Title: Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives.
Journal: Bioorganic & medicinal chemistry 20140401
Title: Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.
Journal: Bioorganic & medicinal chemistry letters 20130601
Title: Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58.
Journal: British journal of pharmacology 20130201
Title: Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.
Journal: Journal of medicinal chemistry 20120809
Title: Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells.
Journal: ChemMedChem 20120801
Title: Structural requirements of pyrimidine, thienopyridine and ureido thiophene carboxamide-based inhibitors of the checkpoint kinase 1: QSAR, docking, molecular dynamics analysis.
Journal: Journal of molecular modeling 20120701
Title: 3-(2,4-Dichloro-phen-yl)-5-(4-fluoro-phen-yl)-2-methyl-7-(trifluoro-meth-yl)pyrazolo-[1,5-a]pyrimidine.
Journal: Acta crystallographica. Section E, Structure reports online 20120501
Title: 18F-labeled pyrazolo[1,5-a]pyrimidine derivatives: synthesis from 2,4-dinitrobenzamide and tosylate precursors and comparative biological evaluation for tumor imaging with positron emission tomography.
Journal: Molecules (Basel, Switzerland) 20120327
Title: Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties.
Journal: Bioorganic & medicinal chemistry letters 20120115
Title: Synthesis and biological evaluation of novel F-18 labeled pyrazolo[1,5-a]pyrimidine derivatives: potential PET imaging agents for tumor detection.
Journal: Bioorganic & medicinal chemistry letters 20110815
Title: Efficacy of pharmacological estrogen receptor antagonists in blocking activation of zebrafish estrogen receptors.
Journal: General and comparative endocrinology 20110801
Title: Synthesis of some novel pyrazolo[1,5-a]pyrimidine derivatives and their application as disperse dyes.
Journal: Molecules (Basel, Switzerland) 20110622
Title: Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20110501
Title: Applications of 2-arylhydrazononitriles in synthesis: preparation of new indole containing 1,2,3-triazole, pyrazole and pyrazolo[1,5-a]pyrimidine derivatives and evaluation of their antimicrobial activities.
Journal: European journal of medicinal chemistry 20110501
Title: Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2.
Journal: Bioorganic & medicinal chemistry letters 20110101
Title: Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 1.
Journal: Bioorganic & medicinal chemistry letters 20110101
Title: Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives.
Journal: Pharmacology 20110101
Title: Synthesis of Diarylpyrazoles Containing a Phenylsulphone or Carbonitrile Moiety and their Chalcones as Possible Anti-Inflammatory Agents.
Journal: Scientia pharmaceutica 20110101
Title: A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Journal: Journal of medicinal chemistry 20101223
Title: Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties.
Journal: Bioorganic & medicinal chemistry letters 20101215
Title: Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO).
Journal: Bioorganic & medicinal chemistry letters 20101001
Title: Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing benzothiazole moiety.
Journal: European journal of medicinal chemistry 20100901
Title: A sensitive and highly selective fluorescent sensor for In(3+).
Journal: Organic & biomolecular chemistry 20100807
Title: Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety.
Journal: European journal of medicinal chemistry 20100501
Title: B-Raf kinase inhibitors: hit enrichment through scaffold hopping.
Journal: Bioorganic & medicinal chemistry letters 20100415
Title: Facile synthesis and in-vitro antitumor activity of some pyrazolo[3,4-b]pyridines and pyrazolo[1,5-a]pyrimidines linked to a thiazolo[3,2-a]benzimidazole moiety.
Journal: Archiv der Pharmazie 20100101
Title: Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20091215
Title: Enaminonitrile in heterocyclic synthesis: synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety.
Journal: European journal of medicinal chemistry 20091201
Title: Discovery of highly potent and selective type I B-Raf kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20091201
Title: Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase.
Journal: Bioorganic & medicinal chemistry letters 20091115
Title: Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses.
Journal: Bioorganic & medicinal chemistry letters 20091001
Title: Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.
Journal: European journal of medicinal chemistry 20090901
Title: Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090515
Title: Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as anti-proliferative agents.
Journal: Bioorganic & medicinal chemistry 20090301
Title: Human cytochrome P450 1A2 involvement in the formation of reactive metabolites from a species-specific hepatotoxic pyrazolopyrimidine derivative, 5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine.
Journal: Chemical research in toxicology 20090201
Title: Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20080801
Title: Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety.
Journal: Bioorganic & medicinal chemistry 20080615
Title: Facile and efficient synthesis of carbohybrids as stereodivergent druglike small molecules.
Journal: The Journal of organic chemistry 20080418
Title: Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform.
Journal: Journal of fluorescence 20080301
Title: 2-Methyl-5-(4-tol-yl)-7-(trifluoro-meth-yl)pyrazolo[1,5-a]pyrimidine.
Journal: Acta crystallographica. Section E, Structure reports online 20080101
Title: Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: Selective inhibition of c-Myc/Max dimerization by a pyrazolo[1,5-a]pyrimidine.
Journal: ChemMedChem 20070501
Title: Pyrazolo[1,5-a]pyrimidines. Identification of the privileged structure and combinatorial synthesis of 3-(hetero)arylpyrazolo[1,5-a]pyrimidine-6-carboxamides.
Journal: Journal of combinatorial chemistry 20070101
Title: The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20061201
Title: A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.
Journal: Journal of medicinal chemistry 20051020
Title: Liquid-phase synthesis of combinatorial libraries based on 7-trifluoromethyl-substituted pyrazolo[1,5-a]pyrimidine scaffold.
Journal: Journal of combinatorial chemistry 20050101
Title: Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.
Journal: Journal of medicinal chemistry 20041118
Title: Pyrazolo[1,5-a]pyrimidines as estrogen receptor ligands: defining the orientation of a novel heterocyclic core.
Journal: Bioorganic & medicinal chemistry letters 20041115
Title: Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as alpha 1 selective ligands.
Journal: Journal of medicinal chemistry 20030116
Title: Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.
Journal: Bioorganic & medicinal chemistry letters 20021216
