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271-71-6,MFCD05663981
Catalog No.:AA00C3HZ

271-71-6 | 1H-Pyrazolo[3,4-b]pyridine

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  • Technical Information
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Technical Information
Catalog Number:
AA00C3HZ
Chemical Name:
1H-Pyrazolo[3,4-b]pyridine
CAS Number:
271-71-6
Molecular Formula:
C6H5N3
Molecular Weight:
119.1240
MDL Number:
MFCD05663981
SMILES:
c1cnc2c(c1)cn[nH]2
Properties
Computed Properties
 
Complexity:
105  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.8  

Literature

Title: Synthesis of a new series of pyridine and fused pyridine derivatives.

Journal: Molecules (Basel, Switzerland) 20120911

Title: Synthesis of pyrazolo[3,4-b]pyridines under microwave irradiation in multi-component reactions and their antitumor and antimicrobial activities - Part 1.

Journal: European journal of medicinal chemistry 20120201

Title: Multicomponent approaches to 8-carboxylnaphthyl-functionalized pyrazolo[3,4-b]pyridine derivatives.

Journal: Organic & biomolecular chemistry 20120128

Title: Ultrasound assisted one-pot, three-components synthesis of pyrimido[1,2-a]benzimidazoles and pyrazolo[3,4-b]pyridines: A new access via phenylsulfone synthon.

Journal: Ultrasonics sonochemistry 20120101

Title: Hydrogen-bonded assembly in six closely related pyrazolo[3,4-b]pyridine derivatives; a simple chain, three types of chains of rings and a complex sheet structure.

Journal: Acta crystallographica. Section C, Crystal structure communications 20120101

Title: Synthesis, X-ray crystal structure and fluorescent spectra of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015

Title: Phosphodiesterase inhibitors. Part 2: design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: developments in understanding the receptor stereoselectivity.

Journal: Organic & biomolecular chemistry 20110621

Title: A copper-mediated cyclization reaction of hydrazine with enediynones providing pyrazolo[1,5-a]pyridines.

Journal: Organic & biomolecular chemistry 20110207

Title: 3,4,6-Trimethyl-1-phenyl-1H-pyrazolo-[3,4-b]pyridine.

Journal: Acta crystallographica. Section E, Structure reports online 20100801

Title: One-step synthesis of diarylpyrazolo[3,4-b]pyridines from isoflavones.

Journal: Journal of combinatorial chemistry 20100712

Title: Synthesis and fluorescence properties of donor-acceptor-substituted novel dipyrazolo[3,4-b:3',4'-d]pyridines (DPP).

Journal: Journal of fluorescence 20100501

Title: (E)-N-{[6-chloro-4-(4-chlorophenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl]methylene}benzene-1,2-diamine: a three-dimensional framework structure built from only two hydrogen bonds.

Journal: Acta crystallographica. Section C, Crystal structure communications 20100315

Title: A convenient ultrasound-promoted regioselective synthesis of fused polycyclic 4-aryl-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridines.

Journal: Ultrasonics sonochemistry 20100201

Title: Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091215

Title: An efficient one-step synthesis of heterobiaryl pyrazolo[3,4-b]pyridines via indole ring opening.

Journal: Organic letters 20091119

Title: Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents.

Journal: European journal of medicinal chemistry 20091101

Title: Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.

Journal: Journal of medicinal chemistry 20090326

Title: Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives.

Journal: Bioorganic & medicinal chemistry 20080901

Title: Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model.

Journal: ChemMedChem 20080601

Title: Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems.

Journal: Journal of medicinal chemistry 20080410

Title: Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.

Journal: Journal of medicinal chemistry 20080327

Title: Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones.

Journal: Organic & biomolecular chemistry 20080107

Title: Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.

Journal: Bioorganic & medicinal chemistry letters 20071115

Title: Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20070801

Title: Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.

Journal: Bioorganic & medicinal chemistry letters 20070801

Title: Pyrazolo[1,5-a]pyridine antiherpetics: effects of the C3 substituent on antiviral activity.

Journal: Bioorganic & medicinal chemistry letters 20070515

Title: Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series.

Journal: Bioorganic & medicinal chemistry 20070101

Title: Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.

Journal: Bioorganic & medicinal chemistry letters 20060115

Title: New pyrazolo[3,4-b]pyridones as selective A(1) adenosine receptor antagonists: synthesis, biological evaluation and molecular modelling studies.

Journal: Organic & biomolecular chemistry 20050621

Title: Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core.

Journal: Journal of medicinal chemistry 20050616

Title: Synthesis and antibacterial activity of 1H-pyrazolo[3,4-b]pyrazine and -pyridine derivatives.

Journal: Farmaco (Societa chimica italiana : 1989) 20050101

Title: 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues.

Journal: Bioorganic & medicinal chemistry letters 20030721

Title: 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.

Journal: Bioorganic & medicinal chemistry letters 20030324

Title: Synthesis and biological evaluation of some acyclic 4,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidine nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Synthesis and antiproliferative activity in vitro of new derivatives of 3-aminopyrazolo[3,4-b]pyridine. Part 1. Reaction of 3-aminopyrazolo[3,4-b]pyridine with 1,3-, 1,4-diketones and alpha,beta-unsaturated ketones.

Journal: Archiv der Pharmazie 20010701

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