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2846-96-0,MFCD09999140
Catalog No.:AA002V9Z

2846-96-0 | 9H-Purine, 6-(4-morpholinyl)-

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100mg
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$32.00   $22.00
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1g
95%
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$140.00   $98.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002V9Z
Chemical Name:
9H-Purine, 6-(4-morpholinyl)-
CAS Number:
2846-96-0
Molecular Formula:
C9H11N5O
Molecular Weight:
205.2165
MDL Number:
MFCD09999140
SMILES:
O1CCN(CC1)c1ncnc2c1nc[nH]2
NSC Number:
351559
Properties
Properties
 
BP:
527.1°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
221  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
0.3  

Downstream Synthesis Route

[1]Litinas,KonstantinosE.;Thalassitis,Andreas[TetrahedronLetters,2010,vol.51,#49,p.6451-6453]

[2]Roitshtein,L.N.etal.[JournalofgeneralchemistryoftheUSSR,1969,vol.39,p.2077-2080][ZhurnalObshcheiKhimii,1969,vol.39,p.2125-2129]

[1]Girgis;Pedersen[Synthesis,1982,vol.No.6,#6,p.480-482]

[1]Maurin'sh,Yu.A.;Paegle,R.A.;Zhola,I.Ya.[ChemistryofHeterocyclicCompounds,1986,vol.22,#1,p.85-88][KhimiyaGeterotsiklicheskikhSoedinenii,1986,vol.22,#1,p.103-106]

[1]Staderini,Matteo;Bolognesi,MariaLaura;Menndez,J.Carlos[AdvancedSynthesisandCatalysis,2015,vol.357,#1,p.185-195]

[2]Chen,Liu;Chen,Danqi;Tang,Le;Ren,Jing;Chen,Jiaojiao;Zhen,Xuechu;Liu,Yu-Chih;Zhang,Chenhua;Luo,Haibin;Shen,Jingkang;Xiong,Bing[BioorganicandMedicinalChemistry,2017,vol.25,#13,p.3315-3329]

[3]Huang,Ling-Kuen;Cherng,Yen-Chih;Cheng,Yann-Ru;Jang,Jing-Pei;Chao,Yi-Ling;Cherng,Yie-Jia[Tetrahedron,2007,vol.63,#24,p.5323-5327]

[4]CurrentPatentAssignee:ZHENGZHOUUNIVERSITY-CN109293727,2019,ALocationinpatent:Paragraph0024;0029;0031;0032

[5]Neporozhneva;Studentzsov;Ramsh[RussianJournalofGeneralChemistry,2020,vol.90,#12,p.2248-2254][Zh.Obshch.Khim.,2020,vol.90,#12,p.1839-1846,8]

[6]Huang,Ke-Xin;Xie,Ming-Sheng;Zhao,Guo-Feng;Qu,Gui-Rong;Guo,Hai-Ming[AdvancedSynthesisandCatalysis,2016,vol.358,#22,p.3627-3632]

[7]MurthyBandaru,SivaSankar;Bhilare,Shatrughn;Chrysochos,Nicolas;Gayakhe,Vijay;Trentin,Ivan;Schulzke,Carola;Kapdi,AnantR.[OrganicLetters,2018,vol.20,#2,p.473-476]

[8]Bhujabal,YuvrajB.;Vadagaonkar,KamleshS.;Gholap,Aniket;Sanghvi,YogeshS.;Dandela,Rambabu;Kapdi,AnantR.[JournalofOrganicChemistry,2019,vol.84,#23,p.15343-15354]

[9]Parmar,Udaysinh;Somvanshi,Dipesh;Kori,Santosh;Desai,AmanA.;Dandela,Rambabu;Maity,DilipK.;Kapdi,AnantR.[JournalofOrganicChemistry,2021,vol.86,#13,p.8900-8925]

[10]Lougiakis,Nikolaos;Gavriil,Efthymios-Spyridon;Kairis,Markelos;Sioupouli,Georgia;Lambrinidis,George;Benaki,Dimitra;Krypotou,Emilia;Mikros,Emmanuel;Marakos,Panagiotis;Pouli,Nicole;Diallinas,George[BioorganicandMedicinalChemistry,2016,vol.24,#22,p.5941-5952]

Literature

Title: Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening.

Journal: Bioorganic & medicinal chemistry letters 20120615

Title: Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing.

Journal: Journal of medicinal chemistry 20111222

Title: Synthesis of modified homo-N-nucleosides from the reactions of mesityl nitrile oxide with 9-allylpurines and their influence on lipid peroxidation and thrombin inhibition.

Journal: Bioorganic & medicinal chemistry letters 20091115

Title: Identification of inhibitors of checkpoint kinase 1 through template screening.

Journal: Journal of medicinal chemistry 20090813

Title: Kinase-likeness and kinase-privileged fragments: toward virtual polypharmacology.

Journal: Journal of medicinal chemistry 20080313

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

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Tags:2846-96-0 Molecular Formula|2846-96-0 MDL|2846-96-0 SMILES|2846-96-0 9H-Purine, 6-(4-morpholinyl)-