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27591-69-1,MFCD00134071
Catalog No.:AA002U3J

27591-69-1 | Tilorone dihydrochloride

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1mg
98%
in stock  
$7.00   $5.00
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25mg
98%
in stock  
$11.00   $8.00
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100mg
98%
in stock  
$23.00   $16.00
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250mg
98%
in stock  
$34.00   $24.00
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1g
98%(HPLC)
in stock  
$120.00   $84.00
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5g
98%(HPLC)
in stock  
$407.00   $285.00
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25g
98%(HPLC)
in stock  
$1,381.00   $967.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002U3J
Chemical Name:
Tilorone dihydrochloride
CAS Number:
27591-69-1
Molecular Formula:
C25H36Cl2N2O3
Molecular Weight:
483.4709
MDL Number:
MFCD00134071
SMILES:
CCN(CCOc1ccc2c(c1)C(=O)c1c2ccc(c1)OCCN(CC)CC)CC.Cl.Cl
Properties
Properties
 
BP:
552.3°C at 760 mmHg  
Form:
Solid  
MP:
230-233 °C(lit.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
477  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
12  

Literature

Title: SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.

Journal: Bioorganic & medicinal chemistry letters 20120215

Title: [The antiviral activity of diphenyl derivatives in different model systems].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20120101

Title: Dose-dependent IFN-stimulating and immunomodulating properties of 6H-indolo[2,3-B] quinoxaline derivatives.

Journal: Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20120101

Title: [Perspectives of prevention and treatment of herpes symplex with regular recurrence].

Journal: Terapevticheskii arkhiv 20110101

Title: Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines.

Journal: European journal of medicinal chemistry 20100301

Title: Performance of tiloronoxim and tilorone determination in human blood by HPLC-MS/MS: method validation, uncertainty assessment and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

Title: Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

Journal: Annals of the New York Academy of Sciences 20081201

Title: Simultaneous quantification of tiloronoxim and tilorone in human urine by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081115

Title: Chemically induced accumulation of GAGs delays PrP(Sc) clearance but prolongs prion disease incubation time.

Journal: Cellular and molecular neurobiology 20081101

Title: alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues.

Journal: British journal of pharmacology 20080301

Title: DNA binding of tilorone: 1H NMR and calorimetric studies of the intercalation.

Journal: Biochemistry 20070710

Title: [Interferonogenic activity of amixin analogs and diphenyl derivatives].

Journal: Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20070101

Title: Possible implication of macrophages in the regulation of cytochrome P450 activities in carp (Cyprinus carpio).

Journal: Fish & shellfish immunology 20060701

Title: [Individual changes of gene expression in the interferon system in human blood cells due to amixin and cycloferon].

Journal: Voprosy virusologii 20050101

Title: [Interferon status of patients with non-specific ulcerous colitis and its correction with interferon inducers].

Journal: Terapevticheskii arkhiv 20020101

Title: [Intestinal microflora in rats under the conditions of a chronic toxic lesion of the liver].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20020101

Title: Correlations between in vitro effects of preparations of interferon and its inducers on blood cells in patients with multiple sclerosis.

Journal: Bulletin of experimental biology and medicine 20010401

Title: Antiviral and interferon-inducing properties of interferon inducers administered with prostaglandins.

Journal: Antimicrobial agents and chemotherapy 19800301

Title: Effects of tilorone hydrochloride on experimental flavivirus infections in mice.

Journal: Acta virologica 19770301

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