Title: Synthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1-(2-aminoethyl)pyrrolidine, diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity.
Journal: Journal of biochemical and molecular toxicology 20180401
Title: Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20160601
Title: Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.
Journal: Bioorganic & medicinal chemistry letters 20160215
Title: Two related pyrrolidinedione synthetase loci in Fusarium heterosporum ATCC 74349 produce divergent metabolites.
Journal: ACS chemical biology 20130719
Title: Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20121115
Title: Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20121101
Title: Synthesis and reduction kinetics of sterically shielded pyrrolidine nitroxides.
Journal: Organic letters 20121019
Title: Highly enantioselective and recyclable organocatalytic Michael addition of malonates to α,β-unsaturated aldehydes in aqueous media.
Journal: Organic & biomolecular chemistry 20121003
Title: α-Geminal dihydroxymethyl piperidine and pyrrolidine iminosugars: synthesis, conformational analysis, glycosidase inhibitory activity, and molecular docking studies.
Journal: The Journal of organic chemistry 20120921
Title: Enantioselective construction of a polyhydroxylated pyrrolidine skeleton from 3-vinylaziridine-2-carboxylates: synthesis of (+)-DMDP and a potential common intermediate for (+)-hyacinthacine A1 and (+)-1-epi-australine.
Journal: The Journal of organic chemistry 20120921
Title: Synthesis of 2,5-bis(spirocyclohexane)-substituted nitroxides of pyrroline and pyrrolidine series, including thiol-specific spin label: an analogue of MTSSL with long relaxation time.
Journal: The Journal of organic chemistry 20120921
Title: Spiro-fused pyrrolidine, piperidine, and oxindole scaffolds from lactams.
Journal: Organic letters 20120921
Title: Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates.
Journal: Organic & biomolecular chemistry 20120914
Title: A synthetic method to access symmetric and non-symmetric 2-(N,N'-disubstituted)guanidinebenzothiazoles.
Journal: Molecules (Basel, Switzerland) 20120824
Title: Enantioselective organocatalytic Michael addition of ketones to alkylidene malonates.
Journal: Chirality 20120801
Title: Antimycobacterial activity: a facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines.
Journal: Bioorganic & medicinal chemistry letters 20120801
Title: Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity.
Journal: Bioorganic & medicinal chemistry 20120701
Title: Pyrrolidine based chiral organocatalyst for efficient asymmetric Michael addition of cyclic ketones to β-nitrostyrenes.
Journal: Bioorganic & medicinal chemistry letters 20120701
Title: Expanded bacteriochlorins.
Journal: Angewandte Chemie (International ed. in English) 20120604
Title: A convenient route to optically pure α-alkyl-β-(sec-amino)alanines.
Journal: Amino acids 20120601
Title: Organocatalytic stereocontrolled synthesis of 3,3'-pyrrolidinyl spirooxindoles by [3+2] annulation of isocyanoesters with methyleneindolinones.
Journal: Chemical communications (Cambridge, England) 20120525
Title: A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines.
Journal: Organic & biomolecular chemistry 20120521
Title: Evolving P450pyr hydroxylase for highly enantioselective hydroxylation at non-activated carbon atom.
Journal: Chemical communications (Cambridge, England) 20120514
Title: Docking and 3D-QSAR investigations of pyrrolidine derivatives as potent neuraminidase inhibitors.
Journal: Chemical biology & drug design 20120501
Title: Effects of the inhibition of cytosolic phospholipase A(2)α in non-small cell lung cancer cells.
Journal: Journal of cancer research and clinical oncology 20120501
Title: Enantioselective biotransformations of racemic and meso pyrrolidine-2,5-dicarboxamides and their application in organic synthesis.
Journal: The Journal of organic chemistry 20120420
Title: A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
Journal: Bioorganic & medicinal chemistry letters 20120415
Title: Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists.
Journal: Bioorganic & medicinal chemistry letters 20120415
Title: Asymmetric Michael reaction of aldehydes with β-nitroalkenes catalyzed by pyrrolidine-camphor derived organocatalysts bearing hydrogen-bond donors.
Journal: Chirality 20120401
Title: Pharmacophore modeling, 3D-QSAR studies, and in-silico ADME prediction of pyrrolidine derivatives as neuraminidase inhibitors.
Journal: Chemical biology & drug design 20120301
Title: Enantioselective conjugate addition of ketones to nitroalkenes catalyzed by pyrrolidine-sulfamides.
Journal: Chirality 20120301
Title: Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions.
Journal: Molecular diversity 20120201
Title: First chemoenzymatic synthesis of (+)-2-carboxypyrrolidine-3-acetic acid, the nucleus of kainoid amino acids.
Journal: Chirality 20120201
Title: [Design, synthesis and characterization of cyanopyrrolidine-bearing compounds as DPP-4 inhibitors].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120201
Title: Enantioselective synthesis of pyrrolidine-, piperidine-, and azepane-type N-heterocycles with α-alkenyl substitution: the CpRu-catalyzed dehydrative intramolecular N-allylation approach.
Journal: Organic letters 20120120
Title: Different binding modes of free and carrier-protein-coupled nicotine in a human monoclonal antibody.
Journal: Journal of molecular biology 20120106
Title: Effects of ring contraction on the conformational preferences of α-substituted proline analogs.
Journal: Biopolymers 20120101
Title: The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: Identification of biaryl sulfone derivatives as antagonists of the histamine H₃ receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: Molecular dynamics simulation study and hybrid pharmacophore model development in human LTA4H inhibitor design.
Journal: PloS one 20120101
Title: Label-free capacitive DNA sensor using immobilized pyrrolidinyl PNA probe: effect of the length and terminating head group of the blocking thiols.
Journal: Biosensors & bioelectronics 20120101
Title: Rapid probe of the nicotine spectra by high-resolution rotational spectroscopy.
Journal: Physical chemistry chemical physics : PCCP 20111221
Title: Biophysical and cellular-uptake properties of mixed-sequence pyrrolidine-amide oligonucleotide mimics.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20111216
Title: Development of an asymmetric trimethylenemethane cycloaddition reaction: application in the enantioselective synthesis of highly substituted carbocycles.
Journal: Journal of the American Chemical Society 20111207
Title: 1,2-Dihydropentalenes from fulvenes by [6 + 2] cycloadditions with 1-isopropenylpyrrolidine.
Journal: Organic letters 20111118
Title: A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state.
Journal: Biochemistry 20111108
Title: Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes.
Journal: Molecular diversity 20111101
Title: Multiple photosynthetic reaction centres using zinc porphyrinic oligopeptide-fulleropyrrolidine supramolecular complexes.
Journal: Physical chemistry chemical physics : PCCP 20111014
Title: Regio- and enantioselective hydroamination of dienes by gold(I)/menthol cooperative catalysis.
Journal: Angewandte Chemie (International ed. in English) 20111010
Title: Volatile compounds in the stem bark of Sclerocarya birrea (Anacardiaceae) possess antimicrobial activity against drug-resistant strains of Helicobacter pylori.
Journal: International journal of antimicrobial agents 20111001
Title: α-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors.
Journal: Chemical communications (Cambridge, England) 20110914
Title: Pressure-induced pseudorotation in crystalline pyrrolidine.
Journal: Physical chemistry chemical physics : PCCP 20110914
Title: Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics.
Journal: Journal of the American Chemical Society 20110817
Title: Detailed ab initio first-principles study of the magnetic anisotropy in a family of trigonal pyramidal iron(II) pyrrolide complexes.
Journal: Inorganic chemistry 20110815
Title: Structure-activity relationships in group 3 metal catalysts for asymmetric intramolecular alkene hydroamination. An investigation of ligands based on the axially chiral 1,1'-binaphthyl-2,2'-diamine motif.
Journal: Dalton transactions (Cambridge, England : 2003) 20110814
Title: Two solutions for the same problem: multiple binding modes of pyrrolidine-based HIV-1 protease inhibitors.
Journal: Journal of molecular biology 20110722
Title: Ruthenium-catalyzed selective hydrogenation of bis-arylidene tetramic acids. Application to the synthesis of novel structurally diverse pyrrolidine-2,4-diones.
Journal: Molecules (Basel, Switzerland) 20110720
Title: Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.
Journal: Chemical research in toxicology 20110718
Title: Neighboring pyrrolidine amide participation in thioether oxidation. Methionine as a 'hopping' site.
Journal: Organic letters 20110603
Title: Asymmetric construction of 3-vinylidene-pyrrolidine derivatives containing allene moiety via Ag(I)/TF-BiphamPhos-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with diethyl 2-(3,3-diphenylpropa-1,2-dienylidene) malonate.
Journal: Organic & biomolecular chemistry 20110521
Title: Novel pyrrolidine-thiohydantoins/thioxotetrahydropyrimidinones as highly effective catalysts for the asymmetric Michael addition.
Journal: Organic & biomolecular chemistry 20110507
Title: 4-Fluoropyrrolidine-2-carbonyl fluorides: useful synthons and their facile preparation with 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride.
Journal: The Journal of organic chemistry 20110506
Title: CoMFA and CoMSIA of diverse pyrrolidine analogues as dipeptidyl peptidase IV inhibitors: active site requirements.
Journal: Molecular diversity 20110501
Title: Novel pyrrolidine melanin-concentrating hormone receptor 1 antagonists with reduced hERG inhibition.
Journal: Bioorganic & medicinal chemistry letters 20110415
Title: Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1.
Journal: Bioorganic & medicinal chemistry letters 20110415
Title: Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors.
Journal: European journal of medicinal chemistry 20110401
Title: Concise synthesis of pyrrolidine and indolizidine alkaloids by a highly convergent three-component reaction.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110307
Title: Development of an indole-based chemically cleavable linker concept for immobilizing bait compounds for protein pull-down experiments.
Journal: Bioconjugate chemistry 20110216
Title: Parallel synthesis of natural product-like polyhydroxylated pyrrolidine and piperidine alkaloids.
Journal: Molecular diversity 20110201
Title: Design of new chemotherapeutics against the deadly anthrax disease. Docking and molecular dynamics studies of inhibitors containing pyrrolidine and riboamidrazone rings on nucleoside hydrolase from Bacillus anthracis.
Journal: Journal of biomolecular structure & dynamics 20110201
Title: Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110201
Title: Development of a robust QSAR model to predict the affinity of pyrrolidine analogs for dipeptidyl peptidase IV (DPP- IV).
Journal: Journal of enzyme inhibition and medicinal chemistry 20110201
Title: Access to β,γ-diamino acids. Application to the synthesis of 3-deoxyaminostatine.
Journal: Organic & biomolecular chemistry 20110121
Title: Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists.
Journal: Bioorganic & medicinal chemistry letters 20110115
Title: A novel synthetic approach to very late antigen-4 antagonist trans-4-[1-[[2,5-dichloro-4-(1-methyl-3-indolylcarboxyamide)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid via tert-butyl trans-[(4S)-Methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate as a key intermediate.
Journal: Chemical & pharmaceutical bulletin 20110101
Title: Synthesis of all-cis 2,5-imino-2,5-dideoxy-fucitol and its evaluation as a potent fucosidase and galactosidase inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20101215
Title: In situ trapping of Boc-2-pyrrolidinylmethylzinc iodide with aryl iodides: direct synthesis of 2-benzylpyrrolidines.
Journal: The Journal of organic chemistry 20101203
Title: Rational design of novel pyrrolidine derivatives as orally active neurokinin-3 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20101115
Title: Direct construction of imino-pyrrolidine-thione scaffold via isocyanide-based multicomponent reaction.
Journal: Journal of combinatorial chemistry 20101108
Title: One-pot formation of piperidine- and pyrrolidine-substituted pyridinium salts via addition of 5-alkylaminopenta-2,4-dienals to N-acyliminium ions: application to the synthesis of (±)-nicotine and analogs.
Journal: Organic letters 20101105
Title: Cooperative catalysis with metal and secondary amine: synthesis of 2-substituted quinolines via addition/cycloisomerization cascade.
Journal: The Journal of organic chemistry 20101015
Title: Brightening and locking a weak and floppy N-H chromophore: the case of pyrrolidine.
Journal: The journal of physical chemistry. A 20101007
Title: Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor.
Journal: Bioorganic & medicinal chemistry letters 20101001
Title: Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain.
Journal: Bioorganic & medicinal chemistry letters 20100915
Title: Novel pyrrolidine heterocycles as CCR1 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20100915
Title: Direct acylation of aryl chlorides with aldehydes by palladium-pyrrolidine Co-catalysis.
Journal: Organic letters 20100820
Title: Pyrrolidine constrained bipyridyl-dansyl click fluoroionophore as selective Al(3+)sensor.
Journal: Chemical communications (Cambridge, England) 20100707
Title: A fast, efficient and stereoselective synthesis of hydroxy-pyrrolidines.
Journal: Carbohydrate research 20100702
Title: Organocatalytic Michael addition of aldehydes to protected 2-amino-1-nitroethenes: the practical syntheses of oseltamivir (Tamiflu) and substituted 3-aminopyrrolidines.
Journal: Angewandte Chemie (International ed. in English) 20100621
Title: Chemical synthesis of heterocyclic-sugar nucleoside analogues.
Journal: Chemical reviews 20100609
Title: Nitric oxide-releasing silica nanoparticle inhibition of ovarian cancer cell growth.
Journal: Molecular pharmaceutics 20100607
Title: Recyclable Merrifield resin-supported organocatalysts containing pyrrolidine unit through A3-coupling reaction linkage for asymmetric Michael addition.
Journal: Chirality 20100505
Title: The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20100501
Title: Catalytic hydrogenation of meso-octamethylporphyrinogen (calix[4]pyrrole).
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100412
Title: Regio- and stereoselective synthesis of novel dispiropyrrolidine bisoxindole derivatives via multicomponent reactions.
Journal: Journal of combinatorial chemistry 20100308
Title: CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields.
Journal: Journal of computational chemistry 20100301
Title: Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers.
Journal: Bioorganic & medicinal chemistry letters 20100215
Title: Evaluation of the influence of proline, hydroxyproline or pyrrolidine in the presence of sodium nitrite on N-nitrosamine formation when heating cured meat.
Journal: Analytica chimica acta 20100111
Title: Stereoselective synthesis and structure-affinity relationships of bicyclic kappa receptor agonists.
Journal: Organic & biomolecular chemistry 20100107
Title: Pseudorotation in pyrrolidine: rotational coherence spectroscopy and ab initio calculations of a large amplitude intramolecular motion.
Journal: Physical chemistry chemical physics : PCCP 20100107
Title: Discovery of orally available integrin alpha5beta1 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20100101
Title: Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
Journal: Bioorganic & medicinal chemistry letters 20100101
Title: [DNA mimics on the base of pyrrolidine and hydroxyproline].
Journal: Bioorganicheskaia khimiia 20100101
Title: Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).
Journal: Journal of medicinal chemistry 20091210
Title: Enantioselective total synthesis of (-)-acutumine.
Journal: The Journal of organic chemistry 20091204
Title: Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties.
Journal: Protein science : a publication of the Protein Society 20091101
Title: Evaluation of molecular pharmaceutical and in-vivo properties of spray-dried isolated andrographolide-PVP.
Journal: The Journal of pharmacy and pharmacology 20091101
Title: Synthesis, photophysical properties and sugar-dependent in vitro photocytotoxicity of pyrrolidine-fused chlorins bearing S-glycosides.
Journal: Journal of photochemistry and photobiology. B, Biology 20091006
Title: Imidazoline-N-oxyl: a DFT study of its protonation reaction.
Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20091005
Title: Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors.
Journal: Bioorganic & medicinal chemistry 20090915
Title: An investigation into the electrophilic cyclisation of N-acyl-pyrrolidinium ions: a facile synthesis of pyrrolo-tetrahydroisoquinolones and pyrrolo-benzazepinones.
Journal: Organic & biomolecular chemistry 20090907
Title: A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines.
Journal: European journal of medicinal chemistry 20090901
Title: Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: a double diversity for the identification of new antitubercular compounds.
Journal: Bioorganic & medicinal chemistry letters 20090901
Title: Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
Journal: Bioorganic & medicinal chemistry letters 20090815
Title: Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors.
Journal: European journal of medicinal chemistry 20090801
Title: Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography.
Journal: Nuclear medicine and biology 20090801
Title: Synthesis, characterisation and in vitro cytotoxicity studies of a series of chiral platinum(II) complexes based on the 2-aminomethylpyrrolidine ligand: X-ray crystal structure of [PtCl2(R-dimepyrr)] (R-dimepyrr=N-dimethyl-2(R)-aminomethylpyrrolidine).
Journal: European journal of medicinal chemistry 20090701
Title: Calcium-independent phospholipase A2 participates in KCl-induced calcium sensitization of vascular smooth muscle.
Journal: Cell calcium 20090701
Title: Synthesis of pyrrolidine homoazasugars and 3,4-dihydroxy-5-hydroxymethylprolines using aldol additions of metalated bislactim ethers to 2,4-O-ethylidene-D-erythroses.
Journal: Organic & biomolecular chemistry 20090607
Title: Synthesis and biological evaluation of 3,4,6-triaryl-2-pyranones as a potential new class of anti-breast cancer agents.
Journal: Bioorganic & medicinal chemistry 20090601
Title: In vitro heavy-atom effect of palladium(II) and platinum(II) complexes of pyrrolidine-fused chlorin in photodynamic therapy.
Journal: Journal of medicinal chemistry 20090514
Title: Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate.
Journal: Journal of inorganic biochemistry 20090501
Title: Characterization of diverse heterocyclic amine-degrading denitrifying bacteria from various environments.
Journal: Archives of microbiology 20090401
Title: Synthesis of labeled BCX-4208, a potent inhibitor of purine nucleoside phosphorylase.
Journal: Drug testing and analysis 20090301
Title: Synthesis of new aza-analogs of staurosporine, K-252a and rebeccamycin by nucleophilic opening of C2-symmetric bis-aziridines.
Journal: Organic & biomolecular chemistry 20090221
Title: The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.
Journal: European journal of medicinal chemistry 20090201
Title: A rational approach to predict and modulate stereolability of chiral alpha substituted ketones.
Journal: Chirality 20090101
Title: Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090101
Title: Highly enantioselective synthesis of gamma-nitro heteroaromatic ketones in a doubly stereocontrolled manner catalyzed by bifunctional thiourea catalysts based on dehydroabietic amine: a doubly stereocontrolled approach to pyrrolidine carboxylic acids.
Journal: Organic letters 20090101
Title: Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.
Journal: Analytical biochemistry 20081215
Title: Three-dimensional QSAR analyses of 1,3,4-trisubstituted pyrrolidine-based CCR5 receptor inhibitors.
Journal: European journal of medicinal chemistry 20081201
Title: Mild conditions for Pd-catalyzed carboamination of N-protected hex-4-enylamines and 1-, 3-, and 4-substituted pent-4-enylamines. Scope, limitations, and mechanism of pyrrolidine formation.
Journal: The Journal of organic chemistry 20081121
Title: Access to pyrrolidine imino sugars via tin(II)-mediated aldol reactions of bislactim ethers: synthesis of 2,5-dideoxy-2,5-imino-D-glucitol.
Journal: Organic & biomolecular chemistry 20081107
Title: Antioxidative capacity of C(60) (buckminsterfullerene) and newly synthesized fulleropyrrolidine derivatives encapsulated in liposomes.
Journal: Biotechnology and applied biochemistry 20081101
Title: Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors.
Journal: European journal of medicinal chemistry 20081001
Title: Synthesis and biological evaluation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors.
Journal: Journal of medicinal chemistry 20080911
Title: Investigations into the effectiveness of deuterium as a 'protecting group' for C-H bonds in radical reactions involving hydrogen atom transfer.
Journal: Organic & biomolecular chemistry 20080907
Title: Experimental and theoretical studies of the redox potentials of cyclic nitroxides.
Journal: The Journal of organic chemistry 20080905
Title: In situ quantitative measurement of concentration profiles in a microreactor with submicron resolution using multiplex CARS microscopy.
Journal: Journal of the American Chemical Society 20080903
Title: How close can you get? Studies of ultrafast light-induced processes in ruthenium-[60] fullerene dyads with short pyrazolino and pyrrolidino links.
Journal: Inorganic chemistry 20080818
Title: Insight into why pyrrolidinyl peptide nucleic acid binding to DNA is more stable than the DNA x DNA duplex.
Journal: Biochemical and biophysical research communications 20080808
Title: Total synthesis of (-)-kainic acid via intramolecular Michael addition: a second-generation route.
Journal: Organic letters 20080501
Title: Detection and characterization of cyclic hydroxylamine adducts by mass spectrometry.
Journal: Free radical research 20080501
Title: Asymmetric synthesis of an N-acylpyrrolidine for inhibition of HCV polymerase.
Journal: The Journal of organic chemistry 20080418
Title: Structure-guided design of C2-symmetric HIV-1 protease inhibitors based on a pyrrolidine scaffold.
Journal: Journal of medicinal chemistry 20080410
Title: New stimuli-responsive polymers derived from morpholine and pyrrolidine.
Journal: Journal of materials science. Materials in medicine 20080401
Title: Catalysis of 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives in enantioselective anti-Mannich-type reactions: importance of the 3-acid group on pyrrolidine for stereocontrol.
Journal: Journal of the American Chemical Society 20080123
Title: RNA-selective cross-pairing of backbone-extended pyrrolidine-amide oligonucleotide mimics (bePOMs).
Journal: Organic & biomolecular chemistry 20080107
Title: Asymmetric synthetic access to the hetisine alkaloids: total synthesis of (+)-nominine.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101
Title: Catalytic asymmetric Michael reactions of acetaldehyde.
Journal: Angewandte Chemie (International ed. in English) 20080101
Title: Convenient synthesis of pyrrolidines by amphiphilic allylation of imines with 2-methylenepropane-1,3-diols.
Journal: Angewandte Chemie (International ed. in English) 20080101
Title: One-electron oxidation and reduction potentials of nitroxide antioxidants: a theoretical study.
Journal: The journal of physical chemistry. A 20071227
Title: Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.
Journal: Bioorganic & medicinal chemistry letters 20071215
Title: Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor.
Journal: Bioorganic & medicinal chemistry letters 20071201
Title: Organocatalyzed cyclizations of pi-allylpalladium complexes: a new method for the construction of five- and six-membered rings.
Journal: Organic letters 20071122
Title: Stereocontrolled synthesis of 2,4-diamino-3-hydroxyacids starting from diketopiperazines: a new route for the preparation of statine analogues.
Journal: Organic letters 20071108
Title: (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
Journal: Bioorganic & medicinal chemistry letters 20071015
Title: Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles.
Journal: Journal of the American Chemical Society 20070926
Title: Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070601
Title: Novel cyclopropane fatty acids from the phospholipids of the Caribbean sponge Pseudospongosorites suberitoides.
Journal: Lipids 20070601
Title: Pyrrolidine and piperidine formation via copper(II) carboxylate-promoted intramolecular carboamination of unactivated olefins: diastereoselectivity and mechanism.
Journal: The Journal of organic chemistry 20070511
Title: Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070501
Title: Lewis acid catalyzed reaction of arylvinylidenecyclopropanes with ethyl (arylimino)acetates: a facile synthetic protocol for pyrrolidine and 1,2,3,4-tetrahydroquinoline derivatives.
Journal: Organic letters 20070426
Title: General strategy for the construction of enantiopure pyrrolidine-based alkaloids. Total synthesis of (-)-monomorine.
Journal: The Journal of organic chemistry 20070413
Title: Ether-directed, stereoselective aza-Claisen rearrangements: synthesis of the piperidine alkaloid, alpha-conhydrine.
Journal: Organic letters 20070412
Title: Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.
Journal: Bioorganic & medicinal chemistry letters 20070401
Title: Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
Journal: Bioorganic & medicinal chemistry letters 20070401
Title: N-nitrosation of amines by NO2 and NO: a theoretical study.
Journal: The journal of physical chemistry. A 20070322
Title: A short, efficient, and stereoselective total synthesis of a pyrrolidine alkaloid: (-)-codonopsinine.
Journal: The Journal of organic chemistry 20070316
Title: Efficient method for the synthesis of chiral pyrrolidine derivatives via ring-closing enyne metathesis reaction.
Journal: Organic letters 20070301
Title: Total synthesis of (+)-nakadomarin A.
Journal: Journal of the American Chemical Society 20070207
Title: Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione.
Journal: Free radical biology & medicine 20070201
Title: Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties.
Journal: Organic & biomolecular chemistry 20070121
Title: Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA/RNA binding properties.
Journal: Organic & biomolecular chemistry 20070121
Title: A new, efficient and stereoselective synthesis of tricyclic and tetracyclic compounds by samarium diiodide induced cyclisations of naphthyl-substituted arylketones--an easy access to steroid-like skeletons.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
Title: Reaction of the indole group with malondialdehyde: application for the derivatization of tryptophan residues in peptides.
Journal: Bioconjugate chemistry 20070101
Title: Transannular rearrangement of activated lactams: stereoselective synthesis of substituted pyrrolidine-2,4-diones from diketopiperazines.
Journal: Angewandte Chemie (International ed. in English) 20070101
Title: Synthesis and properties of pyrrolidine-based negatively charged DNA mimics.
Journal: Nucleosides, nucleotides & nucleic acids 20070101
Title: Anti-cancer activities of 5-acyl-6-[2-hydroxy/benzyloxy-3-(amino)-propylamino]-1,3-dialkyl-1H-pyrimidin-2,4-diones.
Journal: Bioorganic & medicinal chemistry 20061215
Title: Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors.
Journal: Bioorganic & medicinal chemistry 20061215
Title: Evolution of pyrrolidine-type asymmetric organocatalysts by 'click' chemistry.
Journal: The Journal of organic chemistry 20061124
Title: Physiological, biochemical, and genetic characterization of an alicyclic amine-degrading Mycobacterium sp. strain THO100 isolated from a morpholine-containing culture of activated sewage sludge.
Journal: Archives of microbiology 20061101
Title: C-Branched pyrrolidines from 2-C-acetylmethyl-glycosylazides. Reduction of imines formed by monosaccharide ring opening.
Journal: Carbohydrate research 20061016
Title: The synthesis of N,O-ferrocenyl pyrrolidine-containing ligands and their application in the diethyl- and diphenylzinc addition to aromatic aldehydes.
Journal: The Journal of organic chemistry 20060929
Title: Synthesis of enantiopure pyrrolidine-derived peptidomimetics and oligo-beta-peptides via nucleophilic ring-opening of beta-lactams.
Journal: The Journal of organic chemistry 20060929
Title: Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist.
Journal: Bioorganic & medicinal chemistry letters 20060915
Title: Rhodococcus sp. strain TM1 plays a synergistic role in the degradation of piperidine by Mycobacterium sp. strain THO100.
Journal: Archives of microbiology 20060901
Title: Determination of the absolute configuration and solution conformation of a novel disubstituted pyrrolidine acid A by vibrational circular dichroism.
Journal: Chirality 20060901
Title: Regiocontrolled synthesis of pyrrole-2-carboxaldehydes and 3-pyrrolin-2-ones from pyrrole Weinreb amides.
Journal: The Journal of organic chemistry 20060818
Title: [Asymmetric intramolecular conjugate addition of chiral enolates via non-equilibrium].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060801
Title: Preparation of highly substituted pyrrolidines via an organometallic dipole.
Journal: Organic & biomolecular chemistry 20060721
Title: A recyclable fluorous (S)-pyrrolidine sulfonamide promoted direct, highly enantioselective Michael addition of ketones and aldehydes to nitroolefins in water.
Journal: Organic letters 20060706
Title: Modeling proline ligation in the heme-dependent CO sensor, CooA, using small-molecule analogs.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20060701
Title: New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids.
Journal: European journal of medicinal chemistry 20060701
Title: Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Journal: Bioorganic & medicinal chemistry letters 20060615
Title: 2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20060601
Title: Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor.
Journal: Immunology 20060601
Title: Theoretical and experimental investigation of the energetics of cis-trans proline isomerization in peptide models.
Journal: The journal of physical chemistry. A 20060525
Title: Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM).
Journal: Chemical communications (Cambridge, England) 20060407
Title: Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20060315
Title: [60]fullerene-pyrrolidine-N-oxides.
Journal: The Journal of organic chemistry 20060303
Title: Reactivity of the C2'-oxidized abasic lesion and its relevance to interactions with type I base excision repair enzymes.
Journal: Chemical research in toxicology 20060301
Title: Organocatalytic C3-selective Friedel-Crafts alkylations of indoles with alpha,beta-unsaturated ketones.
Journal: Chemical communications (Cambridge, England) 20060221
Title: A QSAR study on influenza neuraminidase inhibitors.
Journal: Bioorganic & medicinal chemistry 20060215
Title: Enantioselective total synthesis of (-)-flustramines A, B and (-)-flustramides A, B via domino olefination/isomerization/Claisen rearrangement sequence.
Journal: Chemical communications (Cambridge, England) 20060128
Title: Caffeoyl pyrrolidine derivative LY52 inhibits tumor invasion and metastasis via suppression of matrix metalloproteinase activity.
Journal: Anticancer research 20060101
Title: Stereocontrolled syntheses of kainoid amino acids from 7-azabicyclo[2.2.1]heptadienes using tandem radical addition-homoallylic radical rearrangement.
Journal: The Journal of organic chemistry 20051028
Title: Alpha-rhamnosidase inhibitory activities of polyhydroxylated pyrrolidine.
Journal: Bioorganic & medicinal chemistry letters 20051001
Title: Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids.
Journal: The Journal of organic chemistry 20050819
Title: Locked conformations for proline pyrrolidine ring: synthesis and conformational analysis of cis- and trans-4-tert-butylprolines.
Journal: The Journal of organic chemistry 20050805
Title: Direct, facile aldehyde and ketone alpha-selenenylation reactions promoted by L-prolinamide and pyrrolidine sulfonamide organocatalysts.
Journal: The Journal of organic chemistry 20050708
Title: Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2.
Journal: Bioorganic & medicinal chemistry letters 20050701
Title: Synthesis and triplex forming properties of pyrrolidino pseudoisocytidine containing oligodeoxynucleotides.
Journal: Organic & biomolecular chemistry 20050507
Title: Conformationally constrained PNA analogues: structural evolution toward DNA/RNA binding selectivity.
Journal: Accounts of chemical research 20050501
Title: Synthesis of 2,2-disubstituted pyrrolidine-4-carboxylic acid derivatives and their incorporation into beta-peptide oligomers.
Journal: The Journal of organic chemistry 20050429
Title: Novel and potent cyclic cyanamide-based cathepsin K inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20050401
Title: Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity.
Journal: The Journal of biological chemistry 20050304
Title: The impact of pyrrolidine hydroxylation on the conformation of proline-containing peptides.
Journal: The Journal of organic chemistry 20050218
Title: Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Journal: Bioorganic & medicinal chemistry letters 20050103
Title: Glycoprotein isolated from Solanum nigrum L. modulates the apoptotic-related signals in 12-O-tetradecanoylphorbol 13-acetate-stimulated MCF-7 cells.
Journal: Journal of medicinal food 20050101
Title: Synthetic methods for azaheterocyclic phosphonates and their biological activity.
Journal: Chemical reviews 20041201
Title: Towards organo-click chemistry: development of organocatalytic multicomponent reactions through combinations of aldol, Wittig, Knoevenagel, Michael, Diels-Alder and Huisgen cycloaddition reactions.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20041025
Title: Design, synthesis, and activity of caffeoyl pyrrolidine derivatives as potential gelatinase inhibitors.
Journal: Bioorganic & medicinal chemistry 20041001
Title: Total synthesis of (+)-cocaine via desymmetrization of a meso-dialdehyde.
Journal: Organic letters 20040916
Title: Palladium--phosphinous acid-catalyzed Sonogashira cross-coupling reactions in water.
Journal: Organic & biomolecular chemistry 20040807
Title: Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase.
Journal: Bioorganic & medicinal chemistry letters 20040716
Title: Design of temperature sensitive imprinted polymer hydrogels based on multiple-point hydrogen bonding.
Journal: Macromolecular bioscience 20040714
Title: The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum.
Journal: The international journal of biochemistry & cell biology 20040701
Title: Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state.
Journal: Biochemistry 20040504
Title: Synthesis of 1-Aza-8-thiabicyclo[4.2.1]nona-2,4-diene 8,8-dioxide and its conversion to a strained spirocycle via photoinduced SO2-N bond cleavage.
Journal: Organic letters 20040415
Title: Differential modulation of mediator release from human basophils and mast cells by mizolastine.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040201
Title: Molecular cloning, nucleotide sequencing and expression of genes encoding a cytochrome P450 system involved in secondary amine utilization in Mycobacterium sp. strain RP1.
Journal: Research in microbiology 20040101
Title: [Change of the antioxidant status and free radicals production in hemolymph of Galleria mellonella larvae in microsporidiosis].
Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20040101
Title: Cycloreversion and other gas-phase reactions of neutral and cationic pyrrolidine-fused chlorins and isobacteriochlorins under ion bombardment and electrospray.
Journal: Rapid communications in mass spectrometry : RCM 20040101
Title: Synthesis of pyrrolidine-based oxy-peptide nucleic acids that contain four bases and their properties.
Journal: Nucleic acids symposium series (2004) 20040101
Title: Synthesis of N-methyl-N-[(1S)-1-[(3R)-pyrrolidin-3-yl]ethyl]amine.
Journal: The Journal of organic chemistry 20031212
Title: Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease.
Journal: Organic letters 20031127
Title: Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic optimization of inhibitors of hepatitis C virus NS3/4A protease.
Journal: Organic letters 20031127
Title: [Development of novel carbon-carbon bond forming reactions using zirconocene complex].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20031101
Title: Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM).
Journal: Organic & biomolecular chemistry 20031007
Title: First total synthesis and stereochemical definition of isodomoic acid G.
Journal: Organic letters 20031002
Title: Developmental outcome of levetiracetam, its major metabolite in humans, 2-pyrrolidinone N-butyric acid, and its enantiomer (R)-alpha-ethyl-oxo-pyrrolidine acetamide in a mouse model of teratogenicity.
Journal: Epilepsia 20031001
Title: Synthesis and biological activity of 1beta-methyl-2-[5-(2-N-substituted aminoethylcarbamoyl)pyrrolidin-3-ylthio]carbapenem derivatives.
Journal: European journal of medicinal chemistry 20030901
Title: Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.
Journal: The Journal of biological chemistry 20030808
Title: Pyrrolidine carbamate nucleic acids: synthesis and DNA binding studies.
Journal: Bioorganic & medicinal chemistry 20030805
Title: Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational properties.
Journal: Bioorganic & medicinal chemistry letters 20030519
Title: Highly enantioselective hydrolysis of alicyclic meso-epoxides with a bacterial epoxide hydrolase from Sphingomonas sp. HXN-200: simple syntheses of alicyclic vicinal trans-diols.
Journal: Chemical communications (Cambridge, England) 20030421
Title: Dipeptidyl peptidase IV inhibitors for the treatment of impaired glucose tolerance and type 2 diabetes.
Journal: Current opinion in investigational drugs (London, England : 2000) 20030401
Title: Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione derivatives.
Journal: Chemical & pharmaceutical bulletin 20030301
Title: Biodegradation of cyclic amines by a Pseudomonas strain involves an amine mono-oxygenase.
Journal: Canadian journal of microbiology 20030301
Title: The nitroxides pirolin and pirolid protect the plasma membranes of rat cardiomyocytes against damage induced by anthracyclines.
Journal: Cellular & molecular biology letters 20030101
Title: Effects of pyrroline and pyrrolidine nitroxides on lipid peroxidation in heart tissue of rats treated with doxorubicin.
Journal: Cellular & molecular biology letters 20030101
Title: 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases.
Journal: Journal of the American Chemical Society 20021016
Title: Dopamine D3 receptor ligands with antagonist properties.
Journal: Chembiochem : a European journal of chemical biology 20021004
Title: Total synthesis of batzelladine D.
Journal: Organic letters 20020822
Title: Content of biogenic amines in a Chardonnay wine obtained through spontaneous and inoculated fermentations.
Journal: Journal of agricultural and food chemistry 20020814
Title: Anaerobic degradation of pyrrolidine and piperidine coupled with nitrate reduction.
Journal: Chemosphere 20020701
Title: Aqueous aldol catalysis by a nicotine metabolite.
Journal: Journal of the American Chemical Society 20020403
Title: Total synthesis of spirotryprostatin B via asymmetric nitroolefination.
Journal: Organic letters 20020124
Title: Thermodynamic analysis of hybridization between POPNA and DNA.
Journal: Nucleic acids research. Supplement (2001) 20020101
Title: Ab-initio molecular geometry and normal coordinate analysis of pyrrolidine molecule.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20011101
Title: Efficient enantiomeric synthesis of pyrrolidine and piperidine alkaloids from tobacco.
Journal: The Journal of organic chemistry 20010921
Title: Synthesis of conformationally constrained arginine and ornithine analogues based on the 3-substituted pyrrolidine framework.
Journal: The Journal of organic chemistry 20010921
Title: Novel alpha- and beta-amino acid inhibitors of influenza virus neuraminidase.
Journal: Antimicrobial agents and chemotherapy 20010901
Title: Dicaffeoyl- or digalloyl pyrrolidine and furan derivatives as HIV integrase inhibitors.
Journal: Bioorganic & medicinal chemistry 20010601
Title: Bocdene and mocdene derivatives of catechols and catecholamines.
Journal: Organic letters 20010503
Title: Inhibition of herpes simplex virus type 1 ribonucleotide reductase by substituted tetrapeptide derivatives.
Journal: Journal of medicinal chemistry 19931001
