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27415-25-4,MFCD00065747
Catalog No.:AA00BE6J

27415-25-4 | 8-ISO PROSTAGLANDIN E2

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1mg
≥99%
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$150.00   $105.00
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5mg
≥99%
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$613.00   $429.00
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10mg
≥99%
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$1,069.00   $748.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BE6J
Chemical Name:
8-ISO PROSTAGLANDIN E2
CAS Number:
27415-25-4
Molecular Formula:
C20H32O5
Molecular Weight:
352.4651
MDL Number:
MFCD00065747
SMILES:
CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@H]1C/C=C\CCCC(=O)O)O
Properties
Computed Properties
 
Complexity:
469  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
12  
XLogP3:
2.8  

Literature

Title: EV-077 in vitro inhibits platelet aggregation in type-2 diabetics on aspirin.

Journal: Thrombosis research 20121101

Title: Isoprostanes as physiological mediators of transition to newborn life: novel mechanisms regulating patency of the term and preterm ductus arteriosus.

Journal: Pediatric research 20120801

Title: Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tone.

Journal: Placenta 20111201

Title: Partial inhibition of estrogen-induced mammary carcinogenesis in rats by tamoxifen: balance between oxidant stress and estrogen responsiveness.

Journal: PloS one 20110101

Title: Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes.

Journal: Diabetologia 20100801

Title: Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.

Journal: Neurochemical research 20091201

Title: Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss.

Journal: Clinical immunology (Orlando, Fla.) 20091101

Title: Thromboxane and isoprostanes as inflammatory and vasoactive mediators in black walnut heartwood extract induced equine laminitis.

Journal: Veterinary immunology and immunopathology 20090615

Title: Marginal zinc deficiency increases magnesium retention and impairs calcium utilization in rats.

Journal: Biological trace element research 20090601

Title: Opposite effects of anandamide and N-arachidonoyl dopamine in the regulation of prostaglandin E and 8-iso-PGF formation in primary glial cells.

Journal: Journal of neurochemistry 20090401

Title: Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis.

Journal: Circulation research 20081024

Title: Regulation of retinal morphology and posterior segment amino acids by 8-isoprostaglandin E2 in bovine eyes ex vivo.

Journal: Methods and findings in experimental and clinical pharmacology 20081001

Title: 8-iso-PGE2 stimulates anion efflux from airway epithelial cells via the EP4 prostanoid receptor.

Journal: American journal of respiratory cell and molecular biology 20080201

Title: Expression levels of mRNA for Rho A/Rho kinase and its role in isoprostane-induced vasoconstriction of human placental and maternal vessels.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20080201

Title: Involvement of endothelial thromboxane A2 in the vasoconstrictor response induced by 15-E2t-isoprostane in isolated human umbilical vein.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20060801

Title: Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction.

Journal: Reproduction (Cambridge, England) 20060701

Title: The isoprostanes - unique products of arachidonate peroxidation: their role as mediators of oxidant stress.

Journal: Current pharmaceutical design 20060101

Title: 8-isoprostaglandin E(2) activates Ca(2+)-dependent K(+) current via cyclic AMP signaling pathway in murine renal artery.

Journal: European journal of pharmacology 20050927

Title: Isoprostanes and the kidney.

Journal: Antioxidants & redox signaling 20050101

Title: Augmentation of bovine airway smooth muscle responsiveness to carbachol, KCl, and histamine by the isoprostane 8-iso-PGE2.

Journal: American journal of physiology. Lung cellular and molecular physiology 20041101

Title: The bronchodilators 8-iso-prostaglandin E2 and prostaglandin E2 induce K+ current suppression via thromboxane A2 receptors in porcine tracheal smooth muscle.

Journal: European journal of pharmacology 20041006

Title: Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) on human umbilical vein.

Journal: European journal of pharmacology 20040919

Title: Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers.

Journal: European journal of clinical pharmacology 20040401

Title: Aqueous humor dynamics in monkeys after topical 8-iso PGE(2).

Journal: Investigative ophthalmology & visual science 20040301

Title: Increased oxidative stress following acute and chronic high altitude exposure.

Journal: High altitude medicine & biology 20040101

Title: Vasoconstrictor responses, and underlying mechanisms, to isoprostanes in human and porcine bronchial arterial smooth muscle.

Journal: British journal of pharmacology 20031001

Title: Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase.

Journal: The Journal of biological chemistry 20030801

Title: Isoprostane-mediated secretion from human airway epithelial cells.

Journal: Molecular pharmacology 20030801

Title: Vasodilatory and electrophysiological actions of 8-iso-prostaglandin E2 in porcine coronary artery.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: Effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F2 alpha on the release of noradrenaline from the isolated rat stomach.

Journal: European journal of pharmacology 20030530

Title: Regulation of activator protein-1 by 8-iso-prostaglandin E2 in a thromboxane A2 receptor-dependent and -independent manner.

Journal: Molecular pharmacology 20030501

Title: The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways.

Journal: Antioxidants & redox signaling 20030401

Title: Selective neuromicrovascular endothelial cell death by 8-Iso-prostaglandin F2alpha: possible role in ischemic brain injury.

Journal: Stroke 20030301

Title: Receptors and signaling pathway underlying relaxations to isoprostanes in canine and porcine airway smooth muscle.

Journal: American journal of physiology. Lung cellular and molecular physiology 20021101

Title: Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature.

Journal: The Journal of pharmacology and experimental therapeutics 20020601

Title: 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway.

Journal: The Journal of biological chemistry 20020419

Title: Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes.

Journal: Free radical research 20010901

Title: Effect of pilocarpine 4% in combination with latanoprost 0.005% or 8-iso prostaglandin E2 0.1% on intraocular pressure in laser-induced glaucomatous monkey eyes.

Journal: Journal of glaucoma 20010601

Title: Isoprostaglandin E2 type-III (8-iso-prostaglandin E2) evoked contractions in the human internal mammary artery.

Journal: Life sciences 20010413

Title: Effects of isoprostanes and prostanoids on porcine small intestine.

Journal: The Journal of pharmacology and experimental therapeutics 20010201

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Tags:27415-25-4 Molecular Formula|27415-25-4 MDL|27415-25-4 SMILES|27415-25-4 8-ISO PROSTAGLANDIN E2