Home Amines 26148-68-5
26148-68-5,MFCD00210750
Catalog No.:AA002RS1

26148-68-5 | 9H-Pyrido[2,3-b]indol-2-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$111.00   $78.00
- +
25mg
98%
in stock  
$165.00   $115.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002RS1
Chemical Name:
9H-Pyrido[2,3-b]indol-2-amine
CAS Number:
26148-68-5
Molecular Formula:
C11H9N3
Molecular Weight:
183.2093
MDL Number:
MFCD00210750
SMILES:
Nc1ccc2c(n1)[nH]c1c2cccc1
Properties
Computed Properties
 
Complexity:
219  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
2.6  

Downstream Synthesis Route

[1]Sadovoy;Golubeva;Nasakin[ChemistryofHeterocyclicCompounds,2001,vol.37,#9,p.1145-1149]

Literature

Title: Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20171001

Title: Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells.

Journal: Archives of toxicology 20170901

Title: Aryl hydrocarbon receptor activation and CYP1A induction by cooked food-derived carcinogenic heterocyclic amines in human HepG2 cell lines.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20161101

Title: Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice.

Journal: Chemical research in toxicology 20151221

Title: DNA adducts of the tobacco carcinogens 2-amino-9H-pyrido[2,3-b]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes.

Journal: Chemical research in toxicology 20130916

Title: QSAR and metabolic assessment tools in the assessment of genotoxicity.

Journal: Methods in molecular biology (Clifton, N.J.) 20130101

Title: UDP-glucuronosyltransferase-mediated metabolic activation of the tobacco carcinogen 2-amino-9H-pyrido[2,3-b]indole.

Journal: The Journal of biological chemistry 20120427

Title: DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.

Journal: Chemical research in toxicology 20110620

Title: Screening of non-polar heterocyclic amines in urine by microextraction in packed sorbent-fluorimetric detection and confirmation by capillary liquid chromatography.

Journal: Talanta 20110215

Title: Naturally occurring food toxins.

Journal: Toxins 20100901

Title: Identification of carcinogen DNA adducts in human saliva by linear quadrupole ion trap/multistage tandem mass spectrometry.

Journal: Chemical research in toxicology 20100719

Title: Simultaneous determination of six non-polar heterocyclic amines in meat samples by supercritical fluid extraction-capillary electrophoresis under fluorimetric detection.

Journal: Electrophoresis 20100701

Title: Suitability of ionic liquids as mobile-phase additives in HPLC with fluorescence and UV detection for the determination of heterocyclic aromatic amines.

Journal: Journal of separation science 20100201

Title: Biomonitoring of carcinogenic heterocyclic aromatic amines in hair: a validation study.

Journal: Chemical research in toxicology 20090817

Title: The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole.

Journal: Chemical research in toxicology 20090401

Title: Effect of 2-amino-9H-pyrido[2,3-b]indole (AalphaC), a carcinogenic heterocyclic amine present in food, on atherosclerotic plaque development in apoE deficient mice.

Journal: Toxicology letters 20090310

Title: Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker.

Journal: Journal of toxicologic pathology 20090301

Title: Prospective study of dietary patterns and colorectal cancer among Singapore Chinese.

Journal: British journal of cancer 20081104

Title: Binding of heterocyclic aromatic amines by lactic acid bacteria: results of a comprehensive screening trial.

Journal: Molecular nutrition & food research 20080301

Title: Model studies of lignified fiber fermentation by human fecal microbiota and its impact on heterocyclic aromatic amine adsorption.

Journal: Mutation research 20071101

Title: Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070801

Title: Solid-matrix luminescence of heterocyclic aromatic amines in several new sugar-glass systems.

Journal: Talanta 20070415

Title: Metabolites of the carcinogen 2-amino-alpha-carboline formed in male Sprague-Dawley rats in vivo and in rat hepatocyte and human HepG2 cell incubates.

Journal: Chemical research in toxicology 20070301

Title: Differential effects of heterocyclic amines on poly(ADP-ribose) polymerase-1 and mono-ADP-ribosyltransferase A.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060901

Title: Influence of lignification and feruloylation of maize cell walls on the adsorption of heterocyclic aromatic amines.

Journal: Journal of agricultural and food chemistry 20060308

Title: Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051025

Title: Quantitation of carcinogenic heterocyclic aromatic amines and detection of novel heterocyclic aromatic amines in cooked meats and grill scrapings by HPLC/ESI-MS.

Journal: Journal of agricultural and food chemistry 20050420

Title: Two food-borne heterocyclic amines: metabolism and DNA adduct formation of amino-alpha-carbolines.

Journal: Molecular nutrition & food research 20050301

Title: Analysis of alpha- and beta-carbolines in mainstream smoke of reference cigarettes by gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20040813

Title: Syntheses of DNA adducts of two heterocyclic amines, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) and 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and identification of DNA adducts in organs from rats dosed with MeAalphaC.

Journal: Carcinogenesis 20040801

Title: Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry.

Journal: Chemical research in toxicology 20040801

Title: Excretion of metabolites in urine and faeces from rats dosed with the heterocyclic amine, 2-amino-9H-pyrido[2,3-b]indole (AalphaC).

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040601

Title: Relationship between content and activity of cytochrome P450 and induction of heterocyclic amine DNA adducts in human liver samples in vivo and in vitro.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040601

Title: Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040325

Title: DNA adduct formation of 14 heterocyclic aromatic amines in mouse tissue after oral administration and characterization of the DNA adduct formed by 2-amino-9H-pyrido[2,3-b]indole (AalphaC), analysed by 32P_HPLC.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20040101

Title: Prevention of heterocyclic amine-induced DNA damage in colon and liver of rats by different lactobacillus strains.

Journal: Carcinogenesis 20031201

Title: Impact of five cytochrome p450 enzymes on the metabolism of two heterocyclic aromatic amines, 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC).

Journal: Pharmacology & toxicology 20030501

Title: Probiotic mixture decreases DNA adduct formation in colonic epithelium induced by the food mutagen 2-amino-9H-pyrido[2,3-b]indole in a human-flora associated mouse model.

Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20030401

Title: The food mutagen 2-amino-9H-pyrido[2,3-b]indole (AalphaC) but not its methylated form (MeAalphaC) increases intestinal tumorigenesis in neonatally exposed multiple intestinal neoplasia mice.

Journal: Carcinogenesis 20020801

Title: Effects of soy sauce and sugar on the formation of heterocyclic amines in marinated foods.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020701

Title: Mutagenic and carcinogenic heterocyclic amines as affected by muscle types/skin and cooking in pan-roasted mackerel.

Journal: Mutation research 20020325

Title: In vitro metabolism of two heterocyclic amines, 2-amino-9H-pyrido[2,3-b]indole (A(alpha)C) and 2-amino-3-methyl-9H-pyridol2,3-b]indole (MeA(alpha)C) in human and rat hepatic microsomes.

Journal: Pharmacology & toxicology 20020301

Title: Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats.

Journal: The journal of medical investigation : JMI 20020201

Title: Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.

Journal: Cancer research 19911001

Title: Initiating activity in a two-stage mouse skin model of nine mutagenic pyrolysates of amino acids, soybean globulin and proteinaceous food.

Journal: Carcinogenesis 19870901

Title: Carcinogenicity in mice and rats of heterocyclic amines in cooked foods.

Journal: Environmental health perspectives 19860801

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:26148-68-5 Molecular Formula|26148-68-5 MDL|26148-68-5 SMILES|26148-68-5 9H-Pyrido[2,3-b]indol-2-amine