Home Other Building Blocks 2892-62-8
2892-62-8,MFCD00037150
Catalog No.:AA002X0E

2892-62-8 | Dibutyl squarate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$16.00   $12.00
- +
5g
98%
in stock  
$34.00   $24.00
- +
10g
98%
in stock  
$42.00   $29.00
- +
25g
98%
in stock  
$102.00   $71.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002X0E
Chemical Name:
Dibutyl squarate
CAS Number:
2892-62-8
Molecular Formula:
C12H18O4
Molecular Weight:
226.2689
MDL Number:
MFCD00037150
SMILES:
CCCCOC1=C(C(=O)C1=O)OCCCC
NSC Number:
113489
Properties
Properties
 
BP:
353.2°C at 760 mmHg  
Form:
Liquid  
Refractive Index:
n20/D 1.494(lit.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
274  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
8  
XLogP3:
2.4  

Upstream Synthesis Route

[1]CanadianJournalofChemistry,1986,vol.64,p.2267-2273

[2]BulletindelaSocieteChimiquedeFrance,1990,#3,p.367-374

[3]BioorganicandMedicinalChemistry,2017,vol.25,#14,p.3803-3814

[4]JournalofMolecularStructure,2009,vol.936,#1-3,p.239-249

[5]ComptesRendusChimie,2012,vol.15,#5,p.454-462

[6]JustusLiebigsAnnalenderChemie,1965,vol.686,p.55-63

[7]ZeitschriftfuerNaturforschung,B:ChemicalSciences,1990,vol.45,#4,p.490-496

[8]Tetrahedron,2001,vol.57,#45,p.9325-9333

[9]Patent:US4927970,1990,A,

[10]Patent:US4927970,1990,A,

[11]Patent:US4927970,1990,A,

[12]Chemistry-AEuropeanJournal,2016,vol.22,#29,p.10179-10186

[13]DyesandPigments,2017,vol.147,p.120-129

[1]ChemischeBerichte,1980,vol.113,#1,p.1-8

[2]JustusLiebigsAnnalenderChemie,1965,vol.686,p.55-63

[1]SyntheticCommunications,1997,vol.27,#12,p.2177-2180

Downstream Synthesis Route

[1]Patent:BE840884,1976,    Chem.Abstr.,1977,vol.87

[1]Patent:BE840884,1976,    Chem.Abstr.,1977,vol.87

[1]CanadianJournalofChemistry,1986,vol.64,p.2267-2273

[2]BulletindelaSocieteChimiquedeFrance,1990,p.367-374

[3]BioorganicandMedicinalChemistry,2017,vol.25,p.3803-3814

[4]JournalofMolecularStructure,2009,vol.936,p.239-249

[5]ComptesRendusChimie,2012,vol.15,p.454-462

[6]JustusLiebigsAnnalenderChemie,1965,vol.686,p.55-63

[7]ZeitschriftfurNaturforschung,B:ChemicalSciences,1990,vol.45,p.490-496

[8]Tetrahedron,2001,vol.57,p.9325-9333

[9]Chemistry-AEuropeanJournal,2016,vol.22,p.10179-10186

[10]DyesandPigments,2017,vol.147,p.120-129

[11]Patent:US4927970,1990,A

[12]Patent:US4927970,1990,A

[13]Patent:US4927970,1990,A

[1]ChemischeBerichte,1980,vol.113,p.1-8

[2]JustusLiebigsAnnalenderChemie,1965,vol.686,p.55-63

[1]CanadianJournalofChemistry,1986,vol.64,p.2267-2273

Literature

Title: Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents.

Journal: European journal of medicinal chemistry 20131101

Title: Delayed type hypersensitivity-induced myeloid-derived suppressor cells regulate autoreactive T cells.

Journal: European journal of immunology 20111001

Title: Does immunotherapy of viral warts provide beneficial effects when it is combined with conventional therapy?

Journal: Annals of dermatology 20110801

Title: Cutaneous lymphoid hyperplasia related to squaric acid dibutyl ester.

Journal: Journal of the American Academy of Dermatology 20110701

Title: Alopecia areata - probing the deforestation.

Journal: International journal of trichology 20110101

Title: Alopecia: evaluation and treatment.

Journal: Clinical, cosmetic and investigational dermatology 20110101

Title: Alopecia areata: a new treatment plan.

Journal: Clinical, cosmetic and investigational dermatology 20110101

Title: Renbok phenomenon and contact sensitization in a patient with alopecia universalis.

Journal: Archives of dermatology 20100401

Title: Contact immunotherapy-induced Renbök phenomenon in a patient with alopecia areata and psoriasis vulgaris.

Journal: European journal of dermatology : EJD 20100101

Title: Vitiligo after diphencyprone for alopecia areata.

Journal: Dermatology research and practice 20100101

Title: Management of alopecia areata.

Journal: BMJ (Clinical research ed.) 20100101

Title: Topical immunotherapy in alopecia areata.

Journal: International journal of trichology 20100101

Title: Usefulness of topical immunotherapy with squaric acid dibutylester for refractory common warts on the face and neck.

Journal: The Journal of dermatology 20091201

Title: Long-pulsed Nd:YAG laser treatment of warts: report on a series of 369 cases.

Journal: Journal of Korean medical science 20091001

Title: Immunotherapy for childhood warts.

Journal: Pediatric annals 20090701

Title: Treatment of alopecia areata in children.

Journal: Pediatric annals 20090701

Title: Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases.

Journal: The Journal of dermatology 20090601

Title: Discoid lupus erythematosus exacerbated by contact dermatitis caused by use of squaric acid dibutylester for topical immunotherapy in a patient with alopecia areata.

Journal: The Journal of dermatology 20080301

Title: Determination of in vivo dose response and allergen-specific T cells in subjects contact-sensitized to squaric acid dibutyl ester.

Journal: Dermatitis : contact, atopic, occupational, drug 20080101

Title: Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides.

Journal: Bioorganic & medicinal chemistry letters 20071115

Title: The importance of myeloid-derived suppressor cells in the regulation of autoimmune effector cells by a chronic contact eczema.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20071015

Title: A chronic contact eczema impedes migration of antigen-presenting cells in alopecia areata.

Journal: The Journal of investigative dermatology 20060701

Title: Haptens as drugs: contact allergens are powerful topical immunomodulators.

Journal: Journal of drugs in dermatology : JDD 20060501

Title: Efficacy and safety of the topical sensitizer squaric acid dibutyl ester in Alopecia areata and factors influencing the outcome.

Journal: Journal of drugs in dermatology : JDD 20060301

Title: Determination of the sildenafil effect on alopecia areata in childhood: An open-pilot comparison study.

Journal: The Journal of dermatological treatment 20060101

Title: Prolonged dermatitis distant to the site of squaric acid dibutyl ester applications and recovery of alopecia areata.

Journal: Clinical and experimental dermatology 20050901

Title: Topical immunomodulator therapy with squaric acid dibutylester (SADBE) is effective treatment for severe alopecia areata (AA): results of an open-label, paired-comparison, clinical trial.

Journal: The Journal of dermatological treatment 20050201

Title: Topical immunotherapy of severe alopecia areata with diphenylcyclopropenone (DPCP): experience in an Iranian population.

Journal: BMC dermatology 20050101

Title: Topical sensitizers in alopecia areata.

Journal: Dermatology nursing 20040801

Title: Chronic delayed-type hypersensitivity reaction as a means to treat alopecia areata.

Journal: Clinical and experimental immunology 20040301

Title: Alopecia areata: treatment of today and tomorrow.

Journal: The journal of investigative dermatology. Symposium proceedings 20030601

Title: Lentiginous eruption due to topical immunotherapy.

Journal: Archives of dermatology 20030401

Title: The pattern and profile of alopecia areata in Singapore--a study of 219 Asians.

Journal: International journal of dermatology 20021101

Title: Seventeen cases of alopecia areata: combination of SADBE topical immunotherapy with other therapies.

Journal: The Journal of dermatology 20021001

Title: Topical immunotherapy with contact sensitizers: a model to study the natural history of delayed hypersensitivity.

Journal: Contact dermatitis 20021001

Title: Insights into the quantitative relationship between sensitization and challenge for allergic contact dermatitis reactions.

Journal: Toxicology and applied pharmacology 20020815

Title: Adult and paediatric contact immunotherapy with squaric acid dibutylester (SADBE) for recurrent, multiple, resistant, mucocutaneous anogenital warts.

Journal: Sexually transmitted infections 20020801

Title: Topical immunotherapy with squaric acid dibutylester: unusual hair pigmentary changes in two cases of alopecia areata.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20020301

Title: A clinical study of childhood alopecia areata in Singapore.

Journal: Pediatric dermatology 20020101

Title: The therapeutic use of topical contact sensitizers in benign dermatoses.

Journal: The British journal of dermatology 20010901

Title: An answer to some questions raised by skin reactions observed during squaric acid dibutylester contact sensitization.

Journal: Contact dermatitis 20010901

Title: Squaric acid dibutylester: indications for use and efficacy in alopecia areata.

Journal: Archives of dermatology 20010701

Title: Current and potential agents for the treatment of alopecia areata.

Journal: Current pharmaceutical design 20010201

Title: Patients with epidermodysplasia verruciformis show no response to contact immunotherapy.

Journal: Dermatology (Basel, Switzerland) 20010101

Title: [Treatment of alopecia areata with diphencyprone].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20010101

Title: The loss of contact sensitization in man.

Journal: Contact dermatitis 19910301

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