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2730-71-4,MFCD01736965
Catalog No.:AA00C35S

2730-71-4 | thiocolchicine

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5mg
≥98%
in stock  
$55.00   $38.00
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10mg
≥98%
in stock  
$102.00   $71.00
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25mg
≥98%
in stock  
$238.00   $166.00
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100mg
≥98%
in stock  
$729.00   $510.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C35S
Chemical Name:
thiocolchicine
CAS Number:
2730-71-4
Molecular Formula:
C22H25NO5S
Molecular Weight:
415.5026
MDL Number:
MFCD01736965
SMILES:
COc1c2c(CC[C@@H](c3c2ccc(c(=O)c3)SC)NC(=O)C)cc(c1OC)OC
NSC Number:
186301
Properties
Computed Properties
 
Complexity:
744  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
1.8  

Literature

Title: Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents.

Journal: Bioorganic & medicinal chemistry letters 20100715

Title: Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

Journal: Journal of natural products 20100326

Title: Derivatives of thiocolchicine and its applications to CEM cells treatment using 19F magnetic resonance ex vivo.

Journal: Bioorganic chemistry 20100201

Title: Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.

Journal: European journal of medicinal chemistry 20100101

Title: Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds.

Journal: Bioorganic & medicinal chemistry letters 20091115

Title: Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III.

Journal: Bioorganic & medicinal chemistry 20080601

Title: Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis.

Journal: Neoplasia (New York, N.Y.) 20080601

Title: Synthesis and antitumor activity of nitrogen-based thiocolchicine derivatives.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20061101

Title: Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.

Journal: The Journal of organic chemistry 20060331

Title: New synthetic thiocolchicine derivatives as lowtoxic anticancer agents.

Journal: Archiv der Pharmazie 20051201

Title: Thiocolchicine dimers: a novel class of topoisomerase-I inhibitors.

Journal: Biochemical pharmacology 20050101

Title: Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids.

Journal: Chemistry & biodiversity 20040201

Title: Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.

Journal: Journal of medicinal chemistry 20030424

Title: Effects of thiocolchicine on axonal cytoskeleton of the rat peroneus nerve.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20021101

Title: Comparative pharmacokinetics and bioavailability of two oral formulations of thiocolchicoside, a GABA-mimetic muscle relaxant drug, in normal volunteers.

Journal: European journal of drug metabolism and pharmacokinetics 19950101

Title: Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells.

Journal: Journal of natural products 19910101

Title: Klaus M.Hahn, et al. Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent. Bioorganic & Medicinal Chemistry Letters.Volume 1, Issue 9, 1991, Pages 471-476

Title: R De Vincenzo, et al. Antiproliferative Activity of Colchicine Analogues on MDR-positive and MDR-negative Human Cancer Cell Lines. Anticancer Drug Des. 1998 Jan;13(1):19-33.

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