Title: Biological effects of AL622, a molecule rationally designed to release an EGFR and a c-Src kinase inhibitor.
Journal: Chemical biology & drug design 20121201
Title: Design, synthesis, and structure-activity relationships of highly potent 5-HT₃ receptor ligands.
Journal: Journal of medicinal chemistry 20121025
Title: Stereoselective N-glycosylation of 2-deoxythioribosides for fluorescent nucleoside synthesis.
Journal: The Journal of organic chemistry 20121019
Title: Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity.
Journal: Bioorganic & medicinal chemistry 20121015
Title: Therapeutic reactivation of mutant p53 protein by quinazoline derivatives.
Journal: Investigational new drugs 20121001
Title: Some insights into the binding mechanism of Aurora B kinase gained by molecular dynamics simulation.
Journal: Journal of molecular modeling 20121001
Title: Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20121001
Title: Small molecule activators of proteasome-related HslV peptidase.
Journal: Bioorganic & medicinal chemistry letters 20121001
Title: Discovery of 6-substituted 4-anilinoquinazolines with dioxygenated rings as novel EGFR tyrosine kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120915
Title: Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Journal: Journal of medicinal chemistry 20120913
Title: Design, synthesis and biological evaluation of novel quinazoline derivatives as potential anti-cancer agents.
Journal: Journal of enzyme inhibition and medicinal chemistry 20120801
Title: Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety.
Journal: European journal of medicinal chemistry 20120801
Title: Ultrasound-promoted synthesis and immunosuppressive activity of novel quinazoline derivatives.
Journal: Molecular diversity 20120801
Title: A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis.
Journal: Anti-cancer agents in medicinal chemistry 20120701
Title: 2-(4-Bromo-phen-yl)-N-[3-(1H-imidazol-1-yl)prop-yl]quinazolin-4-amine.
Journal: Acta crystallographica. Section E, Structure reports online 20120701
Title: 2-Methyl-3-(2-methyl-phen-yl)-4-oxo-3,4-dihydro-quinazolin-8-yl 4-chloro-benzoate.
Journal: Acta crystallographica. Section E, Structure reports online 20120701
Title: 2-(2-{[4-Oxo-3-(2-phenyl-eth-yl)-3,4-dihydro-quinazolin-2-yl]sulfan-yl}eth-yl)-2,3-dihydro-1H-isoindole-1,3-dione.
Journal: Acta crystallographica. Section E, Structure reports online 20120701
Title: Reactions of phthalazine, quinazoline, 4,7-phenanthroline and 2,3'-bipyridine with ruthenium carbonyl.
Journal: Dalton transactions (Cambridge, England : 2003) 20120628
Title: Structural variety of zinc and copper complexes based on a 2,3-disubstituted 1,2,3,4-tetrahydroquinazoline ligand.
Journal: Dalton transactions (Cambridge, England : 2003) 20120621
Title: Selective elimination of alloreactivity in vitro and in vivo while sparing other T-cell-mediated immune responses.
Journal: Bone marrow transplantation 20120601
Title: Enhancement of the cytotoxic potential of the mixed EGFR and DNA-targeting 'combi-molecule' ZRBA1 against human solid tumour cells by a bis-quinazoline-based drug design approach.
Journal: Anti-cancer drugs 20120601
Title: 6-Methyl-1-({[(2E)-2-methyl-3-phenyl-prop-2-en-1-yl]-oxy}meth-yl)-1,2,3,4-tetra-hydro-quinazoline-2,4-dione.
Journal: Acta crystallographica. Section E, Structure reports online 20120601
Title: 6-Chloro-1-({[(2E)-2-methyl-3-phenyl-prop-2-en-1-yl]-oxy}meth-yl)-1,2,3,4-tetra-hydro-quinazoline-2,4-dione.
Journal: Acta crystallographica. Section E, Structure reports online 20120601
Title: (E)-2-[2-(4-Chloro-benzyl-idene)hydrazin-yl]-4-[3-(morpholin-4-ium-4-yl)propyl-amino]-quinazolin-1-ium bis-(perchlorate).
Journal: Acta crystallographica. Section E, Structure reports online 20120601
Title: 1-{[(2,3-Dihydro-1H-inden-2-yl)-oxy]meth-yl}quinazoline-2,4(1H,3H)-dione.
Journal: Acta crystallographica. Section E, Structure reports online 20120601
Title: 2-Chloro-quinazolin-4(3H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20120601
Title: 3,8-Dimethyl-4-oxo-3,4-dihydro-quinazoline-6-carbonitrile.
Journal: Acta crystallographica. Section E, Structure reports online 20120601
Title: Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles.
Journal: Organic letters 20120504
Title: Recent developments of small molecule EGFR inhibitors based on the quinazoline core scaffolds.
Journal: Anti-cancer agents in medicinal chemistry 20120501
Title: Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists.
Journal: Bioorganic & medicinal chemistry letters 20120501
Title: Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: part 2.
Journal: Bioorganic & medicinal chemistry letters 20120501
Title: (E)-2-[2-(4-Chloro-benzyl-idene)hydrazin-1-yl]-4-{[3-(dimethyl-aza-nium-yl)prop-yl]amino}-quinazolin-1-ium bis-(perchlorate).
Journal: Acta crystallographica. Section E, Structure reports online 20120501
Title: Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.
Journal: Journal of medicinal chemistry 20120426
Title: A 2,6-disubstituted 4-anilinoquinazoline derivative facilitates cardiomyogenesis of embryonic stem cells.
Journal: ChemMedChem 20120401
Title: Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties.
Journal: PLoS computational biology 20120401
Title: Absolute configuration of (1S,2S)-3-methyl-2-phenyl-2,3-dihydro-thia-zolo[2,3-b]quinazolin-5-one.
Journal: Acta crystallographica. Section E, Structure reports online 20120401
Title: 4-(4-Amino-2-fluoro-phen-oxy)-7-meth-oxy-quinazolin-6-ol methanol monosolvate.
Journal: Acta crystallographica. Section E, Structure reports online 20120401
Title: Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.
Journal: Journal of medicinal chemistry 20120322
Title: Effects of an antimalarial quinazoline derivative on human erythrocytes and on cell membrane molecular models.
Journal: Biochimica et biophysica acta 20120301
Title: Synthesis and biological evaluation of quinazoline and quinoline bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors and EPR bio-probe agents.
Journal: European journal of medicinal chemistry 20120301
Title: Quinazoline derivatives as potential anticancer agents: a patent review (2007 - 2010).
Journal: Expert opinion on therapeutic patents 20120301
Title: Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.
Journal: PLoS pathogens 20120301
Title: 3-Benzyl-6-methyl-2-sulfanylidene-2,3-di-hydroquinazolin-4(1H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20120301
Title: 2,4-Dichloro-7-fluoro-quinazoline.
Journal: Acta crystallographica. Section E, Structure reports online 20120301
Title: Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.
Journal: Journal of medicinal chemistry 20120209
Title: Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
Journal: Journal of medicinal chemistry 20120209
Title: [Mechanism of ginsenoside Rg1 regulating the activity of β secretase in N2a/APP695 cells].
Journal: Zhonghua yi xue za zhi 20120207
Title: Identification of a quinazoline alkaloid produced by Penicillium vinaceum, an endophytic fungus from Crocus sativus.
Journal: Pharmaceutical biology 20120201
Title: Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents.
Journal: Nuclear medicine and biology 20120201
Title: 7-Chloro-6,8-dinitro-quinazolin-4(3H)-one acetic acid monosolvate.
Journal: Acta crystallographica. Section E, Structure reports online 20120201
Title: EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications.
Journal: The Lancet. Oncology 20120101
Title: Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.
Journal: European journal of medicinal chemistry 20120101
Title: Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.
Journal: European journal of medicinal chemistry 20120101
Title: Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: synthesis and study of their potential cytotoxic activity in vitro.
Journal: European journal of medicinal chemistry 20120101
Title: Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.
Journal: Bioorganic & medicinal chemistry 20120101
Title: Expression of apoptosis-regulating genes in the rat prostate following botulinum toxin type A injection.
Journal: BMC urology 20120101
Title: High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase.
Journal: PloS one 20120101
Title: Effects of α-adrenoceptor antagonists on ABCG2/BCRP-mediated resistance and transport.
Journal: PloS one 20120101
Title: Synthesis of New 6-{[ω-(Dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones and Evaluation of their Anticancer and Antimicrobial Activities.
Journal: Scientia pharmaceutica 20120101
Title: Anticancer potential of 3-(arylideneamino)-2-phenylquinazoline-4(3H)-one derivatives.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Title: Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain.
Journal: PloS one 20120101
Title: Synthesis and antiepileptic activity of some novel semicarbazones containing 1,3,4-thiadiazole and quinazoline ring.
Journal: Acta poloniae pharmaceutica 20120101
Title: Stroma targeting nuclear imaging and radiopharmaceuticals.
Journal: International journal of molecular imaging 20120101
Title: High-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activity.
Journal: PloS one 20120101
Title: Uses of 2-ethoxy-4(3H) quinazolinone in synthesis of quinazoline and quinazolinone derivatives of antimicrobial activity: the solvent effect.
Journal: Global journal of health science 20120101
Title: Reactivity of 2-ethoxyquinazolin- 4-yl hydrazine and its use in synthesis of novel quinazoline derivatives of antimicrobial activity.
Journal: Global journal of health science 20120101
Title: Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes.
Journal: Biochemical and biophysical research communications 20111111
Title: 3-(4-Bromo-phen-yl)quinazolin-4(3H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20111101
Title: (6aS*,6bS*,11R*,11aR*)-6-(2-Furyl-methyl)-5,12-dioxo-5,6,6a,6b,7,11,11a,12-octa-hydro-furo[3',2':5,6]isoindolo[2,1-a]quinazoline-11-carb-oxy-lic acid.
Journal: Acta crystallographica. Section E, Structure reports online 20111101
Title: Farinamycin, a quinazoline from Streptomyces griseus.
Journal: Journal of natural products 20111028
Title: Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.
Journal: Journal of medicinal chemistry 20111013
Title: Synthesis of a quinazoline derivative: a new α₁-adrenoceptor ligand for conjugation to quantum dots to study α₁-adrenoceptors in living cells.
Journal: Bioorganic & medicinal chemistry letters 20111001
Title: Identification of potent EGFR inhibitors from TCM Database@Taiwan.
Journal: PLoS computational biology 20111001
Title: rac-(6S)-6-Hy-droxy-6-{2-[2-(propan-2-yl-idene)hydrazinyl-idene]prop-yl}indolo[2,1-b]quinazolin-12(6H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20111001
Title: Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.
Journal: Bioorganic & medicinal chemistry letters 20110915
Title: Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.
Journal: Journal of medicinal chemistry 20110908
Title: Bifunctional hydrogen-bond donors that bear a quinazoline or benzothiadiazine skeleton for asymmetric organocatalysis.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110905
Title: The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor.
Journal: International journal of oncology 20110901
Title: TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium.
Journal: The international journal of biochemistry & cell biology 20110901
Title: Targeting the human malaria parasite Plasmodium falciparum: in vitro identification of a new antiplasmodial hit in 4-phenoxy-2-trichloromethylquinazoline series.
Journal: European journal of medicinal chemistry 20110901
Title: 3-(4-Chloro-phen-yl)quinazolin-4(3H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20110901
Title: 2-(5,6-Dihydro-benzimidazo[1,2-c]quinazolin-6-yl)-5-meth-oxy-phenol.
Journal: Acta crystallographica. Section E, Structure reports online 20110901
Title: Metabolite characterization of a novel anti-cancer agent, icotinib, in humans through liquid chromatography/quadrupole time-of-flight tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20110815
Title: The combination of 4-anilinoquinazoline and cinnamic acid: a novel mode of binding to the epidermal growth factor receptor tyrosine kinase.
Journal: Bioorganic & medicinal chemistry 20110815
Title: 4-(4-{[(2-Phenyl-quinazolin-4-yl)-oxy]methyl}-1H-1,2,3-triazol-1-yl)butan-1-ol hemihydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20110801
Title: In vitro and in vivo activities of Peganum harmala extract against Leishmania major.
Journal: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110801
Title: Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling.
Journal: Bioorganic & medicinal chemistry 20110715
Title: Poly[di-μ-chlorido-μ-(1,2,3,9-tetra-hydro-pyrrolo-[2,1-b]quinazolin-9-one-κN:O)-mercury(II)].
Journal: Acta crystallographica. Section E, Structure reports online 20110701
Title: (4-Nitrophenyl)(1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazolin-3-yl)methanol monohydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20110701
Title: 2-Benz-yloxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20110701
Title: Assessing environmental risks for established invasive weeds: Dalmatian (Linaria dalmatica) and yellow (L. vulgaris) toadflax in North America.
Journal: International journal of environmental research and public health 20110701
Title: Novel EGFR inhibitors prepared by combination of dithiocarbamic acid esters and 4-anilinoquinazolines.
Journal: Bioorganic & medicinal chemistry letters 20110615
Title: Thiothymidine combined with UVA as a potential novel therapy for bladder cancer.
Journal: British journal of cancer 20110607
Title: Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: search for anticancer agent.
Journal: European journal of medicinal chemistry 20110601
Title: [Erlotinib in non-small cell lung cancer].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20110601
Title: Anoikis disruption of focal adhesion-Akt signaling impairs renal cell carcinoma.
Journal: European urology 20110501
Title: Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK.
Journal: Chemical biology & drug design 20110501
Title: A comparative QSAR analysis of quinazoline analogues as tyrosine kinase (erbB-2) inhibitors.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20110501
Title: Fourier transform microwave and millimeter wave spectroscopy of quinazoline, quinoxaline, and phthalazine.
Journal: The Journal of chemical physics 20110421
Title: Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110401
Title: High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.
Journal: PLoS neglected tropical diseases 20110401
Title: Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
Journal: Journal of medicinal chemistry 20110324
Title: Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110315
Title: Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110315
Title: One-pot synthesis of luotonin A and its analogues.
Journal: Organic letters 20110304
Title: Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.
Journal: Journal of the American Chemical Society 20110302
Title: Quinolones: from antibiotics to autoinducers.
Journal: FEMS microbiology reviews 20110301
Title: Biotransformation of quinazoline and phthalazine by Aspergillus niger.
Journal: Journal of bioscience and bioengineering 20110301
Title: MGMT is a molecular determinant for potency of the DNA-EGFR-combi-molecule ZRS1.
Journal: Molecular cancer research : MCR 20110301
Title: Pd- and Ni-catalyzed cross-coupling reactions of functionalized organozinc reagents with unsaturated thioethers.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110301
Title: Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.
Journal: Journal of medicinal chemistry 20110224
Title: Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110215
Title: Evaluation of radioiodinated quinazoline derivative as a new ligand for EGF receptor tyrosine kinase activity using SPECT.
Journal: Annals of nuclear medicine 20110201
Title: Convergent assembly of structurally diverse quinazolines.
Journal: Organic & biomolecular chemistry 20110121
Title: Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors.
Journal: Bioorganic & medicinal chemistry 20110115
Title: Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists.
Journal: Bioorganic & medicinal chemistry 20110115
Title: PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury.
Journal: PloS one 20110101
Title: Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components.
Journal: Chinese medicine 20110101
Title: Involvement of the efflux pumps in chloramphenicol selected strains of Burkholderia thailandensis: proteomic and mechanistic evidence.
Journal: PloS one 20110101
Title: Analysis of multiple compound-protein interactions reveals novel bioactive molecules.
Journal: Molecular systems biology 20110101
Title: Structure-based drug design and AutoDock study of potential protein tyrosine kinase inhibitors.
Journal: Bioinformation 20110101
Title: Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.
Journal: PloS one 20110101
Title: Quantitative assays for the measurement of HER1-HER2 heterodimerization and phosphorylation in cell lines and breast tumors: applications for diagnostics and targeted drug mechanism of action.
Journal: Breast cancer research : BCR 20110101
Title: Specific PKC isoforms regulate LPS-stimulated iNOS induction in murine microglial cells.
Journal: Journal of neuroinflammation 20110101
Title: 4-[(7-Fluoro-quinazolin-4-yl)-oxy]aniline.
Journal: Acta crystallographica. Section E, Structure reports online 20110101
Title: Combined 3D-QSAR modeling and molecular docking studies on pyrrole-indolin-2-ones as Aurora A kinase inhibitors.
Journal: International journal of molecular sciences 20110101
Title: Acridine and acridinones: old and new structures with antimalarial activity.
Journal: The open medicinal chemistry journal 20110101
Title: AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo.
Journal: PloS one 20110101
Title: Evodia rutaecarpa and Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-Induced Chemokines Production and Cell Migration.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Prediction of inhibitory activity of epidermal growth factor receptor inhibitors using grid search-projection pursuit regression method.
Journal: PloS one 20110101
Title: Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production.
Journal: PloS one 20110101
Title: Combined 3D-QSAR and docking modelling study on indolocarbazole series compounds as Tie-2 inhibitors.
Journal: International journal of molecular sciences 20110101
Title: Targets in epigenetics: inhibiting the methyl writers of the histone code.
Journal: Current chemical genomics 20110101
Title: Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells.
Journal: BMC research notes 20110101
Title: Spinal muscular atrophy.
Journal: Orphanet journal of rare diseases 20110101
Title: Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines.
Journal: Molecular cancer 20110101
Title: Utility of methyl 2-isothiocyanatobenzoate in the synthesis of some new quinazoline derivatives as potential anticancer and radiosensitizing agents.
Journal: Arzneimittel-Forschung 20110101
Title: Molecular-field-based three-dimensional similarity studies on quinoline-based CNS active agents.
Journal: ISRN pharmaceutics 20110101
Title: Investigational approaches for mesothelioma.
Journal: Frontiers in oncology 20110101
Title: Evaluation of modified PEG-anilinoquinazoline derivatives as potential agents for EGFR imaging in cancer by small animal PET.
Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20101201
Title: Synthesis and antitumor activity of some 2, 3-disubstituted quinazolin-4(3H)-ones and 4, 6- disubstituted- 1, 2, 3, 4-tetrahydroquinazolin-2H-ones.
Journal: European journal of medicinal chemistry 20101201
Title: Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells.
Journal: Investigative ophthalmology & visual science 20101101
Title: Management of ErbB2-positive breast cancer: insights from preclinical and clinical studies with lapatinib.
Journal: Japanese journal of clinical oncology 20101101
Title: Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives.
Journal: European journal of medicinal chemistry 20101101
Title: New octahydroquinazoline derivatives: synthesis and hypotensive activity.
Journal: European journal of medicinal chemistry 20101101
Title: Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.
Journal: Biochemistry 20101005
Title: Diphenyl(1-naphthyl)phosphine ancillary for assembling of red and orange-emitting Ir(III) based phosphors; strategic synthesis, photophysics, and organic light-emitting diode fabrication.
Journal: Inorganic chemistry 20101004
Title: Synthesis, antimicrobial evaluation, and docking studies of novel 4-substituted quinazoline derivatives as DNA-gyrase inhibitors.
Journal: Archiv der Pharmazie 20101001
Title: Refractory aggressive keratoacanthoma centrifugum marginatum of the scalp controlled with the epidermal growth factor receptor inhibitor erlotinib.
Journal: The British journal of dermatology 20100901
Title: Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study.
Journal: European journal of medicinal chemistry 20100901
Title: New substituted 4-arylaminoquinazolines as potent inhibitors of breast tumor cell lines: in vitro and docking experiments.
Journal: European journal of medicinal chemistry 20100901
Title: Design, synthesis, and evaluation of quinazoline T cell proliferation inhibitors.
Journal: Bioorganic & medicinal chemistry 20100901
Title: ONSH: optimization of oxidative alkylamination reactions through study of the reaction mechanism.
Journal: The Journal of organic chemistry 20100806
Title: Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains.
Journal: International journal of antimicrobial agents 20100801
Title: Synthesis, characterization and biological evaluation of In(III) complexes anchored by DOTA-like chelators bearing a quinazoline moiety.
Journal: Metallomics : integrated biometal science 20100801
Title: Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents.
Journal: Bioorganic & medicinal chemistry letters 20100715
Title: Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways.
Journal: Endocrinology 20100701
Title: 3-[(2-Chloro-6-methyl-quinolin-3-yl)meth-yl]quinazolin-4(3H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20100701
Title: (E)-3-[4-(Dimethyl-amino)-benzyl-idene]-2,3-di-hydro-1H,9H-pyrrolo-[2,1-b]quinazolin-9-one.
Journal: Acta crystallographica. Section E, Structure reports online 20100701
Title: N-[3-Chloro-4-(3-fluoro-benz-yloxy)phen-yl]-6-iodo-quinazolin-4-amine.
Journal: Acta crystallographica. Section E, Structure reports online 20100701
Title: Receptor-based virtual screening of EGFR kinase inhibitors from the NCI diversity database.
Journal: Molecules (Basel, Switzerland) 20100604
Title: 7,9-Dichloro-6H,12H-indolo[2,1-b]quinazoline-6,12-dione.
Journal: Acta crystallographica. Section E, Structure reports online 20100601
Title: Enantioseparation and plant virucidal bioactivity of new quinazoline derivatives with alpha-aminophosphonate moiety.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100515
Title: Photoinduced tandem reactions of isoquinoline-1,3,4-trione with alkynes to build aza-polycycles.
Journal: The Journal of organic chemistry 20100507
Title: (E)-3-Propoxymethyl-idene-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one monohydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20100501
Title: Access to original vinylic chlorides in the quinazoline series via a monoelectronic transfer reaction approach.
Journal: Molecules (Basel, Switzerland) 20100413
Title: Taking quinazoline as a general support-Nog to design potent and selective kinase inhibitors: application to FMS-like tyrosine kinase 3.
Journal: ChemMedChem 20100406
Title: F84, a quinazoline derivative, exhibits high potent antitumor activity against human gynecologic malignancies.
Journal: Investigational new drugs 20100401
Title: Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure-activity relationship of the quinazoline ring.
Journal: Bioorganic & medicinal chemistry letters 20100401
Title: Synthesis and antimycobacterial activity of azetidine-, quinazoline-, and triazolo-thiadiazole-containing pyrazines.
Journal: Archiv der Pharmazie 20100401
Title: Quinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer.
Journal: Journal of enzyme inhibition and medicinal chemistry 20100401
Title: Subcellular distribution of a fluorescence-labeled combi-molecule designed to block epidermal growth factor receptor tyrosine kinase and damage DNA with a green fluorescent species.
Journal: Molecular cancer therapeutics 20100401
Title: 11-(2-Oxopyrrolidin-1-ylmeth-yl)-1,2,3,4,5,6,11,11a-octa-hydro-pyrido[2,1-b]quinazolin-6-one dihydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20100401
Title: 6-Chloro-3-phenethyl-2-thioxo-2,3-di-hydro-quinazolin-4(1H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20100401
Title: Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists.
Journal: Journal of medicinal chemistry 20100325
Title: Synthesis and uptake of fluorescence-labeled Combi-molecules by P-glycoprotein-proficient and -deficient uterine sarcoma cells MES-SA and MES-SA/DX5.
Journal: Journal of medicinal chemistry 20100311
Title: Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.
Journal: Biochemistry 20100302
Title: Exploring epidermal growth factor receptor (EGFR) inhibitor features: the role of fused dioxygenated rings on the quinazoline scaffold.
Journal: Journal of medicinal chemistry 20100225
Title: New structures and bioactivity properties of jasplakinolide (jaspamide) analogues from marine sponges.
Journal: Journal of medicinal chemistry 20100225
Title: Complementary medicinal chemistry-driven strategies toward new antitrypanosomal and antileishmanial lead drug candidates.
Journal: FEMS immunology and medical microbiology 20100201
Title: Effect of household processing on fenazaquin residues in okra fruits.
Journal: Bulletin of environmental contamination and toxicology 20100201
Title: Original quinazoline derivatives displaying antiplasmodial properties.
Journal: European journal of medicinal chemistry 20100201
Title: Structural studies of B-type Aurora kinase inhibitors using computational methods.
Journal: Acta pharmacologica Sinica 20100201
Title: Click chemistry: studies on the synthesis of novel fluorous tagged triazol-4-yl substituted quinazoline derivatives and their biological evaluation--theoretical and experimental validation.
Journal: European journal of medicinal chemistry 20100101
Title: Thyroid cancer: current molecular perspectives.
Journal: Journal of oncology 20100101
Title: Marine drugs from sponge-microbe association--a review.
Journal: Marine drugs 20100101
Title: Potent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activation.
Journal: PloS one 20100101
Title: High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.
Journal: Genome medicine 20100101
Title: Structural comparison of human mammalian ste20-like kinases.
Journal: PloS one 20100101
Title: Optimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designing.
Journal: PloS one 20100101
Title: Antipsychotic potential of quinazoline ErbB1 inhibitors in a schizophrenia model established with neonatal hippocampal lesioning.
Journal: Journal of pharmacological sciences 20100101
Title: Molecular docking studies on quinazoline antifolate derivatives as human thymidylate synthase inhibitors.
Journal: Bioinformation 20100101
Title: Silodosin in the treatment of benign prostatic hyperplasia.
Journal: Drug design, development and therapy 20100101
Title: Verrucisidinol and verrucosidinol acetate, two pyrone-type polyketides isolated from a marine derived fungus, Penicillium aurantiogriseum.
Journal: Marine drugs 20100101
Title: 3D-QSAR and molecular docking studies on derivatives of MK-0457, GSK1070916 and SNS-314 as inhibitors against Aurora B kinase.
Journal: International journal of molecular sciences 20100101
Title: Molecular modeling studies of 4,5-dihydro-1H-pyrazolo[4,3-h] quinazoline derivatives as potent CDK2/Cyclin a inhibitors using 3D-QSAR and docking.
Journal: International journal of molecular sciences 20100101
Title: Reactive oxygen species enhance TLR10 expression in the human monocytic cell line THP-1.
Journal: International journal of molecular sciences 20100101
Title: Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones.
Journal: Scientia pharmaceutica 20100101
Title: Toxicity Assessment of the Xanthid Crab Demania cultripes from Cebu Island, Philippines.
Journal: Journal of toxicology 20100101
Title: Cancer chemotherapy: targeting folic acid synthesis.
Journal: Cancer management and research 20100101
Title: Synthesis and anti-microbial screening of novel schiff bases of 3-amino-2-methyl quinazolin 4-(3H)-one.
Journal: Journal of advanced pharmaceutical technology & research 20100101
Title: Apoptosis induction by doxazosin and other quinazoline alpha1-adrenoceptor antagonists: a new mechanism for cancer treatment?
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20091201
Title: Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators.
Journal: Bioorganic & medicinal chemistry letters 20091001
Title: A new therapeutic approach in Parkinson's disease: some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents.
Journal: Bioorganic & medicinal chemistry 20091001
Title: Poly(D,L-lactic-co-glycolic acid) nanoencapsulation reduces Erlotinib-induced subacute toxicity in rat.
Journal: Journal of biomedical nanotechnology 20091001
Title: Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.
Journal: Journal of the American Chemical Society 20090923
Title: Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents.
Journal: Bioorganic & medicinal chemistry letters 20090915
Title: Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines.
Journal: Journal of pineal research 20090901
Title: Disubstituted 4(3H) quinazolones: a novel class of antitumor agents.
Journal: Chemical biology & drug design 20090901
Title: 2-(2-Chloro-phen-yl)-2,3-dihydro-quinazolin-4(1H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090901
Title: 6-(2-Hydroxy-phen-yl)-5,6-dihydro-benzimidazolo[1,2-c]quinazolin-12-ium bromide ethanol solvate.
Journal: Acta crystallographica. Section E, Structure reports online 20090901
Title: Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution.
Journal: International journal of molecular sciences 20090801
Title: 6,7,8,9,10,11-Hexahydro-13H-azocino[2,1-b]quinazolin-13-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090801
Title: Microwave-promoted syntheses of quinazolines and dihydroquinazolines from 2-aminoarylalkanone O-phenyl oximes.
Journal: The Journal of organic chemistry 20090717
Title: Synthesis and in vitro antitumor activities of novel 4-anilinoquinazoline derivatives.
Journal: European journal of medicinal chemistry 20090701
Title: 3D-QSAR studies on the inhibitors of AP-1 and NF-kappaB mediated transcriptional activation.
Journal: European journal of medicinal chemistry 20090701
Title: Nitroimidazole-based bioreductive compounds bearing a quinazoline or a naphthyridine chromophore.
Journal: Anti-cancer drugs 20090701
Title: The discovery of the potent aurora inhibitor MK-0457 (VX-680).
Journal: Bioorganic & medicinal chemistry letters 20090701
Title: 2-(5,6-Di-hydro-benzimidazolo[1,2-c]quinazolin-6-yl)aniline methanol solvate.
Journal: Acta crystallographica. Section E, Structure reports online 20090701
Title: Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
Journal: Investigative ophthalmology & visual science 20090601
Title: Disposable DNA biosensor with the carbon nanotubes-polyethyleneimine interface at a screen-printed carbon electrode for tests of DNA layer damage by quinazolines.
Journal: Analytical and bioanalytical chemistry 20090601
Title: Downregulation of GSTpi expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through c-jun NH2-terminal kinase-mediated apoptosis.
Journal: Anti-cancer drugs 20090601
Title: Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.
Journal: Bioorganic & medicinal chemistry letters 20090601
Title: Advances in marine microbial symbionts in the china sea and related pharmaceutical metabolites.
Journal: Marine drugs 20090601
Title: 3-Amino-2-methyl-4-oxo-3,4-dihydro-quinazolin-1-ium p-toluene-sulfonate monohydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20090501
Title: Methyl 2-amino-4-(3-chloro-prop-oxy)-5-methoxy-benzoate.
Journal: Acta crystallographica. Section E, Structure reports online 20090501
Title: Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090415
Title: Rational design of multitargeted tyrosine kinase inhibitors: a novel approach.
Journal: Chemical biology & drug design 20090401
Title: Three-dimensional quantitative structure-activity relationship studies on c-Src inhibitors based on different docking methods.
Journal: Chemical biology & drug design 20090401
Title: Methyl 4-(3-chloro-prop-oxy)-5-meth-oxy-2-nitro-benzoate.
Journal: Acta crystallographica. Section E, Structure reports online 20090401
Title: Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.
Journal: Bioorganic & medicinal chemistry letters 20090315
Title: Development of a fluorescent chelating ligand for gallium ion having a quinazoline structure with two Schiff base moieties.
Journal: Analytica chimica acta 20090309
Title: Synthesis of quinazolines as tyrosine kinase inhibitors.
Journal: Anti-cancer agents in medicinal chemistry 20090301
Title: 3-Hydr-oxy-1,2,3,9-tetra-hydro-pyrrolo[2,1-b]quinazolin-4-ium chloride dihydrate: (+)-vasicinol hydro-chloride dihydrate from Peganum harmala L.
Journal: Acta crystallographica. Section E, Structure reports online 20090301
Title: Methyl 5-meth-oxy-2-nitro-4-[3-(piperidin-1-yl)prop-oxy]benzoate.
Journal: Acta crystallographica. Section E, Structure reports online 20090301
Title: Methyl 4-(3-chloro-prop-oxy)-3-methoxy-benzoate.
Journal: Acta crystallographica. Section E, Structure reports online 20090201
Title: Methyl 4-but-oxy-3-methoxy-benzoate.
Journal: Acta crystallographica. Section E, Structure reports online 20090201
Title: Molecular and ionic hydrogen bond formation in fluorous solvents.
Journal: The journal of physical chemistry. B 20090108
Title: Promising carboranylquinazolines for boron neutron capture therapy: synthesis, characterization, and in vitro toxicity evaluation.
Journal: European journal of medicinal chemistry 20090101
Title: Aromatic organic compounds as scaffolds for metallocarboxypeptidase inhibitor design.
Journal: Chemical biology & drug design 20090101
Title: RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation.
Journal: Journal of translational medicine 20090101
Title: Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function.
Journal: PloS one 20090101
Title: NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons.
Journal: Molecular pain 20090101
Title: Current available therapies and future directions in the treatment of malignant gliomas.
Journal: Biologics : targets & therapy 20090101
Title: Caveolae contribute to the apoptosis resistance induced by the alpha(1A)-adrenoceptor in androgen-independent prostate cancer cells.
Journal: PloS one 20090101
Title: Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.
Journal: PloS one 20090101
Title: Interpretable correlation descriptors for quantitative structure-activity relationships.
Journal: Journal of cheminformatics 20090101
Title: Side-effects of fenazaquin on a cellular model of Paramecium.
Journal: Communications in agricultural and applied biological sciences 20090101
Title: Synthesis and pharmacological evaluation of schiff bases of 4-(2-aminophenyl)-morpholines.
Journal: Indian journal of pharmaceutical sciences 20090101
Title: 3-(2-Amino-ethyl)-2-(4-chloro-anilino)-quinazolin-4(3H)-one methanol 0.75-solvate.
Journal: Acta crystallographica. Section E, Structure reports online 20090101
Title: 3,3'-Bis(4-chloro-phen-yl)-2,2'-(m-phenyl-enedi-oxy)diquinazolin-4(3H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090101
Title: Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives.
Journal: Chemical communications (Cambridge, England) 20081221
Title: Amine-reactive fluorene probes: synthesis, optical characterization, bioconjugation, and two-photon fluorescence imaging.
Journal: Bioconjugate chemistry 20081217
Title: QSAR of aromatic substances: EGFR inhibitory activity of quinazoline analogues.
Journal: Journal of enzyme inhibition and medicinal chemistry 20081201
Title: Desirability-based multiobjective optimization for global QSAR studies: application to the design of novel NSAIDs with improved analgesic, antiinflammatory, and ulcerogenic profiles.
Journal: Journal of computational chemistry 20081115
Title: Chemical substructures that enrich for biological activity.
Journal: Bioinformatics (Oxford, England) 20081101
Title: 6-(2-Fluoro-phen-yl)-5,6-dihydro-benzimidazolo[1,2-c]quinazoline.
Journal: Acta crystallographica. Section E, Structure reports online 20081101
Title: Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.
Journal: Journal of medicinal chemistry 20081023
Title: N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.
Journal: Journal of medicinal chemistry 20081009
Title: Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities.
Journal: Journal of natural medicines 20081001
Title: Homology models of the mutated EGFR and their response towards quinazoline analogues.
Journal: Journal of molecular graphics & modelling 20081001
Title: Insight into the structural requirements of proton pump inhibitors based on CoMFA and CoMSIA studies.
Journal: Journal of molecular graphics & modelling 20081001
Title: Imaging of EGFR and EGFR tyrosine kinase overexpression in tumors by nuclear medicine modalities.
Journal: Current pharmaceutical design 20081001
Title: Medical therapy options for aging men with benign prostatic hyperplasia: focus on alfuzosin 10 mg once daily.
Journal: Clinical interventions in aging 20080901
Title: Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.
Journal: Journal of medicinal chemistry 20080814
Title: Verrucine F, a quinazoline from Penicillium verrucosum.
Journal: Journal of natural products 20080801
Title: Synthesis of dipicolylamino substituted quinazoline as chemosensor for cobalt(II) recognition based on excited-state intramolecular proton transfer.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080701
Title: Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo.
Journal: Antiviral research 20080701
Title: Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a 99mTc biomarker for EGFR-TK imaging.
Journal: Dalton transactions (Cambridge, England : 2003) 20080628
Title: Molecular docking/dynamics studies of Aurora A kinase inhibitors.
Journal: Journal of molecular graphics & modelling 20080601
Title: Impacts of the quinazoline-based alpha1-antagonist, terazosin, and of the sulfonamide derivative, tamsulosin, on serum prostate-specific antigen and prostate volume.
Journal: Journal of Korean medical science 20080601
Title: Biotransformation of 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878), a novel 5-hydroxytryptamine (5-HT)1A agonist/5-HT3 antagonist, in human hepatic cytochrome P450 enzymes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080501
Title: [Mass spectrometric analysis of quinazoline alkaloid and limonin from Fructus Evodiae].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080501
Title: (S)-Ethyl 1,2,3,9-tetra-hydro-pyrrolo[2,1-b]quinazoline-1-carboxyl-ate.
Journal: Acta crystallographica. Section E, Structure reports online 20080501
Title: Erlotinib hydro-chloride: an anti-cancer agent.
Journal: Acta crystallographica. Section E, Structure reports online 20080501
Title: Towards predictive inhibitor design for the EGFR autophosphorylation activity.
Journal: European journal of medicinal chemistry 20080401
Title: CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors.
Journal: Bioorganic & medicinal chemistry 20080401
Title: Role of phosphodiesterase 5 in synaptic plasticity and memory.
Journal: Neuropsychiatric disease and treatment 20080401
Title: Erlotinib: an EGF receptor tyrosine kinase inhibitor in non-small-cell lung cancer treatment.
Journal: Expert review of respiratory medicine 20080401
Title: Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403).
Journal: British journal of cancer 20080311
Title: EGFR inhibitor enhances cisplatin sensitivity of oral squamous cell carcinoma cell lines.
Journal: Pathology oncology research : POR 20080301
Title: Erlotinib in the treatment of advanced pancreatic cancer.
Journal: Biologics : targets & therapy 20080301
Title: 3D-QSAR and docking studies of 3-arylquinazolinethione derivatives as selective estrogen receptor modulators.
Journal: Journal of molecular modeling 20080201
Title: Quinoline, quinazoline and acridone alkaloids.
Journal: Natural product reports 20080201
Title: Anti-inflammatory preconditioning by agonists of adenosine A1 receptor.
Journal: PloS one 20080101
Title: Synthesis of some new quinazolin-4-one derivatives and evaluation of their antimicrobial and antiinflammatory effects.
Journal: Acta poloniae pharmaceutica 20080101
Title: Synthesis and characterization of novel quinazoline type inhibitors for mutant and wild-type EGFR and RICK kinases.
Journal: Journal of receptor and signal transduction research 20080101
Title: Synthesis and Bronchodilator Studies of Some Novel 6-Alkyl/Aryl-1,2,4-Triazino[4,3-c]Quinazolines.
Journal: The open medicinal chemistry journal 20080101
Title: Validation of Different Methods of Preparation of Adhatoda vasica Leaf Juice by Quantification of Total Alkaloids and Vasicine.
Journal: Indian journal of pharmaceutical sciences 20080101
Title: Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups.
Journal: Bioorganic & medicinal chemistry 20071115
Title: Antifolate screening using yeast expressing Plasmodium vivax dihydrofolate reductase and in vitro drug susceptibility assay for Plasmodium falciparum.
Journal: Molecular and biochemical parasitology 20071101
Title: Effect of alpha1-adrenoceptor antagonist exposure on prostate cancer incidence: an observational cohort study.
Journal: The Journal of urology 20071101
Title: Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives.
Journal: Anti-cancer agents in medicinal chemistry 20071101
Title: Copper(I) cyanide networks: synthesis, luminescence behavior and thermal analysis. Part 1. Diimine ligands.
Journal: Inorganic chemistry 20071015
Title: TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression.
Journal: Journal of cellular physiology 20071001
Title: Quinazoline derivatives as MC-I inhibitors: evaluation of myocardial uptake using Positron Emission Tomography in rat and non-human primate.
Journal: Bioorganic & medicinal chemistry letters 20070901
Title: Protective effect of Adhatoda vascia Nees against radiation-induced damage at cellular, biochemical and chromosomal levels in Swiss albino mice.
Journal: Evidence-based complementary and alternative medicine : eCAM 20070901
Title: The molecular genetics of breast cancer and targeted therapy.
Journal: Biologics : targets & therapy 20070901
Title: Impact of physicochemical and structural properties on the pharmacokinetics of a series of alpha1L-adrenoceptor antagonists.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070801
Title: Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer.
Journal: Bioorganic & medicinal chemistry 20070615
Title: Effect of surfactants on the voltammetric response and determination of an antihypertensive drug.
Journal: Talanta 20070615
Title: The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer.
Journal: Bioorganic & medicinal chemistry letters 20070601
Title: Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats.
Journal: Neuropharmacology 20070601
Title: Erlotinib in cancer treatment.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070601
Title: Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19.
Journal: Journal of natural products 20070501
Title: Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
Journal: Nature chemical biology 20070401
Title: Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy.
Journal: British journal of cancer 20070326
Title: hEGR1 is induced by EGF, inhibited by gefitinib in bladder cell lines and related to EGF receptor levels in bladder tumours.
Journal: British journal of cancer 20070312
Title: Quinazoline and benzimidazole MCH-1R antagonists.
Journal: Bioorganic & medicinal chemistry letters 20070301
Title: Quinoline, quinazoline and acridone alkaloids.
Journal: Natural product reports 20070201
Title: [Fluorescence spectra of Dichroa febrifuga aqueous extraction].
Journal: Guang pu xue yu guang pu fen xi = Guang pu 20070201
Title: QSAR analysis of tyrosine kinase inhibitor using modified ant colony optimization and multiple linear regression.
Journal: European journal of medicinal chemistry 20070101
Title: Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents.
Journal: Current topics in medicinal chemistry 20070101
Title: Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones.
Journal: Beilstein journal of organic chemistry 20070101
Title: Rappertk: a versatile engine for discrete restraint-based conformational sampling of macromolecules.
Journal: BMC structural biology 20070101
Title: The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses proliferation and invasion of human oral squamous carcinoma cells via p53 independent and MMP, uPAR dependent mechanism.
Journal: Annals of the New York Academy of Sciences 20070101
Title: Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3-methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one.
Journal: Metal-based drugs 20070101
Title: Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs.
Journal: Bioorganic & medicinal chemistry 20061215
Title: Single-step synthesis of pyrimidine derivatives.
Journal: Journal of the American Chemical Society 20061108
Title: Structure-affinity relationships of adenosine A2B receptor ligands.
Journal: Medicinal research reviews 20060901
Title: [Synthetic studies on aromatic heterocyclic compounds].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060801
Title: Exploration of a new type of antimalarial compounds based on febrifugine.
Journal: Journal of medicinal chemistry 20060727
Title: Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by dehydroevodiamine through suppression of NF-kappaB activation in RAW 264.7 macrophages.
Journal: Life sciences 20060710
Title: Specific rescue of cystic fibrosis transmembrane conductance regulator processing mutants using pharmacological chaperones.
Journal: Molecular pharmacology 20060701
Title: New symmetrical quinazoline derivatives selectively induce apoptosis in human cancer cells.
Journal: Cancer biology & therapy 20060701
Title: Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach.
Journal: Molecular cancer therapeutics 20060701
Title: 1,3-Dipolar character of 2-vinyl quinazoline 3-oxides; first and second generation cycloaddition products.
Journal: Organic & biomolecular chemistry 20060621
Title: The combi-targeting concept: synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR).
Journal: Journal of medicinal chemistry 20060615
Title: Binding mode of novel 1-substituted quinazoline derivatives to poly(ADP-ribose) polymerase-catalytic domain, revealed by X-ray crystal structure analysis of complexes.
Journal: Biochimica et biophysica acta 20060501
Title: Identification of potent and selective inhibitors of PDGF receptor autophosphorylation.
Journal: Journal of medicinal chemistry 20060406
Title: SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20060301
Title: Synthesis and bronchodilator activity of new quinazolin derivative.
Journal: European journal of medicinal chemistry 20060301
Title: Alkaloids from the roots of Aconitum pseudo-laeve var. erectum.
Journal: Journal of natural products 20060301
Title: Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors.
Journal: Journal of medicinal chemistry 20060223
Title: Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.
Journal: Journal of medicinal chemistry 20060209
Title: Computational study of antagonist/alpha1A adrenoceptor complexes--observations of conformational variations on the formation of ligand/receptor complexes.
Journal: Journal of medicinal chemistry 20060126
Title: Region-, age-, and sex-specific effects of fetal diazepam exposure on the postnatal development of neurosteroids.
Journal: Brain research 20060105
Title: The effect of 3-(5-nitro-2-thienyl)-9-chloro-5-morpholin-4-yl[1,2,4]triazolo[4,3-c]quinazoline on cell growth, cell cycle, induction of DNA fragmentation, and activity of caspase 3 in murine leukemia L1210 cells and fibroblast NIH-3T3 cells.
Journal: Cell biochemistry and function 20060101
Title: Recent advances in the solid-phase combinatorial synthetic strategies for the quinoxaline, quinazoline and benzimidazole based privileged structures.
Journal: Mini reviews in medicinal chemistry 20060101
Title: Cytotoxic/antiproliferative effects of new [1,2,4]triazolo[4,3-c] quinazolines in tumor cell lines HeLa and B16.
Journal: Neoplasma 20060101
Title: Synthesis and antitumor activity of some novel quinazoline derivatives bearing the biologically active thione moiety.
Journal: Arzneimittel-Forschung 20060101
Title: Synthesis and biological evaluation of new quinazoline and cinnoline derivatives as potential atypical antipsychotics.
Journal: Chemistry & biodiversity 20060101
Title: Luminescence ranging from red to blue: a series of copper(I)-halide complexes having rhombic {Cu2(mu-X)2} (X = Br and I) units with N-heteroaromatic ligands.
Journal: Inorganic chemistry 20051226
Title: Bridgehead nitrogen heterocycles which contain the quinazoline moiety -- synthesis and cycloaddition of 1,2-dihydroquinazoline 3-oxides.
Journal: Organic & biomolecular chemistry 20051221
Title: Gefitinib (ZD1839) combined with weekly epirubicin in patients with metastatic breast cancer: a phase I study with biological correlate.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20051201
Title: Cytotoxicity and detection of damage to DNA by 3-(5-nitro-2-thienyl)-9-chloro-5-morpholin-4-yl[1,2,4]triazolo[4,3-c] quinazoline on human cancer cell line HeLa.
Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201
Title: Rescue of folding defects in ABC transporters using pharmacological chaperones.
Journal: Journal of bioenergetics and biomembranes 20051201
Title: Development of a high-throughput robotic fluorescence-based assay for HsEg5 inhibitor screening.
Journal: Analytical biochemistry 20051015
Title: Quinoline, quinazoline and acridone alkaloids.
Journal: Natural product reports 20051001
Title: Synthesis, tautomeric states and crystal structure of (Z)-ethyl 2-cyano-2-(3H-quinazoline-4-ylidene) acetate and (Z)-ethyl 2-cyano-2-(2-methyl-3H-quinazoline-4-ylidene) acetate.
Journal: Molecules (Basel, Switzerland) 20050930
Title: Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.
Journal: Journal of molecular biology 20050909
Title: 3D-QSAR studies on c-Src kinase inhibitors and docking analyses of a potent dual kinase inhibitor of c-Src and c-Abl kinases.
Journal: Bioorganic & medicinal chemistry 20050801
Title: Chemopreventive and therapeutic efficacy of orally active tyrosine kinase inhibitors in a transgenic mouse model of gallbladder carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050801
Title: Diverse small-molecule modulators of SMN expression found by high-throughput compound screening: early leads towards a therapeutic for spinal muscular atrophy.
Journal: Human molecular genetics 20050715
Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.
Journal: Chemical research in toxicology 20050601
Title: Recombinant adeno-associated virus type 2-mediated gene transfer into human keratinocytes is influenced by both the ubiquitin/proteasome pathway and epidermal growth factor receptor tyrosine kinase.
Journal: Archives of dermatological research 20050501
Title: Treatment for methaqualone dependence in adults.
Journal: The Cochrane database of systematic reviews 20050418
Title: High performance liquid chromatography analysis of a 4-anilinoquinazoline derivative (PD153035), a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in rat plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325
Title: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.
Journal: PLoS medicine 20050301
Title: Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.
Journal: Journal of medicinal chemistry 20050210
Title: alpha1-Adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.
Journal: Journal of immunotherapy (Hagerstown, Md. : 1997) 20050101
Title: Biotransformation of desoxypeganine by microsomal enzymes of the rabbit liver.
Journal: Archiv der Pharmazie 20050101
Title: HPTLC determination of vasicine and vasicinone in Adhatoda vasica.
Journal: Phytochemical analysis : PCA 20050101
Title: Rescue of DeltaF508 and other misprocessed CFTR mutants by a novel quinazoline compound.
Journal: Molecular pharmaceutics 20050101
Title: The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats.
Journal: Lipids in health and disease 20050101
Title: The centroidal algorithm in molecular similarity and diversity calculations on confidential datasets.
Journal: Journal of computer-aided molecular design 20050101
Title: The combi-targeting concept: dissection of the binary mechanism of action of the combi-triazene SMA41 in vitro and antitumor activity in vivo.
Journal: The Journal of pharmacology and experimental therapeutics 20041201
Title: Nucleosides XI. Synthesis and antiviral evaluation of 5'-alkylthio-5'-deoxy quinazolinone nucleoside derivatives as S-adenosyl-L-homocysteine analogs.
Journal: Chemical & pharmaceutical bulletin 20041201
Title: Absolute configuration of the alpha (1B)-adrenoceptor antagonist (+)-cyclazosin.
Journal: Farmaco (Societa chimica italiana : 1989) 20041201
Title: Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells.
Journal: Biochemical pharmacology 20041001
Title: Quinoline, quinazoline and acridone alkaloids.
Journal: Natural product reports 20041001
Title: Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839).
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041001
Title: Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20041001
Title: Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
Journal: Journal of natural products 20040901
Title: Induction of anoikis by doxazosin in prostate cancer cells is associated with activation of caspase-3 and a reduction of focal adhesion kinase.
Journal: Urological research 20040801
Title: Epidermal growth factor receptor tyrosine kinase inhibitors.
Journal: British journal of cancer 20040614
Title: Novel carbon-11 labeled 4-dimethylamino-but-2-enoic acid [4-(phenylamino)-quinazoline-6-yl]-amides: potential PET bioprobes for molecular imaging of EGFR-positive tumors.
Journal: Nuclear medicine and biology 20040501
Title: New derivatives of quinazoline and 1, 2-dihydroquinazoline n3-oxide with expected antitumor activity.
Journal: Archiv der Pharmazie 20040501
Title: Gefitinib ('Iressa', ZD1839) inhibits the growth response of bladder tumour cell lines to epidermal growth factor and induces TIMP2.
Journal: British journal of cancer 20040419
Title: Inhibition of cell signaling by the combi-nitrosourea FD137 in the androgen independent DU145 prostate cancer cell line.
Journal: The Prostate 20040401
Title: [How have we found any new reactions in the field of the heterocyclic chemistry?].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040401
Title: Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors.
Journal: Breast cancer research and treatment 20040101
Title: [The antioxidant activity of S-(4-quinazolyl)mercaptoacetic acid benzylidene hydrazides in vitro in the 'nitrosation stress' model].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20040101
Title: Cytotoxic and genotoxic effects of some substituted tetrazolo[1,5-c]quinazolines.
Journal: Neoplasma 20040101
Title: Protonation site and hydrogen bonding in anhydrous and hydrated crystalline forms of doxazosin mesylate from powder data.
Journal: Acta crystallographica. Section B, Structural science 20031201
Title: The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies.
Journal: Bioorganic & medicinal chemistry letters 20031117
Title: Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 3. Replacement of quinazoline moiety and improvement of metabolic polymorphism of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
Journal: Journal of medicinal chemistry 20031106
Title: Alfuzosin for the management of benign prostate hyperplasia.
Journal: Expert opinion on pharmacotherapy 20031101
Title: [Radiotherapy and inhibitors of epidermal growth factor receptor: preclinical findings and preliminary clinical trials].
Journal: Bulletin du cancer 20031101
Title: Quinoline, quinazoline and acridone alkaloids.
Journal: Natural product reports 20031001
Title: The combi-targeting concept: chemical dissection of the dual targeting properties of a series of 'combi-triazenes'.
Journal: Journal of medicinal chemistry 20030925
Title: Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
Journal: Bioorganic & medicinal chemistry letters 20030915
Title: Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.
Journal: Acta crystallographica. Section D, Biological crystallography 20030901
Title: A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives.
Journal: Bioorganic & medicinal chemistry 20030901
Title: Erlotinib: a new therapeutic approach for non-small cell lung cancer.
Journal: Expert opinion on investigational drugs 20030801
Title: Assessment of the stereoselective metabolism of methaqualone in man by capillary electrophoresis.
Journal: Electrophoresis 20030801
Title: Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor.
Journal: Biochemical and biophysical research communications 20030725
Title: Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.
Journal: The Journal of biological chemistry 20030711
Title: Photodecomposition of an acaricide, fenazaquin, in aqueous alcoholic solution.
Journal: Journal of agricultural and food chemistry 20030702
Title: Searching for cyclazosin analogues as alpha(1B)-adrenoceptor antagonists.
Journal: Farmaco (Societa chimica italiana : 1989) 20030701
Title: Pharmacological characterization of unique prazosin-binding sites in human kidney.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030701
Title: Paralytic toxicity in the ribbon worm Cephalothrix species (Nemertea) in Hiroshima Bay, Hiroshima Prefecture, Japan and the isolation of tetrodotoxin as a main component of its toxins.
Journal: Toxicon : official journal of the International Society on Toxinology 20030601
Title: Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction.
Journal: British journal of cancer 20030519
Title: Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance.
Journal: The Journal of urology 20030401
Title: Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG).
Journal: Bioorganic & medicinal chemistry letters 20030324
Title: Anoikis induction by quinazoline based alpha 1-adrenoceptor antagonists in prostate cancer cells: antagonistic effect of bcl-2.
Journal: The Journal of urology 20030301
Title: Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design.
Journal: Molecular cancer therapeutics 20030301
Title: Structure-activity relationships of 6-fluoroquinazolines: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation.
Journal: Bioorganic & medicinal chemistry 20030220
Title: Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation.
Journal: Bioorganic & medicinal chemistry 20030206
Title: Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells.
Journal: The Journal of urology 20030201
Title: Mapping the binding site of a large set of quinazoline type EGF-R inhibitors using molecular field analyses and molecular docking studies.
Journal: Journal of chemical information and computer sciences 20030101
Title: Synthesis and biological evaluation of some quinazoline derivatives as antitumor and antiviral agents.
Journal: Arzneimittel-Forschung 20030101
Title: Anti-HER therapeutic agents in the treatment of non-small-cell lung cancer.
Journal: Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20030101
Title: Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata.
Journal: Journal of natural products 20021201
Title: Quinoline, quinazoline and acridone alkaloids.
Journal: Natural product reports 20021201
Title: Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling.
Journal: Life sciences 20021011
Title: Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function.
Journal: International journal of cancer 20020910
Title: 4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors.
Journal: Current topics in medicinal chemistry 20020901
Title: Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
Journal: Acta crystallographica. Section D, Biological crystallography 20020901
Title: Erlotinib OSI/Roche/Genentech.
Journal: Current opinion in investigational drugs (London, England : 2000) 20020901
Title: Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography.
Journal: Journal of medicinal chemistry 20020829
Title: The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent.
Journal: Journal of medicinal chemistry 20020815
Title: Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.
Journal: Journal of medicinal chemistry 20020815
Title: Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives.
Journal: Journal of medicinal chemistry 20020704
Title: II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).
Journal: Journal of medicinal chemistry 20020704
Title: Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists.
Journal: Current topics in medicinal chemistry 20020601
Title: Other secondary sequelae of treatments for myeloproliferative disorders.
Journal: Seminars in oncology 20020601
Title: Synthesis and bronchodilatory activity of some nitrogen bridgehead compounds.
Journal: European journal of medicinal chemistry 20020501
Title: Sequence-dependent effects of ZD1839 ('Iressa') in combination with cytotoxic treatment in human head and neck cancer.
Journal: British journal of cancer 20020304
Title: Novel quinazoline ring synthesis by cycloaddition of N-arylketenimines with N,N-disubstituted cyanamides.
Journal: Chemical & pharmaceutical bulletin 20020301
Title: CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020101
Title: Alfuzosin: a review of the therapeutic use of the prolonged-release formulation given once daily in the management of benign prostatic hyperplasia.
Journal: Drugs 20020101
Title: Irreversible inhibitors of the erbB family of protein tyrosine kinases.
Journal: Pharmacology & therapeutics 20020101
Title: Synthesis and alpha 1-adrenoceptor antagonistic activity of some 4-amino-5,7-dimethyl-2-(substituted) aminopyrido (2,3-d) pyrimidines.
Journal: Arzneimittel-Forschung 20020101
Title: Induction of prostate apoptosis by alpha1-adrenoceptor antagonists: mechanistic significance of the quinazoline component.
Journal: Prostate cancer and prostatic diseases 20020101
Title: Synthesis and antiinflammatory screening of some quinazoline and quinazolyl-4-oxoquinazoline derivatives.
Journal: Archiv der Pharmazie 20020101
Title: Ferromagnetic exchange coupling of vanadium(IV) dpi spins across pyrimidine rings: dinuclear complexes of oxovanadium(IV) bis(1,1,1,5,5,5-hexafluoropentane-2,4-dionate) bridged by pyrimidine derivatives.
Journal: Inorganic chemistry 20011231
Title: Antihypertensive action and blockade of alpha1-adrenoceptors by DL-017, a quinazoline derivative.
Journal: Journal of cardiovascular pharmacology 20011201
Title: Total solid phase syntheses of the quinazoline alkaloids: verrucines A and B and anacine.
Journal: Journal of natural products 20011201
Title: A novel alkaloid serantrypinone and the spiro azaphilone daldinin D from Penicillium thymicola.
Journal: Journal of natural products 20011201
Title: A(3) adenosine receptor antagonists.
Journal: Mini reviews in medicinal chemistry 20011101
Title: The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.
Journal: Cancer research 20011001
Title: A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011001
Title: Quinoline, quinazoline and acridone alkaloids.
Journal: Natural product reports 20011001
Title: Blockade of alpha1-adrenoceptors and cardiac depressant effect by a newly synthetic antihypertensive drug, DL-017 of quinazoline derivative.
Journal: The Chinese journal of physiology 20010930
Title: Effect of an EGF-R selective tyrosine kinase inhibitor and an anti-androgen on LNCaP cells: identification of divergent growth regulatory pathways.
Journal: The Prostate 20010915
Title: Quantitative study of the structural requirements of phthalazine/quinazoline derivatives for interaction with human liver aldehyde oxidase.
Journal: Chemical & pharmaceutical bulletin 20010901
Title: X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor.
Journal: Journal of medicinal chemistry 20010830
Title: S(+)-4-(1-Phenylethylamino)quinazolines as inhibitors of human immunoglobulin E synthesis: potency is dictated by stereochemistry and atomic point charges at N-1.
Journal: Journal of medicinal chemistry 20010830
Title: Quinazolines as cyclin dependent kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20010507
Title: Structure-based design of novel anticancer agents.
Journal: Current cancer drug targets 20010501
Title: Structure-activity relationships of quinazoline derivatives: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation.
Journal: Bioorganic & medicinal chemistry letters 20010226
Title: OSI-774 OSI Pharmaceuticals.
Journal: Current opinion in investigational drugs (London, England : 2000) 20010201
Title: 4-[3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvate and 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride.
Journal: Acta crystallographica. Section C, Crystal structure communications 20010101
Title: A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010101
Title: The 4-anilinoquinazoline class of inhibitors of the erbB family of receptor tyrosine kinases.
Journal: Farmaco (Societa chimica italiana : 1989) 20010101
Title: The efficacy of alfuzosin treatment in patients with prostatism.
Journal: International urology and nephrology 20010101
