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2620-62-4,MFCD00022822
Catalog No.:AA00BD7N

2620-62-4 | N6,N6-Dimethyladenosine

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Purity
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Price(USD)
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250mg
97%
in stock  
$95.00   $67.00
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500mg
≥95%
in stock  
$189.00   $132.00
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1g
97%
in stock  
$245.00   $171.00
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5g
97%
in stock  
$843.00   $590.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BD7N
Chemical Name:
N6,N6-Dimethyladenosine
CAS Number:
2620-62-4
Molecular Formula:
C12H17N5O4
Molecular Weight:
295.2945
MDL Number:
MFCD00022822
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N(C)C
Properties
Computed Properties
 
Complexity:
374  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
-0.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:KIRINHOLDINGSCO.,LTD.;KyowaKirin(in:KirinHoldings)-US2015/376611,2015,A1Locationinpatent:Paragraph0489;0490

[2]CurrentPatentAssignee:KIRINHOLDINGSCO.,LTD.;KyowaKirin(in:KirinHoldings)-US2017/354673,2017,A1Locationinpatent:Paragraph0715;0716;0717

[3]Kissmanetal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.18,22,23]Andrews;Barber[JournaloftheChemicalSociety,1958,p.2768,2770]

[1]Weissetal.[JournaloftheAmericanChemicalSociety,1959,vol.81,p.4050,4054]

[1]Maki,Yoshifumi;Kameyama,Keiji;Suzuki,Mikio;Sako,Magoichi;Hirota,Kosaku[JournalofChemicalResearch,Miniprint,1984,#12,p.3601-3654]

[2]Kato;Zemlicka[JournalofOrganicChemistry,1980,vol.45,#20,p.4006-4010]

[3]Andrews;Barber[JournaloftheChemicalSociety,1958,p.2768,2770]

[4]Bhattarai,Sanjay;Freundlieb,Marianne;Pippel,Jan;Meyer,Anne;Abdelrahman,Aliaa;Fiene,Amelie;Lee,Sang-Yong;Zimmermann,Herbert;Yegutkin,GennadyG.;Sträter,Norbert;El-Tayeb,Ali;Müller,ChristaE.[JournalofMedicinalChemistry,2015,vol.58,#15,p.6248-6263]

[5]Luo,Xiao;Li,Meng;Zhan,Kaiyu;Yang,Wei;Zhang,Lihe;Wang,KeWei;Yu,Peilin;Zhang,Liangren[ChemicalBiologyandDrugDesign,2018,vol.91,#2,p.552-566]

[1]Kissmanetal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.18,22,23]

[1]Ramalingam;Woodard[Carbohydrateresearch,1985,vol.142,#1,p.123-126]

[2]Patching,SimonG.;Baldwin,StephenA.;Baldwin,AlexanderD.;Young,JamesD.;Gallagher,MauriceP.;Henderson,PeterJ.F.;Herbert,RichardB.[OrganicandBiomolecularChemistry,2005,vol.3,#3,p.462-470]

[3]Rife,JasonP.;Cheng,CharlesS.;Moore,PeterB.;Strobel,ScottA.[NucleosidesandNucleotides,1998,vol.17,#12,p.2281-2288]

[4]Bhattarai,Sanjay;Freundlieb,Marianne;Pippel,Jan;Meyer,Anne;Abdelrahman,Aliaa;Fiene,Amelie;Lee,Sang-Yong;Zimmermann,Herbert;Yegutkin,GennadyG.;Sträter,Norbert;El-Tayeb,Ali;Müller,ChristaE.[JournalofMedicinalChemistry,2015,vol.58,#15,p.6248-6263]

Literature

Title: Control of substrate specificity by a single active site residue of the KsgA methyltransferase.

Journal: Biochemistry 20120110

Title: Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation.

Journal: Nature chemical biology 20100501

Title: Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.

Journal: Bioorganic chemistry 20070201

Title: Analogs of 3'-amino-3'-deoxyadenosine inhibit HIV-1 replication.

Journal: AIDS research and human retroviruses 19891201

Title: Ribosome structure: localization of N6,N6-dimethyladenosine by electron microscopy of a ribosome-antibody complex.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19770401

Title: Chan CT, et al. Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin. Molecules. 2011 Jun 21;16(6):5168-81.

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SDS
Tags:2620-62-4 Molecular Formula|2620-62-4 MDL|2620-62-4 SMILES|2620-62-4 N6,N6-Dimethyladenosine