et al., Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Exp Parasitol, 1999. 91(2): p. 105-14.
