Home Pyridines 272-52-6
272-52-6,MFCD08234560
Catalog No.:AA0035GX

272-52-6 | 1H-Pyrazolo[4,3-b]pyridine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
98%
in stock  
$7.00   $5.00
- +
250mg
98%
in stock  
$15.00   $11.00
- +
1g
98%
in stock  
$21.00   $15.00
- +
5g
95%
in stock  
$77.00   $54.00
- +
10g
95%
in stock  
$140.00   $98.00
- +
25g
95%
in stock  
$331.00   $232.00
- +
50g
95%
in stock  
$595.00   $417.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0035GX
Chemical Name:
1H-Pyrazolo[4,3-b]pyridine
CAS Number:
272-52-6
Molecular Formula:
C6H5N3
Molecular Weight:
119.1240
MDL Number:
MFCD08234560
SMILES:
c1cnc2c(c1)[nH]nc2
Properties
Properties
 
BP:
294.5°C at 760 mmHg  
Form:
Solid  
MP:
95 - 96 °C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
105  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.6  

Literature

Title: 4,5-Dihydro-1H-pyrazolo[3,4-d]pyrimidine containing phenothiazines as antitubercular agents.

Journal: Bioorganic & medicinal chemistry letters 20140315

Title: The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.

Journal: Bioorganic & medicinal chemistry letters 20121201

Title: Synthesis and antioxidant evaluation of some new pyrazolopyridine derivatives.

Journal: Archiv der Pharmazie 20120201

Title: Synthesis of 2- and 2,3-substituted pyrazolo[1,5-a]pyridines: scope and mechanistic considerations of a domino direct alkynylation and cyclization of N-iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes.

Journal: The Journal of organic chemistry 20111021

Title: Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast.

Journal: Bioorganic & medicinal chemistry letters 20110601

Title: Synthesis, structure, photophysical and electrochemiluminescence properties of Re(I) tricarbonyl complexes incorporating pyrazolyl-pyridyl-based ligands.

Journal: Dalton transactions (Cambridge, England : 2003) 20110514

Title: Acylation of heteroaromatic amines: facile and efficient synthesis of a new class of 1,2,3-triazolo[4,5-b]pyridine and pyrazolo[4,3-b]pyridine derivatives.

Journal: Molecules (Basel, Switzerland) 20110504

Title: Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.

Journal: Journal of medicinal chemistry 20110414

Title: Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.

Journal: Bioorganic & medicinal chemistry 20101115

Title: A myosin V inhibitor based on privileged chemical scaffolds.

Journal: Angewandte Chemie (International ed. in English) 20101102

Title: Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO).

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Antiplatelet activity and structure-activity relationship study of Pyrazolopyridine Derivatives as potential series for treating thrombotic diseases.

Journal: Journal of atherosclerosis and thrombosis 20100730

Title: Recent advances in the development of selective, ATP-competitive inhibitors of mTOR.

Journal: Current opinion in drug discovery & development 20100701

Title: Synthesis, structural characterisation and quadruplex DNA binding studies of a new gold(III) pyrazolylpyridine complex.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100322

Title: Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 1-substituent.

Journal: Bioorganic & medicinal chemistry letters 20100215

Title: Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.

Journal: Future medicinal chemistry 20100201

Title: Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).

Journal: Bioorganic & medicinal chemistry letters 20100115

Title: Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.

Journal: Bioorganic & medicinal chemistry letters 20100115

Title: Assessment of the putative binding conformation of a pyrazolopyridine class of inhibitors of MAPKAPK2 using computational studies.

Journal: European journal of medicinal chemistry 20100101

Title: Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091101

Title: Expedient synthesis of 3-alkoxymethyl- and 3-aminomethyl-pyrazolo[3,4-b]pyridines.

Journal: The Journal of organic chemistry 20090116

Title: Regio- and chemoselective metalation of chloropyrimidine derivatives with TMPMgCl x LiCl and TMP(2)Zn x 2 MgCl(2) x 2 LiCl.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

Title: Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20081015

Title: Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20080715

Title: Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides.

Journal: Chemical & pharmaceutical bulletin 20080601

Title: Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: Pyrazolopyridines with potent activity against herpesviruses: effects of C5 substituents on antiviral activity.

Journal: Bioorganic & medicinal chemistry letters 20080201

Title: Synthesis of benzo[1,2-d;3,4-d']diimidazole and 1H-pyrazolo[4,3-b]pyridine as putative A2A receptor antagonists.

Journal: Organic & biomolecular chemistry 20070821

Title: Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.

Journal: Bioorganic & medicinal chemistry 20070315

Title: 3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3beta inhibitors.

Journal: Journal of molecular graphics & modelling 20070301

Title: Modelling of UV-molecular spectra of several bis-pyrazolopyridines derivatives.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061101

Title: Synthesis and structure of a sodium complex of an aromatic beta-diketone and pyrazolylpyridine.

Journal: Molecules (Basel, Switzerland) 20060717

Title: Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses.

Journal: Bioorganic & medicinal chemistry 20060215

Title: Development of ligands for the peripheral benzodiazepine receptor.

Journal: Current medicinal chemistry 20060101

Title: Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses.

Journal: Bioorganic & medicinal chemistry 20050915

Title: New orally active PDE4 inhibitors with therapeutic potential.

Journal: Bioorganic & medicinal chemistry 20040801

Title: Synthesis of some new annulated pyrazolo-pyrido (or pyrano) pyrimidine, pyrazolopyridine and pyranopyrazole derivatives.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20040601

Title: The synthesis of 4-deazaformycin A.

Journal: The Journal of organic chemistry 20030808

Title: Inhibition of tyrosine kinase Src suppresses pancreatic cancer invasiveness.

Journal: Surgery 20030801

Title: Non-imidazole heterocyclic histamine H3 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20030519

Title: Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist.

Journal: Biochemical and biophysical research communications 20021206

Title: Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.

Journal: Bioorganic & medicinal chemistry 20020601

Title: Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production.

Journal: Journal of endotoxin research 20020101

Title: NO-independent regulatory site on soluble guanylate cyclase.

Journal: Nature 20010308

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:272-52-6 Molecular Formula|272-52-6 MDL|272-52-6 SMILES|272-52-6 1H-Pyrazolo[4,3-b]pyridine |Heterocyclic_Building_Blocks