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Home Sulfonamines 268203-93-6
268203-93-6,MFCD20275557
Catalog No.:AA007MNN

268203-93-6 | 3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-4-propoxybenzenesulfonamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$8.00   $6.00
- +
5mg
98%
in stock  
$19.00   $14.00
- +
25mg
98%
in stock  
$47.00   $33.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007MNN
Chemical Name:
3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-4-propoxybenzenesulfonamide
CAS Number:
268203-93-6
Molecular Formula:
C25H36N6O4S
Molecular Weight:
516.6561
MDL Number:
MFCD20275557
SMILES:
CCCOc1ccc(cc1c1nc2c(CCC)nn(c2c(=O)[nH]1)C)S(=O)(=O)NCCC1CCCN1C
Properties
Computed Properties
 
Complexity:
894  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
11  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-US2008/194529,2008,A1Locationinpatent:Page/Pagecolumn59

[2]CurrentPatentAssignee:DONG-ASOCIOHOLDINGSCO.,LTD.-WO2010/13925,2010,A2Locationinpatent:Page/Pagecolumn6

[3]CurrentPatentAssignee:MEZZIONPHARMACO.,LTD.-WO2006/132460,2006,A1Locationinpatent:Page/Pagecolumn7

268203-93-6    144-62-7   
udenafiloxalate 

[1]CurrentPatentAssignee:DONG-ASOCIOHOLDINGSCO.,LTD.-WO2010/95849,2010,A2Locationinpatent:Page/Pagecolumn10-11

268203-93-6    124-04-9   
udenafiladipate 

[1]CurrentPatentAssignee:DONG-ASOCIOHOLDINGSCO.,LTD.-WO2010/95849,2010,A2Locationinpatent:Page/Pagecolumn12-13

[1]CurrentPatentAssignee:DONG-ASOCIOHOLDINGSCO.,LTD.-WO2010/95849,2010,A2Locationinpatent:Page/Pagecolumn13

268203-93-6    621-82-9   
udenafilcinnamate 

[1]CurrentPatentAssignee:DONG-ASOCIOHOLDINGSCO.,LTD.-WO2010/95849,2010,A2Locationinpatent:Page/Pagecolumn12

Literature

Title: Chronic administration of udenafil, a selective phosphodiesterase type 5 inhibitor, promotes erectile function recovery in an animal model of bilateral cavernous nerve crush injury.

Journal: The journal of sexual medicine 20110501

Title: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080601

Title: Transport of a new erectogenic udenafil in Caco-2 cells.

Journal: Archives of pharmacal research 20070901

Title: DA-8159 reverses selective serotonin reuptake inhibitor-induced erectile dysfunction in rats.

Journal: Urology 20050101

Title: Paick, J.S., et al., The efficacy and safety of udenafil, a new selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction. J Sex Med, 2008. 5(4): p. 946-53.

Title: Zhao, C., et al., Activity of phosphodiesterase type 5 inhibitors in patients with lower urinary tract symptoms due to benign prostatic hyperplasia. BJU Int, 2011. 107(12): p. 1943-7.

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SDS
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Tags:268203-93-6 Molecular Formula|268203-93-6 MDL|268203-93-6 SMILES|268203-93-6 3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-4-propoxybenzenesulfonamide