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26788-23-8,MFCD00271573
Catalog No.:AA00C1NC

26788-23-8 | 1,3,5(10)-Estratrien-3,4,17beta-triol 4-methyl ether

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1mg
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$735.00   $515.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C1NC
Chemical Name:
1,3,5(10)-Estratrien-3,4,17beta-triol 4-methyl ether
CAS Number:
26788-23-8
Molecular Formula:
C19H26O3
Molecular Weight:
302.4079
MDL Number:
MFCD00271573
SMILES:
COc1c(O)ccc2c1CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C
Properties
Computed Properties
 
Complexity:
425  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
4  

Literature

Title: Catechol-O-methyltransferase-mediated metabolism of 4-hydroxyestradiol inhibits the growth of human renal cancer cells through the apoptotic pathway.

Journal: Carcinogenesis 20120201

Title: Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats.

Journal: Toxicology and applied pharmacology 20100901

Title: A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.

Journal: The Journal of steroid biochemistry and molecular biology 20100101

Title: Inhibitory effects of nitrative stress on the sulfation of 17β-estradiol and 4-methoxyestradiol by human MCF 10A mammary epithelial cells.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Catechol-o-methyltransferase and methoxyestradiols participate in the intraoviductal nongenomic pathway through which estradiol accelerates egg transport in cycling rats.

Journal: Biology of reproduction 20071201

Title: 4-Methoxyestradiol-induced oxidative injuries in human lung epithelial cells.

Journal: Toxicology and applied pharmacology 20070501

Title: A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells.

Journal: Toxicology and applied pharmacology 20040215

Title: Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines.

Journal: Toxicology and applied pharmacology 20030801

Title: Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1.

Journal: Cancer research 20030615

Title: Selective synthesis of 4-methoxyestrogen from 4-hydroxyestrogen.

Journal: Steroids 20010801

Title: 12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.

Journal: Journal of cellular biochemistry 19980901

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Tags:26788-23-8 Molecular Formula|26788-23-8 MDL|26788-23-8 SMILES|26788-23-8 1,3,5(10)-Estratrien-3,4,17beta-triol 4-methyl ether