Home Other Building Blocks 2657-25-2
2657-25-2,MFCD00016484
Catalog No.:AA002TNW

2657-25-2 | 4'-Hydroxychalcone

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Purity
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1g
97%
in stock  
$11.00   $8.00
- +
5g
97%
in stock  
$15.00   $11.00
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10g
97%
in stock  
$26.00   $18.00
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25g
97%
in stock  
$47.00   $33.00
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100g
97%
in stock  
$184.00   $129.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002TNW
Chemical Name:
4'-Hydroxychalcone
CAS Number:
2657-25-2
Molecular Formula:
C15H12O2
Molecular Weight:
224.2546
MDL Number:
MFCD00016484
SMILES:
Oc1ccc(cc1)C(=O)C=Cc1ccccc1
Properties
Properties
 
BP:
419.6°C at 760 mmHg  
Form:
Solid  
MP:
174-178 °C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
269  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.7  

Literature

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150201

Title: Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.

Journal: Chemical research in toxicology 20121119

Title: Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation.

Journal: Biochimica et biophysica acta 20120201

Title: The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition.

Journal: Biochemical pharmacology 20110915

Title: Sulfonate chalcone as new class voltage-dependent K+ channel blocker.

Journal: Bioorganic & medicinal chemistry letters 20080101

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

Journal: Journal of medicinal chemistry 20050908

Title: Antimalarial activity of ferrocenyl chalcones.

Journal: Bioorganic & medicinal chemistry letters 20020902

Title: Antimalarial alkoxylated and hydroxylated chalcones [corrected]: structure-activity relationship analysis.

Journal: Journal of medicinal chemistry 20011206

Title: Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.

Journal: Journal of medicinal chemistry 20010927

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