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27215-14-1,MFCD07779130
Catalog No.:AA00BBXA

27215-14-1 | Neoandrographolide

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1mg
≥95%
in stock  
$63.00   $44.00
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5mg
≥95%
in stock  
$230.00   $161.00
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10mg
≥95%
in stock  
$398.00   $278.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BBXA
Chemical Name:
Neoandrographolide
CAS Number:
27215-14-1
Molecular Formula:
C26H40O8
Molecular Weight:
480.5910
MDL Number:
MFCD07779130
SMILES:
OC[C@H]1O[C@@H](OC[C@]2(C)CCC[C@@]3([C@@H]2CCC(=C)[C@H]3CCC2=CCOC2=O)C)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Computed Properties
 
Complexity:
811  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
7  
XLogP3:
2.6  

Downstream Synthesis Route

[1]Chemicalandpharmaceuticalbulletin,1984,vol.32,p.2117-2125

[1]Chemicalandpharmaceuticalbulletin,1984,vol.32,p.2117-2125

[2]Chemicalandpharmaceuticalbulletin,1984,vol.32,p.2117-2125

[1]Chemicalandpharmaceuticalbulletin,1984,vol.32,p.2117-2125

27215-14-1   
14-deoxy-12,13-dihydroandrographolide 

[1]NaturalProductResearch,2013,vol.27,p.680-683

27215-14-1   
13,14-dihydroneoandrographolide 

[1]NaturalProductResearch,2013,vol.27,p.680-683

Literature

Title: Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.

Journal: Journal of natural products 20150227

Title: Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations.

Journal: Journal of pharmaceutical and biomedical analysis 20121101

Title: Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20111201

Title: Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm.f.) Nees and their effects on gene expression.

Journal: International immunopharmacology 20101101

Title: Neoandrographolide from Andrographis paniculata as a potential natural chemosensitizer.

Journal: Planta medica 20101001

Title: Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads.

Journal: Medicinal research reviews 20080901

Title: ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata.

Journal: Journal of natural products 20080501

Title: Inhibitory effects of neoandrographolide on nitric oxide and prostaglandin E2 production in LPS-stimulated murine macrophage.

Journal: Molecular and cellular biochemistry 20070401

Title: In vivo and in vitro anti-inflammatory activities of neoandrographolide.

Journal: The American journal of Chinese medicine 20070101

Title: Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation.

Journal: European journal of pharmacology 20061228

Title: [Studies on diterpenoids from Andrographis paniculata].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

Title: ent-Labdane diterpenoids from Andrographis paniculata.

Journal: Journal of natural products 20060301

Title: Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1.

Journal: Phytotherapy research : PTR 20051201

Title: Chemical fingerprinting of Andrographis paniculata using HPLC, HPTLC and densitometry.

Journal: Phytochemical analysis : PCA 20040101

Title: Determination and variation of three active diterpenoids in Andrographis paniculata (Burm.f.) Nees.

Journal: Phytochemical analysis : PCA 20040101

Title: Separation of andrographolide and neoandrographolide from the leaves of Andrographis paniculata using high-speed counter-current chromatography.

Journal: Journal of chromatography. A 20030110

Title: Suppression of NO production in activated macrophages in vitro and ex vivo by neoandrographolide isolated from Andrographis paniculata.

Journal: Biological & pharmaceutical bulletin 20020901

Title: Mechanism of the superoxide scavenging activity of neoandrographolide - a natural product from Andrographis paniculata Nees.

Journal: Journal of agricultural and food chemistry 20020731

Title: Tao Yang, et al. Hypolipidemic Effects of Andrographolide and Neoandrographolide in Mice and Rats. Phytotherapy ResearchVolume 27, Issue 4, pages 618–623, April 2013

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